Clinical trials: Molar
Dental Pain
Evaluation of the Efficacy and Safety of Diclofenac HPBCD 25, 50 mg/ml in the Treatment of Post-surgical Pain Following Dental Surgery
The present study is proposed to evaluate the efficacy and safety of single doses of Diclofenac HPBCD subcutaneous (s.c.) (25 mg/1 ml and 50 mg/1 ml) in the treatment of acute moderate-to-severe pain after dental impaction…
- Trial name
- NCT00942448
- Testing
- Diclofenac HPBCD
- Where
- 6 sites in Poland, United Kingdom
- Volunteers
- 306 people
- Sponsor
- IBSA Institut Biochimique SA
Dental Pain
Study of Long-Acting Acetaminophen in Postoperative Dental Pain
The purpose of the study is to evaluate the efficacy and safety of acetaminophen ER 1500 mg (two 750 mg tablets) over 10 to 12 hours in the dental pain model following third molar extraction(s) and to evaluate the…
- Trial name
- NCT01960114
- Testing
- Acetaminophen ER
- Where
- United States
- Volunteers
- 403 people
- Sponsor
- McNeil Consumer Healthcare Division of McNEIL-PPC, Inc.
Dental Pain
Phase 2 Study of Indomethacin Capsules to Treat Dental Pain
The purpose of this study is to determine whether Indomethacin Test Formulation Capsules are safe and effective for the treatment of dental pain.
- Trial name
- NCT00964431
- Testing
- Celecoxib 400 mg, Indomethacin Test (lower dose), Indomethacin Test (upper dose)
- Where
- United States
- Volunteers
- 203 people
- Sponsor
- Iroko Pharmaceuticals, LLC
Pain
Study to Investigate the Analgesic Efficacy of a Single Dose of AZD1940
The primary aim of this study is to investigate if AZD1940 can relieve the pain induced by the surgical removal of one lower wisdom-tooth.
- Trial name
- NCT00659490
- Testing
- AZD1940, Naproxen
- Where
- United States
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Impacted Third Molar Tooth, Adverse Reaction to Other Local Anesthetics
Lower Third Molar Removal With 2% and 4% Articaine
The present clinical trial randomized compared the clinical efficacy of the local anesthetics articaine in two concentrations, 2% and 4%, in association with 1:200,000 adrenaline, for the removal of lower third molars.
- Trial name
- NCT02457325
- Testing
- Surgery with 2%Articaine first, then Surgery with 4% Articaine, Surgery with 4%Articaine first, then Surgery with 2% Articaine
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Extracted Socket
Effect of Black Tea Extract Impregnated Gauze on Extracted Socket
Black tea is made from the leaves of a bush called Camellia sinensis. The main difference between green tea and black tea is that green tea is not completely oxidized while black tea is fully oxidized.
- Trial name
- BTEIG (NCT06687824)
- Testing
- Black Tea Extract, 0.5% Povidone Iodine Impregnated Sterile Gauze
- Where
- Malaysia
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Manipal University College Malaysia
Carious Exposure, Human Permanent First and Second Molars
RCT of Pulp Capping Over Carious Exposure in Adults
This multicentre study was a randomized, controlled, parallel, patient-blinded, two-arm superiority trial with a 1:1 allocation ratio that followed the CONSORT guidelines.The aim of this study was to investigate whether MTA is…
- Conditions
- Carious Exposure, Human Permanent First and Second Molars, Mature Teeth, Proximal Caries
- Trial name
- NCT01224925
- Testing
- Direct pulp capping with Dycal, Direct pulp capping
- Where
- 4 sites in Lithuania, Norway
- Volunteers
- 80 people
- Sponsor
- University of Tromso
Impacted Third Molar Tooth
Effect of St. John's Wort and Olive Oils on the Postoperative Complications
Surgical removal of impacted third molars is one of the most frequent procedures carried out in the oral and maxillofacial surgery clinics.
- Trial name
- NCT04373421
- Testing
- Chlorhexidine Gluconate 0.12 % Mouthwash + benzydamine hydrochloride, St. John's wort oil, Virgin olive oil
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Yuzuncu Yil University
Dental Caries in Children, Dental Caries Class II
Treatment of Interproximal Cavities on Primary Molar Teeth With Silver Diamine Fluoride
This study investigates whether 1) Silver diamine fluoride (SDF) application using Super Floss can arrest and/or reverse initial interproximal caries on primary molars and 2) whether SDF applied with Super Floss is more effective…
- Conditions
- Dental Caries in Children, Dental Caries Class II, Dental Caries
- Trial name
- NCT03770286
- Testing
- 5% Fluoride Varnish, 38% Silver diamine fluoride, Super Floss
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Anesthesia
A Comparison of Dexmedetomidine Versus Propofol for Use in Intravenous Sedation
Hypothesis: A combination of midazolam with dexmedetomidine for sedation during third molar surgery will provide 1) superior patient satisfaction, 2) superior operator satisfaction and 3) no significant hemodynamic or respiratory…
- Trial name
- NCT03255824
- Testing
- Dexmedetomidine and Midazolam, Propofol, Midazolam, and Fentanyl
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Pain, Post-Operative Pain
Ibuprofen Extended-Release Dental Pain Study
The purpose of this study is to evaluate the efficacy and safety of multiple doses of Ibuprofen 600 mg Extended-Release Tablets in a study of dental pain following extraction of third molar teeth.
