Clinical trials: Microcirculation
Diabetic Retinopathy, GLP-1
Assessment of Retinal-Angio Findings In Patients With Diabetes Type II Treated With Novel Antidiabetic Therapies
ARIADNE is a prospective observational cohort study of patients with type 2 diabetes mellitus (T2DM) treated with daily metformin and scheduled to initiate treatment with newer antidiabetic agents, such as sodium-glucose…
- Conditions
- Diabetic Retinopathy, GLP-1, SGLT 2 Inhibitors, Endothelial Dysfunction
- Trial name
- ARIADNE (NCT07602348)
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- University of Athens
Microcirculation, Intensive Care
Very Old Intensive Care Patients - Perfusion
Shock is a frequent, etiologically heterogeneous and often lethal clinical condition of intensive care medicine. This is particularly true for very old intensive care patients (VIPs), who are among the fastest-growing subgroups…
- Conditions
- Microcirculation, Intensive Care, Very Old Intensive Care Patients
- Trial name
- VIPPER (NCT04169204)
- Testing
- Measurement of microcirculation
- Where
- Germany
- Volunteers
- 47 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Pregnancy, Microcirculation
Parturient Microcirculation
This is an observational study comparing microcirculation of pregnant to non-pregnant women. "Microcirculation" means blood flow to the extremely small blood vessels in one's body.
- Trial name
- NCT01491685
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- IWK Health Centre
Aneurysmal Subarachnoid Haemorrhage
Prediction of Delayed Cerebral Ischemia After Subarachnoid Hemorrhage Using Dynamic 18F-FDG PET/CT
A pilot trial for assessing early microvascular alterations after aneurysmal subarachnoid hemorrhage using dynamic 18F-FDG PET/CT.
- Trial name
- PREDISP (NCT04356599)
- Testing
- Early dynamic 18F-FDG PET/CT assessment of cerebral glucose uptake
- Where
- France
- Volunteers
- 35 people
- Sponsor
- University Hospital, Montpellier
Microcirculation, Intensive Care
Direct Assessment of Microcirculation In Shock (DAMIS)
Maintaining organ perfusion is the key to successful intensive care medicine. Shock is the most dangerous microcirculatory disorder and one of the most hazardous and lethal conditions of critically ill patients still showing high…
- Conditions
- Microcirculation, Intensive Care, Shock
- Trial name
- NCT04173221
- Testing
- Sublingual SDF-Measurement with communication and interpreting checklist to the treating physician, Sublingual SDF-Measurement without communication and interpreting checklist to the treating physician
- Where
- 5 sites in Germany
- Volunteers
- 141 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Microcirculation
Evaluation of Different Priming Solutions Effects on Microcirculation, Oxidative Stress and Morbidity in Cardiovascular Surgery Patients
Single-centre prospective randomized study will be included the patients who undergo elective cardiovascular surgery. Preoperative fluid deficit will be calculated by the formula as starvation period X 4 X weight.
- Trial name
- Acibadem (NCT02501681)
- Testing
- priming solution during cardiovascular surgery
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Frisius Medisch Centrum
Healthy
Healthy Volunteer Study to Assess Microcirculatory Function
The aim of the study is to obtain microvascular data from a healthy, heterogeneous population for assessing reference values for the parameters Functional Capillary Density (FCD), heterogeneity of FCD, Microvascular Oxygen…
- Trial name
- NCT05608798
- Testing
- ODI-Tech medical device
- Where
- Norway
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- ODI Medical AS
Altitude Hypoxia, Perfusion; Complications
The Pre-acclimatization Augmented Extreme Altitude Expedition
The aim of this study is to investigate the effect of pre-acclimatization in a nitrogen tent at home, ventilated with a slightly increased nitrogen percentage, in preparation for an expedition at extreme altitude.
- Trial name
- PRAGMAX (NCT05517044)
- Testing
- Nitrogen tent preacclimatization to high altitude
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Healthy Volunteers
VISUALIZATION OF THE MICROCIRCULATION IN WEIGHTLESSNESS
During weightlessness, the cardiovascular system is subject to rapid changes which has been demonstrated in studies of short term (Space Shuttle) and long term missions to Skylab, MIR, and the International Space Station…
- Trial name
- µGµScan (NCT03561545)
- Testing
- weightlessness (parabolic flight)
- Where
- France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
A Stabilized Definitive Prosthesis (Procedure 1), Definitive Prosthesis With a Contact Socket (Procedure 1)
Contribution of Near-InfraRed Spectroscopy (NIRS) to the Evaluation of Healing After Amputation of the Leg
50 patients will be included for each of the 2 procedures: For procedure 1: Patients will be selected during multidisciplinary consultations for amputees who are stabilized with their definitive prosthesis and have returned to…
- Conditions
- A Stabilized Definitive Prosthesis (Procedure 1), Definitive Prosthesis With a Contact Socket (Procedure 1), Patients in the Initial Phase (Temporary Prosthesis, Rehabilitation) Following Unilateral Post- Transtibial Amputation (Procedure 2)
- Trial name
- NIRS (NCT02551484)
- Testing
- Measurements using NIRS, TCPO2 measurements, 2-minute walk test
- Where
- France
- Volunteers
- 62 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Severe Sepsis, Septic Shock
Microcirculatory Changes During Magnesium Sulphate Infusion in Sepsis
During infections (sepsis) bloodflow in small vessels (microcirculation) becomes disturbed. Restoration of bloodpressure and cardiac performance may not be sufficient to correct these alterations.
