Clinical trials: Microvascular Angina
Hypercholesterolemia, Hypertension
Effectiveness of Nigella Sativa (Kalonji) Seed in Dyslipidemia
This is a pilot study. The aim of the investigators' study is to evaluate the effectiveness of nigella sativa seed in the treatment of dyslipidemia.
- Conditions
- Hypercholesterolemia, Hypertension, Diabetes Mellitus, Metabolic Syndrome X
- Trial name
- NCT00327054
- Testing
- Nigella sativa seed
- Where
- Pakistan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Metabolic Syndrome X, Overweight
Atheroma Reduction With Chloroquine in Patients With the Metabolic Syndrome (ARCH-MS)
Metabolic syndrome consists of a group of co-occuring conditions that increase an individual's risk of developing heart disease, stroke, and diabetes.
- Conditions
- Metabolic Syndrome X, Overweight, Hypertension, Dyslipidemias
- Trial name
- ARCH-MS (NCT00455403)
- Testing
- Chloroquine
- Where
- United States
- Volunteers
- 357 people
- Sponsor
- Washington University School of Medicine
Coronary Artery Disease, Atherosclerosis
Biological Efficacy of Clopidogrel After Implantation of Drug-eluting Stents (SPACE)
The risk of thrombotic complications after implantation of drug-eluting stents (DES) may be increased in patients with diabetes mellitus (DM) or metabolic syndrome (MS).
- Conditions
- Coronary Artery Disease, Atherosclerosis, Diabetes Mellitus, Metabolic Syndrome X
- Trial name
- SPACE (NCT00298428)
- Testing
- blood samples
- Where
- 2 sites in France
- Volunteers
- 159 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Metabolic Syndrome X
Clinical Trial of Chinese Formula AMP-1915 on Metabolic Syndrome
The purpose of this study is to determine whether the Chinese formula AMP-1915 has effect on Metabolic Syndrome (MS) in MS patients. Half of patients received AMP-1915, while the other half received placebo.
- Trial name
- NCT02605655
- Testing
- AMP-1915
- Volunteers
- 60 people
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Metabolic Syndrome, Metabolic Syndrome X
Periodized Aerobic Interval Training in Metabolic Syndrome
Autonomic disfunction present in metabolic syndrome subjects is related by a greater vulnerability of the heart and risk of cardiovascular events.
- Trial name
- NCT03119493
- Testing
- Periodized aerobic interval training
- Where
- Brazil
- Volunteers
- 52 people
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Obesity, Diabetes Mellitus
Activating Brown Adipose Tissue Through Exercise
The energy burning capacity of brown adipose tissue makes it an attractive target for anti-obesity therapies. Sympathetic nervous system (SNS) is the classical regulator of brown adipose tissue; however, recent findings show a…
- Conditions
- Obesity, Diabetes Mellitus, Metabolic Syndrome X
- Trial name
- ACTIBATE (NCT02365129)
- Testing
- Exercise training based on recommendations for adults (WHO)
- Where
- Spain
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Physical Activity, Endothelial Dysfunction
Recreational Physical Activity and Cardiometabolic Profile
The purpose of present study was to investigate the effect of 10 weeks of recreational physical activity program on the irisin levels, progenitor endothelial cells and cardiometabolic profile in healthy children.
- Conditions
- Physical Activity, Endothelial Dysfunction, Metabolic Syndrome x
- Trial name
- NCT02982967
- Testing
- Physical Activity
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Cardiovascular Diseases, Heart Diseases
Central Obesity and Disease Risk in Japanese Americans
To conduct a longitudinal study of central obesity and related risk factors found to be associated with hypertension and atherosclerotic cardiovascular disease (ASCVD) in a previously-examined cross-sectional cohort of…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Atherosclerosis, Hypertension
- Trial name
- NCT00005365
- Sponsor
- University of Washington
Cardiovascular Diseases, Heart Diseases
Epidemiology of Stress and the Metabolic Syndrome
To examine the effects of psychological stress on the metabolic syndrome.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Obesity, Hypertension
- Trial name
- NCT00073775
- Volunteers
- 3,075 people
- Sponsor
- University of Florida
Coronary Microvascular Dysfunction, Coronary Microvascular Disease
Absolute Flow for Ischemia With No Obstructive Coronary Arteries
The main objective is to prospectively validate the capacity of continuous thermodilution coronary flow reserve (CFRflow) as a predictor of the presence of angina measured by SAQ7 in patients with INOCA at 3 months.
- Conditions
- Coronary Microvascular Dysfunction, Coronary Microvascular Disease, Angina, Stable
- Trial name
- AF-INOCA (NCT05825339)
- Testing
- Coronary Flow Reserve
- Where
- 6 sites in Spain
- Volunteers
- 121 people
- Sponsor
- Spanish Society of Cardiology
Obstructive Sleep Apnea, Metabolic Syndrome X
Obstructive Sleep Apnea (OSA) and Metabolic Syndrome: Role of Oxidative Stress
The purpose of this study is to define the mechanism(s) through which Obstructive Sleep Apnea/Hypopnea (OSAH) promotes abnormal metabolic processes which characterize the metabolic syndrome.