- Conditions
- Pain, Post-Operative Pain, Third Molar Extraction
- Trial name
- NCT00707057
- Testing
- Ibuprofen 600 mg Extended-Release Tablets
- Where
- United States
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- SCOLR Pharma, Inc.
Pain
Hydrocodone/Acetaminophen for Acute Pain Following Third Molar Tooth Extraction
The purpose of this study was to evaluate analgesic efficacy and safety of hydrocodone/acetaminophen compared to placebo in moderate to severe pain following molar extraction.
- Trial name
- NCT00935311
- Testing
- ABT-712 Extended-release, Hydrocodone/Acetaminophen Immediate-release
- Where
- 3 sites in United States
- Volunteers
- 122 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Root Canal Therapy
Sonendo GentleWave™ System for Treatment in Molar Teeth Requiring Root Canal Therapy
A prospective, literature controlled, clinical study evaluating healing rates for the Sonendo GentleWave System in the treatment of 1st and 2nd molars indicated for root canal therapy.
- Trial name
- SUPREME (NCT02285595)
- Testing
- Sonendo GentleWave™ System
- Where
- 3 sites in United States
- Volunteers
- 69 people
- Sponsor
- Sonendo, Inc.
Symptomatic Irreversible Pulpitis, Apical Periodontitis
Postoperative Pain and Healing in Teeth Treated With GentleWave or EndoActivator
Patients with painful molars will be randomly assigned to 2 different groups: GentleWave and EndoActivator. The root canals will be completed using identical protocols except in the mode of delivery and activation of irrigation…
- Trial name
- NCT04552132
- Testing
- Multisonic vs Sonic activation of irrigants
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- St. Louis University
Postoperative Edema and Pain
Third Molar Extraction and Pulsed Electromagnetic FieldTherapy
This study is a prospective, randomized, double-blinded, controlled, clinical trial that evaluates the efficacy of using PEMF in the postoperative period in decreasing swelling and pain after extraction of impacted third molars.
- Trial name
- PEMF (NCT02376946)
- Testing
- ActiPatch(TM)
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Tufts University
Surgical Blood Loss, Third Molar
Effect of Warm Saline Irrigation on Bleeding in Mandibular Third Molar Surgery
The objective of this research is to compare the effect of irrigation during impacted mandibular third molar surgery, with normal saline of 25 ± 2 ° C and 37 ± 1 ° C for control and experimental sides, respectively.
- Trial name
- NCT04143373
- Testing
- warm saline irrigation
- Where
- Iran
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tehran University of Medical Sciences
Pain
Analgesic Effect of Different Combinations of Dexketoprofen Trometamol With Tramadol Hydrochloride in a Model of Moderate to Severe Pain
The purpose of this study is to evaluate the analgesic efficacy of Dexketoprofen Trometamol and Tramadol Hydrochloride given in combinations and the analgesic efficacy of each single component in comparison to placebo on moderate…
- Trial name
- DEX-TRA 02 (NCT01307020)
- Testing
- Dexketoprofen Trometamol, Tramadol Hydrochloride, Ibuprofen
- Where
- 16 sites in Germany, Hungary and 4 more
- Volunteers
- 745 people
- Sponsor
- Menarini Group
Breast Cancer, Diagnostic Imaging
Efficacy and Safety of Gadobutrol 1.0 Molar (Gadovist) for Breast MRI
The purpose of this study is to look at the efficacy (how does it work) and safety of gadobutrol when used for obtaining MR images of both breasts.Women with a recent diagnosis of breast cancer by mammogram (X-ray examination of…
- Trial name
- NCT01067976
- Testing
- Gadobutrol (Gadavist, Gadovist, BAY86-4875)
- Where
- 40 sites in United States, Argentina and 7 more
- Volunteers
- 446 people
- Sponsor
- Bayer
Acute Pain
Tramadol/Diclofenac Fixed-dose Combination Phase III Trial in Acute Pain After Third Molar Extraction
This study evaluated a new drug fixed-dose combination tablet (FDC) called tramadol/diclofenac at two different strengths (fixed doses of 25 milligrams [mg] of tramadol and of diclofenac or of 50 mg each).
- Trial name
- NCT03714672
- Testing
- Tramadol/Diclofenac 50/50, Tramadol/Diclofenac 25/25, Tramadol 50
- Where
- 8 sites in Mexico
- Volunteers
- 1,151 people
- Sponsor
- Grünenthal GmbH
Anesthetic Effectiveness
Testing the Anesthetic Effectiveness of Three Different Dental Local Anesthetics Injected Next to a Lower First Molar
Infiltration (injecting next to the tooth) injections are common in dentistry and a number of studies have shown that articaine anesthetic, when injected next to the tooth as a supplemental injection, works very well following a…
- Trial name
- NCT01567839
- Testing
- Mandibular buccal Infiltration injection
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ohio State University