Clinical trials: Muscle Atrophy
Sarcopenia
Clinical Trial of CG-BM1 Allogeneic Human Bone Marrow Mesenchymal Stem Cell Injection in the Treatment of Sarcopenia
1. To evaluate the safety and tolerability of CG-BM1 for the treatment of patients with Sarcopenia. 2. To observe the preliminary effectiveness of CG-BM1 in treating Sarcopenia patients.
- Trial name
- CGBM1-SAR-01 (NCT07865676)
- Testing
- CG-BM1- 5.0 × 10^7 cells, CG-BM1-1.0 × 10^8 cells
- Where
- China
- Volunteers
- 30 people
- Sponsor
- GuangZhou Cellgenes Biotechnology Co., Ltd.
Spinal Muscular Atrophy Type I
Clinical Trial of Sodium Phenylbutyrate in Children With Spinal Muscular Atrophy Type I
The purpose of this study is to identify the maximum tolerated dosage of sodium phenylbutyrate in children with spinal muscular atrophy type I; and to determine if the drug has an effect on SMN mRNA and protein levels.
- Trial name
- NPTUNE 02 (NCT00439218)
- Testing
- sodium phenylbutyrate
- Where
- 5 sites in United States
- Volunteers
- 5 people
- Sponsor
- Westat
Sarcopenia in Elderly, Sarcopenia
Effect of the Consumption of Cookies Enriched With Plant Proteins and of a Vitamin D Supplement on the Progression of Sarcopenia in the Elderly
The ageing population makes it necessary to find effective strategies for the prevention of sarcopenia (the progressive loss of muscle mass and strength and a decline in physical performance) that can be counteracted with foods…
- Conditions
- Sarcopenia in Elderly, Sarcopenia, Nutritional Intervention, Microbiome Analysis
- Trial name
- SARC-PEA (NCT07356440)
- Testing
- Vitamin D3 supplement, Protein-enriched biscuits, Control biscuit
- Where
- 3 sites in Italy
- Volunteers
- 74 people
- Sponsor
- University of Udine
Muscular Atrophy, Spinal
A Study to Find Out How Nusinersen is Processed in the Body When Given Through the ThecaFlex DRx™ System in Adult and Pediatric Participants With Spinal Muscular Atrophy (PIERRE-PK)
In this PIERRE-PK study, researchers will learn how the body processes nusinersen when it is given through the ThecaFlex DRx™ System, compared to when nusinersen is given by lumbar puncture (LP).
- Trial name
- PIERRE-PK (NCT06555419)
- Testing
- Nusinersen, ThecaFlex DRx System
- Where
- 21 sites in United States, France and 5 more
- Volunteers
- 78 people
- Sponsor
- Biogen
Limb-girdle Muscular Dystrophy
MRI on Persons With Mutations in POMT2 Gene (LGMD2N)
POMT2 mutation is known to cause Walker Warburg Syndrome and Muscle-Brain-Eye syndrome. Recently it has been connected to limb girdle muscular dystrophy (LGMD), a disorder characterized by muscle weakness and atrophy of the…
- Trial name
- NCT02759302
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Osteoporosis, Osteopenia
The Effect of 16 Weeks of Hip Adduction and Abduction Resistance Exercise
Performing adduction and abduction resistance exercise will increase hip bone density and strength to a greater extent than doing squat and deadlift exercise.
- Conditions
- Osteoporosis, Osteopenia, Sarcopenia
- Trial name
- Ad/Ab (NCT01228877)
- Testing
- exercise
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Malnutrition, Sarcopenia
Sustainable Eating Pattern to Limit Malnutrition in Older Adults
The SENIOR STUDY is aimed at improving the condition of older adults and malnutrition management in and out Italian hospital settings, since malnutrition is highly prevalent, clinically relevant and potentially treatable…
- Trial name
- SENIOR (NCT05860556)
- Where
- Italy
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- University of Pavia
Neuromuscular Diseases, Cerebral Palsy
Rehabilitative Effect of the Use of a Gait Exoskeleton in Patients With Neuromuscular Disease or Cerebral Palsy
The purpose of this multicentric study is to assess the rehabilitative effect derived from the use of the ATLAS exoskeleton in children with neuromuscular diseases or cerebral palsy and with a level of less than 3 or less in the…
- Conditions
- Neuromuscular Diseases, Cerebral Palsy, SMA II
- Trial name
- NCT04813601
- Testing
- ATLAS 2030
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- MarsiBionics
Muscle Diseases
Acceptance and Commitment Therapy for Muscle Disease
In adults, muscle diseases are usually chronic long-term conditions that do not have a definitive cure. Supportive care has been shown to reduce complications from muscle disease and improved survival in some cases.
- Trial name
- ACTMuS (NCT02810028)
- Testing
- Acceptance and Commitment Therapy (ACT)
- Where
- United Kingdom
- Volunteers
- 155 people
- Sponsor
- King's College Hospital NHS Trust
Older Adults (60 - 85 Years Old), Sarcopenia
Evaluation of Sarcopenia and Muscle Biomechanics in Older Adults After Lumbar Fusion Surgery
Abstract Background: Lumbar fusion (LF) surgery successfully restores the mechanical stability of the spine; however, postoperative kinesiophobia and complications can trigger secondary sarcopenia.
- Conditions
- Older Adults (60 - 85 Years Old), Sarcopenia, Lumbar Fusion Surgery, Low Back Pain
- Trial name
- NCT07866807
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Karamanoğlu Mehmetbey University
Muscular Atrophy, Spinal, Type II, Muscular Atrophy, Spinal, Type III
Home Monitoring of Adult Patients With SMA: a Pilot Multicenter Validation Study
There is no complete cure for SMA yet. However, the discovery of the genetic cause of SMA has led to the development of several treatment options that affect the genes involved in SMA - a gene replacement therapy called…
- Trial name
- SMA-AtHome (NCT05839145)
- Testing
- Strength force measurment, Time tests, Motor scales
- Where
- 6 sites in France
- Volunteers
- 60 people
- Sponsor
- Institut de Myologie, France
Duchenne Muscular Dystrophy (DMD)
A Phase III Double-blind Study With Idebenone in Patients With Duchenne Muscular Dystrophy (DMD) Taking Glucocorticoid Steroids
The purpose of the study is to assess the efficacy of idebenone in delaying the loss of respiratory function in patients with DMD receiving concomitant glucocorticoid steroids
- Trial name
- SIDEROS (NCT02814019)
- Testing
- Idebenone 150 mg film-coated tablets
- Where
- 63 sites in United States, Austria and 13 more
- Volunteers
- 255 people
- Sponsor
- Santhera Pharmaceuticals
Duchenne Muscular Dystrophy
Outcome Measures in Duchenne Muscular Dystrophy: A Natural History Study
Novel emerging therapies for Duchenne Muscular Dystrophy (DMD) require a deeper understanding of DMD natural history. This study aim to assess the natural history of DMD through a composite assessment tool capable of capturing…
- Trial name
- NCT02780492
- Testing
- Set of assessment tools
- Where
- 5 sites in France, Netherlands and 1 more
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University College, London
Spinal Muscular Atrophy
European Registry of Patients With Infantile-onset Spinal Muscular Atrophy
IO-SMA-Registry is a prospective, longitudinal and observational study which objective is to collect prospectively information on longevity, psychomotor development and respiratory function of patients with infantile-onset spinal…
- Trial name
- NCT03339830
- Where
- 6 sites in France
- Volunteers
- 100 people
- Sponsor
- Institut de Myologie, France
Covid19, Sarcopenia
Muscular Rehabilitation by Eccentric Exercise After Severe COVID-19 Infection
With the COVID-19 pandemic, the number of patients to be treated in rehabilitation increased . Hospitalization for severe infection can induce muscular atrophy and muscular dysfunction that persists for several months and…
- Conditions
- Covid19, Sarcopenia, Muscle Weakness
- Trial name
- CovExc (NCT04649086)
- Testing
- Rehabilitation by Eccentric exercises, Rehabilitation by Concentric exercises
- Where
- 3 sites in France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Clermont-Ferrand
Cerebral Palsy, Caregiver Burden
Awareness Levels of Caregivers of Disabled Children
Disability-or apology; It is the inability or incompleteness of individuals to fulfill their roles in life, such as age, gender, culture, social and psychological factors, due to their inadequacies.
- Conditions
- Cerebral Palsy, Caregiver Burden, Disabilities Multiple, Muscular Dystrophy
- Trial name
- caregivers (NCT05228405)
- Testing
- All of the disabled children's caregivers will answer the Questionnaire of Disease, Physiotherapy and Sports Awareness
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Sarcopenia
Efficacy of Virtual Reality Exercises on Sarcopenia in Patients With Liver Transplantation
This study will be conducted to investigate the effect of virtual reality exercises on hand grip strength, pinch strength, quadriceps muscle strength, exercise capacity, fatigue, and quality of life in patients with liver…
- Trial name
- LT (NCT06209073)
- Testing
- Virtual Reality exercise, conventional treatment
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Sarcopenia
Muscle Assessment Through Ultrasound in the Evaluation of Acute Sarcopenia
Traditionally, muscle mass - a part of the concept of sarcopenia - is measured by computed tomography (CT) or dual-energy X-ray absorptiometry (DEXA) scan.
- Trial name
- NCT03740061
- Testing
- Ultrasonographic assessment of muscle
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- Universiteit Antwerpen
Muscle Strain, Multiple Sites
Nutritional Strategies After Muscle Strain Injuries
Muscle strain injuries are a particularly frequent type of sports injury in soccer, athletics, badminton/ tennis and cross-fit fitness, thereby affecting a broad range of popular leisure time activities.
- Trial name
- NCT04100161
- Testing
- Protein supplementation, Carbohydrate supplementation, Active rehabilitation
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Duchenne Muscular Dystrophy (DMD)
Research on the Relationship Between Scoliosis, Pain, Quality of Life, and Trunk Muscle Compensation Patterns Among Patients with Duchenne Muscular Dystrophy.
Objective: The objective of this observational study is to evaluate and quantify trunk muscle compensatory movement patterns in patients with Duchenne Muscular Dystrophy (DMD) using computer vision technology.
- Trial name
- NCT06755138
- Testing
- Observational Assessment
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital