Clinical trials: Musculoskeletal Disorders
Mitochondrial Myopathies, Mitochondrial Diseases
Mitochondrial Dysfunctions Driving Insulin Resistance
The overarching aim of this observational study is to characterize muscle mitochondrial defects in individuals harboring pathogenic mitochondrial DNA (mtDNA) mutations associated with an insulin-resistant phenotype.
- Conditions
- Mitochondrial Myopathies, Mitochondrial Diseases, Mitochondrial Disorders
- Trial name
- MITO-DYS-IR (NCT06080581)
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Fibromyalgia
Efficacy of Amygdala Retraining With Mindfulness (ART+MF) vs Compassion Therapy (CT) for the Treatment of Patients With Fibromyalgia
Amygdala Retraining Treatment (ART) is a new and promising therapy for patients with Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM), however, randomized controlled trials (RCT) are scarce.
- Trial name
- NCT02454244
- Testing
- ART with Mindfulness, Mindfulness Compassion, Relaxation
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospital Miguel Servet
Proteomics, Exercise
Dynamic Proteomics and Integrated Rates of Muscle Protein Synthesis During an Acute Period of Loading and Unloading
Skeletal muscle plays several different roles in the promotion and maintenance of health and well-being. The loss of muscle mass that occurs with aging, chronic muscle wasting diseases, and physical inactivity puts people at an…
- Conditions
- Proteomics, Exercise, Atrophy, Disuse, Hypertrophy
- Trial name
- HYPAT (NCT04514744)
- Testing
- Knee bracing, Unilateral Resistance Exercise Training
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- McMaster University
Alveolar Bone Loss
Effectiveness of Alveolar Bone Preservation in Alveoli With Infectious Process
Alveolar ridge preservation (ARP) is a surgical technique that aims to minimize the degree of dimensional changes following extraction.
- Trial name
- NCT06661863
- Testing
- alveolar ridge preservation with bioactive glass, alveolar ridge preservation with autologous bone
- Where
- Ecuador
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Universidad de Especialidades Espiritu Santo
Juvenile Idiopathic Arthritis
Methotrexate Alone vs Methotrexate + Etanercept for Minimal/Low Disease Activity in Juvenile Idiopathic Arthritis
This open labelled randomized controlled trial will be carried out at the University of Child Health and the Children's Hospital, Lahore consisting of 6 months .
- Trial name
- NCT07386587
- Testing
- Injection, Etanercept, 25 Mg (Code May Be Used for Medicare When Drug Administered Under the Direct Supervision of A Physician, Not for Use When Drug is Self Administered)
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Child Health Sciences and Children's Hospital, Lahore
Periodontal Bone Loss, Periodontal Pocket
Treatment of Intraosseous Periodontal Defects With Hyaluronic Acid
The aim of the present investigation will be evaluate the healing of periodontal intraosseous defects following Minimally Invasive Non Surgical Debridement (MINSD) and application of a hyaluronic acid-based gel, compared to MINSD…
- Trial name
- NCT05188898
- Testing
- MINSD and Hyaluronic acid, MINSD
- Where
- Italy
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Federico II University
Lupus, Psoriatic Arthritis
A Study to Investigate BMS-986165 and Methotrexate in Healthy Male Patients
The purpose of this study is to investigate effects of BMS-986165 on blood levels of methotrexate given as a single dose in healthy male patients.
- Trial name
- NCT03402087
- Testing
- Methotrexate, Leucovorin, BMS-986165
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Alveolar Process Atrophy
Marginal Bone and Soft Tissue Alterations After Use of OsseoSpeed EV Profile Implants
Evaluation of the marginal bone and soft tissue alterations after the OsseoSpeed™ EV Profile implants placement in anterior maxilla.
- Trial name
- NCT04243421
- Testing
- Implantation
- Where
- Poland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
Alveolar Bone Loss
Efficacy of Customized Zirconia Sheet vs PTFE as a Non-resorbable Barrier in Maxillary Alveolar Ridge Augmentation
The goal of this clinical trial is comparing the efficacy of custom-made zirconia sheet versus Polytetrafluoroethylene as a non-resorbable barrier in maxillary alveolar ridge augmentation.
- Trial name
- NCT06227455
- Testing
- Maxillary alveolar ridge augmentation
- Where
- Egypt
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Delta University for Science and Technology
Spinal Muscular Atrophy, Duchenne Muscular Dystrophy
Public AttitudesTowards SMA and DMD Awareness, Newborn and Carrier Screening and Physiotherapy Practices
The addition of SMA and DMD muscle diseases to newborn screening and premarital carrier screening has been controversial. In this study, researchers aim to measure the awareness level of SMA and DMD muscle diseases of individuals…
- Conditions
- Spinal Muscular Atrophy, Duchenne Muscular Dystrophy, Healthy Individuals
- Trial name
- NCT05110885
- Testing
- Questionnaire
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Avascular Necrosis, Osteonecrosis
The Use of Genex in the Management of Early-Stage Osteonecrosis of the Femoral Head
The purpose of this study is to assess the clinical and x-ray results of patients who are treated with core decompression of the hip and the injection of a bone marrow concentrate and the use of the Bone Graft Substitute Genex®.
