Clinical trials: Moderate Respiratory Distress
Mesenchymal Stromal Cells, Remestemcel-L
MSCs in COVID-19 ARDS
The mortality rate in SARS-CoV-2-related severe ARDS is high despite treatment with antivirals, glucocorticoids, immunoglobulins, and ventilation.
- Conditions
- Mesenchymal Stromal Cells, Remestemcel-L, Acute Respiratory Distress Syndrome, COVID
- Trial name
- NCT04371393
- Testing
- Remestemcel-L
- Where
- 21 sites in United States
- Volunteers
- 223 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Acute Respiratory Distress Syndrome, ARDS (Moderate or Severe)
Multiple Dosing of Mesenchymal Stromal Cells in Patients With ARDS (COVID-19)
This is a multi-center, randomized, placebo controlled, interventional phase 2A trial to evaluate the safety profile and potential efficacy of multi-dosing of mesenchymal stromal cells (MSC) for patients with SARS-CoV-2…
- Conditions
- Acute Respiratory Distress Syndrome, ARDS (Moderate or Severe), COVID-19 Pneumonia
- Trial name
- NCT04466098
- Testing
- Mesenchymal stromal cells
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
COVID-19 Infection, COVID-19-Associated Acute Respiratory Distress Syndrome
Study of Cord Blood Derived Mesenchymal Stem Cells for Treatment of Moderate, Severe or Critical Pneumonia
This is a phase I trial followed by a phase II randomized trial. The purpose of phase I study is the feasibility of treating patients with acute respiratory distress syndrome (ARDS) related to COVID-19 infection (COVID-19) with…
- Conditions
- COVID-19 Infection, COVID-19-Associated Acute Respiratory Distress Syndrome, Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
- Trial name
- NCT04565665
- Testing
- Best Practice, Mesenchymal Stem Cell
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- M.D. Anderson Cancer Center
Covid19, Corona Virus Infection
Expanded Access to Zofin for Patients With COVID-19
This expanded access protocol will provide access to the investigational product Zofin for patients in outpatient facilities infected with SARS-CoV-2 who have mild to moderate COVID-19, or who are judged by a healthcare provider…
- Conditions
- Covid19, Corona Virus Infection, SARS (Severe Acute Respiratory Syndrome), Acute Respiratory Distress Syndrome
- Trial name
- NCT04657406
- Testing
- Zofin
- Sponsor
- ZEO ScientifiX, Inc.
ARDS, TTM
TwichView-guided Atricurium Dose Adjustment Trial
The goal of this clinical trial is to learn if using a monitor that measures muscle response can lower the amount of muscle relaxant medicine needed in adults who are treated in an intensive care unit (ICU) and need a continuous…
- Conditions
- ARDS, TTM, ECMO, Neuromuscular Blockade Monitoring
- Trial name
- NCT07807046
- Testing
- EMG-based quantitative TOF-guided atracurium titration
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Fu Jen Catholic University Hospital
Respiratory Distress Syndrome, Adult
A Clinical Trial to Evaluate the Safety of agenT-797 in COVID-19 Participants With ARDS
A Phase 1 study of agenT-797 to treat moderate to severe acute respiratory syndrome in Coronavirus disease 2019 (COVID-19) participants.
- Trial name
- NCT04582201
- Testing
- agenT-797
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- MiNK Therapeutics
ARDS (Acute Respiratory Distress Syndrome), Electrical Impedance Tomography (EIT)
Cyclic On-off Switching of Pulmonary Blood Flow in Moderate to Severe ARDS
Although the theoretical model of "cyclic on-off switching of pulmonary blood flow" provides a crucial perspective for understanding VILI, its clinical validation and real-time intervention face significant obstacles.
- Conditions
- ARDS (Acute Respiratory Distress Syndrome), Electrical Impedance Tomography (EIT), Pulmonary Perfusion
- Trial name
- NCT07327268
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Southeast University, China
Acute Respiratory Distress Syndrome, COVID19
Ultraprotective Ventilation Without Extracorporeal Circulation During COVID 19 Pneumonia
Mortality of COVID-19 pneumonia with acute respiratory distress syndrome (ARDS) is extremely high in preliminary reports amounting to 50-60%.
- Conditions
- Acute Respiratory Distress Syndrome, COVID19, Sars-CoV2, Pneumonia
- Trial name
- VT4COVID (NCT04349618)
- Testing
- PROTECTIVE VENTILATION, ULTRAPROTECTIVE VENTILATION
- Where
- 11 sites in France
- Volunteers
- 220 people
- Sponsor
- Hospices Civils de Lyon
Acute Respiratory Distress Syndrome
Comparison of Different PEEP Strategies in Moderate-to-Severe ARDS Based on Various Bedside Assessment Tools
Many patients admitted to the intensive care unit (ICU) for a severe lung disease called acute respiratory distress syndrome (ARDS) require mechanical ventilation and positive end-expiratory pressure (PEEP) to improve their…
- Trial name
- OPTI-PEEP (NCT07741916)
- Testing
- Ventilation at different levels of PEP including a test involving a gradual decrease in PEP.
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Acute Respiratory Failure
Physiological Effects of a New Interface on Lung Ventilation and Gas Distribution
Hypoxemic Acute Respiratory Failure (hARF) is a common reason of admission to Intensive Care. Different modalities can be used to administer oxygen, which is the first supportive treatment in these patients.
- Trial name
- NCT04619641
- Testing
- High Flow Nasal Cannula (HFNC), Continuous Positive Airway Pressure (CPAP)
- Volunteers
- 15 people
- Sponsor
- University Magna Graecia
Covid19, ARDS
Noninvasive Ventilation in Moderate-to-severe COVID-19-associated Acute Respiratory Distress-syndrome
Non-invasive ventilation can allow to avoid intubation and improve outcomes in moderate-to-severe COVID-19-associated acute respiratory distress-syndrome (ARDS).
- Trial name
- COVID-NIV (NCT04667923)
- Testing
- Respiratory monitoring, Respiratory muscles ultrasound, Electro impedance tomography
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Newborn Respiratory Distress Syndrome
HHHFNC (Heated Humidified High-Flow Nasal Cannula) Versus NCPAP for Respiratory Distress Syndrome of Prematurity
Preterm infants ranging from 29+0 to 36+6 weeks+days are randomly assigned to one of the following treatments as non invasive respiratory support if they develop mild to moderate Respiratory Distress Syndrome within 72 hrs from…
- Trial name
- NCT02570217
- Testing
- HHHFNC, NCPAP
- Where
- Italy
- Volunteers
- 316 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Acute Respiratory Distress Syndrome
Full-Course ECMO Strategy for Moderate-to-Severe ARDS
China faces major challenges in the ECMO management of patients with moderate-to-severe ARDS, including substantial heterogeneity in clinical practice, low weaning success rates, and high complication rates.
- Trial name
- NCT07726953
- Testing
- Full-Course ECMO Management Pathway, Usual Care
- Where
- 39 sites in China
- Volunteers
- 500 people
- Sponsor
- Southeast University, China
ARDS, Acute Respiratory Distress Syndrome
Effect of Prone Positioning on Mortality in Patients With Mild to Moderate Acute Respiratory Distress Syndrome.
Acute respiratory distress syndrome (ARDS) accounts for almost 10% of intensive care units (ICU) admissions. Three ARDS stages have been defined, based on the PaO2/FIO2 ratio measured with positive end-expiratory pressure (PEEP)…
- Conditions
- ARDS, Acute Respiratory Distress Syndrome, Intensive Care Unit, Mechanical Ventilation
- Trial name
- PROMILD (NCT05056090)
- Testing
- Patients will receive MV in PP
- Where
- France
- Volunteers
- 656 people
- Sponsor
- University Hospital, Grenoble
Acute Respiratory Distress Syndrome (ARDS), Intensive Care Units (ICUs)
Assessment of the PEEP Responsiveness to Titrate End-expiratory Pressure and of the Need for Muscle Relaxation During Prone Positioning in Moderate-to-severe Acute Respiratory Distress Syndrome: A Master Protocol
Despite best supportive care, mortality of the Acute Respiratory Distress Syndrom (ARDS) remains high. In the absence of specific treatments, providing safe and efficient mechanical ventilation (MV) is key to survival.
- Trial name
- PEPER (NCT06849570)
- Testing
- Minimal distension, Maximal Recruitment, Prone position + early NMBAs
- Where
- 29 sites in France
- Volunteers
- 1,200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ventilator-Induced Lung Injury
Physiological Effects of Controlled vs. Assisted Ventilation During Moderate-to-severe ARDS (PEARL Study)
Background: In patients with acute hypoxemic respiratory failure or ARDS, mechanical ventilation is often required. Two common strategies are pressure support ventilation (PSV), which allows spontaneous breathing, and…
- Trial name
- PEARL (NCT07315815)
- Volunteers
- 20 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Covid19
Use of Hyperbaric Oxygen Therapy to Treat COVID-19 Patients With Respiratory Distress
Investigate whether hyperbaric oxygen therapy treatment can become a viable treatment option for COVID-19. If successful, providers will be able to provide future COVID-19 patients with mild-to-moderate respiratory distress…
- Trial name
- HBOT (NCT04800120)
- Testing
- Hyperbaric Oxygen Therapy
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Steward St. Elizabeth's Medical Center of Boston, Inc.
Acute Respiratory Distress Syndrome, Ventilator-Induced Lung Injury
Impact of the Depth of Neuromuscular Blockade on Respiratory Mechanics in Moderate to Severe ARDS Patients
Neuromuscular blockade (NMB) is proposed in patients with moderate to severe acute respiratory distress syndrome (ARDS). The supposed benefit of these muscle relaxants could be partly linked to their effects on respiratory…
- Trial name
- NCT05697666
- Testing
- Modulation of the depth of the neuromuscular blockade
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Centre Hospitalier de Saint-Brieuc
Multiple Trauma, Respiratory Distress Syndrome, Adult
Inhaled Dornase Alpha to Reduce Respiratory Failure After Severe Trauma
Severe hypoxemia following trauma may happen in many circumstances (aspiration, ventilation-associated pneumonia, lung contusion...), most of which are not exclusively associated with a direct injury to the lungs.
- Trial name
- TRAUMADORNASE (NCT03368092)
- Testing
- Dornase Alfa Inhalant Solution [Pulmozyme]
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Strasbourg, France
Moderate to Severe Acute Respiratory Distress Syndrome
Effects on Biotrauma of NMBAs and PP Association During ARDS
The improved survival of patients with acute respiratory distress syndrome (ARDS) over the last decades is related to the use of so-called "protective" mechanical ventilation.
- Trial name
- CURA-PRONE (NCT06212492)
- Testing
- NMBAs, Prone positioning
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique Hopitaux De Marseille