Clinical trials: Movement Disorder
Parkinson Disease
Long-Term Dopamine Transporter Imaging and Clinical Assessment of Parkinson's Disease Progression
The purpose of this project is to assess the change in dopamine transporter density in Parkinson's disease subjects during a sixty month period including a nine month treatment trial of levodopa.
- Trial name
- ELLDOPA (NCT00134784)
- Testing
- [123I]B-CIT SPECT imaging
- Volunteers
- 142 people
- Sponsor
- Institute for Neurodegenerative Disorders
Parkinson's, Disease
Light Therapy Plus Exercise to Improve Motor, Non-Motor Symptoms and QoL in Parkinson's Disease
Parkinson's disease (PD) is a lifelong and progressive disease and is the second most common progressive neurodegenerative disease worldwide.
- Trial name
- NCT06036433
- Testing
- Infrared laser photobiomodulation device, Infrared & Red LED photobiomodulation device
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Gaitway Neurophysio
Pulmonary Disease, Autonomic Dysfunction
Meditative Movement for COPD Symptoms in Non-Smoking Flight Attendants
This study will explore the a Qigong based exercise intervention, here referred to as Meditative Movement (MM), to ameliorate the symptoms associated with chronic obstructive pulmonary disease (COPD) and its co-morbidities.
- Conditions
- Pulmonary Disease, Autonomic Dysfunction, COPD
- Trial name
- MMforFA (NCT02612389)
- Testing
- Meditative Movement taught via DVD
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Parkinson's Disease, Parkinsonian Syndrome
Development of Imaging, Clinical and Biochemical Bio-Markers for Parkinson's Disease
We propose to build on preliminary data evaluating non-dopaminergic/non-motor clinical biomarkers to more fully assess these markers at the threshold of Parkinson disease (PD).
- Trial name
- NCT00315250
- Testing
- [123I]β-CIT
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- Institute for Neurodegenerative Disorders
Parkinson Disease
iDAP Injection in the Treatment of Parkinson's Disease
The goal of this clinical trial is to evaluate the safety, tolerability and preliminary efficacy that iDAP has on Parkinson's disease (PD) patients.
- Trial name
- NCT06583291
- Testing
- Allogeneic dopaminergic neural precursor cell(iDAP)
- Volunteers
- 12 people
- Sponsor
- Anhui Provincial Hospital
Parkinson's Disease
An Unblinded, Single Arm, Pilot Observational Study to Test the Safety, Tolerability, Immunogenicity and the Biological Effects of TRB-001 Vaccination.
An unblinded, single arm, pilot observational study to test the safety, tolerability, immunogenicity and the biological effects of TRB-001 vaccination in individuals who have previously undergone aSyn immunotherapy
- Trial name
- NCT07777484
- Testing
- TRB-001
- Where
- Austria
- Volunteers
- 6 people
- Sponsor
- Tridem Bioscience FlexCo
Parkinson Disease, Gait Disorders, Neurologic
Spinal Cord Stimulation for Gait Disorders in Parkinson's Disease
Our project is based on the fundamental hypothesis that epidural spinal cord stimulation (SCS) improves Freezing of gait (FOG) in patients with Parkinson's disease.
- Trial name
- SCM-PARK (NCT04682678)
- Testing
- Implantation of electrodes for Spinal cord stimulation
- Where
- France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Grenoble
Parkinson Disease, Freezing of Gait
Motor Adaptation to Split-Belt Treadmill in Parkinson's Disease
Freezing of Gait (FOG) is a disabling symptom common in advanced Parkinson's Disease. FOG is an independent contributor to fall risk and is only partially relieved by medication.
- Trial name
- NCT03725215
- Testing
- Split-Belt Treadmill Training
- Where
- 2 sites in Belgium, Germany
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Supranuclear Palsy, Progressive
Study of the Distractibility Syndrome in Patients With Progressive Supranuclear Palsy
The syndrome of distractibility is a behavioral disorder induced by a lesion or a dysfunction of the frontal lobe. This sign is frequent in patients with progressive supranuclear palsy (PSP), a neurodegenerative disorder with…
- Trial name
- NCT00139373
- Testing
- donepezil
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Parkinson's Disease
[11C]Donepezil PET For Imaging The Autonomous Nervous System In Parkinsons Disease
AIM: Investigate wether there are differences in the parasympathetic nervous system in Parkinsons patients compared to controls. MATERIALS AND METHODS: We use the tracer [11C]donepezil to image the parasympathetic nervous system.
