Clinical trials: Musculoskeletal Disorder
Hand Injuries and Disorders, Neurological Conditions
3D Hand Orthosis Trial
In people with chronic hand conditions, hand orthoses are frequently prescribed to improve performance in activities of daily living (ADL).
- Conditions
- Hand Injuries and Disorders, Neurological Conditions, Neuromuscular Diseases (NMD), Musculoskeletal Conditions (e.g., Tendinitis, Capsulitis)
- Trial name
- NCT07633821
- Testing
- 3D-printed hand orthosis (intervention), Conventional hand orthosis (control)
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Shoulder Musculoskeletal Disorders
Development and Validation of Acceptance Questionnaire for The Use of Virtual Reality in Upper Limb Rehabilitation
The development of an Arabic questionnaire to assess acceptance of VR in upper limb rehabilitation would include adapting Technology Acceptance Model TAM, followed by panel review for content validity.
- Trial name
- NCT07850830
- Testing
- Physical rehabilitation using virtual reality
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Mahmoud Aboraya
Musculoskeletal Diseases, Mental Disorder
Expert@Work - Effectiveness of a Digital Expert Team on Return to Work
Long-term sick leave is a challenge in Norway, and the healthcare and labor- and welfare services are often not coordinated in helping the sick-listed employees return to work.
- Trial name
- Expert@Work (NCT05575908)
- Testing
- Digital expert team
- Where
- 4 sites in Norway
- Volunteers
- 170 people
- Sponsor
- St. Olavs Hospital
Insomnia, Healthy Adult
The Impact of Acute Pain on Sleep Parameters in the Insomnia Population and Healthy Controls
This study investigates how acute exercise-induced muscular pain affects sleep quality and sleep architecture in people with insomnia compared to healthy sleepers.
- Conditions
- Insomnia, Healthy Adult, Sleep, Musculoskeletal Pain
- Trial name
- NCT07826650
- Testing
- Eccentric exercise
- Where
- Hong Kong
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Insomnia, Healthy Adult
The Impact of Insomnia on Pain Sensitivity and the Trajectory of Exercise-induced Muscular Pain
Sleep is a critical determinant of physiological recovery and pain regulation. Growing evidence suggests that sleep disruption directly heightens central and peripheral pain sensitivity to sensory stimuli (e.g., mechanical…
- Conditions
- Insomnia, Healthy Adult, Musculoskeletal Pain, Pain Sensitivity
- Trial name
- NCT07827664
- Testing
- Eccentric exercise
- Where
- Hong Kong
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Musculoskeletal Disorder
Early Identification of Risk for and Prevention of Sickness Absence Due to Musculoskeletal Pain - an RCT
Background: Musculoskeletal pain is a leading cause of disability in the world. Although the majority of musculoskeletal-related pain conditions, such as low back pain, often resolves spontaneously, pain may recur or persist over…
- Trial name
- PREVSAM (NCT03913325)
- Testing
- PREVSAM model, Treatment as usual (standard treatment)
- Where
- Sweden
- Volunteers
- 254 people
- Sponsor
- Vastra Gotaland Region
Orthopedic Disorder, Trauma Injury
X-BS Ortho Bone Graft Study
Randomised investigation of the osteoconductive performance and safety of CE-marked FDBS bone graft (GraftR3®), with contextual reference to CE-marked IBS (MBCP® Putty), in the filling of orthopaedic bone defects.
- Conditions
- Orthopedic Disorder, Trauma Injury, Extremity Injury
- Trial name
- NCT06326827
- Testing
- FDBS (GraftR3®), IBS (MBCP® Putty)
- Volunteers
- 200 people
- Sponsor
- Advanced Medical Solutions Ltd.
Non-traumatic Musculoskeletal Conditions, Carpal Tunnel Syndrome (CTS)
Understanding Patient Preferences When Deciding on a Voluntary Musculoskeletal Test
The goal of this clinical trial is to understand how people make decisions about imaging tests for common musculoskeletal problems (like arthritis, tendon problems, or nerve compression).
- Conditions
- Non-traumatic Musculoskeletal Conditions, Carpal Tunnel Syndrome (CTS), Lateral Epicondylitis, Osteoarthritis
- Trial name
- NCT07158892
- Testing
- Diagnostic Advance Care Planning Discussion, Informational Statement Only
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- University of Texas at Austin
Insomnia, Healthy Adult
The Effect of Different rTMS Interventions on Acute Experimental Muscular Pain in Individuals Comorbid With Insomnia
Insomnia exacerbates pain sensitivity and impairs physiological recovery from acute musculoskeletal pain. Repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising non-invasive neuromodulation intervention to…
- Conditions
- Insomnia, Healthy Adult, Exercise Induced Muscle Damage, Pain Sensitivity
- Trial name
- NCT07827677
- Testing
- Repetitive transcranial magnetic stimulation (rTMS) on L M1, Repetitive transcranial magnetic stimulation (rTMS) on R DLPFC
- Where
- Hong Kong
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Post-Traumatic Neck Pain, Whiplash-associated Disorders
StressModex for Post-Traumatic Neck Pain
Post-traumatic neck pain is a common consequence of traffic-related and other accidental injuries. While many individuals recover, a subgroup develops persistent pain, disability, and psychological distress.
