Clinical trials: Muscle Physiology
Pre-diabetes, Type 2 Diabetes
Mechanisms of Fatigability With Diabetes
Pre-diabetes (Pre-D) is a precursor to type 2 diabetes (T2D) and characterized by increased exercise fatigability of lower limb muscles, that can impede exercise performance.
- Trial name
- NCT04442451
- Testing
- Control Exercise, Blood Flow Restriction Exercise
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Michigan
Respiratory Muscle, Exercise
The Effect of Functional Respiratory Muscle Training on Respiratory Function and Physical Performance
The study aims to investigate the effects of core stabilization exercise, which includes functional respiratory muscle training, on respiratory function, aerobic capacity, trunk stabilization, and physical performance in football…
- Trial name
- NCT06494930
- Testing
- F-IMT, Core Stabilization Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istinye University
Asthma in Children
Video Game-Based and Conventional Breathing Exercises on Pulmonary and Extrapulmonary Features in Children with Asthma
Conventional breathing exercises are recommended as a support to drug therapy, which is the primary treatment modality for symptom management in asthma patients.
- Trial name
- NCT06546566
- Testing
- Video Game-Based Breathing Exercises, Conventional Breathing Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Atlas University
Sarcopenia
Neuromuscular Electrical Stimulation Study
In this study, the investigators will use feasibility RCT design to determine whether it is justifiable to conduct a large-scale clinical trial of neuromuscular electrical stimulation with or without additional protein…
- Trial name
- IMMI (NCT04792307)
- Testing
- Neuromuscular electrical stimulation , no high protein ice cream supplementation
- Volunteers
- 66 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Core Stability, Respiratory Function
Effects of Diaphragmatic Breathing During Equipment-Based Pilates in Women
This randomized controlled study aims to investigate the effects of diaphragmatic breathing exercises on core stabilization muscle strength, peak expiratory flow (PEF), and chest expansion in women performing equipment-based…
- Conditions
- Core Stability, Respiratory Function, Diaphragmatic Breathing
- Trial name
- NCT07652229
- Testing
- Diaphragmatic Breathing Exercise, Equipment-Based Pilates Training
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Istanbul Aydın University
Muscle Loss
The Effect of Leucine on Carnitine Transport to Skeletal Muscle
The primary aim of the current research project is to explore whether leucine stimulates carnitine transport, and thus affecting muscle carnitine content.
- Trial name
- ROL (NCT05009654)
- Testing
- L-carnitine, L-leucine
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Laparoscopic Renal Surgery, Laparoscopy
Effects of Deep Neuromuscular Blockade on Intraoperative Respiratory Mechanics
The primary objective of the current study is to compare intraoperative respiratory mechanics in patients receiving laparoscopic renal surgery under deep neuromuscular blockade (dNMB) and under moderate neuromuscular blockade…
- Conditions
- Laparoscopic Renal Surgery, Laparoscopy, Muscle Relaxation
- Trial name
- NCT02185339
- Testing
- Rocuronium
- Where
- South Korea
- Volunteers
- 61 people
- Sponsor
- Seoul St. Mary's Hospital
Burns, Pediatric Burns
Resistance, Plyometric, and Combined Exercise Training in Children With Severe Burns
Children who experience severe burns may continue to have reduced muscle strength, power, balance, and physical function after their wounds have healed.
- Conditions
- Burns, Pediatric Burns, Burn Injury
- Trial name
- NCT07843355
- Testing
- Traditional Resistance Training, Plyometric Training, Combined Resistance and Plyometric Training
- Where
- Egypt
- Volunteers
- 78 people
- Sponsor
- Qassim University
Hamstring Flexibility, Hamstring Muscle Tightness
Effects of Combining PNF With NMES in Young Football Players
Hamstring muscle injuries are common in sports like football and often lead to extended periods of inactivity. This study aims to compare the effects of two different stretching programs on hamstring flexibility, with a secondary…
- Trial name
- PNF+NMES (NCT07075497)
- Testing
- Neuromuscular electrical stimulation (NMES), Contract-Relax PNF (crPNF)
- Where
- Spain
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Cardenal Herrera University
Geriatric, Kinesiophobia
The Effect of Exergame Games on Geriatric Individuals With Kinesiophobia
The study included 15 geriatric individuals over the age of 65 staying in Kızılay Zeynep Nedim Oyvar Nursing Home and Elderly Nursing Home.
