Clinical trials: Moderate Sedation
Aortic Valve Stenosis
RanDOmized stUdy Comparing Both Latest Generation Self-Expanding Valves and a Minimalist approaCH vs. Standard Of Care In transCathEter Aortic Valve Implantation
Open-label, 2 x 2 factorial, prospective, randomized, national, multicenter study to compare latest-generation self-expanding valves and a minimalist approach versus standard of care in transcatheter aortic valve implantation.
- Trial name
- DOUBLE-CHOICE (NCT05036018)
- Testing
- ACURATE neo2, minimalist approach, CoreValve Evolut Pro, Pro+ and FX
- Where
- 10 sites in Germany
- Volunteers
- 836 people
- Sponsor
- Leipzig Heart Science gGmbH
Multiple Pulmonary Diseases
Uncuffed Endotracheal Tube vs. no Endotracheal Tube
This is a comparison of uncuffed endotracheal tube (UCETT) vs. no endotracheal tube (ETT) in endobronchial ultrasound-transbronchial needle aspiration (EBUS-TBNA) procedure under moderate sedation in terms of procedure tolerance…
- Trial name
- NCT06799455
- Testing
- Endotracheal tube
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Minnesota
Conscious Sedation
Effects of Oral Midazolam in Comparison Promethazine With Nitrous Oxide for Uncooperative Children
The purpose of this study is to compare the safety and efficacy of sedation using orally administered midazolam and promethazine with nitrous oxide/oxygen in uncooperative children receiving dental treatments.
- Trial name
- NCT01118884
- Testing
- Promethazine
- Where
- Iran
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University
Conscious Sedation, Simple Lacerations Less Than 4 cm
A Comparison of Intranasal Midazolam and Nitrous Oxide (N2O) Minimal Sedation for Minor Procedures in a Pediatric Emergency Department
The objective of this project is to compare the sedative effects of intranasal midazolam versus inhaled nitrous oxide (N2O) for minor procedures in the pediatric emergency department.
- Conditions
- Conscious Sedation, Simple Lacerations Less Than 4 cm, Lumbar Punctures, Minor Incision Drainage of Abscesses Not Requiring Extensive Debridement
- Trial name
- NCT03085563
- Testing
- Nitrous Oxide, Midazolam
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- University of Colorado, Denver
Conscious Sedation, Pathologic Processes
Prospective Electroencephalography Evaluation of Sedation in COVID-19
Sedation of severe COVID-19 disease are often complicated. We try to find a correlate for this observation by encephalographic studies.
- Conditions
- Conscious Sedation, Pathologic Processes, Electroencephalogram, Acute Respiratory Distress Syndrome
- Trial name
- NCT04815109
- Testing
- Encephalography measurement
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Goethe University
Conscious Sedation
An Effectiveness and Safety Study of AQUAVAN® Injection (Fospropofol Disodium) for Sedation During Colonoscopy
Very often patients receive medication before a diagnostic procedure, like a colonoscopy, to help them relax and stay calm during the procedure. This is called procedural or minimal-to-moderate sedation.
- Trial name
- NCT00261599
- Testing
- AQUAVAN® (fospropofol disodium) Injection, Midazolam HCI
- Where
- 20 sites in United States
- Volunteers
- 300 people
- Sponsor
- Eisai Inc.
Hypoventilation, Hypoxia
Using Capnography to Reduce Hypoxia During Pediatric Sedation
The investigators hypothesize that the addition of capnography during moderate sedation will improve recognition of hypoventilation and apnea.
- Trial name
- NCT01463527
- Testing
- Nellcor NPB-70 Capnograph
- Where
- United States
- Volunteers
- 167 people
- Sponsor
- Yale University
Respiratory Insufficiency, Respiration, Artificial
Effects of Remifentanil on Respiratory Function in Mechanically Ventilated Patients
Sedation is widely used in mechanically ventilated patients. Propofol, benzodiazepines and opioids are the most used drugs. The study hypothesis is that sedation with remifentanil (an opioid drug) could improved respiratory…
- Conditions
- Respiratory Insufficiency, Respiration, Artificial, Conscious Sedation
- Trial name
- NCT00665119
- Testing
- remifentanil
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- Fondazione Poliambulanza Istituto Ospedaliero
Midazolam
Pharmacokinetic Evaluation of MDZ028
Plasma concentration data were collected from 37 paedriatic patients and 12 healthy adults recruited in a single dose, open-label phase II pharmacokinetic study and in a single dose, randomised, open-label two-peiod crossover…
- Trial name
- MIDAZOLAM (NCT03639428)
- Testing
- Midazolam
- Volunteers
- 37 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Hydrocele, Spermatocele
Evaluating Patient Tolerability and Success for Penile and Scrotal Urologic Procedures Under Conscious Sedation: A Prospective Study
The goal of this observational study is to evaluate patient reported outcomes and tolerability of scrotal and penile urologic procedures under the administration of minimal conscious sedation.
- Conditions
- Hydrocele, Spermatocele, Varicocele, Epididymal Cyst
- Trial name
- NCT05617261
- Testing
- Conscious sedation
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- University of Manitoba
Effect of Drug
Analgesia From Conscious Sedation Versus Paracervical Block for Manual Vacuum Aspiration
Miscarriage is one of the major causes of early pregnancy losses. Incomplete miscarriage is a major cause of maternal morbidity and mortality.
