Clinical trials: NETs
Advanced and Metastatic Silent Neuro-Endocrine Tumors, Carcinoma
RAMSETE: RAD001 in Advanced and Metastatic Silent Neuro-endocrine Tumors in Europe
To evaluate the preliminary efficacy and safety of RAD001 as monotherapy for first-line treatment of patients with metastatic papillary carcinoma of the kidney.
- Conditions
- Advanced and Metastatic Silent Neuro-Endocrine Tumors, Carcinoma, Neuroendocrine, Non Functioning Neuroendocrine Tumors (NETs)
- Trial name
- RAMSETE/CDE16 (NCT00688623)
- Testing
- Everolimus
- Where
- 40 sites in France, Germany and 6 more
- Volunteers
- 73 people
- Sponsor
- Novartis Pharmaceuticals
Osteoporosis
A Study on Vertebral Bone Strength by Micro-CT-Like Image
In this study, we use conditional generation adversarial network to enhance the resolution of MSCT images and obtain micro-CT-like images.
- Trial name
- NCT04954417
- Testing
- Radiological scanning, Deep learning, Bio-mechanical testing
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University Third Hospital
Malaria
Impact of School-based Delivery of Long Lasting Insecticide Nets
Insecticide-treated nets (ITNs), and more recently long lasting insecticide nets (LLINs), have been shown to effectively protect those groups most biologically vulnerable to the burden of malaria across Africa.
- Trial name
- NCT00878397
- Testing
- School-based delivery of long lasting insecticide nets
- Where
- Kenya
- Volunteers
- 5,113 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Neuroendocrine Tumors
68Ga-DOTA-TATE PET/CT Imaging in NETs
This clinical trial is a pragmatic study aiming to evaluate the innocuity/safety profile of the PET radiotracer 68Ga-DOTA-TATE, and to establish the procedure as a routine standard-of-care diagnostic tool for all neuro-endocrine…
- Trial name
- NCT04847505
- Testing
- 68Ga-DOTA-TATE
- Where
- 2 sites in Canada
- Volunteers
- 5,000 people
- Sponsor
- Centre de recherche du Centre hospitalier universitaire de Sherbrooke
Lung Atypical Carcinoid Tumor, Lung Typical Carcinoid Tumor
Survivin Long Peptide Vaccine in Treating Patients With Metastatic Neuroendocrine Tumors
This phase I trial studies the side effects of survivin long peptide vaccine and how it works with the immune system in treating patients with neuroendocrine tumors that have spread to other parts of the body (metastatic).
- Conditions
- Lung Atypical Carcinoid Tumor, Lung Typical Carcinoid Tumor, Metastatic Pancreatic Neuroendocrine Tumor
- Trial name
- NCT03879694
- Testing
- Incomplete Freund's Adjuvant, Octreotide Acetate, Sargramostim
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Roswell Park Cancer Institute
GEP-NET, Gastroenteropancreatic Neuroendocrine Tumor
Study of RYZ401 in Subjects With Solid Tumors Expressing SSTRs.
The primary objectives are to determine the recommended Phase 2 dose (RP2D) and optimal treatment regimen, characterize safety and tolerability, and evaluate preliminary efficacy of RYZ401 in subjects with NETs and other selected…
- Conditions
- GEP-NET, Gastroenteropancreatic Neuroendocrine Tumor, Gastroenteropancreatic Neuroendocrine Tumor Disease, Neuroendocrine Tumors
- Trial name
- NCT07165132
- Testing
- RYZ401
- Where
- 14 sites in United States, Canada
- Volunteers
- 104 people
- Sponsor
- RayzeBio, Inc.
Malaria, Anemia
Efficacy of Two Dual Active Ingredient Long Lasting Insecticidal Nets for Control of Malaria Transmitted by Pyrethroid Resistant Vectors in Benin
The massive scale-up of Long Lasting Insecticidal Nets (LLIN) has led to a major reduction in malaria burden (up to 50%) in many sub-Saharan African countries.
