Clinical trials: Movement Disorder
Parkinson's Disease
Deep Brain Stimulation Therapy in Movement Disorders
Background: In deep brain stimulation (DBS), a device called a neurostimulator is placed in the chest. It is attached to wires in parts of the brain that affect movement.
- Trial name
- NCT02119611
- Testing
- Deep Brain Stimulation management
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson's Disease (PD), Tremor
Cerebellar Transcranial Alternating Current Stimulation (tACS) to Modulate Parkinson's Disease Tremor
Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by different motor symptoms, including tremor, which is particularly difficult to manage.
- Trial name
- tACS_PD_TR (NCT06993571)
- Testing
- Active-tACS, Unlocked-tACS
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Tourette Syndrome
Safety and Efficacy of Cannabis in Tourette Syndrome
For many individuals with Tourette syndrome (TS), available medications do not help with their symptoms, or cause significant side effects.
- Trial name
- NCT03247244
- Testing
- Cannabis
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University Health Network, Toronto
Parkinson Disease, Cognition Disorder
The Impact TDCS-linked Motor and Cognitive Training Gains in Parkinson's Disease
This study is a group controlled clinical trial. Parallel study, patients aged 40-70 years, with Parkinson disease. Twelve sessions, three times a week, for 30 minutes, simultaneously to the rehabilitation program.
- Conditions
- Parkinson Disease, Cognition Disorder, Motor Disorders
- Trial name
- NCT04581590
- Testing
- Cognitive training
- Where
- Brazil
- Volunteers
- 242 people
- Sponsor
- Federal University of Paraíba
Idiopathic Parkinson Disease, Parkinson's Disease and Parkinsonism
Adipose-derived Stromal Vascular Fraction Cells to Treat Parkinson
This is an interventional study to treat 10 patients with a diagnosis of Parkinson's disease with neurological assessment from the Oxford Parkinson's Disease Quotient-39 (PDQ-39) and Movement Disorders Society Universal…
- Trial name
- SVFP1 (NCT05699161)
- Testing
- Adipose-derived stromal vascular fraction cells
- Where
- Nicaragua
- Volunteers
- 10 people
- Sponsor
- Samuel Vilchez, PhD
Hemiplegic Gait
Efficacy of VR Based Sword Fighting Exercises to Improve Upper Body Movements in Hemiplegic Patients
this thesis endeavors to shed light on the efficacy of VR-based sword-fighting exercises as a rehabilitation tool for improving upper body movement in hemiplegic patients.
- Trial name
- NCT06459570
- Testing
- Virtual reality based exercises, standard physical therapy
- Where
- Pakistan
- Volunteers
- 62 people
- Sponsor
- Superior University
Dexmedetomidine, Deep Brain Stimulation
Dexmedetomidine on Basal Ganglia Neuronal Activity in Parkinson's Disease
The implantation of a deep brain stimulator (DBS) is an established option to improve the symptoms of Parkinson's disease (PD) in patients that do not respond adequately to medical therapy.
- Conditions
- Dexmedetomidine, Deep Brain Stimulation, Parkinson Disease
- Trial name
- NCT02982512
- Testing
- Dexmedetomidine
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Parkinson Disease
Non Invasive Neuromodulation for Patients With Motor Control Disorders
Movement disorders are neurological syndromes leading to excessive movements or to limited control of voluntary and automatic movements.
- Trial name
- NCT04017481
- Testing
- Repetitive transcranial magnetic stimulation (rTMS), EEG guided Neurofeedback (NFB)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidad Francisco de Vitoria
Parkinson Disease
Neurophysiology Biomarkers of Cognitive Impairment Associated With Deep Brain Stimulation
The study aims to investigate cognitive impairment associated with Deep Brain Stimulation (DBS) in Parkinson's Disease patients, with a focus on identifying neurophysiology biomarkers of DBS associated cognitive changes.
- Trial name
- NCT05933681
- Testing
- Neural recordings and stimulation
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Vanderbilt University Medical Center
Mild Cognitive Impairment (MCI), Parkinsons Disease (PD)
Study to Investigate Vagus Nerve Stimulation to Augment Executive Function in Healthy and Cognitively Impaired Populations
This study plans to learn more about how stimulating the vagus nerve through gentle electrical stimulation applied to the ear can affect decision-making, problem-solving, and other thinking abilities.