- Trial name
- NCT05993624
- Testing
- virtual reality
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Istanbul Medipol University Hospital
Septic Shock
Association Between Muscle L3 CT Scan Muscle Derived Parameters of Muscle Function Upon Intensive Care Unit Admission and 3 Months Mortality After ICU Discharge for Patients Admitted for Septic Shock. The SIMS Study
Muscle dysfunction in intensive care units is associated with significant morbidity and mortality. During septic shock, there is an increased catabolism and systemic inflammation resulting in quantitative and qualitative muscle…
- Trial name
- SIMS (NCT07483710)
- Testing
- Evaluation of muscle dysfunction in intensive care units for septic schock patients
- Where
- 4 sites in France
- Volunteers
- 196 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Burns
Evaluation of Pulmonary Function in Burn Injury
This study evaluates the pulmonary function, respiratory muscle strength and peripheral muscle strength in patients with burn injury on the week that they will be discharge from the hospital.
- Trial name
- NCT03780218
- Testing
- Respiratory function
- Where
- Turkey (Türkiye)
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Sarcopenia, Gestational Diabetes Mellitus (GDM)
Sarcopenia in Gestational Diabetes
Sarcopenia is a syndrome characterized by loss of skeletal muscle mass and strength, and physical performance deterioration. Prevalence of sarcopenia in elderly people is remarkably high (prevalence of about 25% in 60+ years…
- Conditions
- Sarcopenia, Gestational Diabetes Mellitus (GDM), Pregnancy Complications, Adverse Maternal and Neonatal Outcomes
- Trial name
- SiGnal-D (NCT06876090)
- Testing
- Sarcopenia tests (for muscle mass, muscle function, physical performance), Oral Glucose Tolerance Test, Montreal Cognitive Assessment
- Where
- 3 sites in Austria, Italy
- Volunteers
- 200 people
- Sponsor
- Istituto di Neuroscienze Consiglio Nazionale delle Ricerche
Total Hip Arthroplasty
Strength and Function Following Total Hip Arthroplasty
To determine if patients who receive an 8 week, comprehensive, multi-component rehabilitation program (CMC) have better strength and functional performance compared to a control group (CON).
- Trial name
- NCT01817010
- Testing
- Multi-Component Rehabilitation (CMC), Control (CON)
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of Colorado, Denver
Growth Hormone Deficiency, Idiopathic Short Stature
Skeletal Muscle Effects of GH in Boys
The purpose of the study is to measure the functional effects of recombinant GH in skeletal muscle, in addition to growth promotion, in short prepubertal boys with either growth hormone deficiency or idiopathic short stature.
- Trial name
- NCT04020913
- Testing
- Somatropin injection
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Obesity, Sarcopenia
Biological Effects of Weight Loss In Older, Obese Women
Obesity and sedentary lifestyle are associated with physical impairments and biological changes in older adults. Weight loss combined with exercise may reduce inflammation and may improve physical functioning in older adults who…
- Trial name
- WL+E (NCT01032733)
- Testing
- Lifestyle Counseling, Educational Control
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Florida
Musculoskeletal Manipulations, Shoulder
Effects of Manual Therapy on Shoulder Function
The purpose of this study is to directly compare the effects of four distinct interventions commonly used in the treatment of shoulder pathology on shoulder range of motion (ROM) and strength in asymptomatic shoulders: grade III…
- Conditions
- Musculoskeletal Manipulations, Shoulder, Range of Motion, Muscle Strength
- Trial name
- NCT04513535
- Testing
- Thoracic Manipulation, Cervical Manipulation, glenohumeral posterior glide mobilization
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Hartford
Cervicogenic Headache, Proprioceptive Disorders
Manual Therapy vs. Multicomponent Exercise in Cervicogenic Headache
The purpose of this study is to compare the effects of manual therapy and a multicomponent exercise program on suboccipital muscle thickness, joint position sense, pain, central sensitization, balance, and kinesiophobia in…
- Conditions
- Cervicogenic Headache, Proprioceptive Disorders, Neck Pain Musculoskeletal
- Trial name
- NCT07776093
- Testing
- Manual Therapy Protocol, Multicomponent Exercise Program
- Volunteers
- 32 people
- Sponsor
- Pamukkale University
Vitamin D Deficiency, Sarcopenia
Impact of Vitamin D on 25-hydroxyvitamin D Levels and Physical Function
This one-year study will test the hypothesis that supplementation with vitamin D will improve lower extremity muscle performance in older men and women with vitamin D insufficiency.
- Trial name
- NCT02293187
- Testing
- vitamin D3
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tufts University
Pancreatic Cancer
Impact of Hypertrophy-oriented Resistance Training on Muscle Mass and Quality of Life in Patients With Unresectable Pancreatic Cancer
To determine the efficacy of a 12-week supervised, hypertrophy-oriented strength training program in preserving skeletal muscle mass, physical function, and quality of life in patients with unresectable pancreatic cancer compared…
- Trial name
- HY-PANC (NCT07470268)
- Testing
- supervised, hypertrophy-oriented strength training program
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Universidad Europea de Madrid