Clinical trials: Mild to Moderate Hypertension, open to volunteers
Hypertension
Effect of Electro-Acupuncture on Blood Pressure
Based on previous published research in animals and human, the investigators hypothesize that electroacupuncture (EA) will have a positive effect on hypertension.
- Trial name
- NCT00932139
- Testing
- Electro-acupuncture control, Electro-acupuncture test
- Where
- 2 sites in United States
- Volunteers
- 160 people
- Sponsor
- University of California, Irvine
Glaucoma
Glaucoma Laser Assessment of Stability and Sustainability
The GLASS Study is designed to help researchers learn whether repeating a non-invasive laser treatment called DSLT (Direct Selective Laser Trabeculoplasty) can better control eye pressure in patients with early-stage glaucoma or…
- Trial name
- GLASS (NCT06963684)
- Testing
- Dual-Treatment Direct Selective Laser Trabeculoplasty (DSLT)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Twin Cities Eye Consultants
Hypertension
A Study to Evaluate ALN-AGT01 RVR in Adult Patients With Mild to Moderate Hypertension Pretreated With Zilebesiran
The purpose of this study is to evaluate the efficacy, pharmacodynamics (PD), and safety of ALN-AGT01 RVR in participants with mild to moderate hypertension pretreated with zilebesiran.
- Trial name
- NCT07553442
- Testing
- ALN-AGT01 RVR, Zilebesiran
- Where
- 3 sites in United States
- Volunteers
- 93 people
- Sponsor
- Alnylam Pharmaceuticals
Glaucoma
Glaukos® iStent Infinite Trabecular Micro-Bypass System in Subjects With Mild to Moderate Primary Open-angle Glaucoma
Prospective, multicenter, single-arm study of the iStent infinite in adult pseudophakic or phakic subjects with mild to moderate primary open angle glaucoma who have not failed conventional medical and surgical treatment
- Trial name
- NCT06057051
- Testing
- iStent Infinite
- Where
- United States
- Volunteers
- 245 people
- Sponsor
- Glaukos Corporation
Overweight, Obesity
Efficacy and Safety of IBI362 in Hypertensive Patients With Overweight/Obesity
A multicenter, randomized, double-blind, placebo-controlled clinical study to evaluate the efficacy and safety of IBI362 in participants with mild to moderate hypertension complicated by overweight/obesity who have not received…
- Conditions
- Overweight, Obesity, Hypertensive
- Trial name
- NCT07469800
- Testing
- IBI362
- Where
- China
- Volunteers
- 336 people
- Sponsor
- Innovent Biologics (Suzhou) Co. Ltd.
Glaucoma, Ocular Hypertension
Evaluation of the Safety, Efficacy, Dose Response of the Bimatoprost Drug Ring System (BIM-DRS) in Pseudophakic Patients Diagnosed With Open Angle Glaucoma or Ocular Hypertension
The goal of this clinical trial is to learn if two different doses of the SpyGlass Bimatoprost-Drug Ring System (BIM-DRS) work to treat adult pseudophakic patients with either glaucoma or ocular hypertension.
- Trial name
- NCT07641296
- Testing
- BIM-DRS Low Dose, BIM-DRS High Dose, SpyGlass IOL with silicone pads (no drug)
- Volunteers
- 24 people
- Sponsor
- SpyGlass Pharma, Inc.
Mild to Moderate Hypertension and Elevated Low-Density Lipoprotein Cholesterol
A Study of BEBT-701 in Patients With Mild to Moderate Hypertension and Elevated Low-Density Lipoprotein Cholesterol（LDL-C）
This Phase I/II clinical trial is designed to evaluate, through a single-dose Phase I segment and a multiple-dose Phase II segment, the safety/tolerability, pharmacokinetic (PK) profile, and pharmacodynamic (PD) characteristics…
- Trial name
- NCT07368608
- Testing
- BEBT-701 Injection
- Where
- China
- Volunteers
- 340 people
- Sponsor
- BeBetter Med Inc
Glaucoma, Open-angle, Primary Open Angle Glaucoma (POAG)
Nicotinamide for Retinal Protection in Primary Open-Angle Glaucoma (NADIR Trial)
The goal of this clinical trial is to learn whether a high-dose vitamin B3 supplement called nicotinamide can protect retinal nerve cells in adults with primary open-angle glaucoma (POAG) who are already receiving standard…
- Trial name
- NADIR (NCT07808333)
- Testing
- Nicotinamide, Standard Glaucoma Therapy
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- University of Chicago
Hypertension
A Study of IBI3016 in Japanese Participants
A phase I clinical study to evaluate the safety ,tolerability, pharmacokinetic and pharmocodynamic characteristics of a single subcutaneous does of IBI3016 in Japanese participants with mild to moderate hypertension.
