Clinical trials: Myocardial Viability
Coronary Artery Disease, Ischemic Heart Disease (IHD)
Prognostic Value of Hyperpolarized 13C MRI for Clinical Myocardial Viability
Heart failure due to coronary artery disease represents a significant cause of mortality. The detection of patients eligible for bypass surgery is a pivotal concern.
- Conditions
- Coronary Artery Disease, Ischemic Heart Disease (IHD), Myocardial Viability
- Trial name
- NCT06047028
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Cardiac Pacing, Artificial
Transcoronary Pacing and Myocardial Viability
Narrowing of the coronary arteries can cause chest pain and weaken the heart. In patients who have had heart attacks, blocked or severely narrowed arteries should be investigated (with coronary artery x-rays, or angiography) with…
- Trial name
- NCT04258228
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Chronic Total Occlusion of Coronary Artery, Percutaneous Coronary Intervention
The Success of Opening Concurrent CTO leSion to Improve Cardiac Function Trial in Patients With Multi-vessel Disease
The purpose of this study is to investigate the effect of percutaneous coronary intervention (PCI) on cardiac function in multi-vessel disease patients with concurrent chronic total occlusion (CTO) lesion.
- Conditions
- Chronic Total Occlusion of Coronary Artery, Percutaneous Coronary Intervention, Coronary Artery Disease, Viable Myocardium
- Trial name
- SOS-moral (NCT03372785)
- Testing
- aspirin, betaloc, atorvastatin, rosuvastatin, clopidogrel, ticagrelor, coronary wires. stents or coronary balloons
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Beijing Anzhen Hospital
Coronary Artery Disease, Coronary Artery Bypass Graft (CABG)
Hyperpolarized 13C Pyruvate-MRI and FDG-PET in a Single Exam for the Prognosis of Ischemic Cardiomyopathy
This prospective, non-blinded, single-center, translational research study aims to validate a multimodal advanced imaging exam for cardiac viability.
- Trial name
- FDG PET-HP MRI (NCT06814587)
- Testing
- Hyperpolarized 13C Pyruvate Magnetic Resonance Imaging (HP-13C MRI), [¹⁸F]Fluorodeoxyglucose Positron Emission Tomography (FDG-PET), SPECT MPI (Single Photon Emission Computed Tomography Myocardial Perfusion Imaging)
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Heart Disease
Magnetic Resonance Imaging of the Blood Vessels of the Heart
This study is directed at evaluating patients with "myocardial ischemia" or poor blood supply to the heart muscle due to coronary artery disease.
- Trial name
- NCT00001638
- Where
- 2 sites in United States
- Volunteers
- 2,916 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Arteriosclerosis, Heart Failure, Congestive
Evaluation of Myocardial Viability by Means of Low-dose Dobutamine Gated SPECT (the DOGS Study)
Viability assessment remains a clinical challenge in patient with coronary artery disease and left ventricular dysfunction. Several imaging modalities are available for evaluating myocardial viability, based either on perfusion…
- Conditions
- Coronary Arteriosclerosis, Heart Failure, Congestive, Myocardial Infarction, Myocardial Ischemia
- Trial name
- NCT00213746
- Where
- 8 sites in Belgium, France
- Volunteers
- 75 people
- Sponsor
- University Hospital, Rouen
Heart Failure, Ischemic Heart Disease
Cardiac FDG PET Viability Registry
Positron Emission Tomography (PET) is a non-invasive, unique nuclear imaging technique that allows the evaluation of blood flow in the heart and provides information about the cell activity of specific organs such as the heart…
- Conditions
- Heart Failure, Ischemic Heart Disease, Myocardial Dysfunction
- Trial name
- CADRE (NCT00766987)
- Where
- 4 sites in Canada
- Volunteers
- 2,000 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Ischemic Cardiomyopathy
Stress Cardiac MRI in Ischemic Patients
The aim of this study is to assess the diagnostic accuracy of CMR feature-tracking (FT) at rest \& during stress with low dose dobutamine (LDD) in the evaluation of viability in ischemic cardiomyopathy (ICM) patients and compare…
- Trial name
- NCT04588675
- Testing
- MRI
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Ischemic Heart Disease
A Clinical Study of Evaluating Myocardial Viability in Ischemic Heart Disease with Integrated 18F-FDG PET/MR
The main purpose is to evaluate the accuracy of myocardial imaging obtained through integrated 18F-FDG PET/MR in detecting viable myocardium.
- Trial name
- NCT06712862
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai East Hospital
Myocardial Scarring
Viability Imaging in Volumetric Angiography (VIVA 1)
The primary objective of this study is twofold: 1. To define inter-reader variability of myocardial viability imaging within the first pass and delayed enhancement cardiac CT perfusion imaging 2.
