Clinical trials: Myelopathy, Compressive
Spinal Cord Compression, Unspecified Adult Solid Tumor, Protocol Specific
Spinal Cord Compression. ICORG 05-03, V6
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. It is not yet known which radiation therapy schedule is more effective in treating patients with malignant spinal cord compression.
- Trial name
- NCT00968643
- Testing
- radiation therapy
- Where
- 4 sites in Ireland
- Volunteers
- 126 people
- Sponsor
- Cancer Trials Ireland
Pain, Radiation Toxicity
Spinal Cord Compression Re-Treat Study
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Radiation therapy may be effective in treating malignant spinal cord compression in patients who have received previous radiation therapy to the spine.
- Conditions
- Pain, Radiation Toxicity, Spinal Cord Compression, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00974168
- Testing
- Cumulative BED ≤ 100, Cumulative BED ≤ 130 Gy2
- Where
- 2 sites in Ireland
- Volunteers
- 22 people
- Sponsor
- Cancer Trials Ireland
Radiculopathy, Cervical, Myelopathy Cervical
Cervical Arthroplasty Cost Effectiveness Study (CACES)
To date, no consensus exists on which anterior surgical technique is more cost-effective to treat cervical degenerative disc disease (CDDD).
- Conditions
- Radiculopathy, Cervical, Myelopathy Cervical, Myelopathy, Compressive, Radiculopathy, Cervical Region
- Trial name
- CACES (NCT04623593)
- Testing
- ACDF, ACDA
- Where
- Netherlands
- Volunteers
- 198 people
- Sponsor
- Valérie Schuermans
Neoplasm Metastasis, Spinal Cord Diseases
Laser Interstitial Thermal Ablation and Stereotactic Radiosurgery for Patients With Spine Metastases
The purpose of this research is to combine two complementary modes of treatment, spinal interstitial laser ablation and stereotactic spine radiosurgery (SSRS) for the treatment for spinal tumors near the spinal cord with an…
- Conditions
- Neoplasm Metastasis, Spinal Cord Diseases, Spinal Cord Compression, Spinal Cord Tumor
- Trial name
- NCT05023772
- Testing
- Stereotactic Laser Ablation, Stereotactic Radiosurgery, MRI guided laser ablation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Henry Ford Health System
Spinal Cord Injury, Spinal Cord Injuries
Testosterone Therapy With or Without Finasteride After Spinal Cord Injury: TRT-SCI Trial
Spinal cord injury (SCI) results in lower limb muscle loss, bone loss, and high fat mass that impede the recovery of physical function, increase bone fracture risk, and worsen health and quality of life.
- Conditions
- Spinal Cord Injury, Spinal Cord Injuries, Injuries, Spinal Cord, Spinal Cord Contusion
- Trial name
- TRT-SCI (NCT07742553)
- Testing
- testosterone cypionate, finasteride
- Where
- 4 sites in United States
- Volunteers
- 300 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Compression Due to Metastasis to Spine
High-precision Radiotherapy of Motor Deficits Due to Metastatic Spinal Cord Compression
The major goal of this clinical study is to investigate to which extent high-precision radiotherapy (RT) with modern techniques can prevent progression or recurrence of motor deficits (weakness) of the legs following RT.
- Trial name
- PRE-MODE (NCT03070431)
- Testing
- High-precision RT 5x5 Gy in 1 week
- Where
- Germany
- Volunteers
- 44 people
- Sponsor
- University Hospital Schleswig-Holstein
Bone Metastases
Study of Denosumab vs. Zoledronic Acid to Treat Bone Metastases in Subjects With Advanced Cancer or Multiple Myeloma.
The purpose of this study is to determine if denosumab is non-inferior to zoledronic acid (Zometa®) in the treatment of bone metastases (lytic bone lesions from multiple myeloma) in subjects with advanced cancer and multiple…
- Trial name
- NCT00330759
- Testing
- Denosumab, Zoledronic Acid
- Volunteers
- 1,779 people
- Sponsor
- Amgen
Hernia Lumbar, Lumbar Canal Stenosis
Erector Spinae Plane Block in Lumbar Release Surgery
The aim of this study is to observe or not a reduction in the consumption of morphine within 72 hours of the realization of an erector spinae plane block when preparing for a non-instrumented spine surgery.
- Conditions
- Hernia Lumbar, Lumbar Canal Stenosis, Spinal Cord Compression
- Trial name
- MERLIBERTION (NCT04925882)
- Testing
- Erector spinae plane block
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Clinique Saint Jean, France
Hypertension
Cervical Cord Compression and Hypertension
Myelopathy from cervical cord compression may induce hypertension and sympathetic hyperactivity. Anesthesia may suppress sympathetic activity and lead to hypotension that require vasopressor treatment.
- Trial name
- NCT04345822
- Testing
- Decompression surgery
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Cancer, Spine Metastasis
A Pilot Study to Explore Serum and Imaging Biomarkers in Patients With Spinal Cord Compression
One of the complications of having cancer in the spinal vertebrae is that it can spread and lead to compression of the spinal cord.
- Trial name
- NCT00928382
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Degenerative Cervical Spinal Myelopathy, Cervical Spinal Cord Compression
Quantitative MR Parameters in Non-myelopathic Degenerative Cervical Spinal Cord Compression: a Longitudinal Study.
