Clinical trials: Multiple Sclerosis
Multiple Sclerosis
Aggressive Onset Multiple Sclerosis: A Practical Definition and Study of Its Clinical Course
Chart review.
- Trial name
- NCT02301572
- Where
- United States
- Volunteers
- 750 people
- Sponsor
- Weill Medical College of Cornell University
Multiple Sclerosis
Therapy Optimization in Multiple Sclerosis (MS)
The purpose of this study is to determine if higher compliance and adherence rates to drug therapy for MS result in better health outcomes than lower rates of therapy compliance and adherence.
- Trial name
- TOP MS (NCT00819000)
- Testing
- Glatiramer Acetate, IFN-beta 1a (IM), IFN-beta 1a (Subcutaneous), and IFN-beta 1b
- Where
- 3 sites in United States
- Volunteers
- 2,878 people
- Sponsor
- Teva Neuroscience, Inc.
Multiple Sclerosis
Using Motor Imagery-based Brain-computer Interface With Multiple Sclerosis Patients.
The goal of this clinical trial is to evaluate the effectiveness of a wearable brain-computer interface (BCI)-based neurofeedback system using motor imagery (MI) to support upper limb motor rehabilitation in patients with…
- Trial name
- BCI_MI_SM_2026 (NCT07472556)
- Testing
- Brain Computer Interface
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Pasquale Arpaia
Multiple Sclerosis, Chronic Progressive, Multiple Sclerosis
MUSCLE - Nordic Walking in MUltiple SCLErosis
The aim of the study is to analyze the effects of Nordic Walking and free walking in the clinical-functional, postural balance, motor control, muscular echographic quality, and gait analysis (pendulum gait mechanism), in people…
- Conditions
- Multiple Sclerosis, Chronic Progressive, Multiple Sclerosis, Multiple Sclerosis, Primary Progressive, Multiple Sclerosis, Secondary Progressive
- Trial name
- MUSCLE (NCT05385731)
- Testing
- Nordic Walking (NWG), Free Walking (FWG), Health Education (HEG)
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Leonardo A. Peyré-Tartaruga
Multiple Sclerosis, Relapsing-Remitting
Pilot Test of ACTOS in Multiple Sclerosis: Safety and Tolerability
The purpose of this study is to determine whether an already FDA approved drug is safe and tolerable in Relapsing Remitting Multiple Sclerosis patients.
- Trial name
- NCT00242177
- Testing
- ACTOS (Pioglitazone)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Illinois at Chicago
Multiple Sclerosis
Relıabılıty and valıdıty of the supıne-to-stand Test wıth Multiple Sclerosis
Background: Supine-to-Stand Test (SST) requires muscle strength, flexibility, and dynamic balance and can be used as a marker of functional motor competence in patients with Multiple Sclerosis (pwMS).
- Trial name
- NCT06790992
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Sanko University
Physical Therapy, Upper Extremity Function
Upper Extremity Function, Shoulder Position Sense and Disability Level İn Patients With Multiple Sclerosis
The purposes of this study is to investigate the relationship between upper extremity muscle function and shoulder position sense in patients with Multiple Sclerosis (MS) and which best projects the disability status.
- Conditions
- Physical Therapy, Upper Extremity Function, Position Sense
- Trial name
- NCT03846336
- Testing
- Upper extremity function, Shoulder position sense
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Relapsing Forms of Multiple Sclerosis
A 6-month, Randomized, Open-label, Patient OutComes, Safety and Tolerability Study of Fingolimod (FTY720) 0.5 mg/Day vs. Comparator in Patients With Relapsing Forms of Multiple Sclerosis
The purpose of this study is to evaluate the change in patient-reported outcomes, physician assessment of a change as well as safety and tolerability in patients with Relapsing Forms of Multiple Sclerosis on previous Disease…
- Trial name
- EPOC (NCT01216072)
- Testing
- Fingolimod, Standard MS DMTs
- Where
- 149 sites in United States, Canada and 1 more
- Volunteers
- 1,053 people
- Sponsor
- Novartis Pharmaceuticals
Multiple Sclerosis, Pregnancy Related
PREG-MS: New England MS Pregnancy Registry
The purpose of the study is to develop a detailed pregnancy registry of patients with Multiple Sclerosis in the New England states.
- Trial name
- NCT03368157
- Where
- United States
- Volunteers
- 168 people
- Sponsor
- Brigham and Women's Hospital
Multiple Sclerosis, Cognitive Impairment
Early Cognitive Impairment in Multiple Sclerosis
Cognitive impairment is one of the symptoms of Multiple Sclerosis (MS), and it may occur during the first years of the disease. It usually affects attention, information processing speed and short term memory.
