Clinical trials: Mineralocorticoid Excess
Cushing Syndrome, Primary Aldosteronism
Continuous Steroid Monitoring in Interstitial Fluid With Wearable and Nanoparticle-enhanced Biosensors for Improved Management of Adrenal Disorders
The goal of this project is to provide novel technology that will pave the way from the present single-point (analogue) endocrinology towards continuous cortisol and aldosterone monitoring with full time resolution.
- Conditions
- Cushing Syndrome, Primary Aldosteronism, Adrenal Insufficiency
- Trial name
- NCT06980753
- Testing
- Participants will use the biossensor for 48 h
- Where
- Brazil
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Primary Aldosteronism, Hypertension
Effects of Adrenal Artery Ablation and Adrenalectomy in Patients With Primary Aldosteronism
Primary aldosteronism (PA) is the main cause of secondary hypertension, affecting 5-15% of the general hypertensive population. Early diagnosis and treatment are of crucial importance as patients with PA are more susceptible to…
- Trial name
- NCT04269928
- Testing
- Endovascular chemical ablation of adrenal gland
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Third Military Medical University
Apparent Mineralocorticoid Excess Syndrome
Natural History of Apparent Mineralocorticoid Excess Syndrome
Apparent mineralocorticoid excess (AME) is a rare inherited disease that can cause severe high blood pressure and low blood potassium in children and adults. It is caused by abnormal hormone metabolism and can be fatal.
- Trial name
- NCT00474942
- Where
- 4 sites in United States, Brazil and 1 more
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Apparent Mineralocorticoid Excess (AME)
The Role of Mineralocorticoid Receptors in Vascular Function
The purpose of this study is to figure out how decreasing the activity of 11-beta hydroxysteroid dehydrogenase (11-beta HSD) will affect your blood vessel function.
- Trial name
- NCT00759525
- Testing
- Glycyrrhetic Acid
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Hyperaldosteronism
China National Study of Adrenal Venous Sampling
This multicenter study intends to combine retrospective analysis and prospective registry to evaluate the success rate and safety of adrenal venous sampling (AVS) via antecubital and femoral approach for patients with primary…
- Trial name
- CNAVS (NCT06192238)
- Testing
- adrenal venous sampling
- Where
- 48 sites in China
- Volunteers
- 1,500 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Idiopathic Hyperaldosteronism, Hyperaldosteronism
Superselective Adrenal Arterial Embolization Versus Oral Spironolactone for Treatment of Idiopathic Hyperaldosteronism
Idiopathic hyperaldosteronism (IHA) represents about 65% of primary hyperaldosteronism cases. Although mineralocorticoid receptor antagonists (MRAs) are the standard first-line treatment, they are often limited by adverse…
- Trial name
- NCT07328230
- Testing
- Superselective Adrenal Arterial Embolization, Spironolactone
- Where
- 3 sites in China
- Volunteers
- 172 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Insulinoma; Pancreas, MEN1
Endoscopic Ultrasound-guided Radiofrequency Ablation for Upper Gastrointestinal Tract Lesions
The goal of this observational study is to evaluate the long-term clinical effectiveness of EUS-RFA and quality of life in patients with pancreatic or adrenal tumors recieving EUS-RFA.
- Conditions
- Insulinoma; Pancreas, MEN1, NETs, Radiofrequency Ablation
- Trial name
- EURAGIL (NCT07272187)
- Testing
- observational study
- Where
- Denmark
- Volunteers
- 138 people
- Sponsor
- Herlev Hospital
Primary Aldosteronism, Hypertension
Cardiovascular Manifestations of MR Activation in Primary Aldosteronism: Pilot Clinical Study
This research study aims to learn more about the impact the hormone aldosterone on the heart. Primary aldosteronism is a condition where the body's adrenal glands make too much of the hormone aldosterone, which can cause high…
- Trial name
- NCT05030545
- Testing
- Eplerenone
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Brigham and Women's Hospital
Primary Aldosteronism, Hypertension
Regular Sauna Use to Lower Blood Pressure in Primary Aldosteronism
1. Background and Rationale: Primary aldosteronism is a hypertension-related disorder where salt restriction/salt loss is a central part of therapy.
- Trial name
- SAUNA-PA (NCT07796048)
- Testing
- sauna session
- Volunteers
- 10 people
- Sponsor
- University of Calgary
Primary Aldosteronism
DP13 - A Phase II Study in Patients With Primary Aldosteronism
The purpose of the present phase II study is to determine whether DP13 displays the clinical safety and efficacy profile to support further development in patients with primary aldosteronism.