- Trial name
- NCT01332734
- Testing
- Magnesium Sulfate
- Where
- Lithuania
- Volunteers
- 14 people
- Sponsor
- Frisius Medisch Centrum
Old Age (Focus; Not a Recognized Condition)
Dysfunction of Nutritive Blood Flow as a Determinant of Anabolic Resistance With Age; the Role of Amino Acids in Modulating Muscle Metabolism
The investigators plan to measure changes in muscle protein metabolism in response to feeding, comparing between a single large essential amino acid (EAA) feed (the normal building blocks of protein) and the provision of the same…
- Trial name
- Ajinomoto1A (NCT01735539)
- Testing
- 15g EAA bolus, 4 x 3.75g Mixed EAA Pulses, 15g EAA Bolus supplemented with 3g Arginine
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Healthy Volunteers
Mechanisms of Human Cutaneous Microcirculation in Healthy Volunteers
Microvascular dysfunctions are critical events in several diseases including diabetes. This study will develop a methodology for microvascular investigation in human skin.
- Trial name
- NCT00152724
- Testing
- pressure strain system, iontophoresis, scopolamin, emla
- Where
- France
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Type 1 Diabetes Mellitus, Dyslipidemia
Treatment Effects of Atorvastatin on Hemostasis and Skin Microcirculation in Patients With Type 1 Diabetes
Patients with type 1 diabetes are at increased risk of vascular complications both in the micro- and macrocirculation. Hyperglycemia plays a major role in the development of these vascular complications, but other factors such…
- Trial name
- NCT01497912
- Testing
- Atorvastatin
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Karolinska Institutet
End-stage Renal Disease
The Microcirculation, Dialysis Modality and Sequestered Salt
The aim of this clinical trial is to investigate the effect of 5 different dialysis treatments (combinations of dialysis mode and dialysis fluid sodium content) on the microcirculation (MC) and sequestered sodium content (SSC) in…
- Trial name
- MIMOSA (NCT06327750)
- Testing
- Hemodialysis (DNa = PNa), Hemodialysis (DNa<PNa), Hemodialysis after isolated ultrafiltration (DNa=PNa)
- Where
- 2 sites in Netherlands
- Volunteers
- 23 people
- Sponsor
- Amsterdam UMC, location VUmc
STEMI
Effect of rhBNP on CMD in Patients With STEMI After PPCI
The target population of this interventional study was STEMI patients. Primary discussion: Early rhBNP reduces microcirculation obstruction in STEMI patients undergoing primary PCI
- Trial name
- NCT05723315
- Testing
- recombinant human B-type natriuretic peptide
- Volunteers
- 160 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
Heart Failure, Respiratory Failure
Microcirculation in Venoarterial Extracorporeal Membrane Oxygenation Life Support
Extra-corporeal membrane oxygenation (ECMO) life support system can provide both cardiac and respiratory support to patients with heart and respiratory failure.
- Trial name
- NCT02393274
- Testing
- Extra-corporeal membrane oxygenation life support
- Where
- Taiwan
- Volunteers
- 48 people
- Sponsor
- National Taiwan University Hospital
Breast Reconstruction, Radiation Dermatitis
Ultrasonic Perfusion Imaging in Post-mastectomy Irradiated Patients
The purpose of this study is to evaluate post-mastectomy breast skin blood supply (perfusion) after radiation therapy, and before and after fat grafting to the breast(s).
- Conditions
- Breast Reconstruction, Radiation Dermatitis, Radiation Fibrosis, Fat Grafting
- Trial name
- NCT04992650
- Testing
- Fat grafting
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Mayo Clinic
Systemic Sclerosis, Raynaud's Phenomenon
The Effects of Exercise in Patients With Systemic Sclerosis
Systemic sclerosis (SSc) is a multisystem connective tissue disease characterised by vascular abnormalities and fibrosis, including those of the skin and can be categorised as either Limited cutaneous scleroderma or Diffuse…
- Conditions
- Systemic Sclerosis, Raynaud's Phenomenon, Quality of Life
- Trial name
- NCT03058887
- Testing
- Exercise intervention - Cycling, Exercise intervention - arm cranking
- Where
- 2 sites in United Kingdom
- Volunteers
- 36 people
- Sponsor
- Sheffield Hallam University
Microcirculation, Coronary Artery Disease
The Cerebral Microcirculation Diseases and Coronary Microcirculation Disease Study
Ischaemic heart disease (IHD) and degenerative brain disease are two major sources of death and disability affecting all countries.
- Conditions
- Microcirculation, Coronary Artery Disease, Cerebrovascular Circulation
- Trial name
- CCMD (NCT06368635)
- Testing
- Coronary angiography
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Weijing Wang