- Trial name
- Genex (NCT05706909)
- Testing
- Genex with ABMC
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Tendinopathy, Jumper's Knee
A Study of the Effect of Time-of-day of Training on Chronic Patellar Tendinopathy
The study is a 12-week human study where 60 participants with chronic patellar tendinopathy (more than 3 months symptoms duration) are randomised to undergo 12 weeks of targeted resistance exercise either in the morning or in the…
- Trial name
- TENDOTIME (NCT06217432)
- Testing
- Resistance training for knee extensors
- Where
- Denmark
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Pomegranate (P. Granatum) Peel Compress
The Effect of Pomegranate (Punica Granatum L.) Peel Compress Application on Pain and Physical Function Status
Osteoarthritis is the most common type of arthritis among rheumatologic diseases. Complementary therapies are one of the effective methods for pain control. This study was planned as a randomized controlled experimental study.
- Trial name
- Pomegranate (NCT06034106)
- Testing
- Pomegranate (Punica granatum) peel compress, Hot compress
- Where
- Turkey (Türkiye)
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Edentulous Jaw, Quality of Life
Impact of the Use of New Complete Denture on the Oral Health Related to Quality of Life (OHRQoL)
The aim of this project was to evaluate the impact before and after (3, 6, 9, and 12 months) of oral rehabilitation with conventionalof the insertion of new complete dentures (CD) in the oral health-related quality of life…
- Trial name
- NCT03687047
- Testing
- New complete dentures
- Where
- Brazil
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Universidade Federal Fluminense
Muscle Weakness, Muscle Atrophy
Effect of Neuromuscular Electrical Stimulation Combined With Blood Flow Restriction on Muscular and Cardiovascular Function
Neuromuscular electrical stimulation (NMES) has recently been combined with blood flow restriction (BFR) in controlled trials and has shown increased muscular strength and size compared with NMES and BFR on their own.
- Trial name
- NCT03662555
- Testing
- Neuromuscular electrical stimulation
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- St. Mary's University, Twickenham
Jaw, Edentulous, Partially, Dental Implant Failed
Survival and Success Rates of 6mm Implants With a Micro-rough Surface After 4.5 - 18.2 Years in Function
In this retrospective study, approximately 60 patients treated with 6mm short implants (Straumann, SLA (sandblasted, large-grit, acid-etched surface), SLActive (sandblasted, large-grit, acid-etched, hydrophilic surface), 4.1 or…
- Conditions
- Jaw, Edentulous, Partially, Dental Implant Failed, Implant Complication
- Trial name
- NCT04017026
- Testing
- Implantation
- Where
- Switzerland
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Bern
Osteoporosis
Evaluating the Pharmacokinetic Characteristics of AD-102 in Healthy Volunteers
The purpose of this study is to evaluate the pharmacokinetic characteristics of AD-102 in healthy male subjects
- Trial name
- NCT03824171
- Testing
- Raloxifene 60mg/Cholecalciferol 800IU, AD-102
- Where
- South Korea
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Addpharma Inc.
Osteopenia, Osteoporosis
Calcium-Rich Food Versus Calcium Carbonate for Bone Health
This study will compare adherence, tolerability, safety, and treatment satisfaction between a calcium-rich food and a traditional calcium carbonate supplement in women ages 40 to 90 who are at increased risk for osteoporosis.
- Conditions
- Osteopenia, Osteoporosis, Bone Health in Perimenopausal Women, Menopause Related Conditions
- Trial name
- NCT07763509
- Testing
- 500 mg calcium from milk-derived minerals, Calcium Carbonate 500 MG
- Where
- United States
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- Cornell University
Subacromial Impingement Syndrome
Effects of KT and Scapular Stabilization Exercises.
The distance between the acromion bone and the head of the humerus narrows in subacromial impingement syndrome. This narrowing leads to the compression of sensitive structures and results in pain and decreased functional…
- Trial name
- NCT06688214
- Testing
- Kinesio Taping treatment, Scapular Stabilization Exercises
- Where
- Pakistan
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Sehat Medical Complex
Flexible Flatfoot
Pilates on Dynamic Balance in Flexible Flat Feet
Flexible flatfoot is one of the most common types of flatfeet. It has an arch that is present in open kinetic chain and lost in closed kinetic chain Balance is defined as the process that maintains the center of gravity within…
- Trial name
- NCT06539533
- Testing
- pilates training
- Where
- Egypt
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Cairo University