- Trial name
- NNP (NCT03931473)
- Testing
- Bed nets
- Where
- Benin
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Acute Pancreatitis, Organ Failure, Multiple
Safety, Tolerability and Performance of the NucleoCapture Extracorporeal Therapeutic Apheresis Device in the Reduction of Circulating cfDNA/NETs in Subjects With Pancreatitis
This is a single-centre, randomised-controlled, open-label, feasibility study to assess the safety, tolerability and performance of the NucleoCapture extracorporeal apheresis device in the reduction of circulating cell-free DNA…
- Trial name
- NUC-SAP1 (NCT06566638)
- Testing
- NucleoCapture device
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Neuroendocrine Tumors, Frailty
Metronomic Temozolomide in Unfit NENs Patients Metronomic Temozolomide in Unfit Patients With Advanced Neuroendocrine Neoplasms (NENs): MeTe Study
Study design and rationale: Neuroendocrine neoplasms (NENs ) represent a heterogeneous group of malignancies, which differ in terms of behavio r and prognosis.
- Conditions
- Neuroendocrine Tumors, Frailty, Chemotherapy Effect
- Trial name
- MeTe (NCT05554003)
- Testing
- Temozolomide capsule
- Where
- Italy
- Volunteers
- 46 people
- Sponsor
- European Institute of Oncology
Iodine-resistant Thyroid Cancer, Meningioma
A Dual-targeting Tracer TATE-RGD for the Diagnosis of SSTR- and RGD- Positive Tumors
The US FDA approved a targeted somatostatin receptor 2 imaging agent, 68Ga-DOTATATE, in 2016. It has higher uptake in small cell lung cancer, pulmonary carcinoid, and medullary thyroid cancer.
- Conditions
- Iodine-resistant Thyroid Cancer, Meningioma, NETs
- Trial name
- NCT06632860
- Testing
- 68Ga-TATE-RGD, 18-FDG
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking Union Medical College Hospital
Malaria
Estimating the Malaria Prevention Impact of New Nets: Observational Analyses to Evaluate the Evidence Generated During Piloted New Net Distributions in Mozambique
The use of insecticide-treated bed nets (ITNs) has contributed to the substantial reduction in malaria cases and deaths. This progress is threatened by increasing resistance to commonly used insecticides in important mosquito…
- Trial name
- NCT04716387
- Testing
- Standard LLIN, Piperonyl butoxide ITN, Pyriproxyfen ITN
- Where
- Mozambique
- Volunteers
- 8,726 people
- Sponsor
- PATH
Gastroenteropancreatic Neuroendocrine Tumours
Quality of Life, Treatment Experience and Cost of Treatment With Somatostatin Analogues in Patients With Gastroenteropancreatic Neuroendocrine Tumours
Data from this study will contribute additional knowledge regarding patient outcomes and direct somatostatin analogue (SSA) treatment related costs in clinical practice in the Nordic countries.
- Trial name
- STREET (NCT02788565)
- Where
- 2 sites in Sweden
- Volunteers
- 156 people
- Sponsor
- Ipsen
Carcinoid Tumors, Pancreatic NET
Phase II Study of Ibrutinib in Advanced Carcinoid and Pancreatic Neuroendocrine Tumors
This is a prospective phase II open-label trial, stratifying patients equally into two cohorts consisting of carcinoid tumors and pancreatic neuroendocrine tumors (pNETs).
- Trial name
- NCT02575300
- Testing
- Ibrutinib
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Gastroenteropancreatic Neuroendocrine Tumors
Sirolimus for Injection (Albumin Bound) Combined With Octreotide Long-acting Injection in Patients With Metastatic Gastroenteropancreatic Neuroendocrine Tumors
There is limited evidence regarding the benefit of adding somatostatin analogs to molecular targeted agents for well-differentiated gastroenteropancreatic neuroendocrine tumors (GEP-NETs) with poor prognostic factors.