- Trial name
- NCT07838220
- Testing
- IBI3016 Dose 4, IBI3016 Dose 3, IBI3016 Dose 2
- Where
- Japan
- Volunteers
- 30 people
- Sponsor
- Innovent Biologics (Suzhou) Co. Ltd.
Hypertension
Safety & Efficacy of Qurs e Fishar in Mild to Moderate Hypertensive Patients in Pakistan
The herbal medicine Qurs-e-Fishar to treat mild to moderate High blood pressure or hypertension comprises of Rauwolfia serpentina. A product of Hamdard Laboratories (Waqf) Pakistan.
- Trial name
- NCT06852079
- Testing
- Qurs e Fishar
- Where
- Pakistan
- Volunteers
- 119 people
- Sponsor
- Abdul Bari
Mild to Moderate Hypertension
Acupuncture Therapy and Hypertension
Acupuncture therapy will be provided to reduce blood pressure in hypertensive patients. The mild to moderate hypertensive patients will be either on or off hypertensive medications.
- Trial name
- NCT05530512
- Testing
- electroacupuncture
- Where
- 2 sites in United States
- Volunteers
- 72 people
- Sponsor
- University of California, Irvine
GLAUCOMA 1, OPEN ANGLE, D (Disorder), Cataract
Comparison of Visual Outcomes and Patient Satisfaction in Mild to Moderate Glaucoma Patients Undergoing Cataract Surgery With EDOF Versus Monofocal IOLs
Cataract is the leading cause of reversible vision loss, while glaucoma remains the primary cause of irreversible blindness, often impairing contrast sensitivity (CS), glare tolerance, and dark adaptation.
- Trial name
- NCT07436871
- Testing
- Cataract surgery (Monofocal intraocular lens implantation), cataract surgery (Extended depht of focus intraocular lens implantation)
- Volunteers
- 74 people
- Sponsor
- OMIQ Research
Mild-to-moderate Essential Hypertension
A Phase III Clinical Trial Evaluating the Efficacy and Safety of Valsartan/Levamlodipine (SYH9056) Tablets In Hypertensive Patients
SYH9056 tablets are a combination of valsartan and levamlodipine maleate. This is a multicenter, randomized, double-blind, parallel-controlled phase III study, designed to validate the efficacy and safety of SYH9056 tablets in…
- Trial name
- NCT06771245
- Testing
- SYH9056, Levamlodipine, Valsartan
- Volunteers
- 606 people
- Sponsor
- CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Preeclampsia Mild to Moderate
The Effect of Awareness-Based Stress Reduction Training on Preeclampsia and Anxiety
Preeclampsia is a multisystem disease that occurs during pregnancy and carries risks into the postpartum period. This condition, which threatens maternal and fetal health, requires close monitoring and good care.
- Trial name
- NCT06841367
- Testing
- Mindfulness-based stress reduction training
- Volunteers
- 80 people
- Sponsor
- Istanbul University - Cerrahpasa
Hypertension
Sitogilun Malate Plus Amlodipine in Patients With Hypertension and Risk of Early Kidney Damage
This is a multicenter, randomized, double-blind, parallel-controlled Phase IV clinical trial designed to evaluate the efficacy and safety of sitogilun malate tablets in combination with amlodipine besylate tablets in patients…
- Trial name
- SABER (NCT07876544)
- Testing
- Sitogilun Malate, Allisartan Isoproxil, Amlodipine besylate
- Where
- China
- Volunteers
- 456 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Primary Open Angle Glaucoma
Cataract Surgery in Conjunction With Ab-interno Canaloplasty Compared to Cataract Surgery Only in Patients With Mild to Moderate Primary Open-Angle Glaucoma
A prospective, multicenter, randomized, single-masked, post-market clinical trial comparing cataract surgery in conjunction with ab-interno canaloplasty utilizing the iTrack Advance canaloplasty device (Nova Eye, Inc.) to…
- Trial name
- CATALYST (NCT05564091)
- Testing
- Cataract surgery combined with ab-interno canaloplasty utililzing the iTrack Advance canaloplasty device, Cataract surgery
- Where
- 4 sites in United States, Germany
- Volunteers
- 78 people
- Sponsor
- Nova Eye, Inc.