Clinical trials: N-Acetylcysteine
Head and Neck Cancer
Effect of N-Acetyl Cysteine (NAC) on the Oral Microbiome
This is a Phase II treatment, randomized 3:1 ratio, open label clinical trial to study the effect of short duration administration of N-acetyl cysteine on oral microbiome and on mucositis caused by concurrent chemotherapy and…
- Trial name
- NCT03982537
- Testing
- N-Acetyl-L-Cysteine dietary supplement, Chemotherapy and Radiation
- Sponsor
- Wake Forest University Health Sciences
Nephropathy
A Prospective, Randomized TrialComparing Oral N-Acetylcysteine and Intravenous Sodium Bicarbonate
The purpose of this study is to compare the efficacy of oral N-acetylcysteine and intravenous sodium bicarbonate for the prevention of Contrast-Induced Nephropathy (CIN) after cardiac catheterization.
- Trial name
- PROTECt (NCT00579995)
- Testing
- Oral N-Acetylcysteine, Sodium Bicarbonate
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Stage 0/1 Breast Cancer, Post Biopsy
Pilot Study of Anti-oxidant Supplementation With N-Acetyl Cysteine in Stage 0/I Breast Cancer
NAC is the N-acetyl derivative of the naturally occurring amino acid, L-cysteine. It is a common over-the-counter supplement and also is available as an injectable pharmaceutical that protects the liver in cases of acetaminophen…
- Conditions
- Stage 0/1 Breast Cancer, Post Biopsy, Pre-surgery
- Trial name
- NAC (NCT01878695)
- Testing
- IV/oral n-acetylcysteine
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Diabetic Nephropathies, Proteinuria
N-Acetylcysteine and Milk Thistle for Treatment of Diabetic Nephropathy
The study is designed to test if the combination of two potent antioxidant nutritional supplements, N-acetylcysteine and the milk thistle extract silibin, is capable of correcting the shedding of urine protein, the oxidative…
- Conditions
- Diabetic Nephropathies, Proteinuria, Oxidative Stress
- Trial name
- NCT00915200
- Testing
- N-acetylcysteine, silibin, high-dose silibin
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Corrosive Injury
Evaluation of the Role of N Acetyl Cysteine and Vitamin D in Improving Outcomes After Corrosive Ingestion
The goal of this clinical trial is to learn if N acetyl cysteine and vitaminD work to improve outcomes after corrosive ingestion in children.
- Trial name
- NCT07229456
- Testing
- N Acetyl Cysteine, Vitamin D (Cholecalciferol ), control group
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Bipolar Disorder
Efficacy of N-Acetyl-Cysteine in Bipolar Disorder and Tobacco Use Disorder
Effects of N-Acetyl-Cysteine in patients with bipolar depression (primary outcome is Hamilton Depression Rating Scale) with and without tobacco use disorder and on inflammatory and oxidative stress biomarkers
- Trial name
- NACBD (NCT02252341)
- Testing
- N-Acetyl-Cysteine
- Where
- Brazil
- Volunteers
- 130 people
- Sponsor
- Universidade Estadual de Maringá
Liver Failure, Liver Failure, Acute
Use of N-Acetylcysteine During Liver Procurement
Randomized prospective study on the impact on the post-LT outcome by the infusion of N-acetylcysteine (NAC) during the liver procurement procedure, as an anti-oxidant agent to reduce the ischemia-reperfusion damage of organs for…
- Conditions
- Liver Failure, Liver Failure, Acute, Liver Diseases, Carcinoma, Hepatocellular
- Trial name
- NCT01394497
- Testing
- N-acetylcystein
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Azienda Ospedaliera di Padova
Atherosclerosis of Artery, Peripheral Artery Disease
NAC Treatment and Outcomes in Patients With Advanced Atherosclerosis and DM
Atherosclerosis and diabetes are related to coronary artery disease and peripheral artery disease. The mechanisms are related to increased reactive oxygen species (ROS) formation and inflammatory cytokine secretion.
- Conditions
- Atherosclerosis of Artery, Peripheral Artery Disease, Diabetes Mellitus, Inflammation
- Trial name
- RENEWAL (NCT05908513)
- Testing
- N-acetylcysteine
- Where
- 2 sites in China
- Sponsor
- University of Missouri-Columbia
Acetaminophen Toxicity
Treatment of Acetaminophen Toxicity With N-acetylcysteine
Retrospective chart review of patients who received N-acetylcysteine for APAP toxicity to assess length of oral vs IV treatment and overall healthcare costs.
