Clinical trials: Microsurgery
Endodontic Disease, Endodontic Re-treatment Failure
The 3-Dimensional Printed Guide in Endodontic Microsurgery
In recent years, there was a great interest in employing the surgical guide in dentistry due to the development occurred in the 3D printing which became available widely.
- Trial name
- NCT05283252
- Testing
- 3-D printed Guide, Conventional Endodontic Micro-Surgery
- Where
- Syria
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Damascus University
Head and Neck Neoplasms, Head and Neck Squamous Cell Carcinoma
Phonosurgical Augmentation After Laser Resection of Early Glottic Carcinoma
Objectives: Transoral Laser Microsurgery (TLM) is widely used in for treating T1/T2 glottic cancers. Hyaluronic acid (HA) is a safe and commonly-used injectable in vocal cord augmentation.
- Conditions
- Head and Neck Neoplasms, Head and Neck Squamous Cell Carcinoma, Voice Disorders, Laryngeal Cancer
- Trial name
- NCT04525066
- Testing
- Hyaluronic acid, No Hyaluronic Acid Injection Injection
- Volunteers
- 39 people
- Sponsor
- Ayhman Al Afif
Laryngeal Neoplasm, Glottic Carcinoma
Precision Medicine: MRI-Guided Stereotactic Ablative Radiotherapy (MRI-SABR) for Early-Stage Glottic Laryngeal Cancer
This randomized phase III trial will compare the outcomes of three treatment modalities for early-stage glottic laryngeal cancer (T1-T2N0): transoral CO₂ laser microsurgery (TLM), volumetric modulated arc therapy (VMAT), and…
- Trial name
- SMART - 1_1 (NCT07391345)
- Testing
- Transoral CO₂ laser cordectomy (Type I-VI depending on tumor localization), VMAT radiotherapy, MRI-SABR
- Where
- Lithuania
- Volunteers
- 105 people
- Sponsor
- Viktoras Rudzianskas
Lymphedema
Use of Reconstructive Microsurgery for the Treatment of Lymphedema
Lymphedema is a chronic condition characterized by the accumulation of lymphatic fluid in tissues, frequently resulting from oncological treatments, trauma, or cancer.
- Trial name
- NCT07889856
- Testing
- Surgery with and without the aid of Indocyanine Green (ICG)
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Istituto Ortopedico Rizzoli
Periapical Periodontitis
Hyaluronic Acid in Endodontic Microsurgery
This randomized clinical trial (RCT) will evaluate the effectiveness of cross-linked hyaluronic acid as an adjunct to endodontic microsurgery in adult patients with apical periodontitis affecting maxillary or mandibular first…
- Trial name
- NCT07501585
- Testing
- Hyaluronic Acid, Endodontic microsurgery
- Where
- Russia
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Bern
Rectal Cancer Stage I
Preoperative Chemoradiotherapy and Transanal Endoscopic Microsurgery Versus Ttransanal Endoscopic Microsurgery in T1 N0, M0 Rectal Cancer (TAUTEM-T1 Study)
Introduction: The standard treatment for rectal adenocarcinoma is total mesorectal excision (TME), a technique involving resection of the rectum, with or without a temporary or permanent stoma.
- Trial name
- TAUTEM-T1 (NCT06450574)
- Testing
- Capecitabine (Xeloda), 50.4 Gy, Transanal Endoscopic Microsurgery (TEM)
- Volunteers
- 106 people
- Sponsor
- Corporacion Parc Tauli
Larynx Disease, Laryngeal Stenosis
The Effectiveness of Reconstructive Microsurgery on the Clinical and Functional State of Laryngeal Stenosis
To improve diagnostic methods for patients with laryngeal stenosis for the optimal determination of the technique of surgical treatment.
- Trial name
- NCT04734483
- Testing
- spirometry, MRI and CT, Laryngoscopy
- Where
- 2 sites in Kazakhstan, Russia
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Astana Medical University
Oral Cancer, Head and Neck Cancer
Assessment of the Effects of Pressors on Graft Blood Flow After Free Tissue Transfer Surgery
Following surgery to remove tumours of the head and neck, patients undergo reconstruction with free flaps - tissue that is taken from elsewhere in the body and given a new blood supply by attaching it to vessels in the neck.
- Conditions
- Oral Cancer, Head and Neck Cancer, Free Flap, Hypotension
- Trial name
- Free4Flow (NCT01418118)
- Testing
- Epinephrine, Norepinephrine, Dobutamine
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Oxford University Hospitals NHS Trust
Microsurgery, Lymphedema
CONNECT: A Multi-Cohort, Prospective Investigation of the Symani® Surgical System
The objective of this clinical study is to evaluate the Symani System's safety and effectiveness for microsurgical anastomosis during free tissue transfer surgery and lymphatic surgery.
- Conditions
- Microsurgery, Lymphedema, Free Tissue Transfer
- Trial name
- CONNECT (NCT06866197)
- Testing
- Symani Surgical System
- Where
- Australia
- Volunteers
- 180 people
- Sponsor
- MMI (Medical Microinstruments, Inc.)