- Trial name
- CogniSEP (NCT01157728)
- Where
- France
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Adult Caregivers of Individuals With TSC, Tuberous Sclerosis Complex (TSC)
TANDem-2: Closing the Gap to Interventions for TAND
The goal of this pilot study is to determine the feasibility, acceptability and impact of a brief behavioral intervention - the "Well-Beans for Caregivers" program, for adult caregivers of individuals with tuberous sclerosis…
- Trial name
- TANDem-2 (NCT06879665)
- Testing
- Well-Beans for Caregivers Program
- Where
- 2 sites in United States, Australia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Relapsing Remitting Multiple Sclerosis
Impact of Vitamin A on RAR Gene Expression in Multiple Sclerosis
The aim of this study is the comparison between the effects of supplementation with 25000 IU preformed vitamin A (retinyl palmitate)on retinoic acid receptor and retinoic x receptor expression.
- Trial name
- RAR (NCT01705457)
- Testing
- Dietary Supplement: vitamin A
- Where
- Iran
- Volunteers
- 20 people
- Sponsor
- Tehran University of Medical Sciences
Multiple Sclerosis
Effects of ACTHAR on Advanced MRI Surrogate Markers of Disease Activity and on Comprehensive Immune Signature During MS Relapses
ACTHAR is a FDA approved drug for MS relapses. The purpose of the study is to examine the efficacy of this agent in improving relapses as measured by advanced MRI and laboratory techniques: 1.
- Trial name
- ACTHAR (NCT03021317)
- Testing
- ACTHar
- Volunteers
- 5 people
- Sponsor
- University of Chicago
Detrusor Muscle Hyperactivity
Neurogenic Detrusor Overactivity Following Spinal Cord Injury or Multiple Sclerosis
The purpose of this study is to determine the efficacy and safety of a single dose of 750 U of Dysport compared to placebo for the improvement in the daily incontinence episode frequency for each administration mode in subjects…
- Trial name
- NCT01357980
- Testing
- Botulinum toxin type A
- Where
- 17 sites in Czechia, France and 3 more
- Volunteers
- 47 people
- Sponsor
- Ipsen
Sarcopenic Obesity, Spinal Cord Injuries
Sarcopenic Obesity in Neurodisabilities
To describe the frequency and thresholds for sarcopenic obesity in neurodisabled persons and the fat and lean mass distribution based on various neurodisabilities
- Conditions
- Sarcopenic Obesity, Spinal Cord Injuries, Stroke, Multiple Sclerosis
- Trial name
- SarcObeNDS (NCT03863379)
- Testing
- whole body DXA
- Where
- Greece
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Dionyssiotis, Yannis, M.D.
Multiple Sclerosis
Biomarkers in Multiple Sclerosis
This study will identify biomarkers (genes and proteins) in patients with relapsing-remitting multiple sclerosis (MS) and link them with clinical disease parameters, such as the extent of inflammation and rate of disease…
- Trial name
- NCT00325988
- Where
- United States
- Volunteers
- 858 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Multiple Sclerosis, Pain
Management of Pain in Persons With Multiple Sclerosis
The purpose of this study is to see if treatments that include components of self-hypnosis training and cognitive behavioral therapy (CBT) can help decrease pain in people with MS.
- Trial name
- NCT00621374
- Testing
- Cognitive Behavioral Therapy (CBT) +Hypnosis (HYP), Cognitive Behavioral Therapy (CBT), Self-Hypnosis Training (HYP)
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Washington
Multiple Sclerosis
Effect of Multimodal Exercise Training in Patients With Multiple Sclerosis
The study aims to examine the effects of multimodal exercise training including aerobic, strengthening and balance exercises via face-to-face and asynchronous video-based telerehabilitation on disease activity, disability level…
- Trial name
- PwMS (NCT06676618)
- Testing
- Multimodal Exercise Training, Control Group
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul University - Cerrahpasa
Multiple Sclerosis, Hypertension
Vascular Mechanisms, Functional Outcomes, & Exercise Among Persons With Multiple Sclerosis With Hypertension
The goal of this study is to determine if 12 weeks of cycling exercise training at home will improve three parameters: 1) blood pressure, 2) cognition, and 3) walking ability among persons with multiple sclerosis who have high…
- Trial name
- NCT06554340
- Testing
- Home-based aerobic training
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Massachusetts, Boston
Multiple Sclerosis
Bacille Calmette-Guérin (BCG) Vaccine In Radiologically Isolated Syndrome (RIS)
Multiple sclerosis (MS) witnessed relevant therapeutic progress in the last decade. Following the extraordinary progress in the treatment of relapsing-remitting (RR) multiple sclerosis (MS), two major unmet needs remain to be…
- Trial name
- NCT03888924
- Testing
- Bacille Calmette-Guerin vaccine
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- S. Andrea Hospital