Clinical trials: Microvascular Disease
Coronary Microvascular Dysfunction, Cardiotoxicity
Effects of Immune Checkpoint Inhibitors on Coronary Microvasculature
This is an observational study that includes patients with breast cancer or non-small cell lung cancer who will be treated with immune checkpoint inhibitor (ICI) therapy.
- Conditions
- Coronary Microvascular Dysfunction, Cardiotoxicity, Breast Cancer, Lung Cancer (NSCLC)
- Trial name
- NCT06332131
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Non-ST-elevation Myocardial Infarction
Thrombus Aspiration in ThrOmbus Containing culpRiT Lesions in Non-ST-Elevation Myocardial Infarction (TATORT-NSTEMI)
Whereas thrombus aspiration in patients with ST-elevation myocardial infarction (STEMI) is recommended by current guidelines, there are insufficient data to unequivocally support thrombectomy in patients with non-STEMI (NSTEMI).
- Trial name
- NCT01612312
- Testing
- Thrombectomy, Standard percutaneous coronary intervention
- Where
- 7 sites in Germany
- Volunteers
- 400 people
- Sponsor
- University of Leipzig
Microvascular Angina
Ranolazine and Microvascular Angina by PET in the Emergency Department
The purpose of this study is to determine the effectiveness of Ranolazine for the treatment chest pain from disease of small vessels of the heart also known as 'microvascular angina'.
- Trial name
- RAMP-ED (NCT02052011)
- Testing
- Ranolazine
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Yale University
Diabetic Retinopathy, Neurodegeneration
Glycemic Control and Retinal Microvascular Changes
The goal of this prospective, observational study is to compare in the association of glycemic control and retinal microvascular changes in patients with type 2 diabetes mellitus (T2DM) without diabetic retinopathy (DR).
- Conditions
- Diabetic Retinopathy, Neurodegeneration, Blood Sugar; High
- Trial name
- NCT06150495
- Where
- South Korea
- Volunteers
- 259 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Trigeminal Neuralgia, Microvascular Decompression Surgery
Assessment in Patients With Essential Trigeminal Neuralgia of Nerve Involvement by MRI in DTI and Functional Connectivity in "Resting State"
Essential trigeminal neuralgia is the most common facial pain. In forms resistant to drug and disabling treatments, surgical treatment may be offered to the patient.
- Conditions
- Trigeminal Neuralgia, Microvascular Decompression Surgery, Diffusion Tensor Imaging
- Trial name
- SENSE (NCT05051072)
- Testing
- Assessment of the trigeminal nerve by diffusion tensor MRI and in "resting state" in the context of essential neuralgia
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Microvascular Angina
Effect of ACE-Inhibition on Microvascular Function in Women With Assessed Microvascular Dysfunction
The aim of this study is to explore effects of long term treatment with ACE-inhibitor on the small vessel function assessed by coronary flow reserve (CFR) by transthoracic echocardiography and flow mediated dilation in…
- Trial name
- NCT02525081
- Testing
- Ramipril (ACE-inhibitor)
- Where
- Denmark
- Volunteers
- 63 people
- Sponsor
- Bispebjerg Hospital
Myocardial Infarction
Myocardial Perfusion Study to Detect Coronary Microvascular Abnormality in Diabetic Patients With Nonfatal Myocardial Infarction
The goal of this study is to use MCE (myocardial contrast/perfusion echocardiography) to study and compare short/long term change of myocardial perfusion abnormality and cardiac outcome in diabetic patients after nonfatal MI…
- Trial name
- GEMyCE 1 (NCT01749683)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- State University of New York - Upstate Medical University
Liver Cirrhosis, Liver Cancer
Development of a Set of Auxiliary Decision-making System for the Perioperative Period of Hepatectomy Based on Static CT and Artificial Intelligence.
The study will prospectively recruit patients with chronic liver disease and liver cancer for static CT scans to establish a high-definition CT database.
- Trial name
- NCT07056270
- Testing
- static CT scans
- Volunteers
- 500 people
- Sponsor
- Tongji Hospital
Cardiac Allograft Vasculopathy, Endothelial Dysfunction
Determining the Association of Microvascular Disease as Assessed by PET and Graft Injury by Donor Derived Cell Free DNA
The goal of this research study is to understand if a blood test in people who have had heart transplants can detect and predict the following: Blockages in the small blood vessels of the heart.
- Conditions
- Cardiac Allograft Vasculopathy, Endothelial Dysfunction, Microvascular Coronary Artery Disease
- Trial name
- DEPICT (NCT05756088)
- Testing
- Blood draw to measure the levels of dd-cf DNA
- Where
- United States
- Sponsor
- Yale University
Syndrome X
Syndrome X and Endothelial Dysfunction
Cardiac syndrome X is characterized by angina, positve stress test, and patent coronary angiography, and its probable mechanism is microvascular dysfunction associated with endothelial dysfunction.
