Clinical trials: Mild Cognitive Decline
Mild Cognitive Impairment, Delirium
Remote Cognitive Assessment for Surgical Patients
This is a pilot study to evaluate the use of remote cognitive testing to identify patients who may have cognitive vulnerability and may benefit from cognitive care pathways.
- Trial name
- Remote OR (NCT05566275)
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of California, San Francisco
Mild Cognitive Impairment
Effect of Medium Chain Triglyceride Oil Supplementation in Mild Cognitive Impairment
The primary aim of this study is to assess whether daily dosing with medium chain triglycerides in subjects with mild cognitive impairment (MCI) will improve cognitive performance.
- Trial name
- NCT01669200
- Testing
- Medium Chain Triglyceride Oil
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Pennington Biomedical Research Center
Depression in Old Age, Psychotherapy
Engage for Late-Life Depression and Comorbid Executive Dysfunction
Although there are an increasing number of mental health treatment adaptations for older adults, there are still a number of factors to consider when making these adaptations.
- Conditions
- Depression in Old Age, Psychotherapy, Mild Cognitive Impairment, Executive Dysfunction
- Trial name
- NCT05356611
- Testing
- Engage
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Nevada, Las Vegas
Alzheimer Disease, Mild Cognitive Impairment
Early Diagnosis of Alzheimer-like Dementia: Benefit of MRI and PET Imaging
The physio-pathology of Alzheimer's disease (AD) remains unknown and there is no cure. Thus, the search for objective markers of preclinical first signs of cognitive impairment, is currently a major public health issue.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Vascular Dementia
- Trial name
- NCT01815112
- Testing
- Magnetic resonance imaging, Positron emission tomography
- Where
- 2 sites in France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Traumatic Brain Injury
Effects of LEDs on Memory in TBI Patients
The purpose of the study is to investigate whether transcranial, high-intensity LED placed on the scalp can improve working memory in people who have sustained a concussion with lingering effects or a mild brain injury.
- Trial name
- LED (NCT01598532)
- Testing
- MedX Health Phototherapy (light therapy)
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Spaulding Rehabilitation Hospital
Multiple Sclerosis, Multiple Sclerosis (MS) - Relapsing-remitting
Home Based Functional Balance Intervention for Multiple Sclerosis
The study involves a two-arm, Phase 1, randomized controlled clinical trial designed to establish the feasibility and effects of a Functional Balance Intervention (FBI) on physical and cognitive function, as well as measures of…
- Conditions
- Multiple Sclerosis, Multiple Sclerosis (MS) - Relapsing-remitting, Multiple Sclerosis (MS) Primary Progressive, Multiple Sclerosis (MS) Secondary Progressive
- Trial name
- HomeFBIinMS (NCT07355387)
- Testing
- Multicomponent balance intervention consisting of four components including dual-tasking, functional strength, vestibular and dynamic balance., Stretching
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Illinois at Chicago
Mild Cognitive Impairment
Brain and Cognitive Changes After Reasoning Training in Individuals With Mild Cognitive Impairment
Individuals aged 55 and older may experience negative effects of cognitive decline. The proposed research seeks to evaluate the benefits of different types of interventions: reasoning training following transcranial direct…
- Trial name
- NCT02596906
- Testing
- tDCS
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Dallas
Mild Cognitive Impairment
Dual-Task Zumba Gold for Improving the Cognition of Older Adults With MCI
The study aims to assess the preliminary efficacy of a Dual-Task Zumba Gold (DTZ) intervention that will support physical and cognitive training among community-dwelling persons with mild cognitive impairment (MCI).
- Trial name
- NCT04788238
- Testing
- Dual-Task Zumba Gold
- Where
- Philippines
- Volunteers
- 60 people
- Sponsor
- The Hong Kong Polytechnic University
Mild Cognitive Impairment
Effectiveness of Walking Exercise in Improving Cognitive Function in Older Adults With Mild Cognitive Impairment
The increasing prevalence of mild cognitive impairment (MCI) in our rapidly aging population prompts the need for devising effective interventions to prevent the onset of cognitive impairment and delay its progression to…
- Trial name
- NCT04515563
- Testing
- Stretching exercise, Low-frequency, moderate-intensity walking group, High-frequency, moderate-intensity walking group
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- The University of Hong Kong
Mild Cognitive Impairment
The Effects of Cannabidiol and Homotaurine in Patients With Mild Cognitive Impairment
A Randomized Clinical Trial that will compare the effects of Cannabidiol and Homotaurine in cognition and mental health in patients with Mild Cognitive Impairment and APOE ε4 carriers.
