Clinical trials: Muscle Function
Heart Failure
The Effects of Sacubitril/Valsartan on Cardiac Oxygen Consumption and Efficiency of Cardiac Work in Heart Failure Patients
This is a phase IV, prospective, randomized, double-blind, double-dummy, parallel-group study. The study assessed the effects of 6 weeks of stable sacubitril/valsartan therapy, as compared with valsartan therapy, on the…
- Trial name
- TurkuPET (NCT03300427)
- Testing
- sacubitril/valsatran, valsartan
- Where
- Finland
- Volunteers
- 55 people
- Sponsor
- Novartis Pharmaceuticals
Constipation
Effects of Exercise Training on Pelvic Floor Symptoms and Function in Adults With Constipation
Constipation is a common problem in the general population. Defecation disorders caused by abnormal contraction or insufficient relaxation of the pelvic floor muscles during defecation may be one of the most possible causes of…
- Trial name
- NCT04661202
- Testing
- multimodal exercise training
- Where
- Taiwan
- Volunteers
- 27 people
- Sponsor
- National Cheng Kung University
Chronic Pain, Musculoskeletal Pain
Improving Health for Older Adults With Pain Through Engagement (Open-pilot)
The goal of this project is to conduct an open-pilot (N=30) to evaluate the feasibility, acceptability, and fidelity of a mind-body and activity program (GetActive+) with older adults with chronic pain.
- Trial name
- iHOPE (NCT05782231)
- Testing
- GetActive+
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Massachusetts General Hospital
Neuromuscular Function, Muscle Activation
Mechanistic Drivers of Acute PAPE Responsiveness: Muscle Architecture, Contractile Kinetics, and Excitability in a Randomized Controlled Trial
The goal of this study is to find out if one short set of heavy half-squats can help football players jump higher right away-and to understand what happens inside their muscles and nerves to make that boost happen.
- Conditions
- Neuromuscular Function, Muscle Activation, Postactivation Potentiation, Ultrasonography
- Trial name
- NCT06982937
- Testing
- High-Intensity Half-Squat, Treadmill running
- Where
- Poland
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- The Jerzy Kukuczka Academy of Physical Education in Katowice
Breast Cancer
Alternative Exercise Program to Improve Skeletal Muscle Function and Fatigue in Cancer Survivors
Exercise training has beneficial effects in cancer survivors to minimize some of the side effects of cancer and its treatment and improve long-term prognosis, but there are numerous hurdles for individuals diagnosed with, and…
- Trial name
- NCT02739620
- Testing
- Neuromuscular electrical stimulation
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Vermont
Hypoglycemia
Hypoglycemia and Autonomic Nervous System Function
The goals of this proposal are to determine the effects of hypoglycemia on the autonomic nervous system.
- Trial name
- HypoANS (NCT01816893)
- Testing
- Hypoglycemic hyperinsulinemic clamp, Euglycemic hyperinsulinemic clamp
- Where
- 2 sites in United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Quadriceps Muscle
Effect of Antibacterial Mouthwash on Muscle Function in Healthy Young Men and Women
The purpose of this study is to determine the effects of antibacterial mouthwash on muscle speed and power in healthy young men and women.
- Trial name
- NCT04095442
- Testing
- Cepacol, Tom's Natural Mouthwash
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Indiana University
Menopause, Hypertension
The Effects of Swimming on Elderly Women With Stage-2 Hypertension
Aging is associated with progressive decreases in arterial health and function as well as overall fitness. It is crucial to prevent or reduce the negative effects of aging on the vasculature and fitness components by implementing…
- Trial name
- NCT03546270
- Testing
- Swimming
- Volunteers
- 100 people
- Sponsor
- Pusan National University
Neuromuscular Function
Vitamin D Supplementation and Muscle Function in Older Adults
The purpose of this study is to see if vitamin D supplementation improves muscle function in older adults.
- Trial name
- EVIDENCE (NCT02015611)
- Testing
- Vitamin D
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Mitochondrial Function, Physical Function
Resveratrol to Enhance Vitality and Vigor in Elders
Resveratrol, a compound found in red wine and dark-skinned grapes, will improve the function of mitochondria (energy producing components) within the leg muscles of moderate functioning older adults.
- Trial name
- REVIVE (NCT02123121)
- Testing
- Resveratrol 1000 mg/day, Resveratrol 1500 mg/day, Vegetable cellulose
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Florida
Amputation
Transfemoral Socket Design and Muscle Function
The objective of this pilot research project is to evaluate the effect of prosthetic socket design on amputated limb hip muscle strength and endurance in Service members, Veterans, and civilians who use above-the-knee prostheses.