- Trial name
- NCT02012595
- Testing
- [11C]donepezil PET
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Per Borghammer
Parkinson Disease
Integration of Auditory, and Deep Brain Stimulation to Enhance Deep Sleep in Parkinson's Disease
The study is an open-label trial to validate the local field potential (LFP) activity in the subthalamic nucleus (STN) for slow-wave detection during acoustic stimulation during nighttime sleep in Parkinson's disease patients…
- Trial name
- NCT05184270
- Testing
- Acoustic stimulation
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- Christian Baumann
Low Back Pain, Kinesiophobia (Fear of Movement)
Feasibility of an Augmented Reality Novel Approach for the Rehabilitation of Chronic Low Back Pain Patients With Kinesiophobia
The goal of this clinical trial is to evaluate the feasibility, safety, and initial effectiveness of a new augmented reality (AR) system in adults over 18 years old suffering from chronic low back pain and kinesiophobia (fear of…
- Conditions
- Low Back Pain, Kinesiophobia (Fear of Movement), Healty Volunteers
- Trial name
- NCT07527845
- Testing
- Augmented Reality (AR) Rehabilitation System
- Where
- Chile
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Autonomic Nervous System Disorders, Pure Autonomic Failure
Blood Pressure Lowering Effects of Angiotensin-(1-7) in Primary Autonomic Failure
Pharmacologic approaches to increase levels or actions of the vasodilatory peptide angiotensin-(1-7) are currently in development for the treatment of hypertension based on findings from animal models.
- Conditions
- Autonomic Nervous System Disorders, Pure Autonomic Failure, Shy-Drager Syndrome, Orthostatic Hypotension, Dysautonomic
- Trial name
- NCT02591173
- Testing
- Angiotensin-(1-7), Saline
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Vanderbilt University Medical Center
Parkinson's Disease
A Long Term Safety Study of ND0612 Administered as a Continuous SC Infusion in Advanced Parkinson's Disease
This is a multi-center, international, open-label, safety study of ND0612, a solution of levodopa/carbidopa (LD/CD) delivered via a pump system as a continuous SC infusion in subjects with advanced Parkinson's Disease (PD).
- Trial name
- BeyoND (NCT02726386)
- Testing
- ND0612
- Where
- 57 sites in United States, Austria and 7 more
- Volunteers
- 214 people
- Sponsor
- NeuroDerm Ltd.
Parkinson Disease
Effects of Home-based High-speed Bodyweight Resistance Training in Individual With Parkinson's Disease
Exercises that involve increasing the speed of movements are beneficial for individuals with Parkinson's disease (PD) and have the potential to reduce bradykinesia and improve mobility.
- Trial name
- NCT06646523
- Testing
- High-speed bodyweight resistance training, Control group (Bodyweight intervention, usual speed)
- Where
- Brazil
- Volunteers
- 46 people
- Sponsor
- Federal University of Minas Gerais
Disorder of Consciousness, Consciousness, Loss of
SeeMe: An Automated Tool to Detect Early Recovery After Brain Injury
Early prediction of outcomes after acute brain injury (ABI) remains a major unsolved problem. Presently, physicians make predictions using clinical examination, traditional scoring systems, and statistical models.
- Conditions
- Disorder of Consciousness, Consciousness, Loss of, Trauma, Brain, Traumatic Brain Injury
- Trial name
- NCT06083441
- Testing
- SeeMe, Coma Recovery Scale-Revised (CRS-R)
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Parkinson Disease
Safety Study to Autonomic Rehabilitation o Parkinson's Disease
Introduction: The Parkinson is one of the most common degenerative diseases of the central nervous system , mainly characterized by resting tremor , rigidity, akinesia and postural instability , also featuring the autonomic…
- Trial name
- NCT02680522
- Testing
- Exercise
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade Metodista de Piracicaba
Parkinson's Disease
Ascending Dose Tolerability/Safety of SLV308 for the Treatment of Parkinson's Disease
This study is a multicenter, randomized, double-blind, placebo controlled, parallel group study of a seven-week ascending dose period of SLV308 adjunctive to L-dopa treatment in patients with advanced stage Parkinson's disease…
- Trial name
- NCT00134251
- Testing
- SLV308
- Where
- 10 sites in Bulgaria, Malta and 1 more
- Sponsor
- Solvay Pharmaceuticals
Antidepressive Agents
Wuling Powder for the Treatment and Underlying Mechanism of Depressive Symptoms in Patients With Parkinson's Disease
Depression is one of the most important nonmotor features of idiopathic PD（Parkinson's disease ）which may not just interfere with the motor symptoms of PD but can also cause immense personal suffering as well as decreased quality…
- Trial name
- NCT03195231
- Testing
- Wuling Powder
- Volunteers
- 120 people
- Sponsor
- Beijing Hospital
Hepatolenticular Degeneration; Wilson
Clinical Value of DWI-ADC Matching in the Short-term Prognosis of Wilson's Disease
In earlier studies, it was found that patients of Wilson disease with new diagnosed who only has neurological symptoms often had DWI hyper-intensity in brain MRI, which was more common in putamen and midbrain, indicating that the…
- Trial name
- NCT06196931
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Hospital Affiliated to the Institute of Neurology, Anhui University of Chinese Medicine