Clinical trials: Muscle Hypertrophy
Investigating the Effects of Power Training in the Elderly
Effects of Different Power Training Intensities in Older Adults
Power (strength × velocity) is a crucial component for maintaining independence during aging. Therefore, investigating interventions aimed at improving this physical capacity is essential for this population.
- Trial name
- NCT07023146
- Testing
- Moderate to high intensity (PTMH; 65-80% of 1-repetition maximum [1RM]) ), low to moderate intensity (PTLM; 40-60% of 1-repetition maximum [1RM])
- Where
- Brazil
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Hypertrophic Cardiomyopathy
Studying the Effectiveness of Pacemaker Therapy in Children Who Have Thickened Heart Muscle
A heart condition called hypertrophic cardiomyopathy (HCM) causes abnormal thickening of the heart muscle, which obstructs the flow of blood out of the heart.
- Trial name
- NCT00001960
- Testing
- Pacemaker therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Muscle Strength, Muscle Hypertrophy
Effects of BFR Training on Muscle Strength, Thickness, and Motivation in National Adolescent Male Canoe Athletes
The aim of this study is to evaluate the effects of blood flow restriction (BFR) exercises on lower extremity muscle strength, muscle thickness, and sport-specific motivation in adolescent elite male canoe athletes.
- Conditions
- Muscle Strength, Muscle Hypertrophy, Sport Performance
- Trial name
- BRAVE-CAN (NCT06912867)
- Testing
- Blood Flow Restriction (BFR) Exercise Program
- Where
- Cyprus
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Eastern Mediterranean University
Rotator Cuff Tendinopathy, Rotator Cuff Syndrome
Blood Flow Restriction Therapy and Gua Sha Therapy in Rotator Cuff Tendinopathy Patients
The goal of study is to improve shoulder tendinopathy. By comparing advanced blood flow restriction with traditional Gua sha scraping, it can be identified which therapy is more effective at restoring functional movement and…
- Trial name
- NCT07587502
- Testing
- Blood Flow Restriction, Gua Sha Scraping Therapy
- Where
- Pakistan
- Volunteers
- 34 people
- Sponsor
- Elite College of Management Sciences, Gujranwala, Pakistan
Heart Failure
The Effects of Sacubitril/Valsartan on Cardiac Oxygen Consumption and Efficiency of Cardiac Work in Heart Failure Patients
This is a phase IV, prospective, randomized, double-blind, double-dummy, parallel-group study. The study assessed the effects of 6 weeks of stable sacubitril/valsartan therapy, as compared with valsartan therapy, on the…
- Trial name
- TurkuPET (NCT03300427)
- Testing
- sacubitril/valsatran, valsartan
- Where
- Finland
- Volunteers
- 55 people
- Sponsor
- Novartis Pharmaceuticals
Masseter Muscle Hypertrophy
Botulinum Toxin Type A (BOTOX®) Treatment of Masseter Muscle Hypertrophy
This study will evaluate the safety and efficacy of a range of doses of botulinum toxin Type A (BOTOX®) for the treatment of patients with bilateral Masseter Muscle Hypertrophy (MMH).
- Trial name
- NCT02010775
- Testing
- botulinum toxin Type A, Normal saline
- Where
- 14 sites in Australia, Canada and 1 more
- Volunteers
- 187 people
- Sponsor
- Allergan
Healthy
The Effects of Lower Extremity Blood Flow Restriction Training on Power, and Muscle Size.
Blood-flow restriction training (BFR) is a technique utilized to provide the benefits of high intensity exercise (strength, power, hypertrophy) when applied to exercise intensities that are insufficient to produce these benefits…
- Trial name
- NCT03983070
- Testing
- Seated Rowing Ergometer, Deadlift, Blood flow restriction
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Campbell University, Incorporated
Hypertrophy, Muscle Strength
Applicability of Tissue Flossing for Blood Flow Restriction in the Upper Limb: Reliability and Performance Analysis
Blood flow restriction (BFR) is a widely studied technique that combines low-intensity exercise with vascular occlusion, resulting in muscular benefits.
- Trial name
- NCT06512961
- Testing
- Tissue Flossing, Blood Flow Restriction Cuff, Training Protocol
- Where
- Brazil
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Paulista University
Cardiomyopathy, Hypertrophic, Muscular Dystrophy, Oculopharyngeal
Study of Muscle Abnormalities in Patients With Specific Genetic Mutations
Hypertrophic cardiomyopathy (HCM) is a genetically inherited disease affecting the heart. It causes thickening of heart muscle, especially the chamber responsible for pumping blood out of the heart, the left ventricle.
