Clinical trials: Mohs Surgery
Squamous Cell Carcinoma (Skin), Squamous Cell Carcinoma in Situ
Hair Regrowth Following Partial Thickness Removal of SSCIS
Participants are being approached to participate in this study because they are undergoing surgery for a skin cancer known as squamous cell carcinoma in situ (SCCIS) on the scalp.
- Conditions
- Squamous Cell Carcinoma (Skin), Squamous Cell Carcinoma in Situ, Alopecia
- Trial name
- NCT07809191
- Testing
- Partial Thickness Excision
- Volunteers
- 15 people
- Sponsor
- The Cooper Health System
Postoperative Pain, Acute, Skin Cancer
Meloxicam in Mohs Micrographic Surgery
The goal of this clinical trial is to explore alternative methods of postoperative pain control in Mohs micrographic surgery. The main aims are: To provide more information to the Mohs surgery community regarding postoperative…
- Trial name
- NCT07200544
- Testing
- Meloxicam 7.5 mg, Meloxicam 15 mg, Acetaminophen 500mg
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Oklahoma
Basal Cell Carcinoma, Squamous Cell Carcinoma
Serum Concentration of Lidocaine After Local Injection During Mohs Micrographic Surgery
The primary objective of this study is to (1) determine whether local injection of lidocaine used during Mohs surgery will elevate serum lidocaine concentrations to a level that could cause systemic symptoms and (2) determine…
- Trial name
- NCT00793169
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Northwestern University
Anesthetics, Local
Split Face Study of the Duration of Local Anesthetics
This is a research study to compare how long injectable pain medications (anesthetics) commonly used in dermatologic surgery are effective for.
- Trial name
- NCT05767749
- Testing
- lidocaine + epinephrine 1:100,000, Ropivacaine 0.5% Injectable Solution, Bupivacaine 0.5% Injectable Solution
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Skin Cancer Face, Quality of Life
Buddy Relationships in DermatoloGic Excisions for Skin Cancer
More than 5 million skin cancer surgeries are performed each year in the United States with 80% of tumors appearing on the head and neck.
- Conditions
- Skin Cancer Face, Quality of Life, Surgical Wound, Peer Mentorship
- Trial name
- BRIDGES (NCT04036344)
- Testing
- Peer Mentorship Program
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Carcinoma, Basal Cell, Carcinoma, Squamous Cell
Optical Imaging for Preoperative Delineation of Nonmelanoma Skin Cancers
The purpose of the study is to evaluate the ability and efficacy of using a polarization-enhanced reflectance and fluorescence imaging device, PERFIS, (see the Device Brochure) for demarcation of nonmelanoma skin cancer margins…
- Trial name
- PERFIS (NCT02666833)
- Testing
- Polarization Enhanced Reflectance and Fluorescence System
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Basal Cell Carcinoma
Investigation of Mohs Surgical Margins Using Two Photon Microscopy
The goal of this clinical trial is to compare the use of two photon fluorescence microscopy for detecting residual basal cell carcinoma during Mohs surgery.
- Trial name
- NCT05814900
- Testing
- Two photon microscopy imaging
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- University of Rochester
Actinic Cheilitis, Squamous Cell Carcinoma In-situ (SCC-is)
Photodynamic Therapy to Treat Actinic Damage in Patients With Squamous Cell Carcinoma (SCC) of the Lip
Our study is designed to evaluate the efficacy of photodynamic therapy (PDT) for treatment of actinic cheilitis (AC) and as an adjunct to Mohs surgery for squamous cell carcinoma (SCC) on the lips.
- Conditions
- Actinic Cheilitis, Squamous Cell Carcinoma In-situ (SCC-is), Squamous Cell Carcinoma (SCC), Photodynamic Therapy (PDT)
- Trial name
- NCT00868088
- Testing
- PDT prior to Mohs surgery
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Tufts Medical Center
Wound Healing After MMS Surgery, BCC - Basal Cell Carcinoma
Effectiveness and Safety of X A-DERM™ Microsurfaced Acellular Dermal Matrix for Wound Healing After MOHS Surgery
The goal of this single-arm clinical trial is to learn about the effectiveness and safety of the X A-DERM™ mADM in promoting wound healing and improving scar formation after MMS surgery for removing BCC, SCC, or MIS lesions on…
- Conditions
- Wound Healing After MMS Surgery, BCC - Basal Cell Carcinoma, SCC - Squamous Cell Carcinoma, Melanoma In Situ
- Trial name
- NCT06919809
- Testing
- A microsurfaced ADM (acellular dermal matrix)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- McGuire Institute
Mohs Micrographic Surgery
3D Printed Models in Mohs Micrographic Surgery
Patients undergoing Mohs micrographic surgery (MMS) frequently experience anxiety. It has been suggested that enhanced patient education prior to the procedure may decrease patient anxiety.
