Clinical trials: Miscarriage
Infertility, Miscarriage
A Trial of Sperm Injection (PICSI) on Miscarriage Rates in Assisted Conception
Physiological intracytoplasmic sperm injection (PICSI) is a technique used to select healthy, mature sperm for use in infertility treatment based on their physiological ability to bind to hyaluronan (HA), a natural compound found…
- Trial name
- PICSI (NCT05762770)
- Testing
- PICSI
- Where
- United Kingdom
- Volunteers
- 140 people
- Sponsor
- Shrewsbury and Telford Hospitals NHS Trust
Pregnancy, Pregestational Diabetes
Safety of Metformin in Pregnancy
This study aims to better characterize the risk linked to metformin use during pregnancy, using a prospective multicentric cohort design enabling a large sample size, in evaluating the rate of birth defects after first trimester…
- Conditions
- Pregnancy, Pregestational Diabetes, Polycystic Ovary Syndrom
- Trial name
- NCT02793505
- Testing
- metformin, any drug not known as a major teratogen or major fetotoxicant
- Volunteers
- 950 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Missed Abortion
Letrozole Pretreatment With Misoprostol Induction of Abortion In First-Trimester Missed Miscarriage
This study compares the success rate of letrozole and misoprostol versus misoprostol alone for medical termination of first-trimester pregnancy among women with one or more previous cesarean deliveries.
- Trial name
- NCT04215835
- Testing
- letrozole then misoprostol
- Volunteers
- 200 people
- Sponsor
- Cairo University
Early Pregnancy Loss, Miscarriage in First Trimester
Letrozole and Misoprostol for Early Pregnancy Loss Management
A pilot cohort study to preliminarily investigate the efficacy of pretreatment with letrozole 10 mg daily for three consecutive days followed by treatment with misoprostol 800 mcg vaginally for medical management of early…
- Conditions
- Early Pregnancy Loss, Miscarriage in First Trimester, Miscarriage
- Trial name
- LeMi (NCT06452719)
- Testing
- Letrozole, Misoprostol
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Pennsylvania
Miscarriage
Womens's Experiences of Pregnancy Loss Aftercare in the Gynecological Emergency
Introduction: Scientific papers on the womens's experiences of pregnancy loss aftercare in the emergency department show that how announcement is made and how much caregivers show empathy to women, help women to face this…
- Trial name
- NCT04190043
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Montpellier
Recurrent Miscarriage
3D Ultrasound to Assess in Recurrent Miscarriage
This observational study aims to compare the prevalence of acquired abnormalities of the uterus (fibroids, polyps, intrauterine adhesions, adenomyosis) in women who have recurrent miscarriages with the fertile population.
- Trial name
- 3D-ARM (NCT06164015)
- Testing
- 3D Ultrasound scan with power Doppler angiography
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Complete Miscarriage
Use of Letrozole Pretreatment With Misoprostol for First-Trimester Medical Abortion
The purpose of this study is to compare the success rate of letrozole and misoprostol versus misoprostol alone for medical termination of first trimester pregnancy.
- Trial name
- NCT02401425
- Testing
- Letrozole, Misoprostol
- Where
- Egypt
- Volunteers
- 423 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Early Miscarriage
Identification of Histories of Pregnancy Termination, Particularly Early Miscarriage, in General Medical Records
Early miscarriage (EM) is defined as the spontaneous expulsion of an intrauterine pregnancy of less than 14 weeks' duration. Early miscarriage is a very common complication, affecting more than 10% of pregnancies.
- Trial name
- NCT07406776
- Where
- France
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Université de Reims Champagne-Ardenne
Obesity, Inflammation
Inflammasome Activation and Cortisol Metabolism in Obese Women With Recurrent Miscarriage
The prevalence of obesity among women of reproductive age is increasing. Obesity represents a chronic low-grade inflammatory state and NLRP3 inflammasome plays a pivotal role in obesity-induced inflammation.
- Trial name
- NCT04275674
- Where
- Taiwan
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Pregnancy, Fertility
Prognostic Value of PIF Detection in Embryo Culture Media Correlation With Pregnancy Outcome
PIF: biomarker of successful implantation To overcome the poor reproductive potential of embryos generated during in vitro fertilization cycles and the lack of markers enabling the identification of the most competent ones, it is…
- Trial name
- PIF-SET1 (NCT01803893)
- Where
- 5 sites in United States, France and 1 more
- Volunteers
- 500 people
- Sponsor
- BioIncept LLC
Miscarriage
Hysteroscopy vs. Endouterine Aspiration in the Management of Trophoblastic Retention
Introduction: Incomplete early miscarriage is defined as early miscarriage with persistent intrauterine material on ultrasound. Intrauterine retention of trophoblastic debris is not an uncommon phenomenon.
