Clinical trials: Mortality
Vitamin A Deficiency, HIV
Single-dose Postpartum Vitamin A Supplementation of Mothers and Neonates
The ZVITAMBO PROJECT is testing whether giving mothers and infants a single large dose of vitamin A during the immediate post partum period will reduce: 1.
- Trial name
- ZVITAMBO (NCT00198718)
- Testing
- Vitamin A (retinyl palmitate)
- Volunteers
- 28,220 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
SARS-CoV 2, COVID
In-vitro Diagnostic Test to Predict COVID-19 Mortality and Disease Severity
The COVID-19 Androgen Sensitivity Test is a non-invasive In-Vitro Diagnostic device that utilizes Next Generation Sequencing Technology (NGS).
- Conditions
- SARS-CoV 2, COVID, COVID-19, Androgenetic Alopecia
- Trial name
- NCT04368897
- Testing
- CAG length <22, CAG length >=22
- Where
- Spain
- Sponsor
- Applied Biology, Inc.
Childhood Illness
Community-Integrated Management of Childhood Illness (IMCI) Programme Evaluation
The proposed four-year randomized study will attempt to test the hypothesis that community-based child health interventions in conjunction with facility-based IMCI will improve child care practices, nutritional status and child…
- Trial name
- NCT00979797
- Testing
- Community-based interventions to promote maternal and child health
- Where
- Bangladesh
- Volunteers
- 140,000 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Prenatal Care
Prenatal Care Program in Dingyuan County
The general objective of this study is to evaluate prenatal care in the specific context of rural China. It also aims to define the optimal content of prenatal care for the context of rural China, to evaluate the effect of such…
- Trial name
- EPCP (NCT01054235)
- Testing
- training
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Finnish Institute for Health and Welfare
Very Preterm Maturity of Infant
Prematurity at the Limit of Viability
Advancements in perinatal care have significantly improved the survival of extremely premature infants, establishing a viability threshold below 25 weeks' gestational age (GA).
- Trial name
- PRELIVIA (NCT06391476)
- Testing
- Study of the evolution of a cohort of children born between 22 and 25 weeks gestational age
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Hospices Civils de Lyon
Stroke
Stroke Outcome Analysis and Registry in Trinidad and Tobago
This is a prospective observational study to assess risk factors, functional outcomes and mortality at three months for persons admitted to hospital with stroke and transient ischemic attack.
- Trial name
- StART (NCT05256550)
- Where
- Trinidad and Tobago
- Volunteers
- 1,320 people
- Sponsor
- Naveen Seecheran
Chronic Kidney Disease (CKD)
Retrospective Analysis Assessing Clinical Risk Factors for Cardiovascular Events and Mortality and Development of a Risk Calculator in Chronic Kidney Disease Stage 5 on Dialysis
The purpose of this study is to evaluate which clinical and laboratory factors are associated with major adverse cardiovascular event (MACE) in chronic kidney disease (CKD) patients on dialysis.
- Trial name
- NCT04042350
- Testing
- Non-interventional
- Where
- Sweden
- Volunteers
- 2,773 people
- Sponsor
- Astellas Pharma Europe Ltd.
Critical Illness
Association Between Resuscitation Orders and Mortality in ICU Patients
The hypothesis of the study is that a resuscitation order other than full code is associated with increased mortality among critically ill patients.
- Trial name
- NCT06373068
- Testing
- Resuscitation orders
- Where
- Sweden
- Volunteers
- 1,500 people
- Sponsor
- Karolinska Institutet
Respiratory Disease
Use of a Respiratory Care Model in Population Older Than 15 Years in Orizaba, Veracruz Mexico
Background. Mexico is lacking guidelines that provide an integral approach for the prevention and control of respiratory diseases in adults.
- Trial name
- NCT03230968
- Testing
- Integral Action Program for Respiration
- Volunteers
- 649 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Salud Publica, Mexico
ARDS
Systematic Early Use of Neuromuscular Blocking Agents in ARDS Patients
The use of neuromuscular blocking agents (NMBA) in ARDS patients has not been extensively investigated. The aim of the study is to show a reduction of the mortality rate of ARDS patients.
- Trial name
- NCT00299650
- Testing
- cisatracurium, Cisatracurium besilate
- Where
- 20 sites in France
- Volunteers
- 340 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Vaginal Bleeding During Pregnancy
Tranexamic Acid in Pregnancies With Vaginal Bleeding
Tranexamic acid has been proposed and used for prevention and management of antepartum and postpartum hemorrhage.
- Trial name
- NCT03632824
- Testing
- Tranexamic Acid
- Where
- Iraq
- Volunteers
- 139 people
- Sponsor
- Hawler Medical University
Malnutrition
Effect of Continued Nutritional Support at Hospital Discharge on Mortality, Frailty, Functional Outcomes and Recovery
This study is to compare the sustained post-discharge nutritional support to reach individual energy and protein goals to usual care home nutrition in medical patients at nutritional risk.
- Trial name
- EFFORT II (NCT04926597)
- Testing
- nutritional supplement, individualized nutritional guidelines, general nutritional information
- Where
- 18 sites in Spain, Switzerland
- Volunteers
- 1,200 people
- Sponsor
- Philipp Schuetz
Bacterial Pneumonia, Viral Pneumonia
Inhaled Corticosteroids in U-5 Children With Acute Respiratory Infection in Uganda: A Randomised Trial
The purpose of this study is to find out whether adjunct treatment with inhaled corticosteroids lead to faster improvement and reduce mortality of children under 5 years of age admitted to hospital with ALRI.
- Conditions
- Bacterial Pneumonia, Viral Pneumonia, Acute Asthma
- Trial name
- ICS (NCT01868113)
- Testing
- Inhaled corticosteroid
- Where
- Uganda
- Volunteers
- 1,010 people
- Sponsor
- Makerere University
Heart Failure With Preserved Ejection Fraction
Clinical Study of Active Intervention in High-risk HFpEF Patients
Based on inclusion and exclusion criteria, this experiment plans to include 924 Heart Failure with Preserved Ejection Fraction(HFpEF) patients with increased risk of all-cause death.
- Trial name
- NCT06532019
- Testing
- Targeted intervention based on risk factors
- Volunteers
- 924 people
- Sponsor
- Xiangtan Central Hospital
Metabolic Acidosis, Acid-Base Imbalance
Frequency of Metabolic Acidosis in the Pediatric Intensive Care Unit
Metabolic acidosis is one of the most common acid-base disturbances encountered in critically ill children and often reflects underlying disease severity.
- Conditions
- Metabolic Acidosis, Acid-Base Imbalance, Critical Illness in Children
- Trial name
- NCT07803263
- Volunteers
- 140 people
- Sponsor
- Assiut University
Shock, Septic
Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis: A Pilot Feasibility Study
The objective of this pilot study is to assess overall feasibility prior to embarking on a larger randomized pragmatic trial comparing the clinical effectiveness of fluid resuscitation with NS versus LR for pediatric patients…
- Trial name
- PRoMPT BOLUS (NCT03340805)
- Testing
- Lactated Ringer, Normal saline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Children's Hospital of Philadelphia
Heart Failure, Diastolic Heart Failure
Heart Failure and Postoperative Outcome in Surgery - a National Registry Study
The study is an exploratory study that aims to explore the incidence of heart failure in a national surgical cohort, and to compare postoperative mortality and morbidity in patients with and without heart failure.
- Conditions
- Heart Failure, Diastolic Heart Failure, Systolic Heart Failure
- Trial name
- NCT07634822
- Where
- 2 sites in Sweden
- Volunteers
- 2,200,000 people
- Sponsor
- Umeå University
Community-Acquired Pneumonia, Fraility
Frailty and Outcomes in Older Emergency Department Patients With Pneumonia
Pneumonia is one of the leading causes of infection-related mortality in the older population. Traditional severity scores used in emergency departments, such as the Pneumonia Severity Index (PSI) and CURB-65, primarily focus on…
- Conditions
- Community-Acquired Pneumonia, Fraility, Hospitalizations
- Trial name
- NCT07442656
- Testing
- Clinical frailty scale, Clinical Frailty Scale (CFS)
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Ege University
Kidney Failure
AKIN Criteria: Acute Kidney Injury After On-Pump Coronary Artery Bypass Graft (CABG)
The purpose of this study is evaluate clinical outcomes and 30-day mortality after on-pump CABG.
- Trial name
- NCT00780845
- Volunteers
- 817 people
- Sponsor
- Hospital de Base
AKI, Renal Replacement Therapy
Hyperoxia vs Normoxia During Cardiopulmonary Bypass
This single-center randomized controlled pilot trial evaluates the effects of intraoperative hyperoxia compared with normoxia during cardiopulmonary bypass (CPB) in adult patients undergoing elective cardiac surgery.
- Conditions
- AKI, Renal Replacement Therapy, NGAL, Arrythmia
- Trial name
- IPEROXIA (NCT07510672)
- Testing
- Hyperoxia group, Normoxia group (control)
- Where
- Italy
- Volunteers
- 104 people
- Sponsor
- University of Padova