Clinical trials: Microcirculatory Dysfunction
Burns, Trauma
Microcirculatory Assessment in Patients With Trauma and Severe Burns
Predict the development of multiple organ failure in patients with trauma and severe burns.
- Trial name
- NCT01922960
- Testing
- micro-imaging
- Where
- United States
- Sponsor
- University of South Alabama
Septic Shock
Modulation of Endothelial Dysfonction Using Vitamin C in Septic Shock Patients
Compare the microcirculatory reactivity before and after a 30-minute intravenous infusion of 40 mg/kg vitamin C and evaluate intra-individual variation of hemodynamic parameters between T0 and T1.
- Trial name
- MYTHICCS (NCT04778605)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sepsis, Multiple Organ Failure
Microcirculatory Alteration and Biomarkers: New Approach for Early Assessment of Septic Multi-organ Dysfunction
The aim of this study is to investigate associations between early structural cellular injury and microvascular alteration with progression of septic organ dysfunction according to total SOFA-Score (an ICU-scoring system - the…
- Trial name
- NCT02426645
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Prof. Dr. Marc-H. Dahlke, Ph. D.
Coronary Microvascular Dysfunction (CMD), Microplastic Exposure
Micro-nanoplastic Exposure and Coronary Microcirculatory Dysfunction as Well as Cardiovascular Outcomes
With strict quality control procedures applied throughout microplastic testing, this study will assess the association between baseline circulating micro-nanoplastic exposure and coronary microvascular dysfunction, as well as…
- Conditions
- Coronary Microvascular Dysfunction (CMD), Microplastic Exposure, Nanoplastics, MACE
- Trial name
- NCT07748767
- Testing
- micro-nanoplastic examination, Microvascular Function Examination
- Volunteers
- 184 people
- Sponsor
- Beijing Anzhen Hospital
Stable Angina
Comparison of the Vasomotor Function and Myocardial Flow in Patients Treated With Bioresorbable and Metallic Stents at 1 Year
Background: A total of 25-50% of patients with stable coronary atherosclerosis treated with metallic stent implantation remain with effort angina despite optimal medical treatment and absence of stent restenosis at 1 year.
- Trial name
- BVS-Flow (NCT02738658)
- Testing
- Bioresorbable vascular scaffold, Everolimus-eluting stent
- Where
- 3 sites in Spain
- Volunteers
- 70 people
- Sponsor
- Institut d'Investigació Biomèdica de Bellvitge
Septic Shock
Assessing the Efficacy of Dapagliflozin as a Vasculoprotective Treatment in Septic Shock Patients With Microcirculatory Dysfunction
Microcirculatory dysfunction is a key driver of organ failure and mortality in septic shock, characterized by endothelial injury and impaired vasoregulation.
- Trial name
- GLIFLOSHOCK (NCT07488689)
- Testing
- Dapaglifozin
- Where
- France
- Volunteers
- 568 people
- Sponsor
- University Hospital, Strasbourg, France
Sepsis, Septic Shock
Cardiovascular Phenotypes in Sepsis
This prospective observational study will investigate cardiovascular phenotypes in adults with sepsis and hemodynamic instability.
- Conditions
- Sepsis, Septic Shock, Cardiovascular Dysfunction, Microcirculatory Dysfunction
- Trial name
- CaPS (NCT07442032)
- Volunteers
- 400 people
- Sponsor
- Karolinska Institutet
Ischemic Heart Disease, Microvascular Coronary Artery Disease
The Cerebral-Coronary Connection (C3) Study
This is a prospective cohort blinded study with the aim to investigate the prevalence and clinical impact of coronary microcirculatory dysfunction (CMD) in patients with ischemic heart disease, and its association with cerebral…
- Conditions
- Ischemic Heart Disease, Microvascular Coronary Artery Disease, Depression, Endothelial Dysfunction
- Trial name
- C3 (NCT04131075)
- Testing
- Coronary Angiography and Multimodal Coronary Physiology Study (FFR, CFR, HMR)
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Instituto de Salud Carlos III
Sepsis, Myocardial Injury
COronary Microcirculation and Troponin Elevation in Septic Shock
Plasma cardiac troponin (cTn) elevation is an indicator of increased mortality in patients with sepsis yet the underlying cause of troponin elevation in sepsis is not known.
- Conditions
- Sepsis, Myocardial Injury, Coronary Microvascular Dysfunction, Endothelial Dysfunction
- Trial name
- COMTESS (NCT06294730)
- Where
- Sweden
- Volunteers
- 62 people
- Sponsor
- Karolinska Institutet
Septic Shock, Microcirculatory Dysfunction
Papaverine and Sublingual Microcirculation in Septic Shock
This is a prospective, multicenter, single-arm, open-label, pilot physiological study designed to evaluate the effects of intravenous papaverine on sublingual microcirculation and the vascular waterfall phenomenon in adult…
- Conditions
- Septic Shock, Microcirculatory Dysfunction, Sublingual Microcirculation, Hemodynamic Instability
- Trial name
- NCT07657741
- Testing
- Papaverine
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Coronary Artery Disease, Microcirculation Resistance
COronoary Microcirculation Analysis NETwork
COMA.NET (Coronary Microcirculation Analysis Network) is a prospective, randomized, open-label, parallel-group clinical trial designed to determine whether endotype-guided pharmacotherapy is superior to standard care in improving…
- Conditions
- Coronary Artery Disease, Microcirculation Resistance, Microcirculation; Biomarkers; Myocardial Ischemia, Microcirculatory Dysfunction
- Trial name
- COMA-NET (NCT07498231)
- Testing
- Coronary microvascular function assessment
- Where
- Poland
- Volunteers
- 180 people
- Sponsor
- Medical University of Bialystok
Bypass Complications
Transcutaneous-Arterial Carbon Dioxide and Microcirculatory Dysfunction
Evaluation of the microcirculation is currently limited. Continual assessment of the tissue carbon dioxide-arterial carbon dioxide (PtC02-aCO2) offers a new, novel and noninvasive method of determining the state of the…
- Trial name
- NCT02328846
- Sponsor
- University of Virginia
Acute Coronary Syndrome
Index of Microcirculatory Resistance After Drug-Eluting Stent Implantation With High Dose Atorvastatin Loading
Pre-treatment with statins decreased the incidence of cardiac enzyme increase after percutaneous coronary intervention (PCI) and distal embolization suspected to cause post-PCI myocardial damage.
- Trial name
- RESIST-ACS (NCT01491256)
- Testing
- Pre-procedural High dose atorvastatin loading, No pre-procedural high-dose atorvastatin loading
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- The Korean Society of Circulation
Ischemic Heart Disease, Microvascular Coronary Artery Disease
Prognostic Impact of Cardiac Diastolic Function and Coronary Microvascular Function
The DIAST-CMD registry (Prognostic Impact of Cardiac Diastolic Function and Coronary Microvascular Function) is prospective registry which enrolled patients who underwent echocardiography, cnically-indicated invasive coronary…
- Conditions
- Ischemic Heart Disease, Microvascular Coronary Artery Disease, Diastolic Dysfunction, Heart Failure With Preserved Ejection Fraction
- Trial name
- DIAST-CMD (NCT05058833)
- Testing
- Echocardiography, Coronary flow reserve and index of microcirculatory dysfunction
- Where
- 4 sites in United States, South Korea
- Volunteers
- 800 people
- Sponsor
- Samsung Medical Center
Coronary Arterial Disease (CAD), Coronary Microvascular Dysfunction (CMD)
Prognostic Values of Coronary Microvascular Dysfunction Patients Treated with Rotational Atherectomy During Percutaneous Coronary Intervention
The goal of this observational study is to learn about the long-term prognostic of coronary microvascular dysfuction in Patients Treated with Rotational Atherectomy During Percutaneous Coronary Intervention.
- Trial name
- NCT06702748
- Where
- China
- Volunteers
- 452 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Coronary Artery Disease, Ischemia and No Obstructive Coronary Arteries
Coronary Microcirculatory Disease and Inflammation in Patients With Chronic Coronary Syndrome and no Significant Coronary Artery Stenosis
Patients with chronic coronary syndromes (CCS) diagnosed without significant lesions in invasive coronary angiography (ischemia non-obstructive coronary artery disease - INOCA) represent approximately 50% of all patients with…
- Conditions
- Coronary Artery Disease, Ischemia and No Obstructive Coronary Arteries, Ischemic Heart Disease, Microvascular Angina
- Trial name
- MOSAIC-COR (NCT05313919)
- Testing
- Comprehensive functional diagnostics of coronary circulation
- Where
- Poland
- Volunteers
- 160 people
- Sponsor
- Bartlomiej Guzik
Coronary Artery Disease, Myocardial Ischemia
Primary FIbrinolysis and Secondary STenting Versus immEdiate Stenting in ST-segment Elevation Myocardial Infarction
This prospective, multicenter, randomized, controlled, open-label clinical study has a target enrollment of 240 subjects. It will explore whether STEMI patients transferred to a PCI center following thrombolytic therapy and…
- Conditions
- Coronary Artery Disease, Myocardial Ischemia, Acute Coronary Syndrome, Heart Diseases
- Trial name
- FISSTEMI (NCT04663932)
- Testing
- immediate stenting group(one-step strategy), deferred stenting group (two-step strategy)
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Harbin Medical University
Coronary Microvascular Dysfunction (CMD), Angina Pectoris With Normal Coronary Arteriogram
Endothelin Role In COronary Microcirculation
Coronary microvascular dysfunction is an important cause of angina in patients who do not have significant blockages in the major coronary arteries.
- Conditions
- Coronary Microvascular Dysfunction (CMD), Angina Pectoris With Normal Coronary Arteriogram, Microvascular Angina
- Trial name
- ERICOM (NCT07670091)
- Testing
- Cardiac MRI, Invasive Coronary Angiogram, Endothelin Receptor Antagonist
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Septic Shock
Assessment of Microcirculatory Dysfunction in Septic Shock Patients by OCTA
Purpose and rationale: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis and septic shock are major public health problems killing one in every three patients.
- Trial name
- SshOCTA (NCT04593212)
- Testing
- Optical Coherence Tomography Angiography
- Where
- Portugal
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hospital da Luz, Portugal
Cardiac Amyloidosis
Physiologic Assessment of Microvascular Function in Patients With Cardiac Amyloidosis
The aim of the study is to evaluate coronary flow reserve (CFR), index of microcirculatory resistance (IMR), and proportion of overt microvascular disease, defined as depressed CFR as well as elevated IMR in patients with cardiac…
- Trial name
- NCT02798705
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Samsung Medical Center