Clinical trials: Middle Cerebral Artery Stroke
Infarction
Hemicraniectomy for Malignant Middle Cerebral Artery Infarction (HeMMI)
A single-centered, randomized, controlled clinical trial comparing standardized medical care alone with standardized medical care and decompressive hemicraniectomy to determine the effectiveness of decompressive surgery more…
- Trial name
- HeMMI (NCT02002234)
- Testing
- Hemicraniotomy, Standard medical treatment
- Where
- Philippines
- Volunteers
- 29 people
- Sponsor
- University of the Philippines
Cognitive Recovery After Stroke, Cognitive Outcome After Stroke
Long-Term Cognitive Recovery After Arteria Cerebri Media Ischemia: A Digital Assessment Using the TuCAN-App
TuCAN-Media is a longitudinal study investigating cognitive recovery after stroke in severely affected patients (modified Rankin Scale [mRS] score ≥ 3) with large vessel occlusion of the arteria cerebri media/middle cerebral…
- Trial name
- TuCAN-Media (NCT07885189)
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University Hospital Tuebingen
Aphasia, Nonfluent Aphasia
Neural Networks and Language Recovery in Aphasia From Stroke: fMRI Studies
The purpose of this research is to utilize functional magnetic resonance imaging (fMRI) to investigate brain reorganization for language behavior in stroke patients with aphasia.
- Conditions
- Aphasia, Nonfluent Aphasia, Stroke
- Trial name
- NCT00467103
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Cerebral Stroke
Super-Resolution Ultrasound of the Brain in 3D
The goal of this proof of concept study is to determine if the visualization of the middle cerebral artery and its perforators, through 3D transtemporal ultrasound imaging, is possible thanks to an off-line analysis by 3D…
- Trial name
- ESRC3D (NCT06133179)
- Testing
- Transtemporal ultrasound with contrast product (Sonovue)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Middle Cerebral Artery Infarction, Anterior Cerebral Artery Infarction
Stem Cell Therapy For Acute Ischemic Stroke Patients
The purpose of this study is to determine whether patients with subacute ischemic stroke will benefit from infusion of patient's own bone marrow derived stem cells.
- Trial name
- InVeST (NCT02425670)
- Testing
- BMSCs
- Where
- 5 sites in India
- Volunteers
- 120 people
- Sponsor
- All India Institute of Medical Sciences
Stroke, Acute
Embolectomy in Acute SYlvian Thrombosis in Refractory or Ineligible Patients to ALteplase
This trial aims at comparing two strategies currently used to address acute ischemic stroke of the middle cerebral artery : medical treatment without endovascular treatment on the one hand, and medical treatment plus endovascular…
- Trial name
- EASY (NCT02216565)
- Testing
- Hospitalization in specialized neuro-vascular unit, Alteplase if patient is eligible, Supportive care
- Where
- 3 sites in France
- Volunteers
- 2 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Acute Ischemic Stroke, Endovascular Thrombectomy
The Prediction of Hemorrhage Transformation by Cerebral Autoregulation in AIS Patient After Endovascular Thrombectomy
This observational study was designed for observe the cerebral hemodynamics and dynamic cerebral autoregulation (dCA) after endovascular thrombectomy (EVT) in acute ischemic stroke (AIS) patients.
- Conditions
- Acute Ischemic Stroke, Endovascular Thrombectomy, Dynamic Cerebral Autoregulation
- Trial name
- PHASE (NCT06361017)
- Testing
- endovascular thrombectomy
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Xuanwu Hospital, Beijing
Stroke, Middle Cerebral Artery With Infarction, Rehabilitation, Upper Limb Recovery, Economic Burdon
Perception About Upper Limb Functional Recovery, Barriers & Use of Training Devices Among Indian Stroke Survivors.
The goal of this observational study is to evaluate perceptions regarding affected arm and hand function and their willingness to use devices to enhance upper limb functions among stroke survivors.
- Trial name
- NCT05894330
- Where
- India
- Volunteers
- 196 people
- Sponsor
- Mahatma Gandhi Institute of Medical Sciences
Aphasia
Effect of Music on Reading Comprehension for Patients With Aphasia
This investigation uses a single-subject, adapted alternating research design to compare two different experimental conditions using music with lyrics combined with visual stimulation of the written lyrics, to extend the…
- Trial name
- EMRA1 (NCT02875938)
- Testing
- Simultaneous music and reading lyrics, Priming with music, Control
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Carilion Clinic
Stroke
Safety and Efficacy of the Penumbra™ System in Acute Middle Cerebral Artery (MCA) Stroke
Stroke prognosis is intimately related to reperfusion. Reperfusion in acute setting can be achieved with different strategies - varying from intravenous rtPA from mechanical thrombectomy.