- Conditions
- Mild Cognitive Impairment (MCI), Parkinsons Disease (PD), Healthy Adult
- Trial name
- NCT07424365
- Testing
- transcutaneous auricular vagus nerve stimulation
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Parkinson Disease
Evaluation of the Nonmotor Symptomatology of Parkinsonian Patients Treated With Two Strategies Related to Apomorphine Pump Therapy in French Hospitals
There is currently no consensus on the adequate concomitant treatment to apomorphine pump in Parkinson's disease (PD). In practice, some centers withdraw all dopaminergic agonists when initiating apomorphine pump therapy, whereas…
- Trial name
- AGAPO (NCT03693872)
- Testing
- Apomorphine, Dopaminergic Agonist + Apomorphine
- Where
- 6 sites in France
- Volunteers
- 43 people
- Sponsor
- Rennes University Hospital
Parkinson's Disease
Attributional Style and Parkinson's Disease
Parkinson's disease (PD) is a common neurodegenerative disorder affecting 1-2% of the population over 65 years-old. In addition to the motor impairment characterized by resting tremor, bradykinesia, rigidity and postural…
- Trial name
- ParkAIHQ (NCT03371277)
- Testing
- Medical visit for specific questionnaires
- Where
- France
- Volunteers
- 32 people
- Sponsor
- CHU de Reims
Parkinson Disease
Airway Protective Mechanisms in PD (R01)
This study will collect data on various aspects of airway sensation and function, and determine how it relates to the development of swallowing and cough dysfunction in Parkinson's disease.
- Trial name
- NCT03321019
- Testing
- Capsaicin, Resistive respiratory loads, Event-related evoked potential using electroencephalography (EEG).
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- University of Florida
Alzheimer Disease, Healthy Volunteers
Phase 0 Evaluation of [18F]MNI-958 as a Potential PET Radioligand for Imaging Tau Protein in the Brain
The overall goal of this imaging trial is to evaluate [18F]MNI-958, a tau targeted PET radioligand, in individuals with Alzheimer's disease (AD), Progressive Supranuclear Palsy (PSP), and healthy volunteers (HV).
- Conditions
- Alzheimer Disease, Healthy Volunteers, Progressive Supranuclear Palsy
- Trial name
- NCT03058965
- Testing
- [18F]MNI-958, [18F]Florbetapir, DaTscan
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Molecular NeuroImaging
Parkinson's Disease
Exploration of Differences in Metabolite Concentrations by 7Teslas NMR Spectroscopy in Striatum and Subthalamic Nuclei in de Novo Parkinsonian Patients and Control Subjects
Initially, the exploration of brain metabolism by Nuclear Magnetic Resonance Spectroscopy (MRS) of the high magnetic field proton (1H) (11.7T) applied to acute and chronic animal models of Parkinson's disease (PD) showed…
- Trial name
- METABO-NGC-7T (NCT04735172)
- Testing
- specific MRI Acquisition (NMR spectroscopy) at 7T
- Where
- 2 sites in France
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Parkinson Disease, Deep Brain Stimulation
Effect of Mediterranean Diet on Nutrition in Parkinson's Disease Patients With Bilateral Subthalamic Deep Brain Stimulation
The goal of this clinical trial is to evaluate whether Mediterranean diet can help manage body weight and improve body composition in adult Parkinson's disease patients who have undergone bilateral subthalamic nucleus deep brain…
- Conditions
- Parkinson Disease, Deep Brain Stimulation, Deep Brain Stimulation Surgery
- Trial name
- NCT07187739
- Testing
- Mediterranean diet
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Ankara University
Spastic Cerebral Palsy (sCP)
Talocrural Mobilization With Movement in Spastic Cerebral Palsy
The aim of this randomized controlled trial is to find the effect of Mulligan's Mobilization with Movement of Talocrural joint in Cerebral Palsy Patients having spasticity on improving Ankle Range of Motion, improving balance and…
- Trial name
- NCT06598657
- Testing
- Mobilization with Movement MWM, Conventional Treatment
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Riphah International University
Parkinson Disease
Repetitive Transcranial Magnetic Stimulation With H-coil in Parkinson's Disease (rTMS-PD)
Focal repetitive transcranial magnetic stimulation (rTMS) has been applied to improve symptoms in Parkinson disease (PD) with conflicting results.
- Trial name
- rTMS-PD (NCT04638777)
- Testing
- rTMS with H-coil
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Giancarlo Comi
Parkinsonism or Parkinson's Disease Nos, Parkinsonism in Diseases Classified Elsewhere
Evaluation of Neuroinduced Mesenchymal Stem Cells and Mesenchymal Stem Cell-Derived Exosomes in Patients With Parkinsonism
This clinical trial investigates the safety and therapeutic potential of mesenchymal stem cell-based therapies in patients with parkinsonism.
- Trial name
- STEM-PARK (NCT07471230)
- Testing
- Intrathecal (IT), Intravenous
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Biocells Medical
Healthy Volunteer, Alzheimer Disease
Evaluation of [18F]PI-2620 as a Potential Positron Emission Computed Tomography Radioligand for Imaging Tau Protein in the Brain
The overall goal of this imaging trial is to evaluate [18F]PI-2620, a tau targeted positron emission computed tomography radioligand, in individuals with tauopathies and healthy volunteers (HV).
- Conditions
- Healthy Volunteer, Alzheimer Disease, Frontotemporal Dementia, Parkinson Disease
- Trial name
- NCT03510572
- Testing
- [18F]PI-2620
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center