Clinical trials: Muscular Disorders, Atrophic
Anterior Cruciate Ligament Reconstruction, Muscular Atrophy
Nutritional Intervention to Enhance Recovery After Arthroscopic Knee Surgery in Adults
Loss of skeletal muscle mass (atrophy) and strength in the lower limb are consequences of elective knee surgery as result of prolonged disuse from limb immobilization and impaired mobility, as well as pathophysiological trauma.
- Trial name
- NCT06233825
- Testing
- Omega-3 Fatty Acids and Essential Amino Acids, Safflower Oil and Non-Essential Amino Acids
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dr. Chris McGlory, PhD
Obesity, Menopause
Calorie Restriction With Leucine Supplementation
The purpose of this study is to determine whether consuming additional leucine during calorie restriction induced weight loss has beneficial or harmful effects on multi-organ (liver, muscle, adipose tissue) insulin sensitivity…
- Conditions
- Obesity, Menopause, Osteoporosis, Sarcopenia
- Trial name
- NCT01757340
- Testing
- Weight loss with normal protein and leucine intake, Weight loss with protein/leucine supplementation
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Myopathy, Muscular Dystrophies
Muscle Health Measurements Using Electrical Impedance Myography
This study is being done to further develop a device, the mScan, to measure muscle health as compared to measurements of muscle health using MRI (magnetic resonance imaging).
- Conditions
- Myopathy, Muscular Dystrophies, Myositis, Myofibrillar Myopathy
- Trial name
- NCT07502989
- Testing
- Electrical Impedance Myography
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Sarcopenia
Home-based Progressive Resistance Exercise to Enhance Physical Performance of Older Adults With Possible Sarcopenia
The overall aim of the proposed project is to improve muscle strength in older adults with possible sarcopenia by promoting home-based progressive resistance exercise.
- Trial name
- NCT04851262
- Testing
- Exercise
- Where
- Hong Kong
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Post-polio Syndrome
Spinal Cord Gray Matter Imaging in Post Polio Syndrome
This is a longitudinal, observational study with the aims of comparing spinal cord gray matter areas in patients with Post-Polio Syndrome to age and sex matched healthy control subjects and to correlate atrophy with metrics of…
- Trial name
- NCT03561623
- Testing
- magnetic resonance (MR) Imaging, quantitative muscle force assessment
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Muscle Hypotrophy, Exercise Performance
Resistance Training Adaptations and Caffeine Intake
This parallel-group, randomized, double-blind, placebo-controlled trial investigates the effects of three different caffeine supplementation strategies on resistance training-induced adaptations in 120 caffeine-naive, inactive…
- Conditions
- Muscle Hypotrophy, Exercise Performance, Muscle Strength, Adaptation
- Trial name
- NCT07410195
- Testing
- Caffeine (Constant Daily Dose), Caffeine (Escalating Dose), Caffeine (Training Days Only)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Sarcopenia;, Osteoporosis
Effects of Whole-body Vibration in the Frail Elderly
Objective: To study the acute and chronic effects of whole-body vibration (WBV) exercises on the lower extremity blood flow, mobility function, balance, muscle strength, bone density, and general health status, and its…
- Trial name
- NCT02090192
- Testing
- WBV training, PRT training
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Li Zhang
Spinal Muscular Atrophy
A Drug-drug Interaction Study With Risdiplam Multiple Dose and Midazolam in Healthy Participants
This will be a Phase I, 2-part, open-label, non-randomized study to investigate the safety, tolerability, and pharmacokinetics (PK) of a multiple-dosing regimen of risdiplam (Part 1) and the effect of risdiplam on the PK of…
- Trial name
- NCT03988907
- Testing
- Risdiplam, Midazolam
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Hereditary Disease
Non Invasive Prenatal Testing (NIPT) of Single-gene Disorders
Developing a new non-invasive prenatal test for single gene disorders from cell free fetal DNA, retrieved from the mothers blood.