- Trial name
- NCT01133223
- Testing
- Penumbra™ System, Recombinant tissue plasminogen activator
- Where
- Brazil
- Sponsor
- Hospital de Clinicas de Porto Alegre
Middle Cerebral Artery Infarction
Stereotactic Infarct Tissue Aspiration for Malignant Infarction of Middle Cerebral Artery
Malignant middle cerebral artery infarction(MMCI) has a high rate of disability and mortality. At present, there is no effective treatment except for craniotomy decompression, but the controversy of the craniotomy decompression…
- Trial name
- SMART (NCT02609256)
- Testing
- Stereotactic infarct tissue aspiration, Medical therapy
- Where
- China
- Volunteers
- 12 people
- Sponsor
- General Hospital of Shenyang Military Region
Ischemic Stroke, Acute, Intracranial Atherosclerosis
Efficacy of Butylphthalide on Symptomatic Atherosclerotic Stenosis in Middle Cerebral Artery
Ischemic stroke with high incidence, mortality, disability and recurrence rate, has become the leading threat to the health worldwide.
- Trial name
- SICAS (NCT06331494)
- Testing
- Butylphthalide
- Where
- China
- Volunteers
- 140 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Head Injuries, Subarachnoid Haemorrhage
Impact of Cranioplasty On Cerebral Perfusion
The purpose of this study is to examine the impact of cranioplasty on cerebral hemodynamic and blood flow as prognostic factor in patients receiving decompressive craniectomy for Head injuries, Subarachnoid haemorrhage…
- Conditions
- Head Injuries, Subarachnoid Haemorrhage, Intra-cerebral Haemorrhage, Cerebral Thrombosis
- Trial name
- CCP (NCT01113645)
- Testing
- Cerebral perfusion evaluation
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Middle Cerebral Artery Occlusion, Stenting Treatment
Prospective Study on Safety and Efficacy of Stenting for Chronic Middle Cerebral Artery Occlusion With Limb Dysfunction
The goal of this clinical study is to evaluate the safety and efficacy of stenting for revascularization treatment of chronic middle cerebral artery (MCA) occlusion in patients with chronic MCA occlusion.
- Conditions
- Chronic Middle Cerebral Artery Occlusion, Stenting Treatment, Modified Rankin Scale, National Institutes of Health Stroke Scale
- Trial name
- NCT06419283
- Testing
- Middle Cerebral Artery Stent Implantation, standard treatment with aspirin.
- Where
- China
- Volunteers
- 59 people
- Sponsor
- Huizhou Municipal Central Hospital
Ischemic Stroke
Assess the Penumbra System in the Treatment of Acute Stroke
The purpose of this trial is to assess the safety and effectiveness of the Penumbra System as an adjunctive treatment to intravenous (IV) recombinant human tissue plasminogen activator (rtPA)in patients with acute ischemic stroke…
- Trial name
- THERAPY (NCT01429350)
- Testing
- intravenous (IV) recombinant human tissue plasminogen activator (rtPA), Penumbra System
- Where
- 4 sites in United States
- Volunteers
- 108 people
- Sponsor
- Penumbra Inc.
Intracranial Atherosclerosis, Stroke, Ischemic
Role of GLP1 RA Dulaglutide on Severe Intracranial Atherosclerosis
One important mechanism of action of GLP1 RA is the improvement in endothelial function, which may be evaluated by the assessment of cerebral vasodilatory reserve (CVR) in patients with severe ICAD.
- Trial name
- RADIANT (NCT07282041)
- Testing
- Dulaglutide
- Where
- Singapore
- Volunteers
- 130 people
- Sponsor
- National University of Singapore
High Resolution Vessel Wall Imaging, Recurrent Stroke
Plaque Characteristics Predict Recurrent Stroke in MCA Stroke Patients
The epidemiology of TOAST classification in Asian patients seems to differ due to the higher rates of large-artery atherosclerosis.
- Conditions
- High Resolution Vessel Wall Imaging, Recurrent Stroke, Stroke, Mechanism, Atheroscleroses, Intracranial
- Trial name
- NCT06404242
- Where
- Vietnam
- Volunteers
- 75 people
- Sponsor
- University Medical Center Ho Chi Minh City (UMC)
Infarction, Middle Cerebral Artery, Ischemic Stroke,
Implantation of Olfactory Ensheathing Cells (OECs)
Recruited patients should receive the endoscopic surgery for picking the olfactory mucosa 1 to 2 months before transplantation. The Olfactory Ensheathing Cells (OECs) will be cultured and expanded under the rule of GTP.
- Conditions
- Infarction, Middle Cerebral Artery, Ischemic Stroke,, Stroke With Hemiparesis,, Thromboembolic Stroke.
- Trial name
- OECs (NCT01327768)
- Testing
- Olfactory ensheathing cells
- Where
- Taiwan
- Volunteers
- 6 people
- Sponsor
- China Medical University Hospital
Ischemic Stroke
Application of High-Resolution Magnetic Resonance Vessel Wall Imaging in Endovascular Treatment
Intracranial atherosclerotic disease (ICAD) is one of the most important causes of ischemic stroke and is also associated with some recurrent stroke.
- Trial name
- NCT07497152
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Shanghai East Hospital
Stroke, Middle Cerebral Artery Infarction
Gait Training for Persons With Stroke
The objective of this study is to investigate the effects of an automatic gait trainer (Lokomat) handled by physical therapists compared with categorized gait training by physical therapists in ambulatory stroke patients.
- Trial name
- GTS (NCT00612300)
- Testing
- Lokomat - Physical therapy, Physical therapy - Lokomat
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- University of Aarhus