Clinical trials: Microbiota
Overweight and Obesity
Effect of Diet Supplementation With Amaranth Protein on Mexican Children With Overweight and Obesity
The state of San Luis Potosí comprises several municipalities with diverse environmental conditions, ranging from semi-tropical to very arid zones. Arid zones have a high rate of childhood with obesity.
- Trial name
- AmProtObes (NCT07583043)
- Testing
- AmProt (amaranth protein isolate)
- Where
- Mexico
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Instituto Potosino De Investigacion Cientifica Y Tecnologica AC
Endometriosis, Endometriosis-related Pain
Microbiota and Immunoassay in Women With and Without Endometriosis: a Pilot Study
Endometriosis is an estrogen-dependent chronic inflammatory disease characterized by the presence of endometrial tissue outside the uterine cavity. This pathology has a prevalence of about 5-10% in reproductive-aged women.
- Trial name
- NCT05433909
- Testing
- Blood, fecal, vaginal and endometrial liquid samples
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Chronic Renal Insufficiency
Renal Effects of Meditarranean Diet and Low-protein Diet With Ketoacids on Physiological Intestinal Mibrobiota in CKD
Food intake has a deep influence on gut microbiota composition and function, both in health and in disease status. In chronic kidney disease (CKD), a microbiota dysbiosis status is observed.
- Trial name
- MEDIKA (NCT02302287)
- Testing
- Ketoacids diet, Mediterranean diet, Free diet
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Azienda Sanitaria ASL Avellino 2
Suspected or Confirmed COVID-19
NBT-NM108 as an Early Treatment for Suspected or Confirmed Symptomatic COVID-19 Patients
This open-label, randomized, and controlled clinical trial aims to determine the feasibility and effectiveness of using NBT-NM108, a novel botanical-based fixed-combination drug, to modulate the gut microbiota and treat…
- Trial name
- COVGUT20 (NCT04540406)
- Testing
- NBT-NM108, Usual Care Only
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Notitia Biotechnologies Company
Non-Alcoholic Fatty Liver Disease, Obesity
Influence of the Diversity and Composition of the Microbiota in the Development of Pediatric Fatty Liver
The objectives of the present study are: 1) to identify the intestinal and salivary microbiota associated with the presence and severity of hepatic steatosis in children (Study I: case-control study), and 2) to develop a…
- Conditions
- Non-Alcoholic Fatty Liver Disease, Obesity, Metabolic Syndrome
- Trial name
- MicroKid (NCT04575506)
- Testing
- Multidisciplinary intervention program
- Where
- 2 sites in Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad Pública de Navarra
Constipation, Anorexia
Effectiveness of Bacillus Spore Probiotics in Reducing Constipation, Anorexia, and Slow Weight Gain in Children
Constipation is rising globally and is a health concern in Asia. Prolonged constipation, without proper care, can lead to complications affecting a child's physical and psychological development, causing significant health and…
- Conditions
- Constipation, Anorexia, Weight Gain
- Trial name
- NCT06154525
- Testing
- RO water, LiveSpo Preg-Mom, LiveSpo KIDS
- Where
- Vietnam
- Volunteers
- 201 people
- Sponsor
- Anabio R&D
Irritable Bowel Syndrome
Effect of Antibiotic Pretreatment on the Efficacy of WMT in the Treatment of Irritable Bowel Syndrome
This is a randomized controlled trial to explore the efficacy of antibiotic pretreatment on the efficacy of WMT in the treatment of Irritable bowel syndrome in adults: a multi-center, randomized, placebo-controlled clinical study
- Trial name
- NCT06437041
- Testing
- Ornidazole
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Faming Zhang
Periodontitis
Nd:YAG Laser Effects on Subgingival Microbiota in Stage III-IV Periodontitis
This randomized controlled trial (RCT) aims to evaluate the clinical efficacy of Nd:YAG laser adjunctive therapy and its impact on the subgingival microbiome in patients with stage III-IV periodontitis.
- Trial name
- NCT07061756
- Testing
- SRP, ND
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Rui He
Cystic Fibrosis
Microbiota of the Respiratory Flora in Children With Cystic Fibrosis During the First Year of Life
The goal of this study is characterize the changes in bacterial diversity of the upper respiratory tracts of infants with cystic fibrosis (CF).
- Trial name
- NCT00977158
- Testing
- Throat Swab
- Where
- 2 sites in United States
- Sponsor
- Tufts Medical Center
Functional Gastrointestinal Disorders
Intervention Study Focused on the Intestinal Microbiome to Evaluate the Impact of a Wild Thyme Extract (Thymus Serpyllum) Extract With Anti-inflammatory and Metabolic Properties Against Functional Gastrointestinal Disorders.