- Trial name
- NCT00177892
- Testing
- sleep disruption, sleep with and without positive pressure
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Metabolic Syndrome X
Identification and Treatment Response Prediction of Antipsychotic-Related Metabolic Syndrome
The investigators developed an easy identification model to identify metabolic syndrome in patients with schizophrenia or schizoaffective disorder who received treatment of clozapine, olanzapine, or risperidone.
- Trial name
- NCT00956189
- Testing
- amisulpride, aripiprazole
- Where
- 3 sites in Taiwan
- Volunteers
- 132 people
- Sponsor
- National Taiwan University Hospital
Dysmetabolic Iron Overload Syndrome, Genetic Hemochromatosis
Effects of Polyphenols on Iron Absorption in Iron Overload Disorders.
Dysmetabolic iron overload syndrome and genetic hemochromatosis are frequent causes of iron overload. Polyphenols are efficient iron-chelators.
- Conditions
- Dysmetabolic Iron Overload Syndrome, Genetic Hemochromatosis, Iron Absorption, Polyphenols
- Trial name
- POLYFER (NCT03453918)
- Testing
- polyphenols
- Where
- France
- Volunteers
- 41 people
- Sponsor
- University Hospital, Clermont-Ferrand
Metabolic Syndrome X
Efficacy of a Prebiotic Galactooligosaccharide to Reduce Metabolic Syndrome Risk Factors in Overweight Adults
The traditional risk factors for obesity are inappropriate diet, lack of exercise and genetic factors. However, recent observations have involved gut microbiota profiles as having an additional influence.
- Trial name
- NCT01004120
- Testing
- Bimuno, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Clasado
Metabolic Syndrome X
Inflammation and the Metabolic Syndrome in Humans
People who are overweight are at increased risk of heart disease. Being overweight and having heart disease are linked in that both involve inflammation.
- Trial name
- LPS (NCT00954824)
- Testing
- Endotoxin (LPS)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Coronary Vasospasm, Microvascular Angina
Abnormal Coronary Vasomotion in Patients With Suspected Coronary Artery Disease (CAD)
In patients with chest pain and/or shortness of breath coronary artery disease (CAD) is suspected depending on the pattern of symptoms and the electrocardiogram (ECG).
- Conditions
- Coronary Vasospasm, Microvascular Angina, Coronary Artery Disease
- Trial name
- ACOVA (NCT00921856)
- Testing
- Intracoronary acetylcholine provocation test
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Peter Ong, MD
Obstructive Sleep Apnea, Cardiac Syndrome X
A Prevalence Study of Obstructive Sleep Apnea in Subjects With Chest Pain, Positive Exercise Treadmill Test and Normal Coronary Angiogram
Cardiac syndrome X consists of a triad of chest pain, abnormal exercise stress testing and normal coronary angiogram, and is hypothesized to be related to endothelial dysfunction.
- Conditions
- Obstructive Sleep Apnea, Cardiac Syndrome X, Endothelial Dysfunction
- Trial name
- NCT01217346
- Testing
- no intervention is involved in this study
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- The University of Hong Kong
ANOCA - Angina With Non-obstructive Coronary Arteries, Coronary Microvascular Dysfunction (CMD)
Invasive Evaluation and Phenotype-Guided Treatment of ANOCA in Women
This prospective single-center interventional study will include women with angina and non-obstructive coronary arteries. Participants will undergo a standardized invasive coronary assessment combining coronary physiology…
- Conditions
- ANOCA - Angina With Non-obstructive Coronary Arteries, Coronary Microvascular Dysfunction (CMD), Vasospastic Angina
- Trial name
- ANOCA-UY (NCT07593157)
- Testing
- Invasive Coronary Functional and Morphological Assessment, Pharmacological treatment will be individualized according to the invasive coronary phenotype identified. Treatment may include antianginal therapy, vasodilator therapy, endothelial function-targeted
- Where
- Uruguay
- Volunteers
- 50 people
- Sponsor
- Hospital de Clínicas Dr. Manuel Quintela
Coronary Microvascular Disease
Personalized Medicine Using Coronary Microvascular Function Measured in Patient With Percutaneous Coronary Intervention in Angina
The evidence demonstrating the importance of coronary microcirculation in the management of patients with coronary artery disease is growing.
- Trial name
- DECISIONING (NCT05178914)
- Testing
- Treatment adaptation
- Where
- France
- Volunteers
- 280 people
- Sponsor
- University Hospital, Grenoble
Metabolic Syndrome X
The Metabolic Syndrome Among Leukemia Survivors: Physiopathological Analysis
Along with the improvement of childhood acute leukemia treatment, survival rates have increased. Therefore, the number of long term childhood leukemia survivors has increased progressively over the last decades.
- Trial name
- LEAMS (NCT02696304)
- Testing
- Adipose tissu repartition, Visceral and liver adipose tissue repartition, Preadipocyte quantification and adipose tissue inflamation
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique Hopitaux De Marseille