- Trial name
- NCT06539143
- Testing
- Lidocaine
- Where
- Nigeria
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Darlington-Peter Chibuzor Ugoji
Stroke, Endovascular Repair
GA vs. CS for Endovascular Stroke Therapy
After a stroke caused by a blockage (clot) in a blood vessel in the brain, patients may have the clot removed by threading a catheter from the groin up to the affected area of the brain.
- Conditions
- Stroke, Endovascular Repair, Anesthesia
- Trial name
- NCT03247998
- Testing
- General Anesthesia, Conscious Sedation with Remifentanil
- Volunteers
- 20 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Bronchoscopy, Conscious Sedation
Sedation During Bronchoscopy:Dexmedetomidine vs Alfentanil
The purpose of this study is to find the best sedation necessary for patients undergoing bronchoscopy. Patients are randomized to three different regimes of sedation during bronchoscopy were studied: 1.
- Trial name
- NCT01805726
- Testing
- xylocain, Alfentanil, Dexmedetomidine
- Where
- Lebanon
- Volunteers
- 162 people
- Sponsor
- Saint-Joseph University
Patients Undergoing Endoscopic Retrograde Cholangiopancreatography in Prone Position
A Trial Comparing High-flow Nasal Oxygen With Standard Management for Conscious Sedation During Endoscopic Retrograde Cholangiopancreatography in Prone Position
Traditional conscious sedation for endoscopic retrograde cholangiopancreatography in prone position places patients at risk of desaturation, and high-flow nasal oxygen may reduce the risk.
- Trial name
- NCT03872674
- Testing
- high-flow humidified oxygen-delivery system (OptiFlow THRIVE)
- Where
- South Korea
- Volunteers
- 72 people
- Sponsor
- Yonsei University
Otosclerosis
Dexmedetomidine vs. Remifentanil Conscious Sedation for Stapedotomy/Stapedectomy
Dexmedetomidine continuous intravenous infusion vs. remifentanil target-controlled infusion conscious sedation for stapedotomy/stapedectomy- a prospective, single-center, double-masked randomized trial The goal of this clinical…
- Trial name
- NCT06283836
- Testing
- Dexmedetomidine, Remifentanil
- Where
- Romania
- Volunteers
- 74 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Pain Intractable, Delirium
Pilot Study Comparing Treatment With Dexmedetomidine to Midazolam for Symptom Control in Advanced Cancer Patients
Cancer patients with very difficult to control symptoms at the Abbotsford (AC) and Fraser Valley (FVC) Cancer Centers are referred and admitted to the Tertiary Palliative Care Units at the Abbotsford Regional Hospital and Cancer…
- Conditions
- Pain Intractable, Delirium, Dyspnea, Nausea
- Trial name
- NCT01687751
- Testing
- Dexmedetomidine, Midazolam
- Where
- Canada
- Sponsor
- Fraser Health
Conscious Sedation
Propofol Sedation During Upper Endoscopy With and Without Topical Pharyngeal Anesthesia
It is unclear whether a topical pharyngeal anesthesia adds any benefit to the upper gastrointestinal endoscopy under a propofol sedation.
- Trial name
- NCT01081002
- Testing
- Lidocaine 10%, Diluted gentian root solution
- Where
- 2 sites in Switzerland
- Volunteers
- 294 people
- Sponsor
- University Hospital, Basel, Switzerland
Conscious Sedation Under Spinal Anesthesia
The Optimal Effect Site Concentration of Propofol for Conscious Sedation in Elderly Male Patients Undergoing Urologic Surgery Under Spinal Anesthesia With or Without Intrathecal Fentanyl
Since intrathecal fentanyl is known to sedation effect, intrathecal fentanyl will result in lowering propofol requirement for conscious sedation under spinal anesthesia.
- Trial name
- NCT01232270
- Testing
- propofol
- Where
- South Korea
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Conscious Sedation Failure During Procedure, Analgesia
Lidocaine as Local Anesthetics in Children Under Ketamine Sedation
Ketamine seems an obvious choice in the setting of an emergency department in laceration repair. Lidocaine is the local anesthetics widespread used. Ketamine leads to dissociative amnesia.
- Conditions
- Conscious Sedation Failure During Procedure, Analgesia, Anesthesia
- Trial name
- NCT02205502
- Testing
- Lidocaine, Normal saline
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Seoul National University Hospital
Recovery Period, Hypoxemia
Efficacy of Propofol-Ketamine and Sevoflurane in Children Undergoing Magnetic Resonance Imaging
Magnetic resonance imaging (MRI) is becoming increasingly important in the diagnosis and follow-up of pediatric diseases. However, successful MRI requires complete and prolonged immobility, which can be challenging for young…
- Conditions
- Recovery Period, Hypoxemia, Patient Safety
- Trial name
- NCT06832683
- Testing
- Sevoflurane, Propofol, Ketamine
- Where
- Turkey (Türkiye)
- Volunteers
- 230 people
- Sponsor
- Kocaeli City Hospital