- Trial name
- NCT00190086
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital
Type 1 Diabetes, Insulin Sensitivity/Resistance
Effect of GLP-1 on Microvascular Insulin Responses in Type 1 Diabetes
GLP-1 increases skeletal and cardiac microvascular perfusion and improves insulin's microvascular responses in human subjects with T1DM, leading to improved metabolic insulin responses, endothelial function, and increased muscle…
- Trial name
- KML001 (NCT04133922)
- Testing
- GLP-1, Insulin, Dextrose 20 % in Water
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Virginia
Hypertension
Effect of a Polyphenol Rich Diet on Vascular and Platelet Function
Previous work has shown that increasing fruit and vegetable intake in patients with high blood pressure improves cardiovascular function.
- Trial name
- PPhIT (NCT01319786)
- Testing
- Two portions of fruit and vegetables per day (excluding berries and dark chocolate), Six portions of fruit and vegetables per day (one of which must be berries) and 50g dark chocolate.
- Where
- United Kingdom
- Volunteers
- 104 people
- Sponsor
- Queen's University, Belfast
Preeclampsia, Microvascular Function
Prenatal Aspirin and Postpartum Vascular Function
Preeclampsia is a pregnancy disorder affecting ~5-10% of pregnancies in the United States. Women who develop preeclampsia during pregnancy are more likely to develop and die of cardiovascular disease later in life, even if they…
- Trial name
- NCT05653973
- Testing
- Acetylcholine, Endothelin-1
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Anna Stanhewicz, PhD
Hypertension, Mild Cognitive Impairment
Retina Microvascular Remodeling and Cognitive Function In Hypertension
This study aims to determine the relationships between retina micro-vascular remodeling and cognitive function in hypertensive patients.
- Trial name
- EYEBRAIN (NCT02701855)
- Testing
- Cognitive tests, Blood test, Brain and aorta RMI
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Institute of Cardiometabolism and Nutrition, France
Coronary Artery Disease
Prevention of Coronary Microvascular Dysfunction Post-PCI by Intracoronary Nicardipine
This is a single-center double blind, placebo controlled study of patients undergoing a cardiac catheterization where the need for a percutaneous coronary intervention (PCI) is anticipated or will be determined during the early…
- Trial name
- NCT03184155
- Testing
- Nicardipine, Sterile Saline
- Where
- United States
- Sponsor
- Thomas Jefferson University
ST Segment Elevation Myocardial Infarction
Early Prediction of QFR in STEMI-I
The study intends to provide important data on whether the noval method using quantitative flow ratio could predict microvascular dysfunction.
- Trial name
- EARLYmyo-QFR-I (NCT03780335)
- Testing
- Computation of quantitative flow ratio
- Volunteers
- 162 people
- Sponsor
- RenJi Hospital
Coronary Microvascular Dysfunction, Microvascular Angina
Randomized Trial to Examine a Differential Therapeutic Response in Symptomatic Patients With Non-obstructive Coronary Artery Disease
EXAMINE-CAD-DZHK22 is a prospective, randomized, double-blind, placebo-controlled, crossover trial investigating the efficacy of beta blocker (bisoprolol) and calcium channel blocker (diltiazem) therapy in symptomatic patients…
- Conditions
- Coronary Microvascular Dysfunction, Microvascular Angina, Vasospasm, Coronary, Vasospastic Angina
- Trial name
- EXAMINE-CAD (NCT05294887)
- Testing
- Bisoprolol, Diltiazem
- Where
- 15 sites in Germany, Switzerland
- Volunteers
- 132 people
- Sponsor
- Charite University, Berlin, Germany
Angina, Stable, Chest Pain
Acupuncture for Individuals With Stable Angina
This RCT aims to determine if it is possible to perform acupuncture on men and women diagnosed with stable angina who have symptoms, chest pain, and/or chest discomfort.
- Conditions
- Angina, Stable, Chest Pain, Microvascular Angina, Heart Failure
- Trial name
- AIMS-A (NCT02914834)
- Testing
- Acupuncture, Non-pain related video health education
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Illinois Chicago
Congenital Adrenal Hyperplasia
Cardiovascular Risk Profile in Patients With Congenital Adrenal Hyperplasia
Treatment with glucocorticoids and mineralocorticoids has changed congenital adrenal hyperplasia (CAH) from a fatal to a chronic lifelong disease.
- Trial name
- cardiohcs (NCT01807364)
- Where
- France
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Coronary Arteriosclerosis, Coronary Heart Disease
Analysis of Human Coronary Aspirate
During elective percutaneous coronary intervention (PCI), both proximal and distal protection devices are used. The distal occlusion protection device temporarily occludes the vessel distal to the lesion during the intervention…
- Conditions
- Coronary Arteriosclerosis, Coronary Heart Disease, No Reflow Phenomenon
- Trial name
- AHCA (NCT01430884)
- Testing
- Aspirated Coronary Blood
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Universität Duisburg-Essen