Clinical trials: Musculoskeletal Disorder
Oculopharyngeal Muscular Dystrophy
Screening in Oculopharyngeal Muscular Dystrophy
Oculopharyngeal muscular dystrophy (OPMD) is a rare myopathic disease that results in progressive degeneration of the oral and pharyngeal muscular, resulting in severe dysphagia and dysarthria.
- Trial name
- NCT02877784
- Testing
- Videofluoroscopic swallowing study, Functional Oral Intake Scale, Eating Assessment Tool-10
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Florida
Spondylitis, Ankylosing, Psoriatic Arthritis
Enhanced Clinics for Patients Diagnosed With Ankylosing Spondylitis and Psoriatic Arthritis
The 19.5 months project will pilot the introduction of a hospital-based, nurse-led ankylosing spondylitis (AS) and psoriatic arthritis (PsA) service for patients being initiated on biologic therapy in NHS Lothian Edinburgh…
- Trial name
- ECAP (NCT04341233)
- Sponsor
- NHS Lothian
Osteomyelitis
Study on the Safety and Efficacy of Dalbavancin Versus Active Comparator in Adult Participants With Osteomyelitis
This clinical study will be a single-center, randomized, open-label, active-controlled, parallel-group study comparing dalbavancin to standard of care (SOC) therapy in osteomyelitis.
- Trial name
- NCT02685033
- Testing
- Dalbavancin, Comparator
- Where
- Ukraine
- Volunteers
- 80 people
- Sponsor
- Durata Therapeutics Inc., an affiliate of Allergan plc
Osteoarthritis
Chronic Pain Master Protocol (CPMP): A Study of LY3556050 in Participants With Osteoarthritis
This study is being done to test the safety and efficacy of LY3556050 for the treatment of osteoarthritis pain. This trial is part of the chronic pain master protocol, H0P-MC-CPMP (NCT05986292), which is a protocol to accelerate…
- Trial name
- NCT04627038
- Testing
- LY3556050
- Where
- 40 sites in United States, Puerto Rico
- Volunteers
- 202 people
- Sponsor
- Eli Lilly and Company
Plantar Fasciitis
Comparative Effects of Myofascial Release and Instrument Assisted Soft Tissue Moblization in Pregnant Women With Plantar Fasciitis
Plantar fasciitis is a common musculoskeletal disorder characterized by heel pain and functional limitations, which may become more pronounced during pregnancy due to weight gain, hormonal changes, and altered biomechanics.
- Trial name
- MFR-IASM-PF (NCT07676058)
- Testing
- Myofascial Release (MFR), Instrument-Assisted Soft Tissue Mobilization (IASTM)
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- University of Lahore
Hip Fracture
A Proof-of-Concept Study Investigating the Safety and Efficacy of ZT-031 on Hip Fracture Healing in Men and Postmenopausal Women
The purpose of this research study is to test if an experimental drug called ZT-031 can help men over 30 years or post-menopausal women over 55 years of age with certain types of hip fracture to heal better or faster following…
- Trial name
- SHIFT (NCT00787358)
- Testing
- ZT-031
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Zelos Therapeutics
Temporomandibular Joint Disc Displacement, Temporomandibular Joint Disc Displacement, Without Reduction
TMJ Arthroscopy Compared to Arthrocentesis in Disc Displacement Without Reduction
The goal of this clinical trial is to compare the intervention arthroscopic lysis and lavage to the intervention arthrocentesis in treating disabling and painful temporomandibular joint disc displacement without reduction.
- Conditions
- Temporomandibular Joint Disc Displacement, Temporomandibular Joint Disc Displacement, Without Reduction, Temporomandibular Disorders (TMD)
- Trial name
- ACALL (NCT06782178)
- Testing
- Arthroscopic lysis and lavage, Arthrocentesis/Saline
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska Institutet
Osteoarthritis
Fixed Bearing Versus Mobile Bearing Patient Satisfaction and Clinical Outcome Study
The purpose of this study is to determine if there is a patient satisfaction preference of Fixed Bearing versus Mobile Bearing Unicompartmental Knee Arthroplasty (UKA) in patients who are at a minimum two years post operative.
- Trial name
- NCT02633085
- Testing
- Fixed Bearing or Mobile Bearing UKA
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medacta USA
Diabetic Foot Ulcer, Diabetic Foot
Treatment of Chronic Diabetic Foot Ulcers by Minimally Invasive Surgery
Despite the development of the control of DM and the great interest for the complications of the disease, even today the diabetic foot represents a challenge for the orthopaedic surgeon.
- Conditions
- Diabetic Foot Ulcer, Diabetic Foot, Diabetic Foot Infection, Diabetic Foot Ulcer Neuropathic
- Trial name
- DiabeticMIS1 (NCT03010215)
- Testing
- Distal Metatarsal Minimally invasive Osteotomy (DMMO)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Padova
Cervical Spondylosis Symptomatic Neurological Compression
Collar Immobilization Following a Posterior Cervical Laminectomy and Fusion
Cervical collars are commonly used to provide external immobilization after elective Posterior Cervical Laminectomy and Interbody Fusion (PCLIF).