- Trial name
- NCT03461965
- Testing
- 3D printed model, Verbal Counselling
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Case Comprehensive Cancer Center
Carcinoma, Basal Cell
A Randomised Study Comparing Tissue Conservation in Conventional Versus Mohs' Surgery of Basal Cell Carcinoma
We have compared to types of surgery to assess which one leaves the smaller surgical defect.
- Trial name
- NCT00571363
- Testing
- standard surgery, Mohs micrographic surgery
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- NHS Tayside
Lentigo Maligna, Melanoma In Situ
Mohs and Immunofluorescence for Malignant Melanoma In Situ
The purpose of this study is to determine if immunofluorescence (IF) can effectively identify features of malignant melanoma in situ, on sun-damaged skin, in the setting of Mohs Micrographic Surgery.
- Trial name
- NCT02306512
- Testing
- H&E, IHC MART-1, IF MART-1
- Where
- 2 sites in United States
- Sponsor
- University of Miami
Surgery
Ethyl Chloride Spray to Reduce Pain From Local Anesthesia During Mohs Micrographic Surgery
Fear of needles is a well-documented issue that affects many patients. This fear may cause significant anxiety in various medical situations, including in the dermatology office 1.
- Trial name
- NCT06920381
- Testing
- Gebauer's Ethyl Chloride Topical Spray
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- University of California, Davis
Surgical Site Infection, Skin Cancer
Cyanoacrylate Skin Adhesive After Mohs Surgery or Wide Local Excision
This study will compare surgical site infection after linear repair with or without cyanoacrylate skin adhesive following Mohs micrographic surgery or wide local excision.
- Conditions
- Surgical Site Infection, Skin Cancer, Wound Healing
- Trial name
- NCT07844681
- Testing
- Cyanoacrylate Skin Adhesive, Fast Gut Running Epidermal Suture Closure, Vicryl Rapide Running Epidermal Suture Closure
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Minnesota
Wound Edges
Intraoperative CO₂ (Carbon Dioxide)
To evaluate whether intraoperative fractionated CO₂ laser treatment of surgical wound edges improves postoperative scar appearance compared with untreated wound edges following Mohs micrographic surgery (MMS).
- Trial name
- NCT07592468
- Testing
- CO2 Fractionated Laser, Non CO2 Laser Treatment
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Baylor Research Institute
Mohs Surgery
Impact of Videos on Patient Anxiety and Satisfaction
The purpose of this research is to look at how educational videos might affect patient satisfaction and anxiety before Mohs surgery day.
- Trial name
- NCT03485937
- Testing
- Pre-Operative Videos, verbal instructions, written instructions
- Sponsor
- Case Comprehensive Cancer Center
Anesthesia
Comparison of the Total Dose and Efficacy of Two Lidocaine Concentrations Needed for Cutaneous Surgery Local Anesthesia
The purpose of the study will be to demonstrate whether Mohs micrographic surgery can be performed with a lower total dose of local anesthesia (and greater patient safety) when using 0.5% lidocaine with 1:200,000 epinephrine…
- Trial name
- NCT00594542
- Testing
- lidocaine
- Volunteers
- 149 people
- Sponsor
- University of Pennsylvania
Skin Cancer, Complication
Complications and Recurrences After Mohs Micrographic Surgery and Slow Mohs
Mohs micro-graphic surgery (Mohs) is a tissue-sparing, surgical treatment for different types of skin cancer (e.g. basal cell carcinoma, squamous cell carcinoma, lentigo maligna (melanoma).
- Conditions
- Skin Cancer, Complication, Complication of Surgical Procedure, Complication,Postoperative
- Trial name
- NCT06014619
- Testing
- Mohs surgery, Slow Mohs surgery
- Where
- Netherlands
- Volunteers
- 500 people
- Sponsor
- Maastricht University Medical Center
Mohs Micrographic Surgery, Anesthesia, Local
Local Anesthetic Clinical Trial
To compare several local anesthetics when used during dermatological surgery.
- Trial name
- NCT07601750
- Testing
- Lidocaine, Bupivacaine Hydrochloride, Mepivacaine Hydrochloride
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Baylor Research Institute