Clinical trials: Microcirculation Resistance
High Blood Pressure
Microcirculation and Inflammatory Markers in Patients With Resistant, Stages 1/2 Hypertension and Normal Blood Pressure
Nailfold videocapillaroscopy (NVC), Venous occlusion Plethysmography (VOP) and inflammatory biomarkers have been used to study endothelial function in patients with resistant hypertension, stages 1 and 2 hypertension and…
- Trial name
- MICRORAH (NCT02759276)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Daniel Alexandre Bottino
Spinal Cord Injury, Insulin Resistance
IR and Microvascular Blood Flow in SCI
Persons with spinal cord injury (SCI) are at an increased risk for metabolic disorders, including that of insulin resistance. As a result of neurological injury, they often have impaired mechanisms that regulate blood vessel…
- Trial name
- NCT02034331
- Testing
- Insulin iontophoresis, Acetylcholine Iontophoresis, Heat application
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Hypertension
Neural Mechanism of Aldosterone-induced Insulin Resistance
Patients with high aldosterone hormone have higher blood glucose than normal people. This study is being done to understand how aldosterone hormone affects the nerve activity that controls blood flow in the muscles and blood…
- Trial name
- NCT02102243
- Testing
- DEFINITY® infusion, Human Recombinant Regular Insulin infusion, Dextrose infusion
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wanpen Vongpatanasin
Insulin Resistance, Obesity
Tea-beetroot-venous Occlusion Plethysmography
In the present study, muscle perfusion will be studied before and after an oral glucose challenge following a fasting period.
- Trial name
- NCT01746329
- Testing
- Tea, Beet root
- Where
- Netherlands
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Unilever R&D
Coronary Arterial Disease (CAD), Angina (Stable)
Effect of Beta-blockers on Coronary Flow and Resistance in Patients With ANOCA
The goal of this clinical trial is to learn whether beta-blockers can improve coronary blood flow and reduce resistance in patients with angina and no obstructive coronary arteries (ANOCA).
- Conditions
- Coronary Arterial Disease (CAD), Angina (Stable), Microvascular Circulation
- Trial name
- BEACON (NCT06864234)
- Testing
- Saline (NaCl), Metoprolol Tartrate
- Where
- Belgium
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- VZW Cardiovascular Research Center Aalst
Metabolic Syndrome
NWT03 and Arterial Stiffness
Rationale: Subjects with the metabolic syndrome have an increased risk of developing cardiovascular disease and a twofold risk of developing hypertension.
- Trial name
- NCT02561663
- Testing
- NWT-03, an egg-white protein hydrolysate
- Where
- Netherlands
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Newtricious R&D BV
Hypertension, Obesity
Microvascular Dilatation After Endogenous Induced Hyperinsulinemia
In this study we will examine if the insulin-induced microvascular effects will occur after a physiological stimulus (i.e. a oral glucose tolerance test).
- Trial name
- NCT00742456
- Testing
- Glucose solution
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Insulin Resistance
The Effect of Tea on Vascular Function and Insulin Sensitivity
The aim of this research is to explore changes in peripheral/cerebrovascular function and insulin sensitivity after a 7-day combination of physical activity reduction (-50% steps per day) and overfeeding (+50% kcal per day…
- Trial name
- NCT02777853
- Testing
- Green tea
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Insulin Sensitivity, Microcirculation
Role of Angiotensin II in Insulin-induced Microvascular Activity
In this study we hypothesize infusion of Angiotensin II improves the insulin-induced microvascular dilatation and therefore insulin-mediated glucose uptake.
- Trial name
- NCT01024543
- Testing
- Angiotensin II, Phenylephrine
- Where
- Netherlands
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Hypertension, Insulin Resistance
Role of AT1-receptor Blockers in Insulin-induced Vasodilation.
In this study we hypothesize that blocking the angiotensin II AT1-receptor improves the insulin-induced microvascular dilatation. Objectives: 1.
- Conditions
- Hypertension, Insulin Resistance, Microcirculation
- Trial name
- NCT00742066
- Testing
- Irbesartan, Felodipine
- Where
- Netherlands
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Insulin Resistance, Type 2 Diabetes
Microvascular Dysfunction and the Development of Whole-body Insulin Resistance
This study aims to elucidate the role of the microcirculation in the development of whole body insulin resistance. The investigators hypothesize that impaired insulin signaling in the vasculature is an early phenomenon in the…
- Conditions
- Insulin Resistance, Type 2 Diabetes, Obesity
- Trial name
- DESIRE (NCT02628301)
- Testing
- Hypercaloric diet, Normocaloric diet
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Old Age (Focus; Not a Recognized Condition)
Dysfunction of Nutritive Blood Flow as a Determinant of Anabolic Resistance With Age; the Role of Amino Acids in Modulating Muscle Metabolism
The investigators plan to measure changes in muscle protein metabolism in response to feeding, comparing between a single large essential amino acid (EAA) feed (the normal building blocks of protein) and the provision of the same…
- Trial name
- Ajinomoto1A (NCT01735539)
- Testing
- 15g EAA bolus, 4 x 3.75g Mixed EAA Pulses, 15g EAA Bolus supplemented with 3g Arginine
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Insulin Resistance, Microvascular Disease
The Vascular Effects of Vildagliptin in Insulin Resistant Individuals
Animal models have demonstrated that incretins have a glucose-independent effect on vascular perfusion, and there is limited evidence that incretins may enhance endothelial function in healthy subjects.
- Trial name
- NCT01122641
- Testing
- Vildagliptin
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust