Clinical trials: Musculoskeletal Model
Osteoarthritis, Knee, Hypertension
The Clinical Impact of Diet on Medical Conditions Treated Within Bundled Payment Models: a Pilot Study
Diet interventions (e.g., low-energy diets) are recommended as a treatment for obesity, obese patients with osteoarthritis, hypertension (HTN), and type 2 diabetes (T2D).
- Conditions
- Osteoarthritis, Knee, Hypertension, Type 2 Diabetes, Obesity
- Trial name
- NCT05735873
- Testing
- Low-energy diet
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Knee Osteoarthritis
Analgesic Effectiveness of Three Different Doses of a New Formulation of Lamaline in a Model of Painful Knee (Gonarthrosis)
This study aims to assess the analgesic effectiveness and safety of three different doses of a new formulation of Lamaline® versus Dafalgan® Codeine after 10 days administration in subjects with painful gonarthrosis
- Trial name
- NCT00264225
- Testing
- Lamaline® , 3 different doses, Dafalgan codeine
- Where
- 171 sites in France
- Sponsor
- Solvay Pharmaceuticals
Musculoskeletal Function
Immediate Effects of Calf and Plantar Fascia Manual Therapy
This study investigated the immediate effects of two manual therapy approaches, myofascial release and the fascial distortion model, applied to the calf and plantar fascia in healthy adults.
- Trial name
- NCT07319507
- Testing
- Myofascial Release, Fascial Distortion Model
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- JiYoung Kim
Creation of an Italian Network of Biobanks of Rare Diseases
ScATtEred Rare Disease Biobanks: a Model of Sample/Data Collection With susTainablE and Shared Criteria
Rare diseases (RDs) have been defined by the European Union (EU) as life-threatening or chronically debilitating conditions affecting less than 1 person in 2000.
- Trial name
- SATELLITES (NCT06782230)
- Where
- Italy
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Rhabdomyolysis
Pediatric Rhabdomyolysis in the Pediatric Intensive Care Unit: A Retrospective Cohort Study
This retrospective observational cohort study aims to evaluate the clinical characteristics, causes, intensive care management, and outcomes of pediatric patients with rhabdomyolysis admitted to the Pediatric Intensive Care Unit…
- Trial name
- NCT07851987
- Where
- Germany
- Volunteers
- 55 people
- Sponsor
- Hannover Medical School
Osteoporosis, University Students
Awareness Model in Prevention of Osteoporosis
This study investigated the effectiveness of a Healthy Living Awareness Program for the Prevention of Osteoporosis based on the Information-Motivation-Behavioral Skills Model (HLAPPO-IMB) in university students.
- Conditions
- Osteoporosis, University Students, Healthy Lifestyle
- Trial name
- NCT06028243
- Testing
- The Healthy Living Awareness Program for the Prevention of Osteoporosis (HLAPPO-IMB)- Information stage, The Healthy Living Awareness Program for the Prevention of Osteoporosis (HLAPPO-IMB)- Motivation stage, The Healthy Living Awareness Program for the Prevention of Osteoporosis (HLAPPO-IMB)- Behavior skills stage
- Where
- Turkey (Türkiye)
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Musculoskeletal Disease, Orthopedic Patients
Original Medical Notes Versus AI Plain-Language Summaries
The goal of this clinical trial is to learn how patients feel when reading their medical notes. The study compares reading the original doctor's note with reading a simpler, Artificial Intelligence (AI)-generated version written…
- Trial name
- NCT07602725
- Testing
- LLM-Generated Medical Note, Control (Original Medical Note)
- Volunteers
- 135 people
- Sponsor
- University of Texas at Austin
Marfan's Syndrome
Generation of Marfan Syndrome and Fontan Cardiovascular Models Using Patient-specific Induced Pluripotent Stem Cells
Medical researchers of National Heart Centre Singapore will carry out a state-of-the-art study that examines the possibility of changing patients' own cells into multi-functional and potent stem cells called iPS cells.
- Trial name
- NCT02815072
- Testing
- Skin biopsy
- Where
- Singapore
- Volunteers
- 30 people
- Sponsor
- National Heart Centre Singapore
Fibromyalgia
Predictive Models on Pain and Severity in FM Patients
The primary goal of this research project is to develop different prediction models in fibromyalgia disease through the application of machine learning techniques and to assess the explainability of the results.
- Trial name
- NCT04918602
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- University of Castilla-La Mancha
Sepsis, Septicemia
Observational Study of Sepsis and Pneumonia to Develop Diagnostic Tests
We propose to develop novel diagnostic tests for severe sepsis and community acquired pneumonia (CAP). This program, entitled Community Acquired Pneumonia \& Sepsis Outcome Diagnostics (CAPSOD), is a multidisciplinary…
- Conditions
- Sepsis, Septicemia, Sepsis Syndrome, Shock, Septic
- Trial name
- NCT00258869
- Where
- 3 sites in United States
- Volunteers
- 1,200 people
- Sponsor
- National Center for Genome Resources
Aging, Mortality
Longevity Metrics AI/ML Development Study
This study builds AI models that score diagnostic screening tests, and that predict screening results, clinical judgment, and life expectancy.
- Conditions
- Aging, Mortality, Cardiovascular Disease Prevention, Metabolic Syndrome
- Trial name
- NCT07808619
- Testing
- AIML scored health screening battery
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Longevity Metrics, Inc.
Orthopedic Disorder
Evaluation of Personalized Biomechanical Models of the Musculoskeletal System Before and After Orthopedic Surgeries
Advances in biomechanical modeling of musculoskeletal systems make it possible to consider the use of a digital clone of a patient to test surgical procedure before carrying it out on the patient himself.
- Trial name
- OrthosimPro (NCT04668430)
- Testing
- imaging and motion analysis
- Volunteers
- 10 people
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Pain, Muscle, Healthy
Modulation of an Experimental Prolonged Pain Model Using High Definition Transcranial Direct Current Stimulation
The purpose of this double-blinded, parallel group randomized controlled trial is to investigate the effects of high definition transcranial direct current stimulation (HD-tDCS) on an experimental prolonged pain model in healthy…
- Trial name
- NCT04650048
- Testing
- Active HD-tDCS
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Osteoarthritis
Acute Osteoarthritis Experimental Model Study.
This is a methodological study designed to investigate a new model for testing pain agents in the treatment of patients with osteoarthritis (OA).
- Trial name
- NCT01231490
- Testing
- Naproxen
- Where
- 3 sites in United Kingdom
- Volunteers
- 53 people
- Sponsor
- GlaxoSmithKline
Muscle Injury, Pulsed Electromagnetic Therapy
Investıgatıon of The Effıciency of Pulsed Electromagnetıc Field Therapy and Stretching Exercises
In this study, a total of 69 Wistar Albino rats were used, five of which were in the preliminary study. The preliminary study was planned to determine the ideal PEMF treatment time.
- Conditions
- Muscle Injury, Pulsed Electromagnetic Therapy, Muscle Stretching Exercise
- Trial name
- NCT05988476
- Testing
- Exercise, Pulsed Electromagnetic Field Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Suleyman Demirel University
Telemedicine, Telehealth
Towards Telemonitoring in Immune-Mediated Inflammatory Diseases: Implementation of a Mixed Attention Model (IMIDOC)
The main objective is to evaluate the implementation of a hybrid care model called the mixed attention model (MAM) in clinical practice and to evaluate whether its implementation improves clinical outcomes compared to…
- Conditions
- Telemedicine, Telehealth, eHealth, Rheumatic Diseases
- Trial name
- IMIDOC (NCT06273306)
- Testing
- IMIDOC
- Volunteers
- 360 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Temporomandibular Disorder, Temporomandibular Joint Dysfunction Syndrome
Efficacy of Manual Therapy Based on the Fascial Distortion Model in Individuals With Temporomandibular Disorder
The goal of this randomized clinical trial is to investigate the efficacy of Manual Therapy Based on the Fascial Distortion Model (FDM) by comparing it with Core Stabilization Training (CST) or Control in individuals with…
- Conditions
- Temporomandibular Disorder, Temporomandibular Joint Dysfunction Syndrome, Temporomandibular Joint Disorders, Temporomandibular Joint Pain
- Trial name
- NCT06134310
- Testing
- Fascial Distortion Model, Core Stabilization Training, Rocabado's 6x6 Exercises
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 53 people
- Sponsor
- Hacettepe University
Osteoarthritis
New Method of Surgical Treatment of Patients With Osteoarthritis of the 1st Metatarsophalangeal Joint
Relevance The first metatarsophalangeal joint (MPJ) has an important function in the biomechanics of human gait, especially in the toe and thrust phases, as the full range of motion at this joint provides the body with smooth…
- Trial name
- NCT05717413
- Testing
- metatarsophalangeal joint endoprosthesis
- Where
- Russia
- Volunteers
- 46 people
- Sponsor
- Samara State Medical University
Neck Pain, Shoulder Pain
Multiple-component Workplace FRamed Intervention to Decrease Occupational Muscle Pain - FRIDOM
Several RCT studies have aimed to reduce either musculoskeletal disorders, sickness presenteeism, sickness absenteeism or a combination of these among females with high physical work demands.
- Conditions
- Neck Pain, Shoulder Pain, Lifestyle
- Trial name
- FRIDOM (NCT02843269)
- Testing
- Multi-component lifestyle intervention
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Pregnancy, Pregnancy-Related Pain
Integrated Medical, Surgical and Physiotherapy Care for Pregnant Women With Chronic Diseases
This non-randomized controlled quasi-experimental study evaluates the effectiveness of an integrated medical-surgical and physiotherapy community-based care model for pregnant women with chronic diseases.
- Conditions
- Pregnancy, Pregnancy-Related Pain, Musculoskeletal Disorders, Physical Therapy
- Trial name
- IMSP-PregCD (NCT07589946)
- Testing
- Physiotherapy-based Care, control group
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Sinai University