- Trial name
- NCT07165886
- Testing
- Sirolimus for injection (albumin bound), Octreotide long-acting injection, Everolimus
- Where
- China
- Volunteers
- 298 people
- Sponsor
- CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
E-cigarette Use, Microcirculation
The Acute Effects of E-cigarette Inhalation on Vascular Function, Microcirculation and Thrombosis
This is a human randomized controlled cross-over study where the effects of e-cigarette inhalation (with or without nicotine) on vascular function, microcirculation and thrombosis is assessed.
- Conditions
- E-cigarette Use, Microcirculation, Thrombosis, Vascular Function
- Trial name
- NCT04175457
- Testing
- e-cigarette
- Where
- Sweden
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Neuroendocrine Tumors, Carcinoid Tumor of GI System
Evaluating an Amino Acid Based Medical Food w/ Diarrhea in Carcinoid Syndrome & Other NETs
Primary Objective: To assess how an amino acid based medical food (Enterade®) helps maintain the intestine's ability to absorb and retain fluids, leading to a reduction in diarrhea due to Neuroendocrine Tumors (NET) and/or…
- Conditions
- Neuroendocrine Tumors, Carcinoid Tumor of GI System, Diarrhea, Carcinoid Syndrome
- Trial name
- NCT03722511
- Testing
- Amino Acid Based Medical Food/Drink
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Lowell Anthony, MD
Grade1-2 Advanced Midgut Neuroendocrine Tumors (NETs)
Randomized Interval Assessment Trial of Lu177-Dotatate in Slowly Progressive G1-2 Advanced Midgut Neuroendocrine Tumors
This is a randomized Phase II/late phase I de-escalation clinical trial with approved investigational medicinal products in new use condition, low intervention.
- Trial name
- RIALTO (NCT06878664)
- Testing
- 177Lu-Dotatate (7.4 Gigabecquerel/cycle) during 30 min intravenous infusion every 16 weeks (q8w) x 4 cycles; 2) and 3) as in the experimental arm., 177Lu-Dotatate (7.4 Gigabecquerel/cycle) during 30 min intravenous infusion every 8 weeks (q8w) x 4 cycles; 2) and 3) as in the experimental arm., Amino acid solution
- Where
- 21 sites in France, Spain
- Volunteers
- 166 people
- Sponsor
- Grupo Espanol de Tumores Neuroendocrinos
Gastroenteropancreatic Neuroendocrine Tumor, Radiotherapy
Multi-modal Characterisation of Gastroenteropancreatic Neuroendocrine Tumours (GEP-NETs) Treated With Targeted Radionuclide Therapy (TRT): Prospective Interventional Multicentre National Cohort
Operandi project aims to address unmet clinical needs in the current management of GEP-NETs treated with PRRT by exploring new opportunities provided by imaging-based (AI algorithms) and data augmentation, simultaneous…
- Trial name
- OPERANDI-NET (NCT06256705)
- Testing
- Simultaneous 68Ga-DOTATOC PET-MRI
- Where
- 5 sites in France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Neuroendocrine Tumors
Study to Evaluate the Use of Resources and the Costs Associated With Carcinoid Syndrome (CS) in Patients With NETs in Spain
The objective of this study is to describe the use of resources and the costs associated with controlled or uncontrolled CS in patients with NETs in Spain.
- Trial name
- RECOSY (NCT03220087)
- Testing
- Data collection
- Where
- 28 sites in Spain
- Volunteers
- 142 people
- Sponsor
- Ipsen
Pancreatic Neuroendocrine Tumor
ATRX/DAXX in EUS-FNB Specimens of Pan-NETs
P-NENs are classified as functional (F-) or non-functional (NF-) depending on the presence or absence of a clinical hormonal hypersecretion syndrome.
- Trial name
- FORESEE (NCT06406387)
- Testing
- ATRX/DAXX immunohistochemistry
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona