Clinical trials: Morbidity
Pulmonary Arterial Hypertension
Effects of the Combination of Bosentan and Sildenafil Versus Sildenafil Monotherapy on Pulmonary Arterial Hypertension (PAH)
COMPASS-2 is a Phase 4, prospective, randomized, double-blind, placebo-controlled, event-driven study evaluating the effect of bosentan on the time to first confirmed morbidity/mortality event in patients with symptomatic PAH…
- Trial name
- Compass-2 (NCT00303459)
- Testing
- bosentan
- Volunteers
- 334 people
- Sponsor
- Actelion
Hyperglycemia
The Association Between Peri-Operative Hyperglycemia and Major Morbidity and Mortality
Surgery induces a stress effect on the body partially through a catabolic energy state. In turn, glucose levels may rise to levels which have been associated with major morbidity (Golden, 1999) and mortality (Ouattara, 2005).
- Trial name
- NCT00487162
- Testing
- intensive glycemic control, conventional glycemic control
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Chagas Disease, Heart Failure
Efficacy and Safety of Sacubitril/Valsartan Compared With Enalapril on Morbidity, Mortality, and NT-proBNP Change in Patients With CCC
The purpose of this study was to evaluate the effect of sacubitril/valsartan 200 mg BID compared with enalapril 10 mg BID, in addition to conventional heart failure (HF) treatment, in improving a hierarchical composite of…
- Trial name
- PARACHUTE-HF (NCT04023227)
- Testing
- Sacubitril/valsartan, Enalapril
- Where
- 79 sites in Argentina, Brazil and 2 more
- Volunteers
- 922 people
- Sponsor
- Novartis Pharmaceuticals
Stroke, Acute, Ischemic Stroke
Maimonides Minocycline in Stroke Study
The goal of this study is to determine if oral Minocycline's proposed neuroprotective effects further improve the clinical outcomes, including mortality, of acute stroke patients beyond the current standard stroke care in a large…
- Conditions
- Stroke, Acute, Ischemic Stroke, Hemorrhagic Stroke, Mortality
- Trial name
- NCT06107725
- Testing
- Minocycline
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Maimonides Medical Center
Deglutition Disorders
Comparison of Outcomes Between Parenteral and Enteral Nutrition
Short-term outcomes of parenteral and enteral nutrition for patients unable to eat normally were compared and analyzed.
- Trial name
- NCT02512224
- Testing
- Parenteral nutrition, Enteral nutrition
- Volunteers
- 5,824 people
- Sponsor
- Tokyo University
Chronic Heart Failure
Efficacy and Safety of Aliskiren and Aliskiren/Enalapril Combination on Morbidity-mortality in Patients With Chronic Heart Failure
The study will evaluate the efficacy and safety of both aliskiren monotherapy and aliskiren/enalapril combination therapy as compared to enalapril monotherapy, on morbidity and mortality in patients with chronic heart failure…
- Trial name
- ATMOSPHERE (NCT00853658)
- Testing
- Enalapril, Aliskiren
- Where
- 806 sites in United States, Argentina and 42 more
- Volunteers
- 7,064 people
- Sponsor
- Novartis Pharmaceuticals
HIV-associated Co-morbidities
Vitamin D Supplements for HIV-positive Patients on cART
The ability of vitamin D to modulate the immune system and strengthen bones may mitigate the adverse medication consequences of HIV/AIDS, but little is known about either the health benefits of vitamin D supplements, or about the…
- Trial name
- NCT01295034
- Testing
- conventional vitamin D treatment, tiered/titrated vitamin D dosing
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Andrea Branch
Pelvic Organ Prolapse
Smartmesh Technology in Pelvic Floor Repair Procedures
Pelvic organ prolapse repair involves conservative treatments and surgical treatments. Conservative treatments are for patients with moderate prolapse. Treatment of symptomatic prolapse remains essentially surgical.
- Trial name
- Restorelle (NCT03098641)
- Testing
- pelvic organ prolapse repair
- Where
- 16 sites in France
- Volunteers
- 272 people
- Sponsor
- Groupe Hospitalier de la Rochelle Ré Aunis
Breast Cancer
Pilot Study for a Prospective Surveillance Program for Rehabilitation Following Surgery for Breast Cancer
Breast cancer treatment often results in long-term arm morbidity. A prospective surveillance model with arm assessment pre-surgery followed by ongoing surveillance and targeted physiotherapy treatment after breast cancer surgery…
- Trial name
- NCT02754427
- Testing
- Prospective Surveillance Group, Education Group
- Volunteers
- 41 people
- Sponsor
- University of British Columbia
Obstructed Defecation Syndrome, Rectocele
Stapled TransAnal Rectal Resection (STARR) With Contour® TranstarTM
The stapled transanal rectal resection (STARR procedure) is an effective treatment for obstructed defecation syndrome (ODS) caused by intussusception and rectocele.
- Conditions
- Obstructed Defecation Syndrome, Rectocele, Intussusception, SNS
- Trial name
- STARR (NCT00673400)
- Testing
- Stapled transanal rectum resection
- Where
- Switzerland
- Volunteers
- 52 people
- Sponsor
- Cantonal Hospital of St. Gallen
Obstetric Labor Complications, Cesarean Section
Evaluation of a Quality Improvement Project on Impacted Fetal Head at Cesarean Section
This study is an evaluation of a Quality Improvement (QI) project addressing delivery of the impacted fetal head being conducted at Regions Hospital.
- Trial name
- NCT03387189
- Testing
- Quality Improvement Project
- Where
- United States
- Volunteers
- 409 people
- Sponsor
- HealthPartners Institute
Post Operative Pain
The Effect of Platelet Rich Plasma (PRP) on Post Operative Pain in Anterior Cruciate Ligament Reconstruction
The purpose of this research study is to investigate whether or not platelet rich plasma (PRP) may help to improve tendon healing and decrease post operative pain in patients undergoing anterior cruciate ligament (ACL)…
- Trial name
- NCT01765712
- Testing
- Anterior Cruciate ligament reconstruction bone patellar tendon bone autograft, Platelet Rich Plasma
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Brian Walters
Fluid Overload, Anesthesia; Adverse Effect, Spinal and Epidural
Can Vena Cava Ultrasound Guided Volume Repletion Prevent Spinal Induced Significant Hypotension in Elective Patients?
Aim of this study is to determine whether Inferior Vena Cava analyzed by trans-thoracic echocardiography is an effective method to guide titrated fluid repletion in non critical patients, in order both to decrease post procedural…
- Conditions
- Fluid Overload, Anesthesia; Adverse Effect, Spinal and Epidural, Regional Anesthesia Morbidity
- Trial name
- NCT02271477
- Testing
- Ultrasound-guided volemic repletion
- Where
- Switzerland
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Ente Ospedaliero Cantonale, Bellinzona
Heart Failure With Reduced Ejection Fraction (HF-rEF)
Study of Efficacy and Safety of LCZ696 in Japanese Patients With Chronic Heart Failure and Reduced Ejection Fraction
The purpose of this study was to assess the effect of LCZ696 at a target dose of 200 mg b.i.d. compared to enalapril 10 mg b.i.d., in addition to the background heart failure (HF) treatment, on delaying time to first occurrence…
- Trial name
- PARALLEL-HF (NCT02468232)
- Testing
- LCZ696, Enalapril
- Where
- 49 sites in Japan
- Volunteers
- 225 people
- Sponsor
- Novartis Pharmaceuticals
Prospective, Single-blind
Bacille Calmette Guérin Immunisation at Birth and Childhood Morbidity in Danish Children.
In high-income societies the use of health care and medication is steadily increasing. Children have high morbidity, many visits at the general practitioner, an increasing number of hospitalisations, and an increasing use of…
- Conditions
- Prospective, Single-blind, Clinical, Trial
- Trial name
- NCT01694108
- Testing
- BCG-vaccine (SSI)
- Where
- 3 sites in Denmark
- Volunteers
- 4,262 people
- Sponsor
- Lone Graff Stensballe
Chronic Kidney Disease, Left Ventricular Hypertrophy
The PRIMO Study: Paricalcitol Capsules Benefits Renal Failure Induced Cardiac Morbidity in Subjects With Chronic Kidney Disease Stage 3/4
To evaluate the effects of paricalcitol capsules on cardiac structure and function over 48 weeks in patients with Stage 3/4 chronic kidney disease (CKD) who had left ventricular hypertrophy (LVH).
- Trial name
- PRIMO (NCT00497146)
- Testing
- paricalcitol
- Where
- 71 sites in United States, Australia and 10 more
- Volunteers
- 227 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
HIV Infection
REMEMBER: Reducing Early Mortality & Morbidity by Empiric Tuberculosis (TB) Treatment
People with HIV have a high chance of becoming infected with TB, especially when they live in areas where TB infection is common. It can be difficult to diagnose TB in people who need to start HIV treatment right away.
- Trial name
- REMEMBER (NCT01380080)
- Testing
- Atripla (r), Efavirenz, Truvada
- Where
- 18 sites in Brazil, Haiti and 8 more
- Volunteers
- 851 people
- Sponsor
- Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Schizophrenia, Insulin Resistance
Effectiveness of Aripiprazole for Improving Side Effects of Clozapine in the Treatment of People With Schizophrenia
This study will evaluate the effects of combination treatment with aripiprazole and clozapine on insulin resistance, blood fat levels, and weight gain in people diagnosed with schizophrenia.
- Trial name
- NCT00345033
- Testing
- Aripiprazole
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Massachusetts General Hospital
Gestational Diabetes, Maternal Complication of Pregnancy
CAPO: Continuous Glucose Monitoring in A2 Gestational Diabetes and Pregnancy Outcomes
This study will utilize continuous glucose monitoring in women with A2 gestational diabetes. Women will be randomized to continuous glucose monitoring or routine care with fingersticks to check their blood glucose four times…
- Trial name
- CAPO (NCT04219085)
- Testing
- Continuous Glucose Monitor, Routine Care
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Yale University
Obesity, Laparoscopic Gastric Bypass Surgery
CURES: The Effect of Deep Curarisation and Reversal With Sugammadex on Surgical Conditions and Perioperative Morbidity
The purpose of this study is to investigate if a deep neuromuscular block with a continuous infusion of rocuronium titrated to a post-tetanic count (PTC) of 1-2 responses combined with reversal of neuromuscular blockade with…
- Conditions
- Obesity, Laparoscopic Gastric Bypass Surgery, Surgical Conditions, Respiratory Function
- Trial name
- CURES (NCT01748643)
- Testing
- deep neuromuscular blockade with rocuronium, reversal with sugammadex, normal neuromuscular blockade reversal with rocuronium, reversal with neostigmine
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Ziekenhuis Oost-Limburg