Clinical trials: Multiple Drug Use
Allergic Reaction (IgA) Vasculitis
Evaluate the Effectiveness and Safety of BBD-1 Multi-target Immune Enhancement Targeting Agent in the Treatment of Hypersensitivity Reaction (IgA) Vasculitis
Hypersensitivity (IgA) vasculitis is a common vascular allergic disease, the cause of which is not yet clear, and may involve infection, immune disorders, heredity and other factors. It belongs to the category of immune diseases.
- Trial name
- NCT07595367
- Testing
- BBD-1 Multi target Immune Enhancement Targeting Agent
- Where
- 2 sites in United States, China
- Volunteers
- 30 people
- Sponsor
- Qifeng Zhang
Multiple Myeloma, Secondary Immunodeficiency (SID)
Real-world Usage of HyQvia in Multiple Myeloma Adults With Secondary Immunodeficiency
In this study, multiple myeloma participants with secondary immunodeficiency (SID) will be treated with HyQvia according to their clinic's standard practice.
- Trial name
- NCT05879757
- Testing
- No Intervention
- Where
- 27 sites in Argentina, Czechia and 9 more
- Volunteers
- 75 people
- Sponsor
- Takeda
Multiple Myeloma
An Observational Study to Assess Safety and Outcome of the Various Medication Usage Patterns in Clinical Routine Practice in Patients Receiving Lenalidomide.
The study is designed as a prospective, non-interventional, observational single arm study. Hundred-fifty patients over 18 with stable disease or at least partial response while on treatment with lenalidomide will be recruited…
- Trial name
- REVIEW (NCT02528838)
- Volunteers
- 238 people
- Sponsor
- Celgene
Multiple Sclerosis
An Observational Study to Collect Information on Safety and to Document the Drug Utilization of Fampyra (BIIB041) When Used In Routine Medical Practice
The primary objective of the study is to collect additional safety data including the incidence rate of seizure and other specific Adverse Events (AEs) of interest from participants taking Fampyra in routine clinical practice.
- Trial name
- LIBERATE (NCT01480063)
- Testing
- Fampridine
- Where
- 164 sites in Argentina, Canada and 11 more
- Volunteers
- 4,734 people
- Sponsor
- Biogen
Tobacco Dependence
Multiple-dose Nicotine Pharmacokinetics With a New Oral Nicotine Replacement Product.
A comparison of three products for oral nicotine replacement with respect to pharmacokinetics after multiple-doses of nicotine.
- Trial name
- NCT01084707
- Testing
- Oral Nicotine, Nicotine Lozenge, Nicotine gum
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- McNeil AB
Vertebrobasilar Insufficiency
Prospective Evaluation of Safety and Efficacy Vertebral Drug-eluting Stent System
The purpose of this study is to evaluate the safety and efficacy of Firehorus vertebral artery rapamycin-target-eluting stent system (hereinafter referred to as Firehorus) in treatment of symptomatic vertebral artery stenosis.
- Trial name
- PESS (NCT02328781)
- Testing
- Drug-eluting stent
- Where
- China
- Volunteers
- 101 people
- Sponsor
- Zhongrong Miao
Nephrotic Syndrome
IL-2 for Multi Drug Resistant Nephrotic Syndrome
The aim of the study is to design an open-label phase 1-2 trial to assess safety and clinical and immunologic effects of repeated administration of recombinant low dose IL2 (Proleukin) in 5 patients with idiopathic nephrotic…
- Trial name
- NCT02455908
- Testing
- Proleukin®
- Where
- Italy
- Volunteers
- 5 people
- Sponsor
- Istituto Giannina Gaslini
Multiple Sclerosis
Study to Evaluate the Reduction of Cardiac Problems in Multiple Sclerosis Patients With Mitoxantrone and Dexrazoxane in Combination
This study will primarily address the question whether the combination of Mitoxantrone therapy with dexrazoxane can reduce cardiotoxic side effects in the treatment of Multiple Sclerosis patients in comparison to Mitoxantrone…
- Trial name
- MSCardioPro (NCT01627938)
- Testing
- Dexrazoxane (DRZ) plus Mitoxantrone (MX)
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- PD Dr. Andrew Chan
Seizures
Belgian Drug-utilization Study to Evaluate the Use of VIMPAT® as Adjunctive Treatment of Partial Onset Seizures in Subjects Aged 16 and Older
Observational study at the request of the Belgian Institut National d'Assurance Maladie-Invalidité / Rijksinstituut voor Ziekte-en Invaliditeits Verzekering INAMI/RIZIV: type of patient treated with VIMPAT® VIMPAT® dose Effect of…
- Trial name
- NCT01236001
- Testing
- Lacosamide
- Where
- 17 sites in Belgium
- Volunteers
- 192 people
- Sponsor
- UCB Pharma
Infection With Multi-drug Resistant Organisms
FMT for Multidrug Resistant Organism Reversal
This proposed protocol involves the use of the fecal microbiota transplantation (FMT) to suppress or reverse colonization with multidrug resistant organisms (MDRO) in subjects with recurrent MDRO infections due to organisms of…
- Trial name
- NCT02312986
- Testing
- Fecal microbiota transplantation (FMT)
- Volunteers
- 1 people
- Sponsor
