Clinical trials: Movement Disorder
Neurodegenerative Disorders
Development of IPS from Donated Somatic Cells of Patients with Neurological Diseases
Human fibroblasts and possibly other human somatic cells may be reprogrammed into induced pluripotent stem (iPS) cells by the forced expression of transcription factors (1-5).
- Trial name
- NCT00874783
- Where
- Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Parkinson Disease
A Training of the Rhythmic Skills With a Serious Game to Improve Gait and Cognitive Abilities in Parkinson's Disease
This project aims at assessing the opposite relation, namely the effect of a training of the general timing abilities on gait in Parkinson's disease. Timing rehabilitation will be done by the means of a serious game.
- Trial name
- RGP (NCT02855710)
- Testing
- Rhythm workers training Perceptive timing, Rhythm workers training sensorimotor timing, No Rhythm workers training
- Where
- France
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
PARKINSON DISEASE (Disorder)
Gut Microbiota and Tryptophan Metabolites in Parkinson's Disease
Parkinson's disease is a progressive neurological disorder that can also affect the digestive system. Changes in gut microorganisms and tryptophan metabolites may be associated with Parkinson's disease, but these relationships…
- Trial name
- NCT07749261
- Testing
- Stool Microbiome and Targeted Tryptophan Metabolite Profiling
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ningxia Medical University
Parkinson Disease
Cognitive Testing Online in Parkinson's Disease
This is a feasibility and pilot study. Though large-scale online neurocognitive testing is increasingly being done in psychiatry, there are no such efforts in Parkinson's research.
- Trial name
- NCT05025254
- Testing
- Neurocognitive testing
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- McGill University
Parkinson's Disease
LRRK2 and Other Novel Exosome Proteins in Parkinson's Disease
This proposal seeks to 1) determine whether there are biomarkers associated with Parkinson's disease (PD) susceptibility and/or progression in exosome-proteomes derived from PD patients versus controls, and 2) to determine if…
- Trial name
- NCT01860118
- Where
- United States
- Volunteers
- 601 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Migraine
A Study Investigating the Movement of Lu AG09222 Into, Through, and Out of the Body of Healthy Caucasian, Chinese, and Japanese Participants
The main goal of the study is to learn more about how the body absorbs and eliminates Lu AG09222 after a single dose is injected under the skin.
- Trial name
- NCT05304910
- Testing
- Lu AG09222
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- H. Lundbeck A/S
Schizophrenia, Parkinson Disease
Sound and Vision: A Collaboration Between Service-users, Artists and the Public to Explore the Lived Experience of Hallucinations
Sound and Vision: A collaboration between service-users, artists and the public to explore the lived experience of hallucinations
- Conditions
- Schizophrenia, Parkinson Disease, Hallucinations
- Trial name
- NCT04399096
- Where
- 2 sites in United Kingdom
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Cambridge
Parkinson Disease, MSA - Multiple System Atrophy
Differential Diagnosis Between Parkinson's Disease and Multiple System Atrophy Using Digital Speech Analysis
Parkinson's disease (PD) is the second most common neurodegenerative disease. Multiple system atrophy (MSA) is a relentlessly progressing rare neurodegenerative disease of unknown etiology.
- Trial name
- Voice4PD-MSA (NCT03577483)
- Testing
- voice recordings
- Where
- 2 sites in France
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Pain-related Fear, Kinesiophobia (Fear of Movement)
Pain-Related Fear and Motor Control in Healthy Volunteers
The goal of this clinical trial is to learn how experimentally induced movement-related threat affects emotional, autonomic, and motor responses in healthy adults.
- Conditions
- Pain-related Fear, Kinesiophobia (Fear of Movement), Movement-Related Threat
- Trial name
- Domokiss (NCT07636603)
- Testing
- Movement-Related Threat Induction, Neutral Movement Condition
- Where
- France
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Universite de Picardie Jules Verne
Parkinson Disease
Effect of WB-EMS on Parkinson's Disease
The aim is to establish adequate and suitable protocols for PD patients and to determine the WB-EMS effects on muscle strength, balance, walking, cognitive functions,neurotrophic factors and alpha-synuclein.