Quantitative Magnetic Resonance Imaging Parameters as Predictors of Outcome for Non-Myelopathic Degenerative Cervical Cord Compression: A Longitudinal Study
- Trial name
- NOLOST (NCT06094166)
- Testing
- MRI
- Where
- Czechia
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Masaryk University
Cancer, Hematologic Malignancies
Denosumab Compared to Zoledronic Acid in the Treatment of Bone Disease in Patients With Multiple Myeloma
The purpose of this study is to determine if denosumab is non-inferior to zoledronic acid in the treatment of bone disease from multiple myeloma.
- Conditions
- Cancer, Hematologic Malignancies, Multiple Myeloma, Oncology
- Trial name
- NCT01345019
- Testing
- Denosumab, Zoledronic acid, Denosumab (for the open-label treatment phase)
- Where
- 309 sites in United States, Australia and 27 more
- Volunteers
- 1,718 people
- Sponsor
- Amgen
Mucopolysaccharidosis I, Lysosomal Storage Diseases
Intrathecal Enzyme Replacement Therapy for Spinal Cord Compression in Mucopolysaccharidosis (MPS) I
The investigators are studying the use of enzyme replacement therapy into the spinal fluid for treatment of spinal cord compression in the Hurler-Scheie and Scheie forms of mucopolysaccharidosis I (MPS I).
- Conditions
- Mucopolysaccharidosis I, Lysosomal Storage Diseases, Spinal Cord Compression
- Trial name
- NCT00215527
- Testing
- laronidase
- Where
- 2 sites in United States, Finland
- Volunteers
- 4 people
- Sponsor
- Patricia I. Dickson, M.D.
Neoplasm Metastasis, Spinal Cord Compression
Metastatic Spinal Cord Compression (MSCC): Treatment Timing and Survival Rate
Patients with metastatic spinal cord compression (MSCC) are treated with different options according to the life expectancy. Survival and surgical outcome can be influenced by surgical timing in MSCC patients treated with…
- Trial name
- NCT02934594
- Testing
- Palliative Decompression
- Volunteers
- 500 people
- Sponsor
- National Taiwan University Hospital
Spinal Cord Compression, Neoplasm Metastasis
Stereotactic Radiosurgery in Metastatic Spinal Cord Compression
To determine whether stereotactic radiosurgery of metastatic spinal cord compression is equivalent to decompressive surgery followed by external body radiation therapy to maintain ability to walk at 6 weeks.
- Trial name
- Stereocord (NCT02167633)
- Testing
- Decompression surgery, Radiosurgery, Fractionated Radiotherapy
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Malignant Spinal Cord Compression
The Clinical Efficacy of CT-Guided All-in-One Adaptive Emergency Radiotherapy for Spinal Cord Compression Caused by Spinal Metastases
The aim of this study is to implement a new protocol for concurrent and sequential dose-escalation radiotherapy based on CT-guided all-in-one adaptive emergency radiotherapy for spinal cord compression due to spinal metastases…
- Trial name
- NCT06608108
- Testing
- Non-intervention
- Volunteers
- 50 people
- Sponsor
- Peking University Third Hospital
Spinal Cord Compression Due to Metastasis to Spine
RAdiotherapy for Metastatic Spinal Cord Compression with Increased Radiation DosES
This clinical study aims to investigate whether high-precision radiotherapy, as supposed, leads to a better control of the irradiated spinal cord metastases when compared to conventional radiotherapy.
- Trial name
- RAMSES-01 (NCT04043156)
- Testing
- High-precision RT
- Where
- Germany
- Volunteers
- 52 people
- Sponsor
- University Hospital Schleswig-Holstein
Metastatic Epidural Spinal Cord Compression
Single Session Spine Stereotactic Radiosurgery in Metastatic Epidural Spinal Cord Compression
The goal of this clinical study is to learn the feasibility of using a single session of radiation, known as spine stereotactic radiosurgery (SSRS), to treat metastatic epidural spinal cord compression.
- Trial name
- NCT01256554
- Testing
- Stereotactic Radiosurgery (SSRS), Questionnaires
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- M.D. Anderson Cancer Center
Metastatic Spinal Cord Compression, Radiation Toxicity
Esophagus-sparing Radiotherapy for Metastatic Spinal Cord Compression.
Metastatic spinal cord compression (MSCC) is a serious complication to metastatic cancer and when diagnosed life expectancy is short. Treatment is palliative radiotherapy (RT).
- Conditions
- Metastatic Spinal Cord Compression, Radiation Toxicity, Esophagitis, Patient Reported Outcome Measures
- Trial name
- ESO-SPARE (NCT05109819)
- Testing
- Esophagus sparring radiotherapy treatment
- Where
- 2 sites in Denmark
- Volunteers
- 200 people
- Sponsor
- Herlev Hospital
Spondylosis, Cervical, Spinal Cord Compression
Validity of the Turkish Translation of the Modified JOA
Degenerative cervical myelopathy (DCM) is the most common cause of non-traumatic spinal cord dysfunction in adults and may lead to progressive motor, sensory, and autonomic impairment.
- Trial name
- NCT07448883
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Izmir Democracy University