Clinical trials: Muscle Loss
Obesity, Glucose Intolerance
Age, Lifestyle, Muscle Mechanisms in Insulin Resistance
The purpose of this study is to investigate the mechanisms by which physical inactivity and obesity alter skeletal muscle insulin signaling to cause insulin resistance and increase the development of impaired glucose tolerance…
- Conditions
- Obesity, Glucose Intolerance, Exercise Capacity
- Trial name
- NCT00971594
- Testing
- Dietary counseling, AEX
- Where
- 2 sites in United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Weight Loss, Other Effects of High Altitude
Substrate Utilization, Exercise Performance, and Skeletal Muscle Response to Energy Deficit and Altitude Acclimatization
This research will evaluate nutrition requirements for missions at high altitude (i.e. >7800 feet above sea level) and the information obtained can be used to optimize nutrient content specifications for combat rations.
- Trial name
- NCT02731066
- Testing
- Standard pro, High pro, carbo bev
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Critical Illness, Muscle Loss
Investigating the Anabolic Response to Resistance Exercise After Critical Illness (ARTIST-2)
ICU survivors often suffer from long-term functional disability. An attenuated response to physical exercise in skeletal muscle after critical illness may contribute to persisting weakness.
- Trial name
- ARTIST-2 (NCT05261984)
- Testing
- Resistance exercise, Oral protein supplementation
- Where
- Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital
Sarcopenia
Effect of Carnitine Supplementation and Resistance Training on Skeletal Muscle Function
The primary aim of the current research project is to explore whether nutritional supplementation and resistance training might be combined to produce synergistic effects in the prevention of muscle loss during aging.
- Trial name
- NCT03907592
- Testing
- L-carnitine supplementation, Leucine supplementation, Resistance training
- Where
- Poland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Healthy Volunteers
A Clinical Pharmacology Study to Evaluate the Effect of GYM329 on Disuse Muscle Atrophy in Healthy Volunteer
This study will induce disuse atrophy through unilateral immobilization of the thigh and lower leg in healthy male volunteers to evaluate the PD of a single subcutaneous dose of GYM329 prior to or after unilateral thigh and lower…
- Trial name
- NCT04708847
- Testing
- GYM329
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chugai Pharmaceutical
Healthy, Perimenopausal Depression
Multidimensional Determinants of Functional Health In Women Aged 45-60
The goal of this observational study is to learn about the multidimensional determinants of functional health in women aged 45 to 60 years.
- Conditions
- Healthy, Perimenopausal Depression, Menopausal Complaints, Bone Mineral Density
- Trial name
- NCT07667699
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kartal City Hospital
Sarcopenia, Chronic Lower Back Pain
Prevalence and Factors Associated With Sarcopenia in Pre-retirement Aged Adults With Chronic Non-specific Lower Back Pain
To study the prevalence of sarcopenia in a pre-retirement group with chronic lower back pain and factors associated between sarcopenia and chronic lower back pain in the pre-retirement group.
- Trial name
- NCT05894213
- Where
- Thailand
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Male Pattern Baldness
Treatment of Male Pattern Baldness With Botulinum Toxin
This proof of concept study seeks to demonstrate that Botulinum toxin injections are a safe and effective method for treating this form of hair loss.
- Trial name
- NCT00965640
- Testing
- Botulinum Toxin - A injections
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- The Crown Institute
Exercise Training and Sarcopenia
Time Efficient Exercise to Reverse Sarcopenia and Improve Cardio-metabolic Health
Participants will be 60-80 y men and women who vary their physical activity (steps/day) while their lipid metabolism is studied (n=24).
- Trial name
- NCT04641117
- Testing
- Exercise
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Sarcopenia, Fall
Empirical Mode Decomposition and Decision Tree in Sarcopenia
Sarcopenia is quickly becoming a major global public health issue. Falls are the leading cause of mortality among the elderly, and they must be addressed.