Gingival Recession
Platelet Rich Fibrin in the Treatment of Multiple Gingival Recessions
The aim of this randomized controlled clinical study is to evaluate and compare the effectiveness of platelet rich fibrin (PRF) and connective tissue grafts in the treatment of multiple gingival recessions.
- Trial name
- NCT02018120
- Testing
- connective tissue graft, platelet rich fibrin
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Ege University
Glaucoma
Benchmarking Management of Glaucoma Using the Diopsys VEP/PERG Protocols.
Establish electrophysiological benchmarks, using the Diopsys Visual Evoked Potential/ Pattern ERG (VEP/PERG) protocols of populations with Glaucoma following: 1) Baseline VEP/ERG prior to treatment; and 2) VEP/PERG after…
- Trial name
- NCT02594280
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Diopsys, Inc.
Mass Learning, Spaced Learning, Microsurgery
Randomized Prospective Study Comparing the Effectiveness of Massed and Spaced Learning in Microsurgical Procedures
Title: Randomized prospective study comparing the effectiveness of spaced learning to mass learning in microsurgical procedures.
- Trial name
- NCT03626025
- Testing
- Spaced learning
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hand & Reconstructive Microsurgery
Cough
High Flow Nasal Oxygenation vs Endotracheal Intubation on Recovery Profiles in Laryngeal Microsurgery
Transnasal humidified rapid-insufflation ventilatory exchange(THRIVE), or also termed high flow nasal oxygenation (HFNO) is a method of supplying heated, humidified high concentrations of oxygen via nasal cavity.
- Trial name
- NCT05559502
- Testing
- HFNO group, ET group
- Where
- South Korea
- Volunteers
- 52 people
- Sponsor
- Ajou University School of Medicine
Endodontic Re-treatment Failure
Evaluation of Guided Endodontic Microsurgery and Two Different Retrograde Filling Materials
The aim of this study was to evaluate the effect of guided endodontic microsurgical root end resection on bone healing compared to nonguided microsurgery using two different retrograde filling material (Well root putty, MTA) by…
- Trial name
- NCT07184151
- Testing
- well root putty ( premixed bioceramic putty) retrograde filling, MTA retrograde filling
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Suez Canal University
Periodontal Diseases, Periodontal Bone Loss
Entire Papilla Preservation Technique in the Treatment of Periodontal IntraBony Defects: a 1-year Follow-up Study
The aim of this study was to investigate the radiographic and clinical outcomes associated with the whole papilla preservation technique in the treatment of isolated intraosseous defects in patients with stage III periodontitis.
- Trial name
- EPP (NCT06744348)
- Testing
- ENTİRE PAPİLLA PRESERVATİON
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Early Rectal Cancer, Large Rectal Adenomas
Endoscopic Submucosal Dissection Versus Transanal Endoscopic Microsurgery For Early Rectal Neoplasms And Large Rectal Adenomas: Сomparison Of Treatment Efficacy And Safety.
Transanal endoscopic microsurgery is the main treatment option for rectal tumors such as large adenoma, early cancer because of lower complications and mortality rates and shorter hospital stays rather than conventional surgery.
- Trial name
- NCT03718351
- Testing
- transanal endoscopic microsurgery, endoscopic submucosal dissection
- Where
- Russia
- Volunteers
- 236 people
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Laryngeal Disease
Randomized Controlled Trial:High-flow Oxygen Therapy and Tracheal Intubation for Laryngeal Microsurgery
Over time, the accumulation of carbon dioxide reduces the pressure gradient for the alveolar transfer of oxygen, limiting the successful duration of apneic oxygenation.
- Trial name
- NIRS_ORL (NCT05400642)
- Testing
- THRIVE, mechanical ventilation
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Free Tissue Flaps
Detection of Flap Ischemia Using Interstitial Glucose Monitor
A simple device that objectively assesses flap perfusion - either as a stand-alone tool or an adjunct to the current monitoring method - would be a tremendous improvement in detection of early postoperative flap ischemia and, in…
- Trial name
- NCT02604069
- Testing
- Continuous Glucose Monitor
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
LOCALLY ADVANCED RECTAL CANCER
Organ Preservation in Locally Advanced Rectal Cancer
PRONAR trial aims to assess if treatment with organ preservation in stage II and III rectal cancer after a complete or almost complete response to neoadjuvant treatment is feasible and safe in our environment.
- Trial name
- PRONAR (NCT03064646)
- Testing
- Organ Preservation
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
Post-operative Pain, Complications
Study of Unsutured Versus Sutured Closure of Rectal Defects After Rectal Lesion Excisions Using Transanal Endoscopic Microsurgery
Transanal Endoscopic Microsurgery (TEM) is a minimally invasive technique used to remove rectal tumours. After the tumour has been removed from the rectum, the surgeon has a choice to close the defect or leave the defect open and…
- Trial name
- NCT01465945
- Testing
- Defect Unsutured, Defect Sutured
- Where
- 3 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Dr. Carl J Brown