Clinical trials: Multiplex PCR
Viral Respiratory Infection (e.g., Influenza), Bacterial Respiratory Infections
Respiratory Pathogen Distribution During and After the COVID-19 Pandemic
This retrospective observational study aims to evaluate changes in the prevalence and distribution of respiratory pathogens detected by multiplex respiratory polymerase chain reaction (PCR) testing during and after the SARS-CoV-2…
- Trial name
- NCT07601126
- Where
- Turkey (Türkiye)
- Volunteers
- 537 people
- Sponsor
- Hisar Intercontinental Hospital
Pleural Infection
Diagnostic Utility of Pleural Infection-specific Multiplex PCR Panel
Pleural effusion is a common cause of hospitalization. Pleural infection ranked third among the pleural effusions requiring hospitalization in the United States.
- Trial name
- PRISM (NCT07077096)
- Testing
- PRISM PCR panel, Conventional bacterial culture
- Where
- Hong Kong
- Volunteers
- 800 people
- Sponsor
- Chinese University of Hong Kong
Infectious Gastroenteritis
Implementation of a Molecular Diagnostic for Pediatric Acute Gastroenteritis: The FilmArray GI Panel IMPACT Study
BioFire Diagnostics, LLC (BioFire) has developed the FilmArray Gastrointestinal (GI) Panel, a rapid, easy to use PCR-based in vitro diagnostic test for the identification of 22 common microorganisms responsible for infectious…
- Trial name
- IMPACT (NCT02248285)
- Testing
- FilmArray™ Gastrointestinal (GI) Panel
- Where
- 5 sites in United States
- Volunteers
- 1,545 people
- Sponsor
- BioFire Diagnostics, LLC
Neutropenia
The Utility of Multiplex PCR for Detection of DNA in Neutropenic Patients With Hematological Malignancies
Objectives: Invasive infections are the leading cause of morbidity and mortality in patients treated for hematological malignancies.
- Trial name
- MedIso (NCT01669005)
- Volunteers
- 84 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Acute Respiratory Infection
Expanded Diagnostic Strategy in Older Adults Hospitalized With Community-Acquired Acute Respiratory Infection
This study will evaluate whether an expanded diagnostic strategy can reduce antibiotic use in patients aged 65 years or older who are hospitalized with community-acquired acute respiratory infection, without negatively affecting…
- Trial name
- NeuBluMul (NCT07883902)
- Testing
- Expanded Diagnostic Strategy, Conventional Diagnostic Strategy
- Where
- Spain
- Volunteers
- 406 people
- Sponsor
- Santiago Lopez Gil
Community-acquired Pneumonia
Role of Multiplex PCR in CAP
1. role of multiplex PCR in early identifying bacteria in patients with lower respiratory tract infection. 2. effect of early starting targeted antibiotics on outcome
- Trial name
- NCT06097117
- Testing
- MultiplexPCR
- Volunteers
- 66 people
- Sponsor
- Assiut University
Pneumonia, Bacterial Pneumonia
Multiplex Polymerase Chain Reaction in Postoperative Pneumonia After Thoracic Surgery
Background: In thoracic surgery, postoperative pneumonia (POP) is the leading cause of postoperative morbidity and mortality. The clinical diagnosis of POP is difficult and conventional microbiological diagnostic tests perform…
- Trial name
- POP-PCR (NCT03752320)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Waardenburg Syndrome, Large Vestibular Aqueduct Syndrome
Development and Clinical Application of Two New Genetic Deafness Gene Diagnostic Kit
The purpose of this study is to develop and applicate two new genetic deafness gene diagnostic kit for Waardenburg syndrome and large vestibular aquduct syndrome.
- Trial name
- NCT02418936
- Testing
- gene diagnostic kit
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xiangya Hospital of Central South University
Multiplex Respiratory PCR Results in Diabetic Pneumonia Cases
Multiplex Respiratory PCR Results in Diabetic Pneumonia Cases
Multiplex respiratory polymerase chain reaction (PCR) test has gained wide acceptance as an alternative to conventional culture methods for the detection of the causative agent of community-acquired pneumonia (CAP).
- Trial name
- PCR (NCT06459713)
- Testing
- multiplex respiratory polymerase chain reaction test
- Where
- Turkey (Türkiye)
- Volunteers
- 151 people
- Sponsor
- Hisar Intercontinental Hospital
COVID-19
Efficacy of a Multiplex BangasureTM RT-PCR Kit for the Detection of COVID-19
The outbreak of the severe acute respiratory syndrome (SARS) corona virus (CoV)-2 continues to increase globally. To control the coronavirus disease 2019 (COVID-19) transmission, diagnose is very important step which would help…
- Trial name
- COVID-19 (NCT05190016)
- Where
- Bangladesh
- Volunteers
- 150 people
- Sponsor
- DR. MALA KHAN
Lung Transplantation
Film Array Pneumonia Plus Panel® Multiplex PCR for Early Adaptation of Antibiotic Prophylaxis During Lung Transplantation
Postoperative pneumonia significantly worsens the prognosis for patients undergoing lung transplantation (LT). It is therefore recommended to use antibiotic prophylaxis after LT, although the specific types of antibiotics or the…
- Trial name
- FilmArray-TP (NCT07792018)
- Testing
- Early adapation of antibiotic prophylaxis according to FAPP results.
