Clinical trials: Migraine
Migraine Disorders
A Multicenter Assessment of ALD403 in Chronic Migraine
The purpose of this study is to assess ALD403 in the prevention of migraine headache in chronic migraineurs.
- Trial name
- NCT02275117
- Testing
- ALD403
- Where
- 92 sites in United States, Australia and 2 more
- Volunteers
- 665 people
- Sponsor
- Alder Biopharmaceuticals, Inc.
Migraine
A Study of the Effect of a Disease-Specific Migraine Smart Phone Application (App) on Participant Care
The purpose of this study is to determine whether using a smart phone application to foster communication between study participants and their doctor will impact care.
- Trial name
- NCT03559088
- Testing
- Migraine App
- Where
- 16 sites in United States
- Volunteers
- 120 people
- Sponsor
- Eli Lilly and Company
Migraine
Structural and Molecular Neuroplasticity in Migraine
The main purpose of this study is to integrate novel MRI techniques with positron emission tomography(PET) for the study of structural and molecular neuroplasticity in the brain of migraineurs, and its clinical association with…
- Trial name
- NCT03004313
- Testing
- Pet Scan, MRI scan, Quantitative Sensory Testing (QST)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Migraine Disorders, Facial Pain Disorder, Cluster Headache, Trigeminal Neuralgia, Trigeminal Autonomic Cephalalgias
Sphenopalatine Ganglion Pulsed Radiofrequency Treatment Outcomes
Purpose of the Study: This study aims to evaluate the clinical effectiveness and long-term outcomes of "Sphenopalatine Ganglion (SPG) Pulsed Radiofrequency (PRF)" treatment in patients with chronic headaches and facial pain.
- Trial name
- SPG-PRF (NCT07370142)
- Testing
- Pulsed Radiofrequency of the Sphenopalatine Ganglion
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Ankara City Hospital Bilkent
Migraine Headaches
To Evaluate the Safety and Efficacy of Trexima in the Acute Treatment of Migrane Headaches
to demonstrate the superiority of Trexima (combination of sumatriptan as the succinate 85 mg and naproxen sodium 500 mg) versus placebo in the acute treatment of migraine to demonstrate the superiority of Trexima versus the…
- Trial name
- NCT00434083
- Testing
- sumatriptan, naproxen sodium
- Where
- 2 sites in United States
- Volunteers
- 1,200 people
- Sponsor
- POZEN
Migraine
A Four-way Crossover Study of 3 Formulations of M207 With Intranasal Zolmitriptan in Healthy Volunteers
This is a single-center, open-label, randomized, four-way crossover study. Subjects will receive the four study treatments once, followed by in-clinic monitoring and extensive pharmacokinetic analysis.
- Trial name
- NCT03978403
- Testing
- M207 3.8 mg "Sled" (two 1.9 mg patches made on a "Sled" coater, foil pouches), M207 3.8 mg "MACAP" (two 1.9 mg patches made on a "MACAP" coater, foil cups), M207 3.8 mg "MiniMac" (two 1.9 mg patches made on a "MiniMac" coater, foil cups
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Zosano Pharma Corporation
Episodic Migraine
Atogepant for Prophylaxis of Migraine in Participants Who Failed Previous Oral Prophylactic Treatments.
This study will assess the safety, tolerability, and efficacy of Atogepant 60 mg compared with placebo in participants with episodic migraine and who have previously failed 2 to 4 classes of oral prophylactic treatments.
- Trial name
- ELEVATE (NCT04740827)
- Testing
- Atogepant 60 mg
- Where
- 114 sites in United States, Australia and 13 more
- Volunteers
- 315 people
- Sponsor
- Allergan
Chronic Migraine, Headache, Chronic Migraine
Rate , Predictors and Outcome of Chronic Migraine
Nowadays, headache has been considered as one of the top global disabling medical conditions.1 Migraine is an important type of headache, and one of the chronic multifaceted neuro-inflammatory disorders.2 It is characterized by…
- Trial name
- NCT05079659
- Where
- Egypt
- Volunteers
- 296 people, healthy volunteers welcome
- Sponsor
- Assiut University
Migraine
Inflammatory Markers in Patients With Active Migraine Headaches
The purpose of this study is to determine whether C-Reactive Protein (CRP) is elevated in patients with active migraine headaches.
- Trial name
- NCT00471861
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Westside Family Medical Center, P.C.
Migraine, Headache
Cognitive Effects of Immediate Release Topiramate vs Extended Release Topiramate in Patients With Migraine
Crossover, randomized, double blind: Q12h dosing in both periods; matching placebo for evening dosing during XR treatment; target dose: 100mg
- Trial name
- NCT03280342
- Testing
- IR-TPM (Topamax), XR-TPM (Trokendi XR)
- Where
- 2 sites in United States
- Sponsor
- University of Minnesota
Multiple Sclerosis, Alzheimer Disease
Optical Coherence Tomography in Neurological Practice: Utility and Applicability Across Neurological Diseases (OCt.IN.N)
OCt.IN.N is a national, monocentric, prospective, observational cohort study evaluating the utility and applicability of Optical Coherence Tomography (OCT) in the diagnostic workup and longitudinal monitoring of neurological…
- Conditions
- Multiple Sclerosis, Alzheimer Disease, Parkinson Disease, Migraine
- Trial name
- OCT (NCT07720765)
- Testing
- Optical Coherence Tomography (OCT) - Heidelberg SPECTRALIS HRA+OCT
- Where
- Italy
- Volunteers
- 1,050 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Migraine Without Aura, Migraine With Aura
Efficacy and Tolerability of Tonabersat in the Prophylaxis of Migraine Headache
Overall trial objectives: Can treatment with tonabersat reduce the number of days with a migraine headache in patients who suffer from frequent migraine attacks How well tolerated is treatment with tonabersat The study is based…
- Trial name
- NCT00311662
- Testing
- Tonabersat
- Where
- 17 sites in Denmark, Hungary and 2 more
- Volunteers
- 124 people
- Sponsor
- Minster Research Ltd
Migraine With Aura, Migraine Without Aura
Evaluation of the Efficacy of Diclofenac Potassium and Rimegepant for the Acute Treatment of Migraine
In a real-world population of adults with migraine, the investigators would like to investigate whether 50 mg diclofenac potassium is non-inferior to 75 mg rimegepant in terms of pain freedom at 2 hours after drug intake.
- Trial name
- ATOM (NCT05211154)
- Testing
- Diclofenac Potassium 50Mg/Pkt Oral Pwdr, Rimegepant 75 MG
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- Danish Headache Center
OCD, Major Depressive Disorder (MDD)
Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics
This is an observational study which does NOT directly administer a psychedelic substance but rather recruits participants who are already participating in another clinical trial in which they may receive a serotonergic…
- Conditions
- OCD, Major Depressive Disorder (MDD), Alcohol Use Disorder (AUD), Healthy Volunteer
- Trial name
- NCT06624137
- Testing
- Serotonergic Psychedelic
- Where
- 2 sites in United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Yale University
Myofascial Trigger Points, Chronic Musculoskeletal Pain
Clinical Study of Myofascial Trigger Points(MTrPs) Injection in the Treatment of Shoulder Osteoarthritis(OA)
Chronic musculoskeletal pain (CMP) is a common disease in China, with a high incidence among the elderly, and has a significant impact on patients' quality of life. Shoulder osteoarthritis is a common type of CMP.
- Conditions
- Myofascial Trigger Points, Chronic Musculoskeletal Pain, Shoulder Osteoarthritis
- Trial name
- NCT07347054
- Testing
- Joint Cavity Injection, MTrPs Injection
- Where
- China
- Volunteers
- 1,036 people
- Sponsor
- Beijing Tiantan Hospital
Chronic Migraine, Headache
Adjunctive Treatment of Chronic Migraine Using an Oral Dental Device
Single blinding study comparing FDA cleared device for prevention of medically diagnosed migraine pain to placebo.
- Trial name
- NCT04871581
- Testing
- NTI-tss
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- ChairsideSplint.com
Headache, Migraine
Efficacy of Haloperidol vs. Metoclopramide for Treatment of Acute Headaches and Migraines in the Emergency Department
Metoclopramide (Reglan) is a common agent used for relief of headaches in the emergency department (ED).In this study the investigators seek to explore another option for treatment of headaches in the ED, one that may be more…
- Trial name
- NCT02972502
- Testing
- Metoclopramide, Haloperidol, Normal Saline
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- OhioHealth
Headache, Migraine
Short-term Effectiveness of Transcutaneous Nerve Stimulation in Reducing Migraine Related Pain
The purpose of this study is to evaluate the short-term effectiveness of combined occipital and supraorbital transcutaneous nerve stimulation in reducing migraine related pain.
- Trial name
- NCT02438553
- Testing
- OSTNS Neurostimulator
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Neurolief Ltd.
Cluster Headache
Role of Specific microRNAs in Cluster Headache
Cluster headache (CH) is a primary headache included in the trigeminal autonomic cephalalgias (TACs) according to the International Calssification of Headache Disorder, Third Edition.
- Trial name
- 5*1000 (NCT06503328)
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Migraine
A Study Evaluating the Effectiveness of PEA Compared to Placebo for Reducing Pain Severity and Duration of Migraines.
This is a double-blind randomised controlled study to evaluate the effectiveness of orally-dosed Palmitoylethanolamide (PEA) compared to placebo for reducing pain severity and duration of migraines in otherwise healthy…
- Trial name
- NCT05046522
- Testing
- Palmitoylethanolamide sold as Levagen +
- Where
- Australia
- Volunteers
- 80 people
- Sponsor
- RDC Clinical Pty Ltd