Clinical trials: Mood Swings
Bipolar Disorder
N-Acetyl Cysteine and Aspirin as an Adjunctive Treatment for Bipolar Disorder
We propose to conduct a double-blind placebo-controlled trial with a widely available and prototypical non-steroidal anti-inflammatory agent, aspirin, and an antioxidant agent, NAC, involving symptomatic Bipolar Disorder type I…
- Trial name
- SMRI-Bipolar (NCT01797575)
- Testing
- Aspirin, N-acetyl-cysteine (NAC), Sugar Pill
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- The University of Texas Health Science Center, Houston
Emotion Regulation, Mood Disorders
Neurostimulation Versus Therapy for Problems With Emotions
The primary goal of this clinical trial is to evaluate the unique neural and behavioral effects of a one-session training combining emotion regulation skills training, with excitatory repetitive transcranial magnetic stimulation…
- Conditions
- Emotion Regulation, Mood Disorders, Stress Disorder, Anxiety Disorders
- Trial name
- NCT05712057
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS), electrical scalp stimulation, Cognitive Restructuring
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Duke University
Hot Flashes, Night Sweats
Comparison of Hormonal Therapy: Mediating Hot Flashes Tapering Regimens for Mediating Hot Flashes
This study will evaluate whether there is a difference in the proportion of women who report a worsening severity of their hot flashes between three tapering schedules for one accepted HT/ET regimen.
- Trial name
- NCT00547001
- Testing
- Estradiol
- Where
- United States
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Psychological Distress, Self-Assessment
Examining the Efficacy of Acceptance and Commitment Therapy (ACT) Microinterventions for Distressed First-Generation College Students
This research study aims to evaluate the feasibility, safety, and effectiveness of a micro-randomized acceptance and commitment therapy-based (ACT-based) intervention that is delivered to distressed first-generation college…
- Conditions
- Psychological Distress, Self-Assessment, Mood Change
- Trial name
- CompACT (NCT04081662)
- Testing
- compACT Intervention
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Alzheimer&Amp;#39;s Disease-related Dementia, Alzheimer Disease
Novel Brain Stimulation Treatment for Neuropsychiatric Symptoms in Alzheimer's Disease
The goal of this pilot study is to test a combination of two non-invasive brain stimulation methods, called iTBS (intermittent theta burst stimulation) and tDCS (transcranial direct current stimulation), in people with…
- Conditions
- Alzheimer&Amp;#39;s Disease-related Dementia, Alzheimer Disease, rTMS Stimulation
- Trial name
- NCT06835283
- Testing
- Brain Stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Baylor College of Medicine
Inflammatory Bowel Disease 11
Steroid-induced Mood Changes in Patients With Inflammatory Bowel Disease
Steroid is commonly used to treat autoimmune disorders such as rheumatoid arthritis, lupus, and inflammatory bowel disease (Crohn's Disease and Ulcerative Colitis).
- Trial name
- NCT01981889
- Testing
- Prednisone
- Where
- Canada
- Volunteers
- 53 people
- Sponsor
- University of British Columbia
Attention Deficit Hyperactivity Disorder (ADHD)
The Relationship of Essential Fatty Acids to Adult ADHD: The OCEAN Study (Oils and Cognitive Effects in Adult ADHD Neurodevelopment)
Brief summary The aim of the study is to provide preliminary data on the relationship of Essential Fatty Acids (EFAs) to cognitive and electrophysiological measures of brain and behavioural functions in adults with attention…
- Trial name
- OCEAN (NCT01750307)
- Testing
- Experimental fatty acid supplementation
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- King's College London
Exergame, Active Video Games (AVG)
Affective and Physiological Outcomes of Virtual and Mixed Reality Workplace Exergames
The aim of this study was to compare the acute effects of virtual reality (VR) and mixed reality (MR) based exergame practices on physical and psychological health indicators during micro-breaks among university administrative…
- Conditions
- Exergame, Active Video Games (AVG), Virtual Reality, Mood Changes
- Trial name
- NCT06830772
- Testing
- Experimental, Active comparator
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Mood Swings
Effect of Moderate Alcohol Consumption on Postprandial Mood
Rationale: Food choice is influenced by postprandial mood; the feelings of well-being after a meal. Postprandial mood can be measured by subjective responses.
- Trial name
- NCT01426022
- Testing
- Nutrition, mood manipulation
- Where
- Netherlands
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- TNO
Chronic Pain, Opioid Use Disorder
The Acupuncture for Pain, Opioid Use Disorder and Mood
The goal of this study is to determine how patients with chronic pain and opioid use disorder will respond to treatment with acupuncture, including whether there will be any changes in mood (as an exploratory outcome).
- Conditions
- Chronic Pain, Opioid Use Disorder, Mood Change, Opioid Misuse
- Trial name
- AcuPOM (NCT06543355)
- Testing
- Modified Battlefield Acupuncture + National Acupuncture Detoxification Association protocol
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Albert Einstein College of Medicine
Depression
Behavioral Study of Effects of Low-Level Light Therapy on Mood and Reaction Time
The goal of this project is to use low-level light therapy (LLLT) to enhance neural metabolism in the prefrontal cortex of humans, and measure the effects of LLLT on attentional bias change following a single session of attention…
- Trial name
- NCT02390076
- Testing
- Left Low Level Light Therapy, Attention bias modification, Right Low Level Light Therapy
- Volunteers
- 51 people
- Sponsor
- Seth Disner
Depression, Multiple Sclerosis
The Efficacy and Safety of Escitalopram for Depression in Multiple Sclerosis
Emotionally labile, depressed participants with multiple sclerosis treated with escitalopram will have a greater reduction in emotional lability scores and in their psychological distress scores than those who are randomized to…
- Trial name
- NCT00151294
- Testing
- escitalopram oxalate antidepressant
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Weill Medical College of Cornell University
Unipolar Depression, Anxiety Disorders
Effects of Mindfulness Based Cognitive Therapy on Emotional Processing
Background: In the last 30 years mindfulness-based approaches have been extensively used for a variety of mental disorders, including affective disorders characterized by emotional instability.
- Conditions
- Unipolar Depression, Anxiety Disorders, Adjustment Disorders, Emotional Instability
- Trial name
- MESI (NCT03358056)
- Testing
- Mindfulness-Based Cognitive Therapy
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Parc de Salut Mar
Lower Urinary Tract Symptoms, Mood Change
How Does the Mood of the Patients Change Before and After the Invasive Urodynamic Study?
The goal of this study is to learn about the patient's perspective regarding to psychological mood before and after an invasive urodynamic study.
- Conditions
- Lower Urinary Tract Symptoms, Mood Change, Diagnosis
- Trial name
- NCT05948410
- Testing
- The State-Trait Anxiety Inventory (STAI), Perceived Stress Scale, Visual Analog Scale
- Volunteers
- 50 people
- Sponsor
- Koç University
Cognitive Change, Creativity
Naturalistic Study of Microdosing With Psilocybin
This study seeks to understand the neural, cognitive and behavioral effects of low doses of psilocybin administered in the form of dried mushroom material (0.5 g of Psilocybe cubensis) consumed in natural settings following a…
- Conditions
- Cognitive Change, Creativity, Mood Change, Sleep
- Trial name
- NATMICRO (NCT05160220)
- Testing
- Psilocybin
- Where
- Argentina
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- National Council of Scientific and Technical Research, Argentina
Bipolar Disorder I, Bipolar Disorder II
PSYCHE (Personalised Monitoring SYstems for Care in Mental Health)
For the moment, the detection of a mood episode in Bipolar Disorder (BD) relies on the appearance of the first clinical signs that the clinician detect or that the patient becomes aware of and reports to the clinician.
- Conditions
- Bipolar Disorder I, Bipolar Disorder II, Rapid Cycling Bipolar Disorder(DSM-IV-TR)
- Trial name
- PSYCHE (NCT01879982)
- Where
- France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Strasbourg, France
Breakthrough Bleeding, Breakthrough Spotting
Management of Breakthrough Bleeding During Extended Therapy Use With NuvaRing®
The purpose of this research study is to evaluate the best way to manage breakthrough spotting and bleeding during an extended use regimen of NuvaRing®.
- Trial name
- NCT00475553
- Testing
- remove ring if bleeding or spotting occurs more than 5 days, If bleeding does not remove ring
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Scott and White Hospital & Clinic
Attention Deficit Hyperactivity Disorder
Imaging the Effects of Stimulant Medication on Emotional Lability in Patients With ADHD
The aim of this study is to examine the mechanisms by which stimulant medications reduce symptoms in patients with Attention Deficit Hyperactivity Disorder (ADHD).
- Trial name
- NCT01415440
- Testing
- Lisdexamfetamine
- Where
- United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Non-Muscle Invasive Bladder Cancer
Mood Alterations in the Patients With Non-Muscle Invasive Bladder Cancer Treated With BCG
The purpose of this study is to evaluate mood changes in patients with Non-Muscle Invasive Bladder Cancer who are receiving intravesical Bacillus Calmete-Guerin (BCG).
- Trial name
- NCT05672615
- Testing
- Questionnaires, Daily Mood Diaries, Urine Specimen Collection
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Johns Hopkins University
Cognitive Change, Mood Change
Cognitive Effects of Sage in Healthy Humans
Extracts of sage and polyphenols have separately been reported to interact with central nervous system (CNS) mechanisms relevant to cognitive performance but, to date, no trial has combined these interventions.
- Trial name
- NCT03695003
- Testing
- Cognivia
- Where
- United Kingdom
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Northumbria University