- Volunteers
- 98 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Respiratory Viruses
Detecting Respiratory Viruses in Upper and Lower Respiratory Tract Samples
Background: Bronchoalveolar lavage (BAL) is a procedure where a tube is passed through the mouth or nose into the lungs. Fluid is squirted through the tube into a part of the lung and then collected for examination.
- Trial name
- NCT01597089
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Neuroblastoma
A Pilot Study on ALK Gene Mutations in Neuroblastoma
Neuroblastoma (NB) originates from the sympathetic nervous system and is one of the most common cancers in infants and children.
- Trial name
- NCT01986595
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Acute Respiratory Tract Infection
PCOT for Outpatients With Acute Respiratory Tract Infection at Risk of Severe Disease in Primary Healthcare
This study aims to evaluate the clinical value of point-of-care multiplex PCR testing (POCT) in guiding early diagnosis and target treatment for acute respiratory infections in primary healthcare settings.
- Trial name
- NCT07159230
- Testing
- point-of-care multiplex PCR test
- Where
- China
- Volunteers
- 16,868 people
- Sponsor
- Capital Medical University
Immunosuppression, Immune Tolerance
Liver Immune Tolerance Marker Utilization Study
The purpose of this study is to validate and test a tolerance gene expression profile for the identification of operationally tolerant liver transplant recipients, allowing for the successful withdrawal of immunosuppression…
- Trial name
- LITMUS (NCT02541916)
- Testing
- Controlled weaning of immunosuppression
- Where
- Canada
- Volunteers
- 69 people
- Sponsor
- University of Toronto
Community-acquired Pneumonia, Critical Illness
Point-of-Care Multiplex for Adult Patients With Severe Community-acquired Pneumonia
Clinical Impact on Point-of-Care Multiplex PCR Testing for Critically Ill Adult Patients With Community-acquired Pneumonia - A cluster randomization study in ICU units within one medical center.
- Trial name
- NCT04835818
- Testing
- Provide the panel report to the primary care physician
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Diabetes Mellitus, Foot Osteomyelitis
Assessment of PCR Multiplex Tests as a Tool to Obtain a Quicker Diagnosis of Bacteria Responsible for Foot Osteomyelitis Than Usual Cultures
Bone samples from infected diabetic feet will be collected and tests will be performed for the diagnosis of causative bacteria. Samples will be processed by PCR multiplex tests and usual cultures for identification of causative…
- Trial name
- RAPDIAGOS (NCT03434288)
- Testing
- Bone sampling
- Where
- France
- Volunteers
- 48 people
- Sponsor
- University Hospital, Montpellier
Ventilator Associated Pneumonia
Ventilator Associated Pneumonia Multiplex PCR for Anti-Infective Regimens
Ventilator-associated pneumonia (VAP) remains one of the main nosocomial infections acquired in the intensive care unit (ICU). VAP is pneumonia occurring 48 hours after intubation.
- Trial name
- VAMPAIR (NCT06554327)
- Testing
- Multiplex PCR
- Where
- France
- Volunteers
- 265 people
- Sponsor
- CHU de Reims
Spinal Muscular Atrophy, Neonatal Hyperbilirubinemia
Establishing Novel Detection Techniques for Various Genetic-Related Diseases by Applying DHPLC Platform.
In this, here we want to present a new method for analysis variation in gene copy number for patients and carriers of SMA. This is a relative quantitation method and, therefore, relies on the inclusion of one or more internal…
- Conditions
- Spinal Muscular Atrophy, Neonatal Hyperbilirubinemia, Colon Cancer
- Trial name
- NCT00154960
- Where
- Taiwan
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Respiratory Tract Infections (RTI), Influenza-like Illness
Clinical Assessment of Respiratory Events for Kids: Integrating Diagnostics and Stewardship
This study, called Care4Kids, aims to improve the management of respiratory infections in children visiting emergency departments.
- Conditions
- Respiratory Tract Infections (RTI), Influenza-like Illness, Children
- Trial name
- CARE4KIDS (NCT07453914)
- Testing
- SPOTFIRE R
- Where
- 3 sites in France, Greece and 1 more
- Volunteers
- 720 people
- Sponsor
- BioMérieux