Clinical trials: Mild Cognitive Decline
Mild Cognitive Impairment, Memory Disorders
Physical Exercise And Cognitive Engagement Outcomes for Mild Neurocognitive Disorder
Behavioral interventions currently provide the most useful approach to addressing the behavioral and social needs of those with Mild Cognitive Impairment (MCI) due to Alzheimer's or other diseases.
- Conditions
- Mild Cognitive Impairment, Memory Disorders, Mild Dementia, Impaired Cognition
- Trial name
- PEACEOFMND (NCT03095170)
- Testing
- Computerized brain fitness training, Yoga, Wellness Education
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Florida
Alzheimer's Disease (Incl Subtypes), Dementia
Improvisational Movement for People With Memory Loss and Their Caregivers
Dementia is a progressive decline in cognition that impairs a person's ability to perform activities of daily living. Changes in mood, gait, and balance are prominent secondary symptoms of Alzheimer's dementia that can…
- Conditions
- Alzheimer's Disease (Incl Subtypes), Dementia, Mild Cognitive Impairment
- Trial name
- IMOVE (NCT03333837)
- Testing
- Dance Group, Non-Group Dance, Social Group
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Wake Forest University Health Sciences
Mild Cognitive Impairment, Coronary Heart Disease
Computerized Cognitive Training in Patients With Coronary Heart Disease and Mild Cognitive Impairment
In this study, a multicentre, double-blind, randomized controlled study based on cognitive training was conducted in patients with coronary heart disease and cognitive impairment but without dementia， to evaluate the…
- Trial name
- COG-T CHD (NCT05735041)
- Testing
- Multi-domain cognitive digital therapy, Basic cognitive therapy
- Where
- 8 sites in China
- Volunteers
- 224 people
- Sponsor
- Beijing Anzhen Hospital
Mild Cognitive Impairment
Application and Revision of Montreal Cognitive Assessment in Chinese Retirees
The study was designed to employ MOCA to screen mild cognitive impairment (MCI) in military retirees and to analyze the associated risk factors. As such, MOCA was revised to be validated for the Chinese context.
- Trial name
- ARMOCA (NCT02483754)
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Falls, Frailty
Preventing Falls in Older Adults With Cognitive Frailty
The Problem: The proposed trial will address the problem of how to effectively prevent subsequent falls in community-dwelling cognitively frail older adults with a history of falls.
- Conditions
- Falls, Frailty, Mild Cognitive Impairment
- Trial name
- ACTIVE (NCT06854731)
- Testing
- Balance and Strength Training Exercises with Health Coaching, Education Session
- Where
- Canada
- Volunteers
- 328 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
OCT Angiography, Atrial Fibrillation (AF)
OCT-A Biomarkers for Cognitive Impairment in Patients With Chronic Atrial Fibrillation
The OCTAF study is a monocentric, cross-sectional pilot study designed to investigate the relationship between retinal microvascular biomarkers and cognitive impairment in patients with atrial fibrillation (AF).
- Conditions
- OCT Angiography, Atrial Fibrillation (AF), Mild Cognitive Impairment
- Trial name
- OCTAF (NCT07607756)
- Testing
- OCT-angiography
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Universitair Ziekenhuis Brussel
Diabetes Mellitus, Type 2
Diabetes Mellitus and microRNA as Risk Factors for Mild Cognitive Impairment: Impact of Life Style Modification
This is a 2-step study; 1st step was a cross sectional study carried out on 163 consecutive Type 2 Diabetes Mellitus (T2DM) patients employee attending outpatient clinics of the National Research Center (NRC), Egypt.
- Trial name
- NCT04891887
- Testing
- Health education program
- Where
- Egypt
- Volunteers
- 163 people
- Sponsor
- National Research Centre, Egypt
Care Transition
Comparing Two Acute Care Transition Programs for Older Adults and Their Family Caregivers
This study investigates better ways to help people after they leave the hospital and how to involve their families in this process.
- Trial name
- NCT07661355
- Testing
- Patient-Centered Program, Family Caregiver Enhanced Program
- Where
- 4 sites in United States
- Volunteers
- 2,560 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Mild Cognitive Impairment, Mild Dementia
Effect of High Frequency/Low Intensity Transcranial Magnetic Stimulation in Cognitive Traits of an Elderly Population of Subjects With Mild Cognitive Impairment and Mild Dementia.
