Clinical trials: Motor Function
Neurologic Disorder
SWITCH: Stentrode First-in-Human Study of Implantable BCI for Control of a Digital Device
SWITCH Study
- Trial name
- NCT03834857
- Testing
- Stentrode
- Where
- Australia
- Volunteers
- 5 people
- Sponsor
- Synchron Australia Pty Ltd.
Parkinson's Disease With End of Dose Wearing Off
Effects of Carbidopa/Levodopa/Entacapone on Motor Function and Quality of Life in Patients With Parkinson's Disease
To assess motor function and quality of life (QoL) in Parkinson's disease (PD) subjects with end-of-dose wearing off, comparing immediate and delayed switch to carbidopa/levodopa and entacapone.
- Trial name
- NCT00219284
- Testing
- Carbidopa/levodopa/entacapone
- Where
- 42 sites in United States, Puerto Rico
- Volunteers
- 359 people
- Sponsor
- Novartis Pharmaceuticals
Drop Foot, Muscle Weakness
Evaluation of Usability and Human Factors in the Novus System
The Novus system intended to provide ankle dorsiflexion and knee flexion or extension in individuals with foot drop and thigh muscle weakness, following an upper motor neuron injury or disease.
- Conditions
- Drop Foot, Muscle Weakness, Motor Neuron Disease, Upper
- Trial name
- NCT02738242
- Testing
- Novus system
- Where
- Israel
- Volunteers
- 16 people
- Sponsor
- Bioness Neuromodulation
Cerebrovascular Stroke, Upper Extremity Paresis
Pivotal Study of VNS During Rehab After Stroke (VNS-REHAB)
This is a pivotal phase study of up to 120 subjects and 15 clinical sites. All subjects are implanted with the Vivistim System® and then randomized to either study treatment or active-control treatment.
- Trial name
- VNS-REHAB (NCT03131960)
- Testing
- Paired Vagus Nerve Stimulation, Rehabilitation
- Where
- 20 sites in United States, United Kingdom
- Volunteers
- 108 people
- Sponsor
- MicroTransponder Inc.
Parkinson's Disease
Long-term Extension of RECOVER- Long-term Effect of the 24h Transdermal Delivery of Rotigotine in Subjects With Idiopathic Parkinson's Disease
The objective of this open-label extension is to assess the long-term effect of the 24-hour transdermal delivery of rotigotine on motor function, sleep quality, and nocturnal and non-motor symptoms of Parkinson's disease.
- Trial name
- NCT00519532
- Testing
- Rotigotine
- Where
- 21 sites in United States, Australia and 9 more
- Volunteers
- 84 people
- Sponsor
- UCB Pharma
Ischemic Attack, Transient
Cognitive and Physical Functions in Patients With Transient Ischemic Attack. A Randomized Controlled Trial of Physical Activity on Prescription up to One Year After the Event
The purpose of this study is to determine whether Physical Activation on Prescription can help patients with TIA to become more physically active.
- Trial name
- NCT01509924
- Testing
- Physical activation on Prescription
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Tiohundra AB
Healthy Volunteer, Muscular Atrophy, Spinal
Ability of Muscle Imaging and Motor Function Measure (MFM) to Detect Changes in Disease Progression in Ambulant Spinal Muscular Atrophy Patients Compared to Healthy Volunteers.
This non-drug, single center, 24-week, longitudinal study in ambulant spinal muscular atrophy (SMA) patients and in age- and gender-matched healthy volunteers will assess the detection of disease progression by magnetic resonance…
- Trial name
- NCT02044029
- Where
- Switzerland
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Mental Health, Sleep
Apple Health Study
The Apple Health Study aims to build a diverse and inclusive group of participants to help researchers advance our understanding of how signals and information collected from apps and devices relate to health and may be used to…
- Conditions
- Mental Health, Sleep, Exercise, Hormones
- Trial name
- NCT06958523
- Where
- 2 sites in United States
- Volunteers
- 500,000 people, healthy volunteers welcome
- Sponsor
- Apple Inc.
Healthy Female and Male
Clinical Trial of Motilitone on Gastric Motor Function in Healthy Volunteers
The purpose of this study is to compare the effects of Motilitone and placebo on gastric volumes, gastric emptying, small bowel transit and colon transit in female and male healthy volunteers.
- Trial name
- DA-9701 (NCT01719575)
- Testing
- Motilitone
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dong-A Pharmaceutical Co., Ltd.
Stroke
The Effectiveness of Occupation-based Bilateral Arm Training on Motor Functions and Activity Participation Among Stroke Survivors During Inpatient Rehabilitation.
People with stroke often experience limitations in motor functions and activity participation. Occupation-based bilateral upper limb training (OBBT) using occupations as meaningful daily activities, and as part of the therapy.