- Trial name
- NCT04212299
- Testing
- Northwestern University Flexible Sub-Ischial Suction Socket (NU-FlexSIS)
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
Irritable Bowel Syndrome (IBS), Functional Abdominal Pain
Peer Mentorship: An Intervention To Promote Effective Pain Self-Management In Adolescents
This protocol matches child subjects with peer mentors of similar age who have learned to function successfully with a chronic pain disorder.
- Conditions
- Irritable Bowel Syndrome (IBS), Functional Abdominal Pain, Fibromyalgia, Complex Regional Pain Syndrome (CRPS)
- Trial name
- NCT01118988
- Testing
- Mentorship
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of California, Los Angeles
Fibromyalgia
Repetitive Transcranial Magnetic Stimulation (rTMS) in Fibromyalgia
This study aims to evaluate the effectiveness of 10 Hz neuronavigated repetitive transcranial magnetic stimulation (rTMS) to the left dorsolateral prefrontal cortex (DLPFC) on pain, stiffness, fatigue, depression/anxiety, quality…
- Trial name
- NCT03909009
- Testing
- rTMS + Neuronavigation
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Izmir Katip Celebi University
Spastic Gait, Spastic
Exoskeleton Robotic Assisted Gait Training in Spastic Stroke Post Botulinum Toxin A Injection
The purpose of this project is to examine and compare the immediate and long-term effects of combined Botulinum toxin type A(BoNT-A) injection with exoskeleton Robotic assisted gait training (RABT) in patients with post-stroke…
- Trial name
- NCT06070987
- Testing
- BoNT-A injections, RF BoNT-A injection in first period and robot therapy, RF BoNT-A injection in second period and robot therapy
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Chang Gung Memorial Hospital
Hamstring Injury, Muscle Tone Increased
Cranial Laser Reflex Technique for Hamstring Function
Purpose: To conduct a pilot study of the effect of Cranial Laser Reflex Technique (CLRT) compared with sham laser on hamstring muscle flexibility, strength, and pain pressure threshold.
- Conditions
- Hamstring Injury, Muscle Tone Increased, Muscle Pain, Muscle Weakness
- Trial name
- CLRTHam (NCT03044106)
- Testing
- CLRT
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Cirrhosis, Aerobic Exercises
The Efficacy of Aerobic Exercise Training on ANS and Endothelial Function in Compensated Cirrhosis
The goal of this randomized controlled trial is to investigate whether a 16-week structured aerobic exercise program combined with nutritional consultation can improve autonomic and endothelial function in patients with…
- Conditions
- Cirrhosis, Aerobic Exercises, Lifestyle Modification, Endothelial Function
- Trial name
- NCT06288828
- Testing
- Aerobic exercise + Nutrition consultant, Nutrition consultant
- Where
- Thailand
- Volunteers
- 50 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Hypogonadism
Cycled Testosterone Replacement Study
The purpose of this study is to determine whether testosterone (male hormone) therapy is effective if administered in a cyclic fashion (periodic dosing) compared to continuous dosing in men aged 60 to 85 years.
- Trial name
- NCT00957528
- Testing
- Testosterone
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Muscular Dystrophy, Duchenne, Ambulatory Care
Phase III Study of Idebenone in Duchenne Muscular Dystrophy (DMD)
The aim of this Phase III study was to assess the efficacy of idebenone on pulmonary function, motor function, muscle strength and quality of life in patients with DMD.
- Trial name
- DELOS (NCT01027884)
- Testing
- Idebenone
- Where
- 23 sites in United States, Austria and 8 more
- Volunteers
- 65 people
- Sponsor
- Santhera Pharmaceuticals
Multiple Sclerosis
Impact of Direct Current Electrical Stimulation on Spasticity Levels and Functional Muscle Use in MS
In an individual with MS the central nervous system (CNS) is over-protective and causes the threshold for stretch reflex and muscle tightness to be set lower than normal.
- Trial name
- NCT04942938
- Testing
- Neubie
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- CommonSpirit Health
Duchenne Muscular Dystrophy (DMD)
Twice Weekly Steroids and Exercise as Therapy for DMD
The study team will determine the potential of low dose twice weekly prednisone and whether exercise training can synergize to delay disease progression and improve muscle strength/physical function in boys with Duchenne muscular…
- Trial name
- NCT04322357
- Testing
- Prednisone, Exercise Training on standard steroid regimen, Exercise training on twice-weekly steroids
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Florida