- Trial name
- NCT02339402
- Where
- 2 sites in Netherlands
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Diabetes Mellitus, Type 2, Diabetic Peripheral Neuropathy
Muscle and Bone in Patients with Diabetes Mellitus and Neuropathy
The goal of this observational study is to evaluate muscle fiber type composition in people with type 2 diabetes mellitus (T2DM) with a common complication of T2DM: diabetic peripheral neuropathy (DNP), specifically diabetic…
- Conditions
- Diabetes Mellitus, Type 2, Diabetic Peripheral Neuropathy, Sarcopenia
- Trial name
- SVT-DNP (NCT06519942)
- Testing
- Blood sampling, Electromyoneurography (EMNG), Muscle biopsy
- Where
- Belgium
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Myotonic Muscular Dystrophy
Study of Muscle Wasting and Altered Metabolism in Patients With Myotonic Dystrophy
OBJECTIVES: I. Examine the interrelationships between muscle wasting (phenotype), the degree of myotonic dystrophy (DM) gene expression (genotype) in patients with DM. II. Characterize the insulin resistance in these patients.
- Trial name
- NCT00004769
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Frailty, Sarcopenia
A Randomized Control Trial of an Intervention to Reverse Frailty and Enhance Resilience Through Exercise and Education
Resistance training done at home and protein supplementation may be the most effective and easiest to implement interventions to reverse frailty and build resilience.
- Trial name
- REFEREE (NCT04628754)
- Testing
- Exercise and protein
- Where
- Ireland
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Spinal Muscular Atrophy
Neonatal Spinal Muscular Atrophy (SMA) Screening
Parents or legal guardian of neonates who signed agreement will receive SMA screening test if their neonates are affected with SMA.
- Trial name
- SMA (NCT03217578)
- Testing
- SMA Newborn Screening
- Where
- Taiwan
- Volunteers
- 250,000 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Urinary Incontinence, Sarcopenia
The Urinary Incontinence Treatment Study
Investigators plan a prospective cohort study with an adaptive design based on physical function status. The design will involve tracking the number of women recruited with physical function impairment and those without any…
- Trial name
- UNITS (NCT03057834)
- Testing
- Pelvic floor muscle exercise
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Sarcopenia
Multicomponent Intervention for Physical Frailty and Sarcopenia
The SPRINTT study will evaluate the efficacy of a multicomponent intervention programme (physical activity, nutritional counselling/dietary intervention, and information and communications technology intervention) compared with a…
- Trial name
- SPRINTT (NCT02582138)
- Testing
- Multicomponent intervention (MCI), Healthy Aging Lifestyle Education (HALE)
- Where
- Italy
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Catholic University of the Sacred Heart
Sarcopenia, Healthy Elderly
Exercise and Nutritional Supplementation
To understand the effects of a novel dietary supplement when used in conjunction with a healthy lifestyle exercise program and to define biomarkers that are specific to sarcopenia.
- Conditions
- Sarcopenia, Healthy Elderly, Healthy Young
- Trial name
- ENSASL (NCT03536871)
- Testing
- multi-nutrient supplement, Exercise
- Where
- Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- McMaster University
Orthostatic Hypotension, Sarcopenia
Sarcopenia and Orthostatic Hypotension
Elderly patients generally have a tendency for having sarcopenia which refers to muscle loss that may be related to many factors. These patients also have a tendency to falls and injuries.
- Trial name
- NCT03732716
- Testing
- blood pressure measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Myotonic Dystrophy Type 2, Myotonic Dystrophy Type 1
Brain Structure and Clinical Endpoints in Myotonic Dystrophy Type 2
Nearly two-third of patients with myotonic dystrophy type 2 (DM2) report that impaired cognition is among the most disabling symptoms and deeply affects their quality of life.
- Trial name
- BraCE-DM2 (NCT05854433)
- Testing
- Non-interventional study
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Sarcopenia, Aged
HIT Training in the Frail Elderly.
This pilot study aims to investigate whether high intensity interval training can result in rapid improvements in physical fitness amongst the frail elderly (over 70 years old).
- Conditions
- Sarcopenia, Aged, Exercise, Preoperative Care
- Trial name
- eHIT (NCT03138265)
- Testing
- HIIT Device: ergometer
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Osteoporosis, Sarcopenia
Does Potassium Bicarbonate Improve the Effect of Dietary Protein on Bone and Muscle?
The purpose of this study is to examine whether adding the basic salt potassium bicarbonate to the diet will have a positive effect on how dietary protein affects your bone and muscle.
- Trial name
- NCT00730184
- Testing
- potassium bicarbonate
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Tufts University