- Trial name
- NCT07164612
- Testing
- Occupation-Based Bilateral Upper Limb Training (OBBT), Conventional therapy group
- Where
- Qatar
- Volunteers
- 150 people
- Sponsor
- Hamad Medical Corporation
Vasodilation, Exercise
Acute Effect of Polyphenols Supplementation on Endothelial Function and Exercise Related Markers, in Physically Active Healthy Volunteers.
To evaluate the effect of acute polyphenols supplementation on vasodilation and related markers along with exercise related markers (notably performance, respiratory exchanges, perceived exertion), before, during and after a…
- Conditions
- Vasodilation, Exercise, Healthy Adults
- Trial name
- PolypOxy (NCT07518758)
- Testing
- Oral administration
- Where
- France
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Nexira
Stroke
Neurorehabilitation of the Hand
Stroke is the number one cause of adult disability in the world. Due to the neurological damage from stroke, a vast majority of individuals suffer from hand function disability (~70%).
- Trial name
- NCT05549375
- Testing
- MyHand System Hand Rehabilitation
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- IRegained Inc.
Ischemic Stroke
HT-3951 vs. Placebo in Stroke Rehabilitation
This is a randomized, double-blind, placebo-controlled parallel group outpatient study that will utilize standard stroke rehabilitation outcome measures, as well as fMRI techniques in a subset of subjects, to evaluate the effect…
- Trial name
- RESTORE (NCT02530307)
- Testing
- HT-3951
- Where
- 18 sites in United States
- Volunteers
- 61 people
- Sponsor
- Dart NeuroScience, LLC
Stroke, Hand Function
Hand Training & Brain Changes
10 participants with upper-limb impairment will be recruited from community sources. They will be invited to participate in a 15-day trial involving the IRegained device.
- Trial name
- NCT05811819
- Testing
- Treatment using the MyHand System
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- IRegained Inc.
Exercise, Blood Pressure
Effects of Lentil Protein Hydrolysate on Blood Pressure Control, Vascular Function and Exercise Performance
Examining the safety and tolerability of Lentil Protein Hydrolysate in healthy males and females whilst exploring the effects of a dose range on blood pressure control and vascular function and exercise performance
- Conditions
- Exercise, Blood Pressure, Vasodilation, Vascular Function in Healthy Volunteers
- Trial name
- NCT06894875
- Testing
- Lentil protein hydrolysate
- Where
- Australia
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Nuritas Ltd
Sleep, Physical Activity
Determining How Indoor Lighting Affects the Brain Health of Older Adults
The goal of this randomized, cross-over, single-site trial followed by an exploratory third intervention is to understand how indoor lighting affects different measures of brain health in older adults living in independent living…
- Conditions
- Sleep, Physical Activity, Cognitive Function, Social Isolation
- Trial name
- NCT05978934
- Testing
- Static Lighting Condition (L1), Dynamic Lighting Condition (L2), Dynamic Lighting Condition (L3)
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Well Living Lab, Inc.
Amyotrophic Lateral Sclerosis
Effects of Oral Levosimendan (ODM-109) on Respiratory Function in Patients With ALS
This study will evaluate whether prolonged oral levosimendan can preserve respiratory function more effectively than placebo, resulting in better patient functionality as measured by the ALSFRS-R scale.
- Trial name
- REFALS (NCT03505021)
- Testing
- Levosimendan
- Where
- 104 sites in United States, Australia and 12 more
- Volunteers
- 496 people
- Sponsor
- Orion Corporation, Orion Pharma
Multiple Sclerosis
Noninterventional Study Assessing Cognitive Function and Physical Activity in People With Multiple Sclerosis
Study assessing cognitive function and physical activity in people with relapsing remitting multiple sclerosis.
- Trial name
- CogniPlus (NCT01491100)
- Testing
- Interferon beta-1b (Betaseron, BAY86-5046)
- Where
- 17 sites in Albania, Algeria and 15 more
- Volunteers
- 1,085 people
- Sponsor
- Bayer
Stroke
"Evaluation Of ALBA® Device for Upper Extremity Motor Function In Adults With Subacute And Chronic Acquired Brain Injury"
As part of the rehabilitation techniques, robotic equipment has been introduced for the rehabilitation of the upper extremity with promising results.
- Trial name
- NCT05824416
- Testing
- Experimental: ALBA, Conventional Therapy
- Where
- Chile
- Volunteers
- 32 people
- Sponsor
- uMov
Amyotrophic Lateral Sclerosis
Effects of ODM-109 on Respiratory Function in Patients With Amyotrophic Lateral Sclerosis
In the double-blind, cross-over part of the study, ODM-109 capsules and placebo capsules for ODM-109 will be administered for 2 weeks separated by a 19-23 days wash-out period.
- Trial name
- ALS (NCT02487407)
- Testing
- ODM-109
- Where
- 11 sites in Germany, Ireland and 2 more
- Volunteers
- 66 people
- Sponsor
- Orion Corporation, Orion Pharma