- Trial name
- HARET (NCT05789940)
- Testing
- hysteroscopy, Aspiration
- Where
- 4 sites in France
- Volunteers
- 220 people
- Sponsor
- University Hospital, Montpellier
Miscarriage
Mucosal-Associated Invariant T Cells in Cases of Miscarriage
Miscarriage is the most frequently encountered complication of pregnancy ranging from 10% to 30%. The etiology of recurrent spontaneous miscarriage (RSM) in 40%-50% of cases cannot be identified.
- Trial name
- NCT04492098
- Testing
- MAIT cells
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Abortion, Spontaneous
Optimal Treatment of Miscarriage
The main objective of the study is to determine if there is a difference in the number of women with a complete miscarriage after 10 days between expectant management versus treatment with 800 micrograms of misoprostol…
- Trial name
- NCT01033903
- Testing
- misoprostol
- Where
- Sweden
- Volunteers
- 190 people
- Sponsor
- Region Skane
Miscarriage, Pregnancy Loss
Cost-utility Analysis of Outpatient Manual Vacuum Aspiration Versus Operating Room Electric Aspiration for the Management of First-trimester Miscarriage
The ASPIR study aims to evaluate the cost-utility of outpatient manual vacuum aspiration compared with operating room electric aspiration for the management of first-trimester miscarriage.
- Conditions
- Miscarriage, Pregnancy Loss, First Trimester Pregnancy
- Trial name
- ASPIR (NCT07732231)
- Testing
- Manual vacuum aspiration (MVA), Electric aspiration (EA)
- Where
- France
- Volunteers
- 860 people
- Sponsor
- Nantes University Hospital
Miscarriage, Misoprostol
Comparison of Vaginal Versus Sublingual Misoprostol in the Treatment of First Trimester Missed Miscarriage
The miscarriage is one of the adverse outcomes of pregnancy and is responsible for stress and anxiety of the couple. there are different types of miscarriages.missed miscarriage also known as early fetal demise is one of the type…
- Trial name
- NCT04604366
- Testing
- misoprostol
- Where
- Pakistan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Islamabad Medical and Dental College
Miscarriage
Virtual Reality in MVA for Miscarriage
We are investigating the use of a virtual reality programme to reduce pain and anxiety experienced during manual vacuum aspiration.
- Trial name
- NCT04466956
- Testing
- Virtual reality
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Barts & The London NHS Trust
First Trimester Abortion
Unexplained Early Miscarriage : Role and Prevalence of Lower Genital Tract Infections
The study group included 910 women who attended Fayoum university hospital gynecology outpatient clinic for postabortive evaluation.
- Trial name
- NCT03413774
- Testing
- vaginal swab
- Where
- Egypt
- Volunteers
- 1,850 people, healthy volunteers welcome
- Sponsor
- Cairo University
Missed Abortion
Evening Primrose Oil to Misoprostol During Induction of Second-trimester Missed Miscarriage
Termination of pregnancy is an important subject that has complex and emotional controversies. The most common time of termination of pregnancy is the mid-trimester which has two-thirds of all serious abortion-related…
- Trial name
- NCT03584698
- Testing
- Misoprostol 100Mcg Tab, Evening Primrose Oil 1000 MG
- Where
- Egypt
- Volunteers
- 144 people
- Sponsor
- Assiut University
Miscarriage Threatening
Comparison of Dydrogesterone and Micronized Progesterone Treatments in the Treatment of Threatened Miscarriage.
In this study, we aimed to compare the effects of two drugs used for the threated miscarriage on the miscarriage rate.
- Trial name
- NCT05542797
- Testing
- Duphastone
- Volunteers
- 140 people
- Sponsor
- Konya Meram State Hospital
Birth Defects, Miscarriages
Pesticides--Health Fertility and Reproductive Risk
This project is designed to establish whether pesticides or other environmental agents have a role in the excess birth defects identified in the Red River Valley of Minnesota.
- Conditions
- Birth Defects, Miscarriages, Cancer
- Trial name
- NCT00015561
- Where
- United States
- Volunteers
- 1,803 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)