- Trial name
- NCT04878679
- Testing
- Strenght training combined with WB-EMS, Cardiovascular training with WB-EMS, Control group
- Where
- Italy
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Università degli studi di Roma Foro Italico
Parkinson's Disease
An Exploratory, Randomized, Blinded, Placebo-Controlled Trial of Folic Acid and L-methylfolate in Parkinson's Disease
This study is being conducted to assess the impact of folate and L-methylfolate on the progression of Parkinson's. The investigators are specifically looking for the effect of these nutritional supplements in Parkinson's patients…
- Trial name
- NCT00853879
- Testing
- Folic Acid, Vitamin B6, Vitamin B12, B6, B12, L-methylfolate
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Dystonia, Primary
Agency in Dystonia
In this study, using computerized cognitive assessments combined with multi-modal neuroimaging approach investigators aim to address three specific questions on patients with cervical and myoclonus dystonia: (i) investigate…
- Trial name
- AGENT10 (NCT03351218)
- Testing
- Behavioral testing - computerized tasks
- Where
- France
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Dementia With Lewy Bodies, Parkinson Disease
5-HT RBD REM Sleep Behavior Disorder
This project will test the hypotheses that people with 5-HT RBD have systemic alpha- synuclein pathology, prodromal DLB signs, and brainstem lesions in regions that control REM sleep.
- Conditions
- Dementia With Lewy Bodies, Parkinson Disease, REM Sleep Behavior Disorder
- Trial name
- NCT06467461
- Testing
- Skin biopsy, Speech testing, Ultra high field 7T MRI
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Parkinson's Disease
Tango for Treatment of Motor and Non-motor Manifestations in Parkinson's Disease.
Parkinson's disease involves many motor difficulties as well as non-motor ones. Recent research has strongly suggested that exercise is very important for Parkinson's disease.
- Trial name
- NCT01573260
- Testing
- Argentinean Tango classes, Simple pamphlet about the exercise in PD
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Alzheimer's Disease, Mild Cognitive Impairment
Retinal Imaging in Neurodegenerative Disease
This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the…
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment, Parkinson's Disease, Multiple Sclerosis
- Trial name
- NCT03233646
- Testing
- Retinal and Choroidal Imaging
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Parkinson Disease
Dance Well Therapy: a Study for Evaluating Efficacy, Safety, and Feasibility
A new and in-teresting complementary approach for rehabilitation of parkinsonian patients is represented by "Dance Well", which is an artistic, multisensory dance intervention based on art and music.
- Trial name
- DWpsVMF (NCT06896123)
- Testing
- Dance Well: an artistic, multisensory dance intervention based on art and music, Conventional motor therapy group
- Where
- Italy
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Casa di Cura Villa Margherita Fresco
Parkinson Disease
Identifying New Biomarkers of Parkinson's From Routine Brain Imaging
The study will use routine computer tomography (CT), magnetic resonance spectroscopy (MRI) and nuclear medicine (NM) brain imaging data to produce new diagnostic tests for the onset of Parkinson's disease.
- Trial name
- NCT04986020
- Testing
- MRI
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- University of Plymouth
Breast Cancer, Breast Cancer Lymphedema
The Recovery of Reaching Movement in Breast Cancer Survivors: Two Different Rehabilitative Protocols in Comparison
This study emphasizes the importance of rehabilitation in breast cancer survivors after mastectomy, even during the course of radiotherapy and chemotherapy, both for good efficacy in reducing pain and for functional recovery of…
- Conditions
- Breast Cancer, Breast Cancer Lymphedema, Pain, Pain, Postoperative
- Trial name
- NCT04166279
- Testing
- Single rehabilitative treatment, Group rehabilitative treatment
- Where
- Italy
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Healthy, Prodromal Alzheimer's Disease
Exploring the Gut-Brain Axis in Ageing and Neurodegeneration
Neurodegenerative diseases are a major health concern due to their growing societal implications and economic costs. The identification of early markers of pathogenic mechanisms is one of the current main challenges.
- Conditions
- Healthy, Prodromal Alzheimer's Disease, Parkinson Disease, Multiple Sclerosis
- Trial name
- GutBrain (NCT05934188)
- Testing
- Magnetic Resonance Imaging, Neuropsychological protocol, Eating habits
- Where
- 3 sites in Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- IRCCS San Camillo, Venezia, Italy
Parkinson Disease
The Effect of Dual-site Repetitive Transcranial Magnetic Stimulation on Freezing of Gait in PD
This study is a double-blinded randomized study examining the effectiveness of the dual-site repetitive transcranial magnetic stimulation on Freezing of Gait (FOG) in patients with Parkinson's disease.
- Trial name
- NCT05925296
- Testing
- magnetic stimulation
- Where
- China
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
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