- Conditions
- Sarcopenia, Fall, Gait, Unsteady, Balance; Distorted
- Trial name
- NCT05396404
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Changhua Christian Hospital
Sepsis, Primary Myopathies
Muscle Force Assessment in the Intensive Care Unit and in Primary Myopathies
The primary aim of the project is to apply the non-invasive stimulated muscle force assessment system to i) intensive care unit patients and ii) patients with primary myopathy or subclinic myopathy (e.g., Duchenne muscular…
- Trial name
- NCT00735384
- Where
- Switzerland
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Sarcopenia
HIF-1α Stabilization As a Novel Therapeutical Approach for Sarcopenia.
Age-related sarcopenia is associated with reduced mobility, functional decline and disability, falls, and mortality in the elderly.
- Trial name
- HIF2 (NCT06736249)
- Testing
- Sarcopenic group, Muscle harvesting
- Where
- Italy
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Muscular Atrophy
A Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study of ACE-031 in Healthy Postmenopausal Women
The purpose of this study is to establish safe dose levels of ACE-031 in healthy postmenopausal women following multiple dose administration. This study will also evaluate if ACE-031 has an effect on muscle.
- Trial name
- NCT00952887
- Testing
- ACE-031
- Where
- 2 sites in Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Acceleron Pharma, Inc., a wholly-owned subsidiary of Merck & Co., Inc., Rahway, NJ USA
Muscle Weakness, Muscle Loss
A Study on the Effects on Glucose Regulation, Inflammation and Serum Lipids After Fish Protein Supplementation in Elderly (GRIPE)
The elderly population have and increased risk of loss of both muscle mass and function and is therefore recommended a higher protein intake than the healthy adult population.
- Conditions
- Muscle Weakness, Muscle Loss, Blood Sugar; High, Inflammation
- Trial name
- GRIPE (NCT03529344)
- Testing
- Blue whiting protein hydrolysate
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Sarcopenia
Dose Response of Whey and Soy Protein Ingestion With and Without Resistance Exercise in Elderly Men
When we age, we lose muscle. It is not exactly clear why this happens, but we do know that this muscle loss can increase health risks and lead to health problems. Lifting weights (i.e.
- Trial name
- NDC (NCT01062711)
- Testing
- Whey or soy protein
- Where
- Canada
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- McMaster University
Sarcopenia
Carnitine Supplementation and Skeletal Muscle Function
Research project objectives The primary aim of the current research project is to use carnitine supplementation as the anti-inflammatory intervention for exploring the relationship between inflammation and associated with aging…
- Trial name
- NCT02692235
- Testing
- carnitine
- Where
- Poland
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Sarcopenia, Elderly
Alternative to Gait Speed in Sarcopenia Assessment
This study aims to assess the reliability of the Elbow Performance Test as an upper extremity-based alternative for evaluating sarcopenia severity.
- Trial name
- NCT07065448
- Testing
- physical performance tests
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Sarcopenia
Effect of Exercise and Protein Supplementation on Muscle Function in Patients With Hemodialysis
Sarcopenia can be easily observed in patients with hemodialysis. However, there were few studies on the precise concept and diagnostic criteria for sarcopenia in patients with hemodialysis.
- Trial name
- NCT04927208
- Testing
- exercise and nutritional support
- Where
- South Korea
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Chungnam National University Hospital
Aging, Sarcopenia
Dose-response Effect of Dietary Nitrate on Muscle Function in Older Individuals
Nitrate is a naturally-occurring substance found in foods, especially green leafy vegetables and beets. Increasing nitrate intake (by drinking beetroot juice (BRJ) has been shown to improve muscle function young and middle-aged…
- Trial name
- NCT03595774
- Testing
- Beet root juice
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Indiana University
Sarcopenia
Ankle Assistance and Resistance in Older Adults
The goal of this research protocol is to improve mobility in older individuals through advances in wearable assistive devices by focusing on two specific aims.
- Trial name
- NCT06284525
- Testing
- Ankle resistance and biofeedback
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Northern Arizona University