Clinical trials: Mortality
Covid19, Liver Diseases
Silymarin in COVID-19 Patients Admitted to Hospital With Elevated Liver Enzymes
Of patients admitted to an internal medicine ward with internistic diagnosis/es together with COVID-19, substantial proportion has elevated liver enzymes.
- Trial name
- SILCOVINT-21 (NCT04816682)
- Testing
- Silymarin
- Where
- 2 sites in Slovakia
- Volunteers
- 30 people
- Sponsor
- F.D. Roosevelt Teaching Hospital with Policlinic Banska Bystrica
Electrocardiogram, Mortality Risk Prediction
AI-ECG for One-Year Mortality Risk Prediction
Cardiovascular disease (CVD) remains one of the leading causes of death worldwide. While the electrocardiogram (ECG) is a standard, widely accessible tool for cardiovascular screening, traditional risk assessment models often…
- Trial name
- NCT07659262
- Testing
- Chang Gung ECG Mortality Risk Prediction Software (Model: CGMH-DRP-001)
- Where
- 3 sites in Taiwan
- Volunteers
- 461,982 people
- Sponsor
- National Defense Medical Center, Taiwan
Peripheral Arterial Occlusive Disease
Troponin T as Risk Stratification Tool in Peripheral Arterial Occlusive Disease
Study hypothesis: elevated Troponin T is a marker of increased mortality in patients with peripheral arterial occlusive disease (PAOD).
- Trial name
- NCT01087385
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- University Heart Center Freiburg - Bad Krozingen
Obesity
Investigation of Waist Circumference and Waist/Hip Ratio as a Predictive Risk Factor for Morbidity and Mortality After Colorectal Surgery
Despite advances in surgical technique, preoperative patient evaluation and post-operative care, elective colorectal surgery carries a risk of mortality of approximately 2% and a morbidity rate ranging from 20-40%.
- Trial name
- NCT01737515
- Testing
- Abdominal waist and hip circumference
- Volunteers
- 1,415 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Hip Fractures, Anemia
The Effect of Preoperative Ferric Carboxymaltose Administration on Mortality in Geriatric Hip Fractures
Hip fractures (HF) are the most common and serious pathology affecting the hip and are associated with a high mortality risk in elderly patients.
- Conditions
- Hip Fractures, Anemia, Complication,Postoperative
- Trial name
- NCT06080893
- Testing
- Ferric carboxymaltose
- Where
- Turkey (Türkiye)
- Volunteers
- 209 people
- Sponsor
- Istanbul University
Renal Dialysis
Study of the Relationship Between rHuEPO Dose, Serum ADPN, and Mortality in Patients Beginning HD
Responsiveness of recombinant human erythropoietin (rHuEPO) is known to be related with body fatness in hemodialysis (HD) patients.
- Trial name
- NCT00457535
- Sponsor
- Hamamatsu University
Acute Respiratory Failure, Hypoxemic Respiratory Failure
Standard Oxygen Versus High Flow Nasal Cannula Oxygen Therapy in Patients With Acute Hypoxemic Respiratory Failure
First-line therapy of patients with acute respiratory failure consists in oxygen delivery through standard oxygen, high-flow nasal oxygen therapy through cannula or non-invasive ventilation.
- Trial name
- SOHO (NCT04468126)
- Testing
- Standard oxygen, High-flow nasal oxygen therapy
- Where
- France
- Volunteers
- 1,504 people
- Sponsor
- Poitiers University Hospital
Hemoglobins, Albumins
Association Between Preoperative HALP and Immediate Postoperative Outcomes
Multiple inflammation-based prognostic scores have been developed for the prediction of perioperative morbidity and mortality following pancreaticoduodenectomy (PD).
- Conditions
- Hemoglobins, Albumins, Platelets, Lymphocytes
- Trial name
- NCT05506748
- Testing
- pantients undergoing pancreaticoduodenectomy
- Where
- Nepal
- Volunteers
- 22 people
- Sponsor
- Chitwan Medical College
Septic Shock, Arterial Pressure
Assessment of Two Levels of Arterial Pressure on Survival in Patients With Septic Shock
The ideal mean arterial pressure in patients with septic shock is unknown. The expert's recommandations have stated a target between 65 and 70 mm Hg. However the scientific basis are weak.
- Conditions
- Septic Shock, Arterial Pressure, Hemodynamics, Mortality
- Trial name
- SEPSISPAM (NCT01149278)
- Testing
- maintain mean arterial pressure between 80-85 mm Hg, maintain mean arterial pressure between 65-70 mm Hg
- Where
- France
- Volunteers
- 800 people
- Sponsor
- University Hospital, Angers
Hyperdynamic, Left Ventricular Ejection Fraction
Hyperdynamic Left Ventricular Ejection Fraction as a Predictor of Mortality in Intensive Care Unit Patients With Septic Shock
The study aimed to evaluate the cause and prognosis of hyperdynamic left ventricular ejection fraction in critically ill patients with sepsis.
- Conditions
- Hyperdynamic, Left Ventricular Ejection Fraction, Mortality, Intensive Care Unit
- Trial name
- NCT06993948
- Testing
- Transthoracic echocardiography
- Where
- Egypt
- Volunteers
- 235 people
- Sponsor
- Ain Shams University
Non-cardiac Surgery
European Surgical Outcomes Study
The European Surgical Outcomes Study (EuSOS) is a multi-centre, international cohort study of peri-operative care and clinical outcomes for patients undergoing non-cardiac surgery.
- Trial name
- EuSOS (NCT01203605)
- Where
- 28 sites in Belgium, Croatia and 26 more
- Volunteers
- 46,985 people
- Sponsor
- Queen Mary University of London
Leukemia, HSCT
Comparison of Intralipid With SMOF Lipid Following HSCT
The goal of this clinical trial is to have a successful engraftment in after bone transplantation. Acute leukemia patient of both sexes aged 2 to 18 years, who are transplant candidates, participate in this study.
- Trial name
- NCT06625372
- Testing
- SMOF lipid, INTRALIPIDS
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- Shahid Beheshti University
Bone Marrow Failure Syndromes, Immunodeficiencies
Reduced Intensity Conditioning Using CD3+/CD19+ Depletion for Non Malignant Transplantable Diseases
This is a Phase II trial to determine the ability of a reduced intensity conditioning regimen to allow successful engraftment with CD3+ /CD19+ depleted peripheral stem cell grafts from mismatched donors.
- Conditions
- Bone Marrow Failure Syndromes, Immunodeficiencies, Immune Dysregulation Syndromes
- Trial name
- MiniClini (NCT02277639)
- Testing
- CliniMACs device
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Children's Hospital of Philadelphia
Perioperative Complication, Cardiovascular Complication
Cardiovascular Outcomes and Mortality in Vascular Surgical Patients
This is a registry-based study of elective vascular surgical patients undergoing intermediate or high-risk vascular surgical interventions at Groote Schuur hospital, a tertiary academic center, over a 12 month period.
- Trial name
- NCT05208957
- Testing
- No intervention
- Where
- South Africa
- Volunteers
- 175 people
- Sponsor
- University of Cape Town
Influenza
Adjunctive Sirolimus and Oseltamivir Versus Oseltamivir Alone for Treatment of Influenza
Seasonal influenza epidemics are important causes of mortality and morbidity. Cytokine dysregulation, with high levels of pro-inflammatory cytokines, occurs in patients with severe influenza A(H1N1)pdm09 virus infection, A(H5N1)…
- Trial name
- NCT03901001
- Testing
- sirolimus and oseltamivir, Oseltamivir
- Where
- Hong Kong
- Volunteers
- 160 people
- Sponsor
- Chinese University of Hong Kong
Post Partum Hemorrhage
Combating Maternal Mortality in Uganda: An Assessment of the Role of Misoprostol in Prevention of Post-Partum Hemorrhage
Null hypothesis: 10 IU Oxytocin is better than sublingual misoprostol 600µg in management of third stage of labor Alternative hypothesis: Sublingual misoprostol 600µg is non- inferior to 10 IU oxytocin and will not be more than…
- Trial name
- NCT01866241
- Testing
- Misoprostol
- Where
- Uganda
- Volunteers
- 1,140 people
- Sponsor
- Mbarara University of Science and Technology
Liver Dysfunction, Morbidity
Von Willebrand Factor to Predict Postoperative Outcome
vWF is stored in weibel-palade-bodies of endothelial cells as well as alpha-granula of platelets and is released upon their activation.
- Conditions
- Liver Dysfunction, Morbidity, Mortality, Hospitalisation
- Trial name
- NCT02118545
- Where
- 4 sites in Austria, Switzerland
- Volunteers
- 133 people
- Sponsor
- Medical University of Vienna
Diabetes, Clopidogrel Resistance
Platelet Reactivity, B-amyloid, MOTS-c and Mortality of Type II Diabetics With CAD
Increased circulating b-amyloid and decreased Mitochondrial-derived peptide (MOTS-c), a peptide improving tissue insulin sensitivity, are reported in diabetes.
- Conditions
- Diabetes, Clopidogrel Resistance, Amyloid, Insulin Resistance
- Trial name
- NCT04027712
- Where
- Greece
- Volunteers
- 120 people
- Sponsor
- University of Athens
Coronavirus Infections
COVID-19 Patients Characterization, Biobank, Treatment Response and Outcome Predictor
Collection and analysis of demographic, clinical, radiographic and laboratory characteristics of CoViD-19 patients to identify predictors of disease severity, mortality and treatment response, and to identify subgroup of patients…
- Trial name
- COVID-BioB (NCT04318366)
- Testing
- Observational Study
- Where
- 13 sites in Italy
- Volunteers
- 6,000 people
- Sponsor
- Università Vita-Salute San Raffaele
Necrotizing Enterocolitis, Sepsis
Human Milk Fortification in Extremely Preterm Infants
This is a randomised controlled multi-centre trial comparing the effect of diet supplementation of a human breast milk-based nutrient fortifier (H2MF®) with standard bovine protein-based nutrient fortifier in 222 extremely…
- Conditions
- Necrotizing Enterocolitis, Sepsis, Mortality
- Trial name
- N-forte (NCT03797157)
- Testing
- H2MF, Bovine milk-based fortifier
- Where
- 5 sites in Sweden
- Volunteers
- 229 people
- Sponsor
- Thomas Abrahamsson, MD, PhD