There are no pharmacological interventions that delay or prevent the transition of mild cognitive impairment to dementia. Several studies have shown that transcranial magnetic stimulation (TMS) could be useful in increasing…
- Trial name
- NCT03983655
- Testing
- High Frequency Low Intensity TMS
- Where
- Mexico
- Volunteers
- 37 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Cognitive Dysfunction, Subjective Health
Effectiveness of TeleVR App in Cognitive Decline and MCI Patients
The goal of this clinical trial is to evaluate the effectiveness of a telerehabilitation program combined with a virtual reality (VR) app in improving cognitive performance and social skills in patients with Subjective Cognitive…
- Conditions
- Cognitive Dysfunction, Subjective Health, Mild Cognitive Impairment, Alzheimer Disease
- Trial name
- TeleVR24 (NCT06793735)
- Testing
- Telerehabilitation with Virtual Reality, Traditional Cognitive Rehabilitation
- Where
- Italy
- Volunteers
- 480 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Mild Cognitive Impairment (MCI)
AI-Supported Cognitive Rehabilitation for Older Adults With Mild Cognitive Impairment
Mild cognitive impairment (MCI) is associated with increased risk of progression to dementia, highlighting the need for accessible interventions to support cognitive health.
- Trial name
- ReMind-AI (NCT07474038)
- Testing
- AI-Supported Cognitive Rehabilitation
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Kaiser Permanente
Mild Cognitive Impairment, Age-associated Memory Impairment
Effectiveness of an Intervention Using Observation/Action Therapy Among Patients With Mild Cognitive Impairment
Mild cognitive impairment (MCI) is a transitional state between normal aging and early dementia, characterized by memory deficits without functional impairment.
- Trial name
- NCT05934344
- Testing
- Action observation training
- Where
- Spain
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Universidad Europea de Madrid
Mild Cognitive Impairment
GAMES Intervention in MCI (Mild Cognitive Impairment)
The objective of the present study is to evaluate whether online, remote gameplay can facilitate social engagement and reduce feelings of loneliness and isolation in adults with and without mild cognitive impairment (MCI).
- Trial name
- NCT07296133
- Testing
- Online Gameplay Intervention, Waitlist control
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Emory University
Mild Cognitive Impairment, Lack of Physical Activity
Change in Executive Function and IADL Using a Virtual Supermarket Environment Among People With MCI
The aim of the study is to investigate the feasibility of using a virtual supermarket as an intervention tool for overcoming deficits in executive function as well as enhancing IADL performance among persons with Mild Cognitive…
- Trial name
- EF-VAPS (NCT01103453)
- Testing
- Virtual Action Planning Supermarket (VAP-S) Software
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Carmel Medical Center
Alzheimer Disease
Low-Intensity Focused Ultrasound (LIFU) Neuromodulation
This study is a prospective, single-center, single-arm early feasibility study, to establish safety and tolerability of LIFU for neuromodulation in patients with mild cognitive impairment ( MCI) due to Alzheimer's disease.
- Trial name
- NCT05997030
- Testing
- low intensity focused ultrasound (LIFU)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Ali Rezai
Cognitive Impairment, Alzheimer Disease
Validation of a Smartphone Application for the Assessment of Patients With Mild Cognitive Impairment: MemScreen
The clinical evaluation of a patient with a cognitive complaint requires neuropsychological tests, evaluating the integrity of memory and other cognitive functions.
- Trial name
- MemScreen (NCT03811184)
- Testing
- MemScreen
- Where
- France
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- MemScreen
Alzheimers Disease
A Study of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease
The purpose of this study is to assess the efficacy and safety of trontinemab in participants with early symptomatic Alzheimer's disease (AD) (mild cognitive impairment [MCI] to mild dementia due to AD).
- Trial name
- TRONTIER 1 (NCT07169578)
- Testing
- Trontinemab
- Where
- 142 sites in United States, Argentina and 11 more
- Volunteers
- 1,101 people
- Sponsor
- Hoffmann-La Roche
Mild Cognitive Impairment
Center for Research and Education on Aging and Technology Enhancement - CREATE V - Project 1
Project 1: The goal of this research project is to examine usability and acceptance of virtual reality (VR) applications and their efficacy with older adults.
- Trial name
- NCT05811338
- Testing
- Project 1 - Phase 2: VR Program for Social, Activity, and Cognitive Engagement, Project 1 - Phase 2: Tablet for Social, Activity, and Cognitive Engagement
- Where
- 3 sites in United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Alzheimer Disease, Late Onset, Mild Cognitive Impairment
Time-in-bed Restriction in Older Adults With Sleep Difficulties With and Without Risk for Alzheimer's Disease
Dementia caused by Alzheimer's disease affects approximately 5.6 million adults over age 65, with costs expected to rise from $307 billion to $1.5 trillion over the next 30 years.
- Conditions
- Alzheimer Disease, Late Onset, Mild Cognitive Impairment, Sleep, Cognitive Change
- Trial name
- ALPS (NCT05138848)
- Testing
- Time in Bed Restriction, Sleep Schedule
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Alzheimer Disease, Mild Cognitive Impairment (MCI)
Communication Regarding Preclinical Dementia Diagnostic and Diagnostic Disclosure Among Patients with MCI and SCD
The study investigate what information individuals with SCD or MCI and their co-participant would like to receive during pre-diagnostic counseling and diagnostic disclosure, and how this information should be conveyed.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD)
- Trial name
- NCT06621758
- Testing
- questionnaire
- Volunteers
- 120 people
- Sponsor
- Danish Dementia Research Centre