- Trial name
- NCT05022186
- Testing
- Cannabidiol Oil, Homotaurine
- Where
- Greece
- Volunteers
- 90 people
- Sponsor
- Aristotle University Of Thessaloniki
Dementia, Mild Cognitive Impairment
Safety and Modulation of ABCC9 Pathways by Nicorandil for the Treatment of Hippocampal Sclerosis of Aging
Widespread recognition of the current and projected impact of the dementia epidemic has spurred research into novel drug discovery efforts.
- Trial name
- SMArT-HS (NCT04120766)
- Testing
- Nicorandil
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Gregory Jicha, MD, PhD
Subjective Cognitive Concerns, Mild Cognitive Impairment
Digital Accessible Remote Olfactory Mediated Health Assessments for Preclinical AD
The goal of this study is to objectively test one's sense of smell, called olfaction, in participants with Subjective Cognitive Concerns (SCC), Mild Cognitive Impairment, Mild Behavioral Impairment (MBI), and age-matched…
- Conditions
- Subjective Cognitive Concerns, Mild Cognitive Impairment, Mild Behavioral Impairment, Healthy Aging
- Trial name
- NCT05881239
- Testing
- AROMHA Brain Health Test
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Alzheimer's Disease, Mild Cognitive Impairment
Dopaminergic Enhancement of Learning and Memory in Healthy Adults and Patients With Dementia/Mild Cognitive Impairment
This study aims to determine whether levodopa is effective in boosting learning and memory in healthy subjects and patients with dementia or Mild Cognitive Impairment.
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment, Healthy
- Trial name
- NCT00306124
- Testing
- Levodopa
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster
Falls, Gait
Donepezil and the Risk of Falls in Seniors With Cognitive Impairment
Compared with cognitively normal older adults, those with mild cognitive problems (MCI) have a two-fold higher rate of falls, sustain more fractures, and have a higher rate of mortality due to falls.
- Conditions
- Falls, Gait, Balance, Mild Cognitive Impairment (MCI)
- Trial name
- NCT00934531
- Testing
- Donepezil
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Mild Cognitive Impairment
Preventing Loss of Independence Through Exercise (PLIÉ) in Persons With Mild Cognitive Impairment (MCI)
Nearly 1 in 10 older Americans have dementia, which is a devastating condition that leads to a progressive loss of independence and functional status.
- Trial name
- MCI PLIE (NCT03526146)
- Testing
- Behavioral: Preventing Loss of Independence through Exercise (PLIE)
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of California, San Francisco
Alzheimer Disease, Dementia
Exploratory Clinical Study and Validation of Blood Biomarkers for Alzheimer's Disease
This is a 24-month, monocentric, exploratory and observational clinical study aimed at developing and validating a blood-based diagnostic test for Alzheimer's disease (AD).
- Conditions
- Alzheimer Disease, Dementia, Neurodegenerative Disorders, Cognitive Decline
- Trial name
- ADKIT (NCT07294586)
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Amoneta Diagnostics SAS
Breast Cancer, Mild Cognitive Impairment
Activity & Cognition After Treatment for Breast Cancer
This study addresses an important public health concern; impoverished cognitive function associated with treatment of breast cancer.
- Conditions
- Breast Cancer, Mild Cognitive Impairment, Physical Activity
- Trial name
- ACT (NCT02592070)
- Testing
- Walking
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Illinois at Urbana-Champaign
Amnestic Mild Cognitive Impairment
Outcome Predictors of a Cognitive Intervention in aMCI
Cognitive training has been shown to be successful in patients with amnestic mild cognitive impairment (aMCI), a group at high-risk for Alzheimer's disease (AD).
- Trial name
- OutPreC MCI (NCT01525368)
- Testing
- cognitive intervention
- Where
- Germany
- Volunteers
- 110 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Mild Cognitive Impairment
Impact of Combined Behavioral Interventions on Cognitive Outcomes in MCI
Vast evidence supports use of physical exercise and cognitive stimulation for lowering risk for cognitive decline and dementia, with combinations of non-pharmacological interventions providing greatest promise for impacting…
- Trial name
- CBI (NCT02864069)
- Testing
- Walking Intervention, Cognitive Training Intervention, Combined Intervention
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Obstructive Sleep Apnea, Mild Cognitive Impairment
Sleep Apnea and Cognitive Function in Subjects With Subjective or Mild Cognitive Impairment
Obstructive sleep apnea (OSA) is recurrent episodes of partial or complete obstruction of the upper airway during sleep that causes intermittent hypoxia and sleep fragmentation and leads to cardiometabolic and neurocognitive…
- Conditions
- Obstructive Sleep Apnea, Mild Cognitive Impairment, Subjective Cognitive Impairment
- Trial name
- NCT06089096
- Testing
- Home Sleep Apnea test (HSAT)
- Where
- Hong Kong
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong