Clinical trials: Mitral Valve Disease
Mitral Valve Disease
Evaluation of the Elasticity of the Mitral Valve
There is no information in the literature on the mechanobiological characteristics of mitral valve chords in living humans. All examinations were carried out on tissues taken from animals, either from cadavers or from frozen…
- Trial name
- NCT06153563
- Testing
- Data collection on patient history and intraoperative results.
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Mitral Insufficiency, Heart Valve Disease
Early Feasibility Study of the CardiAQ™ TMVI System (Transfemoral and Transapical DS)
The purpose of the study is to generate early US feasibility data of the CardiAQ™ Transcatheter Mitral Valve Implant System. The study will enroll patients with moderate to severe mitral valve regurgitation who are considered…
- Conditions
- Mitral Insufficiency, Heart Valve Disease, Cardiovascular Disease, Heart Disease
- Trial name
- NCT02515539
- Testing
- CardiAQ TMVI System (Transapical & Transfemoral DS)
- Sponsor
- Edwards Lifesciences
Mitral Regurgitation, Silent Stroke
Silent sTROke duriNG MitraClip Implantation
The MitraClip-procedure offers an interventional treatment for high risk patients with severe symptomatic mitral regurgitation. The number of new cerebral ischemic lesions without clinical manifestations is high.
- Trial name
- STRONG (NCT03104556)
- Where
- Germany
- Volunteers
- 54 people
- Sponsor
- Charite University, Berlin, Germany
Mitral Valve Stenosis, Atrial Fibrillation
Efficacy and Safety of Rivaroxiban Compare With Vitamin K Antagonist Warfarin
Title: Efficacy and safety of rivaroxiban compare with vitamin K antagonist warfarin in patients with atrial fibrillation and mitral stenosis among Pakistani population.
- Trial name
- NCT03673605
- Testing
- Rivaroxaban 15 mg, Warfarin
- Where
- Pakistan
- Sponsor
- PharmEvo Pvt Ltd
Mitral Valve Prolapse
Multiparametric SCores for Prediction of Myocardial fIbrosis in Patients With MITral vAlve pRolapse
This is a multicenter, observational prospective and retrospective study which aims are: 1) to compute a scoring model potentially predictive for the diagnosis of fibrosis by CMR in patients with MVP; 2) to identify specific…
- Trial name
- SCIMITAR (NCT06341166)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Centro Cardiologico Monzino
Mitral Valve Insufficiency, Coronary Stenosis
Impact of Mitral Regurgitation on Coronary Haemodynamics and Instantaneous Effect of Transcatheter Mitral Valve Repair
In the present study, the investigators aim to use the in-vivo Transcatheter Mitral Valve Repair (TMVR) model to determine how Mitral Regurgitation (MR) affects coronary hemodynamics in patients affected with severe MR and…
- Conditions
- Mitral Valve Insufficiency, Coronary Stenosis, Mitral Regurgitation, Coronary Artery Disease
- Trial name
- MitraFLOW (NCT04245956)
- Testing
- Measure of hemodynamic indices in a stenosed coronary artery using a pressure wire
- Where
- Switzerland
- Volunteers
- 1 people
- Sponsor
- University Hospital, Geneva
Ischemic Mitral Regurgitation
Serotonin Receptor Blockers in Ischemic Mitral Regurgitation
This study is intended to investigate the effect of cyproheptadine (a 5HT2B receptor blocker) on mitral regurgitation severity.
- Trial name
- CYPRO-MR (NCT05469165)
- Testing
- Cyproheptadine 4 Mg Oral Tablet
- Where
- Canada
- Volunteers
- 214 people
- Sponsor
- Laval University
Mitral Valve Prolapse, Ventricular Arrythmia
Arrhythmic Mitral Valve Prolapse Detection Using Long-term Ambulatory Rhythm Monitoring
Mitral valve prolapse (MVP) affects up to 3% of the general population and a small subset of patients is at risk for ventricular arrhythmias.
- Trial name
- ALARM-PILOT (NCT06378996)
- Testing
- 14-day rhythm monitoring
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Mitral Valve Prolapse
Mitral Valve Prolapse (MVP) - France Study
This prospective nation-wide (France) study aims to search for susceptibility genes in MVP using a genome wide analysis and comparing results obtained in 1000 patients with MVP and 1000 non-MVP subjects.
- Trial name
- MVP-France (NCT00799565)
- Testing
- catch of blood
- Where
- 26 sites in France
- Volunteers
- 1,179 people, healthy volunteers welcome
- Sponsor
- French Cardiology Society
Coronary Artery Bypass Grafting, Heart Diseases
The Short Form-36: Pre- Versus Post-Surgical Administration in Cardiac Surgery Patients
The purpose of this study is to determine whether the SF-36 can be administered reliably to cardiac surgery patients (two to three days) post-surgery, with the patient answering the questions of this survey from a pre-surgical…
- Conditions
- Coronary Artery Bypass Grafting, Heart Diseases, Heart Valve Diseases
- Trial name
- NCT00226265
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Weill Medical College of Cornell University
Rheumatic Heart Disease, Mitral Stenosis
The Effect of Ramipril in Suppressing ST2 Expression in Rheumatic Mitral Stenosis Patients
Objective propose: to investigate the effect of Ramipril in suppressing ST2 (suppression of tumorigenicity 2) in the cardiac mitral valve in patients with Rheumatic Heart Disease.