- Trial name
- NCT00725179
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Akron Children's Hospital
COPD
Pilot Study to Assess the Effect of High Dose N-acetylcysteine (NAC) in Chronic Obstructive Pulmonary Disease (COPD) Patients
Studies suggest that N-acetylcysteine (NAC) potentially reduces inflammation and hyperinflation in patients with COPD. In this pilot study the efficacy, safety and tolerability of high dose NAC in 12 patients with moderate COPD…
- Trial name
- NCT00969904
- Testing
- N-acetylcysteine
- Where
- Belgium
- Volunteers
- 12 people
- Sponsor
- University Hospital, Antwerp
Drug Induced Liver Injury
Efficacy of N-acetylcysteine With or Without Steroids in Drug Induced Liver Injury
Intervention - Subjects will be randomized to 2 groups Group A - subjects will receive Prednisolone for 20 days with NAC (N-Acetylcysteine) Group B - will receive NAC (N-Acetylcysteine) only NAC (N-acetylcysteine) dosing Loading…
- Trial name
- NCT02686385
- Testing
- Prednisolone, N-Acetylcysteine
- Where
- India
- Volunteers
- 4 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Contrast Induced Nephropathy, Critically Ill
N-Acetylcysteine in Critically Ill Patients Undergoing Contrast Enhanced Computed Tomography
Critically ill patients frequently undergo contrast enhanced computed tomography (CT) to establish diagnoses and direct management. Contrast agents can disturb kidney function and result in kidney dysfunction.
- Trial name
- NCT00830193
- Testing
- N-acetylcysteine
- Where
- 2 sites in Canada
- Volunteers
- 45 people
- Sponsor
- Unity Health Toronto
Ulcerative Colitis, Left-sided Ulcerative Colitis
Study of the Safety and Efficacy of Zoenasa® Versus Mesalamine Enema in Subjects With Left-Sided Ulcerative Colitis
This double-blind, randomized, comparator-controlled Phase II study is designed to establish the safety and efficacy of Zoenasa Rectal Gel compared to mesalamine enema in subjects with left-sided ulcerative colitis, as measured…
- Conditions
- Ulcerative Colitis, Left-sided Ulcerative Colitis, Distal Ulcerative Colitis
- Trial name
- NCT01586533
- Testing
- Zoenasa-1:4, Mesalamine Enema
- Where
- 45 sites in United States
- Volunteers
- 120 people
- Sponsor
- Altheus Therapeutics, Inc.
Unspecified Complication of Liver Transplant
Effectiveness of N-acetylcysteine on Preservation Solution During Liver Transplantation
Evaluate the effectiveness of the administration produced antioxidant N-acetylcysteine (NAC), decreasing the incidence of primary graft dysfunction and primary failure.
- Trial name
- NCT01866644
- Testing
- N-acetylcysteine, Saline
- Where
- Spain
- Volunteers
- 214 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Polycystic Ovary Syndrome
The Combined Effect of N-Acetyl Cysteine and Metformin in Polycystic Ovary Syndrome Patients
The study aims to evaluate the effects of combination of metformin with NAC in PCOS on biochemical and hormonal parameters.
- Trial name
- PCOS (NCT06836128)
- Testing
- N-acetyl cysteine, Metfomin
- Where
- Egypt
- Volunteers
- 102 people
- Sponsor
- Cairo University
Sickle Cell Disease, Sickle Cell Anemia
A Pilot Study of N-acetylcysteine in Patients With Sickle Cell Disease
Part 1: A pilot study in patients with homozygous S (HbSS) or hemoglobin S with beta zero thalassemia(HbS-βo thalassemia), with the aim of examining the effect of intravenous NAC treatment on plasma VWF parameters and measures of…
- Trial name
- NACinSCD (NCT01800526)
- Testing
- N-Acetylcysteine
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Bloodworks
Tobacco Smoking, Oxidative Stress
N-acetylcysteine for Tobacco Smoking
The purpose of this study is to investigate the efficacy of N-acetylcysteine (NAC) for smoking cessation in a double blind, randomized, placebo-controlled trial.
- Conditions
- Tobacco Smoking, Oxidative Stress, Inflammation
- Trial name
- NACNOS (NCT02124525)
- Testing
- N-acetylcysteine
- Where
- Brazil
- Volunteers
- 32 people
- Sponsor
- Universidade Estadual de Londrina
Cocaine Dependence
Functional Magnetic Resonance Imaging of N-acetylcysteine in Cocaine Dependence
The objective of this research is to identify the functional neural mechanisms (as assessed using fMRI) of short-term N-acetylcysteine (NAC) administration among methadone-maintained individuals with cocaine dependence.
- Trial name
- NCT02994875
- Testing
- N-acetylcysteine
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Yale University
Chronic Kidney Diseases, General Anesthesia
Effect of N-acetylcysteine on Renal Functioning of Chronic Kidney Diseases(CKD) Patients After General Anesthesia
Acute kidney injury (AKI) is one of the most serious and frequent complication of general anesthesia. Patients suffer from chronic kidney diseases (CKD) predispose to develop AKI.
- Trial name
- NCT01251029
- Testing
- N-acetylcysteine, Siran (N-acetylcysteine)
- Where
- Israel
- Sponsor
- Assaf-Harofeh Medical Center
Bipolar Disorder
N-Acetyl Cysteine and Aspirin as an Adjunctive Treatment for Bipolar Disorder
We propose to conduct a double-blind placebo-controlled trial with a widely available and prototypical non-steroidal anti-inflammatory agent, aspirin, and an antioxidant agent, NAC, involving symptomatic Bipolar Disorder type I…
- Trial name
- SMRI-Bipolar (NCT01797575)
- Testing
- Aspirin, N-acetyl-cysteine (NAC), Sugar Pill
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- The University of Texas Health Science Center, Houston