- Trial name
- VIVA 1 (NCT01408134)
- Testing
- DE CT
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Medstar Health Research Institute
Acute Myocardial Infarction, Myocardial Viability
The Assessment Of Myocardial Viability Based On CTA/MRI Hybrid Models
The aim of HYBRIDHEART study is to develop new imagistic prototype for a complex evaluation of the myocardial viability by superposing computed tomographic angiographic polar maps of the myocardium with magnetic resonance imaging…
- Conditions
- Acute Myocardial Infarction, Myocardial Viability, Vulnerable Coronary Plaques, Coronary Stenosis
- Trial name
- HYBRIDHEART (NCT04397198)
- Testing
- Speckle Tracking echocardiography
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- Cardio Med Medical Center
Hibernation, Myocardial, Complete Occlusion of Coronary Artery
The Success of Opening Single CTO Lesions to Improve Myocardial Viability Study (SOS-comedy)
The purpose of this study is to investigate the effect of percutaneous coronary intervention (PCI) on myocardial viability in coronary artery disease patients with single coronary total occlusion (CTO) lesions.
- Trial name
- NCT02767401
- Testing
- stenting or balloon expansion, aspirin, clopidogrel, ticagrelor, atorvastatin, rosuvastatin, betaloc
- Volunteers
- 200 people
- Sponsor
- The First Affiliated Hospital of Dalian Medical University
Cardiovascular Diseases, Coronary Disease
Home-based Cardiac Rehabilitation: Compliance and Effectiveness
The proposal of this study is to verify if it is feasible and effective to offer a home based cardiac rehabilitation program, that includes the components of health education and physical exercises mostly unsupervised and…
- Conditions
- Cardiovascular Diseases, Coronary Disease, Cardiac Disease
- Trial name
- NCT03605992
- Testing
- Home-based Rehab, CentreRehab
- Where
- Brazil
- Volunteers
- 51 people
- Sponsor
- Federal University of Minas Gerais
Myocardial Infarction, Myocardial Ischemia
Coronary Flow and Myocardial Viability: the FloVITA Study
Evaluation of fractional flow reserve (FFR) is a key method for assessing ischemia with a view to guiding revascularization strategy following acute coronary syndrome.
- Trial name
- FloVita (NCT04818918)
- Testing
- Absolute coronary flow measurement, Microvascular resistance measurement, Cardiac MRI
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Coronary Disease, Heart Diseases
Myocardial Contrast Echocardiography (MCE) to Check for Living and Working Heart Muscle
Coronary artery disease (CAD) can cause poor blood flow and supply to the heart muscle. It can result in irreversible damage to the heart muscle and poor function.
- Trial name
- NCT00001891
- Testing
- Myocardial contrast echocardiography, Dobutamine echocardiography
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiomyopathy, Congenital Heart Disease
Technical Development of Cardiovascular Magnetic Resonance Imaging
This study will explore new ways of using magnetic resonance imaging (MRI) to evaluate the heart and blood vessels of patients with cardiovascular disease, including better detection of myocardial infarction (heart attack) and…
- Conditions
- Cardiomyopathy, Congenital Heart Disease, Cardiovascular Disease, Cardiac Magnetic Resonance Imaging
- Trial name
- NCT00027170
- Testing
- Siemens MRI scanner
- Where
- 2 sites in United States
- Volunteers
- 8,781 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
ISCHEMIC CARDIOMYOPATHY
Efficacy of EVP 1001-1 (SeeMore) in the Assessment of Myocardial Viability in Patients With Cardiovascular Disease
The investigator hopes to introduce a novel MRI contrast agent with SeeMore ™ that directly defines viable myocardium. Identifying viable myocardium non-invasively using cardiac MRI is still a moving target and a question we plan…
- Trial name
- NCT01989195
- Testing
- 'SEEMORE' - MANGANESE-ENHANCED MRI CONTRAST REAGENT
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Stanford University
Myocardial Infarction
Assessment of Myocardial Viability Using Multidetector Computed Tomography
To perform a comprehensive evaluation of multidetector CT myocardial enhancement patterns in patients with an acute ST elevation MI.
- Trial name
- NCT00285064
- Testing
- CT
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Rambam Health Care Campus
Myocardial Infarction, Coronary Artery Disease
The Viability-Guided Angioplasty After Acute Myocardial Infarction-Trial (The VIAMI-Trial)
The VIAMI-trial investigates the effects of balloon angioplasty with stenting of the infarct-vessel in the early phase after acute myocardial infarction.
- Trial name
- NCT00149591
- Testing
- coronary balloon-angioplasty with stenting
- Where
- 12 sites in Netherlands
- Volunteers
- 300 people
- Sponsor
- Netherlands Heart Foundation
Cardiovascular Diseases, Ischemic Cardiomyopathy
Improved Prediction of Functional Recovery After Revascularisation Using Combined Assessment of Myocardial Ischaemia and Viability by CMR - Pilot Study
The study will investigate whether a new high resolution heart Magnetic Resonance Imaging scan, combining assessment of ischemia and viability by perfusion and Late Gadolinium Enhancement -Cardiac Magnetic Resonance is superior…
- Conditions
- Cardiovascular Diseases, Ischemic Cardiomyopathy, Cardiac Ischemia
- Trial name
- NCT03798652
- Testing
- Research CMR scan, Research 3D transthoracic echocardiogram, 6-minute walk test
- Where
- United Kingdom
- Volunteers
- 56 people
- Sponsor
- King's College London