Clinical trials: Microcirculation
Arterial Hypertension, Diabetes Mellitus Type 2 IRC or NIR
Effect of the Known Antihypertensive Drug Telmisartan on Red Blood Cells and Circulation in the Smallest Blood Vessels
The hypothesis of the presented study is: Telmisartan induces an increase of eNOS activity in RBC resulting in an enhanced intravascular NO bioavailability, an ameliorated RBC deformability and a reduction of RBC and platelet…
- Trial name
- ITEM (NCT00559286)
- Testing
- Telmisartan
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- RWTH Aachen University
Cerebral Small Vessel Diseases, Ischemic Stroke
A Registry Study of Microcirculation Disorder After Cerebral Small Vessel Disease and Ischemic Stroke
This study aims to construct a registry platform for microcirculatory disorders in a large sample of Chinese patients with cerebral small vessel disease and ischemic stroke; To explore the role of microcirculatory disorders in…
- Trial name
- MODEST (NCT06077305)
- Where
- China
- Volunteers
- 20,000 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke, Reperfusion
Cilostazol Dexborneol Versus Placebo for Microcirculation Dysfunction After Reperfusion Therapy in Patients With Acute Ischemic Stroke With Large Vessel Occlusion
This study aims to evaluate the efficacy of Y-6 sublingual tablets in improving microcirculation dysfunction and reducing thrombo-inflammation in patients who had AIS caused by LVO and received reperfusion therapy.
- Conditions
- Acute Ischemic Stroke, Reperfusion, Large Vessel Occlusion
- Trial name
- CRYSTAL (NCT05836766)
- Testing
- Y-6 sublingual tablets
- Where
- 3 sites in China
- Volunteers
- 120 people
- Sponsor
- Beijing Tiantan Hospital
Cardiovascular Diseases, Heart Diseases
Racial Differences in the Coronary Microcirculation
To study mechanisms of excess coronary ischemia secondary to alterations in autoregulation and arteriolar vasoreactivity in Black Americans with hypertension, varying degree of left ventricular hypertrophy, and angiographically…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Hypertension
- Trial name
- NCT00005373
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Patients Undergoing Open Resection of Colorectal Tumours
Vascular Changes During Colorectal Surgery
The purpose of this study is to investigate whether increases in the blood flow from the heart (the cardiac output), induced by the administration of intravenous fluids, lead to an increase in the blood flow to the vital organs…
- Trial name
- MaMiFlo (NCT02136277)
- Testing
- Hartmann's solution
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- University of Nottingham
Renal Dialysis, Integrative Medicine
Integrative HD Vascular Access Assessment
The aim of this two-year study is to explore the relationship among function of HVA, nail-fold capillaries and TCM constitutions based on hybridizing data mining techniques.
- Conditions
- Renal Dialysis, Integrative Medicine, Hemodialysis Access Failure
- Trial name
- NCT03140345
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taipei University of Nursing and Health Sciences
Osteoporosis, Multiple Myeloma
Investigation of Bone Defects and Microcirculation With Computed Tomography and Magnetic Resonance Imaging
Subject of the proposed study is the non-invasive in vivo imaging of bone, bone marrow and localized microcirculation in test animals with osteoporosis, fractures and after placement of bone substitute material with volume…
- Conditions
- Osteoporosis, Multiple Myeloma, Vertebral Fracture
- Trial name
- NCT01374412
- Where
- Germany
- Volunteers
- 144 people
- Sponsor
- German Cancer Research Center
Cardiac Disorder
Microcirculation in Cardiac Surgery
The purpose of this study is to determine whether cardiopulmonary bypass affects mesenteric microcirculatory function, using sublingual evaluation, in cardiac surgery.
- Trial name
- MICROCARD (NCT01330745)
- Testing
- sublingual microcirculatory evaluation
- Where
- France
- Volunteers
- 21 people
- Sponsor
- University Hospital, Rouen
Left Ventricular Dysfunction
Cardiac Function and Microcirculation: Type 2 DIABetes and ECHOcardiographic Changes Over Time
The purpose of this study was to investigate the influence of micro- and macrovascular changes on the cardiac function in relation to left ventricular function and coronary arteries during one year in patients with type 2…
- Trial name
- DIABECHO (NCT02956577)
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- Svendborg Hospital
Vascular Function, Healthy
Effects of Sodium Chloride or Its Substitute Salt Potassium Chloride on Vascular Function
This is a prospective, monocentric, randomized trial to investigate how sodium chloride or its substitute potassium chloride acutely affects vascular function by ingestion via a salted soup.
- Conditions
- Vascular Function, Healthy, Diabetes
- Trial name
- ESCAPE-SALT (NCT05970601)
- Testing
- Soup
- Where
- Germany
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Prof. Dr. med. Johannes Stegbauer
Burn Injury, Acute Wound
Cutaneous Microcirculation After Plasma Therapy
In plastic and reconstructive surgery, treatment strategies of second-degree burns, superficial wounds, burn scars, flaps and chronic wounds aim at reducing infection and improving microcirculation.
- Conditions
- Burn Injury, Acute Wound, Chronic Wound, Burn Scar
- Trial name
- NCT02417818
- Testing
- Plasma Therapy (PlasmaDerm), Repetitive Plasma Therapy (repetitive PlasmaDerm)
- Where
- Germany
- Volunteers
- 240 people
- Sponsor
- University Hospital Schleswig-Holstein
Septic Shock
Effects of Dexmedetomidine vs Midazolam on Microcirculation in Septic Shock Patients
To investigate changes in the concentration of glucose, lactate, pyruvate and glycerol in the extracellular fluid of the skeletal muscle following Dexmedetomidine administration in patients with septic shock.
- Trial name
- NCT03434691
- Testing
- Microdialysis Probe (Muscle microdialysis), remifentanyl
- Where
- 2 sites in Tunisia
- Volunteers
- 40 people
- Sponsor
- Military Hospital of Tunis
Physiology of Microvascular Skin
Microvascular Function Assessment in Healthy Subjects
Current stimulation induces microvascular dilation in human skin. The investigators aimed to study (1) whether the current vasodilation is amplified after two segmental current stimulation as compared to one stimulation; (2)…
- Trial name
- MICROTEC (NCT01572961)
- Testing
- acetylsalicilic acids (Aspirin)
- Where
- France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Acute Kidney Injury, Renal Artery Blood Flow
Characteristics of Renal Blood Flow in AKI Patients in ICU and Its Clinical Significance
To study the changes in the renal artery and renal vein with renal cortical and medullary microcirculatory blood flow in patients with sepsis; to study the relationship between renal arteriolar and renal vein with renal cortical…
- Conditions
- Acute Kidney Injury, Renal Artery Blood Flow, Renal Venous Return, Renal Microcirculation
- Trial name
- NCT06090773
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Peking Union Medical College Hospital
Coronary Microvascular Perfusion in Patients With Ischemic Heart Disease
PGE1 Improves Coronary Microcirculation Dysfunction in Patients With CAD and Diabetes
This study is undertaken to determine if intravenous Lipo-PGE1 therapy would improve coronary microvascular perfusion in patients with ischemic heart disease by CMRI.
- Trial name
- NCT03159559
- Testing
- Lipo-PGE1
- Volunteers
- 60 people
- Sponsor
- Tongji Hospital
Hypertension,Essential
Peripheral Vascular Effects of Sulfhydryl-containing Antihypertensive Pharmacotherapy on Microvessels in Humans
High blood pressure can cause physical changes to the blood vessels of the body (remodeling). If a person who has high blood pressure also has a lot of blood vessel remodeling with their condition, they are more likely to have…
- Trial name
- H2SPharm (NCT03179163)
- Testing
- Captopril Pill, Enalapril Pill, Hydrochlorothiazide
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Penn State University
Sepsis, ARDS
Microcirculation and Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit
As medicine advances, many lives can be saved in the intensive care unit. However, when multiple organ failure occurs, the mortality rate of patients increases dramatically.
- Conditions
- Sepsis, ARDS, Liver Failure, Renal Failure
- Trial name
- NCT00808691
- Testing
- Critical care
- Where
- Taiwan
- Volunteers
- 124 people
- Sponsor
- National Taiwan University Hospital
Kidney Transplant, Microcirculation
Effects of Dexmedetomidine on Microcirculation and Residual Kidney Function in Kidney Donors
Kidney transplant can help patients with end-stage kidney disease to get rid of dialysis and have a good quality life. However, during the renal donation operation, the stress response and subsequent inflammatory responses may…
- Trial name
- NCT04346290
- Testing
- Dexmedetomidine
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Diabetes Mellitus, Type 2
PRotective Effect on the Coronary Microcirculation of Patients With DIabetes by Clopidogrel or Ticagrelor
The purpose of this study is to determine whether Ticagrelor has a protective effect on microcirculation during percutaneous coronary interventions in patients with Diabetes mellitus type II or in a pre-diabetic status.
- Trial name
- PREDICT (NCT02698618)
- Testing
- Diagnostic, Randomization, PCI
- Where
- 3 sites in Spain
- Volunteers
- 50 people
- Sponsor
- Fundacion Investigacion Interhospitalaria Cardiovascular
Subarachnoid Hemorrhage
Impact of Nimodipine on Sublingual Microcirculation in Patients With Hemorrhage - a Prospective Monocentric Observational Study
Nimodipine can increase Functional Capillary Density (FCD) as a parameter of the sublingual microcirculation in patients with subarachnoid hemorrhage (SAH) compared to patients without nimodipine.
- Trial name
- NCT04311840
- Where
- Czechia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital Hradec Kralove