- Washington University School of Medicine
Multiple Sclerosis
Drug Risk Aversion Calculator Use to Facilitate MS Patient Self-efficacy
The investigators seek to determine if the use of a Side Effect Aversion Calculator helps patients with multiple sclerosis (MS) more comfortably and rapidly identify the disease modifying drug (DMD) that is best suited for the…
- Trial name
- DRAC (NCT03375541)
- Testing
- Risk Aversion Calculator
- Sponsor
- Duke University
HIV, Substance Use Disorder (SUD)
Long-acting Cabotegravir Injectable Pre-exposure Prophylaxis for People Who Inject Drugs
The goal of this study is to determine the feasibility and impact of delivering long-acting injectable cabotegravir HIV pre-exposure prophylaxis and suite of support services to adults who inject non-prescription drugs who are…
- Conditions
- HIV, Substance Use Disorder (SUD), Injection Drug Use
- Trial name
- ASCEND (NCT07199335)
- Testing
- APRETUDE (cabotegravir)
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Multiple Sclerosis
Dimethyl Fumarate (DMF) Observational Study
The primary objective of the study is to determine the incidence, type, and pattern of serious adverse events (SAEs), including but not limited to infections (including opportunistic infections), hepatic events, malignancies, and…
- Trial name
- ESTEEM (NCT02047097)
- Testing
- dimethyl fumarate
- Where
- 468 sites in United States, Argentina and 20 more
- Volunteers
- 5,487 people
- Sponsor
- Biogen
Multiple Sclerosis
PROmyBETAappGame: a Study to Learn More About the Medication Usage & Patient Reported Outcomes Via the myBETAapp and to Find Out More About the Usage of Game Principles and Game Design Elements (Gamification) in Medical Care of Patients With Multiple Sclerosis Treated With Betaferon
In this study researchers wanted to learn more about the medication usage behavior among multiple sclerosis (MS) patients treated with Betaferon using the myBETAapp which includes the elements to what extent taking medication…
- Trial name
- NCT03808142
- Testing
- myBETAapp, PEAK, Betaferon, BAY86-5046
- Where
- Germany
- Volunteers
- 79 people
- Sponsor
- Bayer
Headache
Medication-overuse Headache (MOH): Withdrawal or Use of Preventative Medications Directly?
It is a common belief that patients with MOH rarely respond of preventative medications whilst overusing acute medications. However, no randomized trial has been done previously to prove such statement.
- Trial name
- NCT00159588
- Testing
- Betablockers or other preventive drugs based on primary headache type
- Where
- Norway
- Volunteers
- 64 people
- Sponsor
- Norwegian University of Science and Technology
Opioid-Use Disorder (OUD)
SafetyNet Program for Opioid Use Disorder (OUD)
The principal aim of this study is to determine whether a novel biopsychosocial intervention following opioid overdose (OD) affects 1) the frequency of secondary opioid OD events and 2) the proportion of individuals who remain…
- Trial name
- NCT04253782
- Testing
- Team Intervention
- Where
- 2 sites in United States
- Volunteers
- 81 people
- Sponsor
- Yale University
Deprescribing, Statin Prescribing
Testing the Impact of Pre-visit Priming for Medications
We will use EHR data to identify eligible patients at BWH primary care clinics. Patients will be eligible if they have an upcoming primary care provider (PCP) appointment at an included BWH clinic, are ≥65 years, and are eligible…
- Trial name
- NCT07281131
- Testing
- Pre-visit prompts
- Where
- United States
- Volunteers
- 1,700 people
- Sponsor
- Brigham and Women's Hospital
Non-Hodgkin's Lymphoma, Leukemia
Use of Topotecan in Patients With Refractory Acute Leukemia
The purpose of this study is to identify the highest tolerated doses in drugs used to treat aggressive leukemia, lymphoma or multiple myeloma not responding to standard chemotherapy treatment.
- Trial name
- NCT00100477
- Testing
- Topotecan, Mitozantrone, Etoposide
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- US Department of Veterans Affairs
Ulcerative Colitis
Golimumab Dried Blood Spot Analysis
This retrospective multi-centric Belgian prospective trial will involve 10 patients initiating or under maintenance subcutaneous golimumab therapy for moderate-to-severe colitis at the University Hospitals Leuven (Leuven…
- Trial name
- GOUDA (NCT02910375)
- Testing
- Cohort A, Cohort B
- Where
- 2 sites in Belgium
- Volunteers
- 10 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Heart Failure
TARGET-LOAD Pilot Study Comparing Hemodynamics-guided LVAD Unloading Vs. Standard of Care
This study is a prospective, randomized-controlled, non-blinded, multi-center, pilot trial to compare standard-of-care left ventricular assist device (LVAD) unloading plus heart failure (HF) medications reverse-remodeling…
- Trial name
- NCT04977310
- Testing
- CardioMEMS
- Where
- 2 sites in United States
- Sponsor
- STAVROS G DRAKOS