- Trial name
- NCT04007406
- Testing
- dexfadrostat phosphate
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- Damian Pharma AG
Primary Aldosteronism, Hypertension
Overnight Dexamethasone in Primary Aldosteronism Screening
The goal of this observational study is to learn whether screening for primary aldosteronism can be improved among patients on chronic blood pressure-lowering medications by ordering intake of 1 mg of dexamethasone prior to…
- Trial name
- ODEPRASC (NCT06740838)
- Where
- Poland
- Volunteers
- 240 people
- Sponsor
- Medical University of Gdansk
Primary Aldosteronism
Efficacy and Safety of Finerenone in Patients With Primary Aldosteronism
To study the efficacy and safety of finerenone in patients with primary aldosteronism
- Trial name
- NCT05924620
- Testing
- finerenone
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Chongqing Medical University
Primary Hyperaldosteronism, Electrolyte Disturbance
Tissue K+ in Primary Hyperaldosteronism
Recent human studies found tissue sodium storage in patients with hyperaldosteronism that could be detected non-invasively by 23Na-MRI. Tissue sodium accumulation could be mobilized upon treatment of hyperaldosteronism.
- Trial name
- NCT04251780
- Testing
- Surgical Treatment of Primary Aldosteronism, Drug treatment of Primary Aldosteronism
- Where
- 2 sites in Germany
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Primary Aldosteronism
The Effect of SAAE on Ventricular Remodeling in PA Patients
The study aims to assess the effect of superselective adrenal arterial embolization on ventricular remodeling in primary aldosteronism without lateralized aldosterone secretion by comparing it with spironolactone therapy.
- Trial name
- NCT05501080
- Testing
- Super selective adrenal artery embolization, Spironolactone
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Primary Aldosteronism
Baxdrostat and Molecular Imaging of Adrenal Cytoreduction in Primary Aldosteronism
The goal of this clinical trial is to find out whether treatment with baxdrostat changes aldosterone-producing activity in the adrenal glands of people with primary aldosteronism.
- Trial name
- EliXir (NCT07800858)
- Testing
- baxdrostat
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Queen Mary University of London
Adrenal Tumors, Adrenocortical Carcinoma
Adrenal Tumors - Pathogenesis and Therapy
The pathogenesis of adrenal tumors is still not fully elucidated and the treatment options for malignant tumors are poor. The current study investigates different aspects of the pathogenesis of adrenal tumors and evaluates…
- Conditions
- Adrenal Tumors, Adrenocortical Carcinoma, Cushing Syndrome, Conn Syndrome
- Trial name
- NCT00669266
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University of Wuerzburg
Primary Aldosteronism
A Phase Ⅱ Clinical Trial of SYH2072 Tablets in Participants With Primary Aldosteronism
This is a multicenter, randomized, double-blind, placebo-controlled Phase II study designed to explore the efficacy and safety of SYH2072 tablets in Chinese participants with primary aldosteronism (PA) .
- Trial name
- NCT07917039
- Testing
- SYH2072 tablets
- Where
- China
- Volunteers
- 60 people
- Sponsor
- InnovStone Therapeutics Limited
Primary Aldosteronism, Adrenal Adenoma
Radiofrequency Ablation for Aldosterone-producting Adenoma in Patients With Primary Aldosteronism
The aim of the study is to evaluate the novel use of adrenal radiofrequency ablation on a prospective cohort of patients with primary aldosteronism and unilateral adrenal adenoma concerning the efficacy on blood pressure control.
- Trial name
- ADERADHTA (NCT02756754)
- Testing
- Radiofrequency ablation
- Where
- 2 sites in France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Toulouse
Primary Aldosteronism
Primary Aldosteronism: Prospective Screening Registry in China
1. Study name: A prospective study of the incidence and outcomes of Primary aldosteronism in Chinese hypertensive patients 2. Rationale: Unlike essential hypertension, secondary hypertension is caused by certain defined diseases…
- Trial name
- NCT04020783
- Testing
- NO Intervention
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Primary Aldosteronism, High Blood Pressure
Diagnosing Variable Primary Aldosteronism.
The goal of this observational study is to see if there is a cyclical or exaggerated diurnal variation in aldosterone production in people with Primary Aldosteronism.
- Trial name
- NCT05765786
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Queen Mary University of London