- Conditions
- Rheumatic Heart Disease, Mitral Stenosis, Rheumatic Mitral Stenosis, Fibrosis; Heart
- Trial name
- NCT03991910
- Testing
- Ramipril 5Mg Oral Capsule
- Where
- Indonesia
- Volunteers
- 66 people
- Sponsor
- Universitas Indonesia
Myocardial Dysfunction
Trans-thoracic Ultrasound VS Invasive Pressure of the Left Atrium
As part of cardiac and hemodynamic evaluation of patients, echocardiographic measurements allow indirect evaluation of left ventricular filling pressures (LVFP).
- Trial name
- ECHOPOG (NCT03012308)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Heart Valve Disease
On-X Heart Valve - 17mm Aortic and 23mm Mitral
This study examines the hemodynamic and hemolytic properties of two additional smaller size valves to the On-X line of valves already approved by FDA.
- Trial name
- NCT01812174
- Testing
- 17mm aortic valve (On-X ), 23mm mitral valve (On-X)
- Where
- 10 sites in United States, Puerto Rico and 1 more
- Volunteers
- 20 people
- Sponsor
- On-X Life Technologies, Inc.
Mitral Valve Insufficiency, Coronary Artery Disease
Comparing the Effectiveness of Repairing Versus Replacing the Heart's Mitral Valve in People With Severe Chronic Ischemic Mitral Regurgitation
People with coronary artery disease (CAD) or people who have had a heart attack may develop a leak in the mitral valve of their heart and may therefore need to undergo surgery to fix the valve.
- Trial name
- NCT00807040
- Testing
- Mitral Valve Repair with Annuloplasty, Mitral Valve Replacement
- Where
- 21 sites in United States, Canada
- Volunteers
- 251 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Mitral Valve Regurgitation, Mitral Valve Prolapse
Safety and Early Feasibility Study of the Harpoon Medical Device (EFS)
The purpose of this study is to evaluate the safety and performance of the Harpoon Medical TSD-5. The Harpoon device will provide many significant advantages over current surgical interventions including: 1) a small minimally…
- Conditions
- Mitral Valve Regurgitation, Mitral Valve Prolapse, Mitral Valve Insufficiency
- Trial name
- EFS (NCT02771275)
- Testing
- Harpoon Medical Device
- Where
- 2 sites in Poland
- Volunteers
- 13 people
- Sponsor
- Edwards Lifesciences
Hypertrophic Cardiomyopathy
Echocardiographic Perspectives on Transient Mitral Regurgitation After Septal Myectomy
Mitral regurgitation (MR) following septal myectomy for hypertrophic obstructive cardiomyopathy may persist despite relief of systolic anterior motion and left ventricular outflow tract obstruction.
- Trial name
- TMRSM_R (NCT07831811)
- Volunteers
- 150 people
- Sponsor
- University Health Network, Toronto
Mitral Annular Calcification, Mitral Valve Disease
MitrAl Valve Calcium aSsEssmEnt With TrueVue Trans-illumination 3D Rendering.
The study of calcifications involving the mitral valve is extremely important for the planning of both surgical and percutaneous procedures.
- Trial name
- MAC-SEE (NCT07612553)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Centro Cardiologico Monzino
Periodontitis, Heart Valve Disease
Effect of Preoperative Periodontal Treatment on Postoperative Infection and Mortality After Aortic and Mitral Valve Surgery
This retrospective observational study aims to evaluate the effect of preoperative periodontal treatment on postoperative infection and mortality in patients undergoing aortic and mitral valve surgery.
- Conditions
- Periodontitis, Heart Valve Disease, Postoperative Infection, Cardiovascular Disease
- Trial name
- Perio-CVS (NCT07626801)
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Istanbul University - Cerrahpasa
Mitral Valve Insufficiency, Heart Valve Diseases
NeoChord TACT Post-Market Surveillance Registry
To monitor the long-term performance of the CE Marked NeoChord Artificial Chordae Delivery System
- Conditions
- Mitral Valve Insufficiency, Heart Valve Diseases, Heart Diseases, Cardiovascular Diseases
- Trial name
- NCT01784055
- Where
- 7 sites in France, Germany and 3 more
- Volunteers
- 126 people
- Sponsor
- NeoChord
Atrial Functional Mitral Regurgitation
Effects of VALsartan On atRIAl Mitral Regurgitation (VALORIA) - Pilot
The goal of this clinical trial is to learn whether valsartan can slow the progression of atrial functional mitral regurgitation (AFMR) in adults with preserved left ventricular ejection fraction.
- Trial name
- VALORIA-Pilot (NCT07539298)
- Testing
- Valsartan
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Jonathan Beaudoin