- Trial name
- NCT01383876
- Testing
- Collar, No Collar
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- Brigham and Women's Hospital
Musculoskeletal Pain, Fractures, Closed
Graded Motor Imagery for Women at Risk for Developing Type I CRPS Following Closed Treatment of Distal Radius Fractures
Nearly 2 out of 10 women will sustain a distal forearm fracture throughout their lifespan.Recent longitudinal studies illustrate that as many as 1/3 of all persons who undergo closed reduction and casting for distal radius…
- Conditions
- Musculoskeletal Pain, Fractures, Closed, Distal Radius Fracture, Complex Regional Pain Syndromes
- Trial name
- NCT02957240
- Testing
- Standard Care, Motor Representation Techniques
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Minnesota
Rheumatoid Arthritis
A Study Comparing CRx-102 Plus Disease-modifying Anti-rheumatic Drug (DMARD) Therapy to Placebo Plus DMARD Therapy in RA
This study was a Multicenter, Randomized, Blinded Study Comparing the Effect of CRx-102 Plus DMARD Therapy to that of Placebo Plus DMARD Therapy on Serum C Reactive Protein (CRP) and Cytokines in Subjects with Rheumatoid…
- Trial name
- NCT00747214
- Testing
- CRx-102, DMARD Therapy
- Volunteers
- 59 people
- Sponsor
- Zalicus
Previous or Actual Colles Fracture
Osteoporosis and Colles Fracture
The primary purpose of the retrospective study is to determine the incidence of osteoporosis in women with previous Colles Fracture.
- Trial name
- NCT00225004
- Testing
- DEXA scan
- Where
- 2 sites in Denmark
- Sponsor
- Northern Orthopaedic Division, Denmark
Scoliosis Idiopathic
Mandibular Evaluation and Facial Analysis In Adolescents With Idiopathic Scoliosis
Fifty-eight participants with AIS and 45 healthy controls were included in the study. Active mandibular movements including depression, protrusion, and left-right deviation were assessed with a ruler.
- Trial name
- NCT05452252
- Testing
- functional mandibular evaluation
- Where
- Turkey (Türkiye)
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Osteoarthritis, Knee
Calypso Knee System Clinical Study, OUS
A study to evaluate the safety and effectiveness of the Calypso Knee System when used in subjects with symptomatic osteoarthritis of the medial compartment of the knee.
- Trial name
- NCT03838978
- Testing
- Calypso Knee System (Implantable Shock Absorber)
- Where
- 5 sites in Belgium, Poland
- Volunteers
- 81 people
- Sponsor
- Moximed
Bone Sarcoma, Osteosarcoma
Efficacy of Regorafenib Combined With Best Supportive Care as Maintenance Treatment in High Grade Bone Sarcomas Patients
This is a multicenter phase II study concerning patients with high-grade bone sarcoma (HGBS) without complete remission after standard treatment at diagnosis or at relapse.
- Trial name
- REGOMAIN (NCT04698785)
- Testing
- Treatment by regorafenib and best supportive care
- Where
- 16 sites in France
- Volunteers
- 36 people
- Sponsor
- Centre Leon Berard
Musculoskeletal Pain
Multimodal Management of Neck and Back Pain in the Emergency Department (Multi-ED)
The purpose of this study is to assess the feasibility and acceptability of psychologically-informed physical therapy (PIPT) in the ED in a pilot study of ED patients with neck or back pain.
- Trial name
- NCT05221125
- Testing
- Psychologically-Informed Physical Therapy (PIPT)
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Duke University
Knee Osteoarthritis
A Prospective, Randomized Study Comparing Cemented and Cementless Total Knee Replacement
The purpose of this study is to compare the the Nexgen knee replacement system using cementless fixation with the same system using cemented fixation.
- Trial name
- NCT01194817
- Testing
- High-Flexion Knee Replacement System using Cemented Fixation, High-Flexion Knee Replacement System using Cementless Fixation
- Volunteers
- 100 people
- Sponsor
- Anderson Orthopaedic Research Institute
Developmental Dysplasia of the Hip
Automatic Characterization of the Neonatal Hip Using Ultrasound Imaging
Ultrasound imaging (US), a radiation-free imaging modality, is currently used in diagnosis of developmental dysplasia of the hip (DDH) in infants.
- Trial name
- NCT02796768
- Testing
- 3D US Scanning, 2D US Scanning
- Where
- Canada
- Volunteers
- 75 people
- Sponsor
- British Columbia Children's Hospital
Lumbosacral Radiculopathy
Caudal Versus S1 Transforaminal Epidural Steroid Injection for the Treatment of Unilateral S1 Radiculopathy
To compare the efficacies of two different interventional techniques (Caudal epidural steroid injection and S1 transforaminal epidural steroid injection) for the treatment of unilateral S1 radiculopathy.
- Trial name
- NCT05711121
- Testing
- Transforaminal epidural steroid injection, Caudal epidural steroid injection
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul Medeniyet University