- Trial name
- NCT00001871
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hypertrophy
D2O Dosing Strategies to Assess Muscle Protein Synthesis
Skeletal muscle mass is regulated by the balance of muscle protein synthesis (MPS) and muscle protein breakdown (MPB). MPS is sensitive to exogenous stimuli, particularly exercise and protein ingestion.
- Trial name
- D2O-MPS (NCT04256343)
- Testing
- Deuterium Oxide (D2O) Dose
- Volunteers
- healthy volunteers welcome
- Sponsor
- McMaster University
Cardiomyopathy, Hypertrophic
Nitrite in Hypertrophic Cardiomyopathy (HCM) Study
Inorganic nitrate, which is found at high levels in green leafy vegetables, is reduced to nitrite by bacteria in the mouth, swallowed, and absorbed in the stomach into the blood.
- Trial name
- NCT03251287
- Testing
- Sodium Nitrate, Phosphorous Magnetic Resonance Spectroscopy, Exercise Stress Transthoracic Echocardiogram
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- University of East Anglia
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- 2 sites in United States, Australia
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Mitochondria, Strength
BFR and Muscle Mitochondrial Oxidative Capacity
Blood flow restricted (BFR) exercise has been shown to improve skeletal muscle adaptations to resistance exercise. BFR uses blood pressure cuffs (i.e., tourniquets) to reduce skeletal muscle blood flow during resistance exercise.
- Conditions
- Mitochondria, Strength, Hypertrophy
- Trial name
- NCT03723226
- Testing
- Low Load Resistance Exercise, Low Load Resistance Exercise + BFR
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Louisiana State University and A&M College
Cardiomyopathy, Hypertrophic, Coronary Disease
Analysis of Heart Muscle Function in Patients With Heart Disease and Normal Volunteers
Myocardial ischemia is a heart condition in which not enough blood supply and oxygen reaches the heart muscle. Damage to the major blood vessels of the heart (coronary artery disease), minor blood vessels of the heart…
- Conditions
- Cardiomyopathy, Hypertrophic, Coronary Disease, Healthy, Myocardial Ischemia
- Trial name
- NCT00001459
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hypertrophy, Contraction
Resistance Training Effects on Muscle Morphological, Mechanical and Contractile Properties
The aim of the research project is to investigate the influence of resistance-training prescription (repetition duration, time under tension and training volume) and sex have on morpho-functional adaptations of upper and…
- Trial name
- NCT04845295
- Testing
- resistance training
- Where
- Serbia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Belgrade
Muscle Hypertrophy in Healthy Young Men
Chronic Beta2-adrenergic Stimulation and Cardiac and Skeletal Muscle Hypertrophy
Studies in animals have shown that beta2-adrenoceptor activation with selective agonists regulates protein metabolism and muscle growth in skeletal and cardiac muscle tissue.
- Trial name
- NCT02551276
- Testing
- Salbutamol, Resistance training
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Muscle Hypertrophy
The Load-velocity Relationship: Neuromuscular Adaptations to Resistance Training
Adaptations to resistance training are highly specific and depend on the combination of external loading and the level of individual adaptability.
- Trial name
- NCT06760663
- Testing
- The load-velocity relationship: Neuromuscular adaptations to resistance training
- Where
- Portugal
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Lisbon
Sarcopenia, Muscular Atrophy
Exercise and Nutrition Interventions in Age-related Sarcopenia
This project will investigate the synergistic effects of Aerobic and Resistance type Exercise, in combination with Protein Supplementation, on; Body Composition, Musculoskeletal Functioning, Nutritional Status and Quality of Life…
- Trial name
- NCT02912130
- Testing
- Protein Supplementation, Aerobic Exercise, Resistance Exercise
- Where
- United Kingdom
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Liverpool Hope University
Hypertrophy, Muscle Strength
Reliability and Performance Analysis of the Use of Tissue Flossing for Blood Flow Restriction.
Blood flow restriction (RFS) is a widely studied technique that combines low-intensity exercise with vascular occlusion, resulting in muscular benefits.
- Trial name
- NCT06075901
- Testing
- Tissue Flossing, Blood Flow Restriction Cuff, Training Protocol
- Where
- Brazil
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Paulista University
Aging
Metformin to Augment Strength Training Effective Response in Seniors (MASTERS)
The purpose of this study is to determine whether a commonly prescribed drug, metformin, can enhance the benefits seen during resistance exercise such as increased muscle mass and strength.
- Trial name
- NCT02308228
- Testing
- Progressive Resistance Training, Metformin
- Where
- 2 sites in United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Philip Kern