- Trial name
- StressModex (NCT07824557)
- Testing
- StressModex plus Treatment as Usual
- Where
- 3 sites in Denmark
- Volunteers
- 30 people
- Sponsor
- University of Southern Denmark
Musculoskeletal Disorders (MSDs), Musculoskeletal Diseases or Conditions
Exercise and Health Education for Textile Workers: A Pre-Post Study
Musculoskeletal disorders (MSDs) significantly impact quality of life, health status, and work ability. Standard treatments include ergonomic interventions, therapeutic exercise programs, education on risk prevention, active…
- Trial name
- LACOR-HEALTH (NCT07360626)
- Testing
- Combined Exercise Training and Health Education Program
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad San Jorge
DM1, Muscular Dystrophies
Extension of AOC 1001-CS1 (MARINA) Study in Adult Myotonic Dystrophy Type 1 (DM1) Patients
AOC 1001-CS2 (MARINA-OLE) (NCT05479981) is a Phase 2 extension of the AOC 1001-CS1 (MARINA) (NCT05027269) study to evaluate the safety, tolerability, efficacy, pharmacokinetics and pharmacodynamics of multiple-doses of AOC 1001…
- Conditions
- DM1, Muscular Dystrophies, Myotonic Dystrophy, Myotonic Dystrophy 1
- Trial name
- MARINA-OLE (NCT05479981)
- Testing
- AOC 1001
- Where
- 8 sites in United States
- Volunteers
- 37 people
- Sponsor
- Avidity Biosciences, Inc.
Hallux Valgus, Orthopedic Disorder
A Study to Compare Early and Partial Weight-bearing After Hallux Valgus Surgery
This is a two-arm randomized controlled trial with the aim to evaluate the effectiveness and safety of post-operative management after a modified Lapidus arthrodesis with/without an Akin or a Weil/Hohmann surgery fusion with…
- Trial name
- NCT05534724
- Testing
- Partial weight-bearing (10 - 15kg), Complete weight-bearing
- Where
- Switzerland
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Ente Ospedaliero Cantonale, Bellinzona
Orthopedic Disorder
Accelerometry and Rehabilitation After Knee Replacement Study (ARK)
Total knee replacement (TKR) is a successful and cost-effective treatment for end-stage arthritis. Its usage is increasing due to changing population demographics and quality of life (QoL) expectations.
- Trial name
- ARK (NCT05412940)
- Testing
- Remote monitoring of home-based exercises following knee replacement using a wearable sensor, Standard Care (in control arm)
- Where
- United Kingdom
- Volunteers
- 250 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Work-Related Musculoskeletal Disorders
Reducing Physical Workload Among Assistant Nurses Through Ergonomic Work Technique Training With or Without Biofeedback
Assistant nurses often develop work-related pain in the back, neck and shoulders because their work involves frequent patient handling and movement.
- Trial name
- HUMLA (NCT07805629)
- Testing
- Group A. Patient handling and movement training, Group B: Patient handling and movement training plus biofeedback
- Volunteers
- 60 people
- Sponsor
- Linkoeping University
Osteoarthritis, Articular Cartilage
Platelet Rich Plasma Injections In Young And Old Human Subjects
This is a randomized, double-blind, placebo-controlled phase 2 study with a secondary crossover phase at the end of the initial trial to ensure all subjects receive one PRP injection.
- Conditions
- Osteoarthritis, Articular Cartilage, Musculoskeletal Disorders
- Trial name
- PRP-KOBE (NCT06451120)
- Testing
- Platelet-Rich Plasma (PRP) Injections, Centrifuge, Control saline injection
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Chronic Back Pain, Chronic Pain
Active Coping: Interdisciplinary Program for Chronic Pain, Physiotherapy Unit (Spain)
The goal of this observational intervention study is to evaluate the impact of a multidisciplinary active coping program for chronic back pain in adults referred from Primary Care to the Physiotherapy Unit of Teruel Ensanche.
- Conditions
- Chronic Back Pain, Chronic Pain, Back Pain, Low Back Pain, Chronic
- Trial name
- NCT07504094
- Testing
- Pain Neuroscience Education (PNE), Healthy Habits and Psychological Intervention, Therapeutic Exercise
- Where
- 2 sites in Spain
- Volunteers
- 20 people
- Sponsor
- Universidad de Zaragoza
Musculoskeletal Health, Fertility
The Weight of Victory: Exploring Short- and Long-term Health Outcomes in Former Male & Female Elite Athletes From Weight-sensitive Sports
The health of former elite athletes has been identified as a critical research gap where there is limited knowledge about both short- and long-term consequences after ending their careers.
- Conditions
- Musculoskeletal Health, Fertility, Mental Health, Quality of Life
- Trial name
- NCT06801210
- Where
- Norway
- Volunteers
- 1,500 people
- Sponsor
- Norwegian School of Sport Sciences
Musculoskeletal Disorders (MSDs)
Back on Track: Evaluation of an Occupational Reintegration Protocol for Employees With Musculoskeletal Disorders
The objective of the Back on Track study is to evaluate a computer-assisted reintegration protocol for musculoskeletal disorders of a major occupational health service in the Netherlands on its (cost-)effectiveness and conduct a…
- Trial name
- NCT07793526
- Testing
- The computer-assisted reintegration protocol for musculoskeletal disorders
- Where
- Netherlands
- Volunteers
- 140 people
- Sponsor
- Amsterdam UMC, location VUmc
Musculoskeletal Disorders, Skeletal Disorder
Observational Prospective PMCF Study to Confirm Performance and Safety of Intelect® Devices in Real World
DJO UK Ltd (ENOVIS) is conducting this study to confirm the performance and safety of the Chattanooga Intelect® devices in real world use.
- Conditions
- Musculoskeletal Disorders, Skeletal Disorder, Muscle Disorder
- Trial name
- INTELECT (NCT06809283)
- Where
- 4 sites in France, Italy and 1 more
- Volunteers
- 144 people
- Sponsor
- DJO UK Ltd