Functional gastrointestinal disorders (FGD), now known as disorders of gut-brain interactions (DGBI), are characterized by gastrointestinal symptoms linked to motility issues, visceral sensitivity, intestinal permeability, immune…
- Trial name
- InT-FGD (NCT06639126)
- Testing
- Wild thyme extract
- Where
- Spain
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Fundación Pública Andaluza para la Investigación Biomédica Andalucía Oriental
NAFLD, Obesity
Intermittent Fasting, Mediterranean Diet and NAFLD
This study aims to evaluate the effects of Intermittent Fasting (IF) 14/10 compared with the Low Glycemic Index Mediterranean Diet on NAFLD.
- Conditions
- NAFLD, Obesity, Intermittent Fasting, Mediterranean Diet
- Trial name
- RC2024-21 (NCT06615817)
- Testing
- Intermittent Fasting
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Acute Respiratory Distress Syndrome (ARDS), Acute Lung Injury(ALI)
A Study on the Treatment of Patients With Acute Lung Injury Caused by Sepsis Through Microbiota Transplantation
Sepsis is a systemic inflammatory response syndrome triggered by infection, and it is a common critical illness in clinical practice, often leading to multiple organ dysfunction.
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Acute Lung Injury(ALI), Sepsis Related Acute Lung Injury/Acute Respiratory Distress Syndrome
- Trial name
- NCT07342205
- Testing
- Human-derived active intestinal bacterial liquid group
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Preterm Birth
Preterm Labor Prevention Using Vaginal Antiseptics Prior to 16 Weeks of Gestation
The aim of this prospective observational study was to evaluate the efficacy of a universal strategy of primary prevention of preterm birth using intravaginal chlorhexidine (CLX) applied before 16 weeks.
- Trial name
- PLUVA (NCT05944094)
- Testing
- Clorhexidine
- Where
- Spain
- Volunteers
- 1,117 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Hypertension, Gut -Microbiota
How a Plant-Based Diet Affects Blood Pressure and Gut Health in Kidney Transplant Patient
Kidney transplant improves the quality of life (QoL) and survival of appropriate patients with advanced chronic kidney disease (CKD) and end-stage kidney disease (ESKD).
- Conditions
- Hypertension, Gut -Microbiota, Kidney Function, Quality of Life (QOL)
- Trial name
- PLANET-KT (NCT06871722)
- Testing
- Plant based diet
- Where
- Thailand
- Volunteers
- 102 people
- Sponsor
- Mahidol University
GLP-1, Gut Microbiota
Effects of Sucralose in Gut Intestinal Microbiota and Postprandial GLP-1
Recently, it has been proposed that the consumption of non-nutritive sweeteners, including sucralose, it's not harmless and is related with metabolic effects.
- Conditions
- GLP-1, Gut Microbiota, Insulin Resistance
- Trial name
- NCT06094894
- Testing
- sucralose
- Where
- Mexico
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Microbial Colonization
Preterm Infant Intestinal Microbiota Development and Maternal Fecal Transplant
The goal of this clinical trial is to study if a oral maternal fecal transplant given to a premature infant born by cesarean section (CS) is safe.
- Trial name
- PREFLOR (NCT06227845)
- Testing
- Fecal microbiota transplant
- Where
- Finland
- Volunteers
- 36 people
- Sponsor
- Otto Helve
Prevention & Control
Substantivity of Oral Rinses: Comparative Study
A desirable quality of mouthrinses is substantivity an intrinsic feature of some molecules. Substantivity requires the adsorption of the agent on the oral surfaces and subsequently antimicrobial activity bacteriostatic along…
- Trial name
- SORCOS (NCT05365737)
- Testing
- Oral rinse, Saliva harvest
- Where
- Spain
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Barcelona
Antibiotic-associated Diarrhea
Evaluation of Butyrate Effect on Diarrhea
The goal of this clinical trial is to evaluate the effects of a Food Supplement containing calcium butyrate, vitamin D, and zinc, on the variation of intestinal microbiota and prevention of antibiotic-induced diarrhea, in…
- Trial name
- DBZ (NCT06982703)
- Testing
- Food Supplement DBZ (acronym for: DIBUZIN) containing calcium butyrate, vitamin D and zinc,
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Padova
Intestinal Microbiota Between Different Groups
Study of the Intestinal Microbiota
The intestinal microbiota is the set of numerous microorganisms (between 1012 and 1014 bacteria, viruses, parasites, and non-pathogenic fungi) that live in our digestive tract, mainly in the small intestine and colon.
- Trial name
- NEUROBIOTE (NCT07058961)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Rouen
Head and Neck Cancer
Microbiota-guided Radiotherapy for Head and Neck Cancer
Head and neck cancer (HNC) is the sixth most common cancer worldwide. Therapeutic outcomes for HNC remain unsatisfactory and heterogeneous, with 5-year survival rates ranging from 28% to 67% overall.
- Trial name
- MIGRAHN (NCT07253402)
- Testing
- External beam radiotherapy for head and neck cancer
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano