Clinical trials: Microbiota
COVID-19 Complicated With Refractory Intestinal Infections
Washed Microbiota Transplantation for Patients With 2019-nCoV Infection
Gut dysbiosis co-exists in patients with coronavirus pneumonia. Some of these patients would develop secondary bacterial infections and antibiotic-associated diarrhea (AAD).
- Trial name
- NCT04251767
- Testing
- washed microbiota transplantation
- Where
- China
- Sponsor
- The Second Hospital of Nanjing Medical University
Chronic Pancreatitis, Pancreatic Exocrine Insufficiency
Intestinal Microbiota Composition in Patients With Chronic Pancreatitis and Pancreatic Exocrine Insufficiency
Assessment of qualitative and quantitative composition of the intestinal microbiota in patients with CP; in patients with CP and PEI complication of mild to severe degree; patients with CP and PEI who underwent surgical…
- Trial name
- NCT05132309
- Testing
- enzyme replacement therapy
- Where
- 2 sites in Russia
- Volunteers
- 96 people
- Sponsor
- Federal Research and Clinical Center of Physical-Chemical Medicine
Chronic Pouchitis, Pouchitis
Fecal Microbiota Transplant for Patients With Chronic Pouchitis
The purpose of this research study is to assess the safety and efficacy of fecal microbiota transplant (FMT) in the treatment of chronic pouchitis.
- Trial name
- NCT05829109
- Testing
- Fecal Microbiota Transplant (FMT)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Maia Kayal
Iron Deficiency Anemia in Childbirth
Iron Administration Via Colonic TET Combined With WMT for ID
The colon can absorb iron.We propose an integrated approach utilizing colonic transendoscopic enteral tubing to deliver iron in different valence states, coupled with washed microbiota transplantation .
- Trial name
- NCT06487299
- Testing
- Ferrous Lactate, Iron sucrose, 0.9% NaCl solution
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Preterms With Gestational Age Ranging From 30 to 35 Weeks
Evaluation of Safety, Tolerance and Effects on the Intestinal Flora of a New Fermented Milk for Preterm Infants
The intestinal flora is a complex ecosystem which is known to play various important functions in the gut. Recent data have reported a delay in intestinal colonization in preterm.
- Trial name
- NCT00711633
- Testing
- Milk with probiotic and prebiotic activities, Milk without probiotic and prebiotic activities
- Where
- France
- Volunteers
- 58 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Eating Disorders in Adolescence, Eating Disorders in Children
A Study of the Intestinal Microbiota in Children and Adolescents With Eating Disorders. A Perspective From Psychoneuroimmunology
The goal of this observational study is to learn if behavioral and psychological factors are associated with the intestinal microbiota composition and function in children and adolescents with eating disorders (ED).
- Trial name
- PSYNIGED (NCT07066033)
- Where
- 2 sites in Spain
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Esther Nova
Advanced Gastric Cancer
Fecal Microbiota Transplantation (FMT) in Patients With Advanced Gastric Cancer
This study is a randomized, double-blind and placebo-controlled study. The purpose of this study is to evaluate the efficacy and safety of FMT capsules combined with chemotherapy and anti-PD1/PDL1 therapy in the advanced gastric…
- Trial name
- NCT06346093
- Testing
- Fecal Microbiota Transplantation Capsules
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Changhai Hospital
Irritable Bowel Syndrome, Diarrhea
Fecal Microbiota Transplantation for IBS
The purpose of this study is to learn the efficacy and safety of fecal microbiota transplantation (FMT) using stool from a donor with low proteolytic activity and containing the bacteria Alistipes putredinis in patients with…
- Trial name
- NCT05776914
- Testing
- Donor Fecal Microbiota Transplantation, Autologous Fecal Microbiota Transplantation
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Madhusudan (Madhu) Grover, MBBS
CKD, PAD
lncRNAs as a Biomarker to Assess the Therapeutic Impact of Oral Absorbent ± Probiotics in CKD Patients With PAD
Participants with chronic kidney disease (CKD) are at a higher risk of developing atherosclerotic peripheral artery disease (PAD).
- Trial name
- NCT04788914
- Testing
- Active bamboo charcoal± probiotics
- Where
- Taiwan
- Volunteers
- 180 people
- Sponsor
- National Taiwan University Hospital
Healthy
The Relationship Between Diet, Cognition, Stress, and the Gut Microbiota
This study aims to investigate the relationship between diet and the microbiota-gut-brain axis.
- Trial name
- NMB (NCT05931536)
- Testing
- Dietary fibre
- Where
- Ireland
- Volunteers
- 350 people
- Sponsor
- University College Cork
Gastrointestinal Diseases, Colic
Effect of Lactobacillus Reuteri DSM17938 in Neonates Treated With Antibiotics
The aim of the study is to elucidate the relationship between postnatal antibiotic administration on development of gut microbiota and possible protective influence of simultaneously administration of probiotic during antibiotic…
- Trial name
- NCT02865564
- Testing
- Lactobacillus reuteri DSM 17938, ampicillin and gentamicin
- Where
- Slovenia
- Volunteers
- 98 people
- Sponsor
- University Medical Centre Ljubljana
Preeclampsia
A Novel Multiomic AI Approach for Early Preeclampsia Prediction in Pregnancy
Preeclampsia (PE) is a leading cause of maternal-fetal morbidity and mortality, affecting 3-8% of pregnancies and causing over 76,000 maternal deaths annually.
- Trial name
- PREMEM (NCT06430398)
- Where
- Italy
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Dietary Exposure
Investigation on the Effect of Carnitine Supplement on Gut Microbiota and TMAO Production Capacity
In this project, the investigators aim to explore the impact of dietary L-carnitine supplementation on the TMAO production capacity of gut microbiota.
- Trial name
- NCT02838732
- Testing
- L-carnitine supplementation (500 mg per tablet per day, purchased from GNC company)
- Where
- Taiwan
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Feeding and Eating Disorders of Childhood, Enteral Nutrition Dependence
Gut Microbiota Changes in Children Receiving Exclusive Enteral Nutrition With Compleat® Paediatric
This observational, prospective, single-center study aims to evaluate changes in the fecal microbiota of pediatric patients receiving exclusive enteral nutrition following the introduction of Compleat® Paediatric Nature Mix, an…
- Trial name
- COMPLEAT (NCT07816536)
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Establishment for Children and Adolescents in the Nantes Region
Clostridium Difficile Infections
Safety Registry of a Fecal Microbiota Transplant Cohort
Clostridium difficile infection (CDI) is a major cause of infectious diarrhea and the most important cause of nosocomial diarrhea. Recurrent forms are a major problem with this infection.
- Trial name
- COSMIC-FMT (NCT06311006)
- Where
- France
- Volunteers
- 305 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Pancreatitis
FMT for the Prevention of Infectious Complications in Patients With Moderately Severe and Severe Acute Pancreatitis
The goal of this clinical trial is to learn whether fecal microbiota transplantation (FMT) works to prevent infections complications in patients in the late phase of moderately severe or severe acute pancreatitis.
- Trial name
- NCT07464392
- Testing
- Fecal Microbiota Transplantation
- Where
- 12 sites in China
- Volunteers
- 150 people
- Sponsor
- Changhai Hospital
Ascitic Fluid, Microbiota, Microbiota
Ascitic Fluid Microbiome in Liver Cirrhosis
Ascitic fluid microbiome is going to be investigated in this study by using internal transcripted spacer (ITS) and 16S ribosomal RNA (rRNA) polymerase chain reaction (PCR) and sequencing as conventional culture methods are…
- Conditions
- Ascitic Fluid, Microbiota, Microbiota, Sequence Analysis, Polymerase Chain Reaction
- Trial name
- NCT02813590
- Testing
- Ascitic fluid puncture, Skin swaps from puncture side, Stool samples
- Where
- Austria
- Sponsor
- Medical University of Graz
Microbiota, SIBO
Capillary Endoscopy Aspiration Catheter
The small intestine is an understudied frontier of microbiome research. While aspiration during endoscopy is considered the gold standard to assess small bowel bacteria, the tools for sterile retrieval are primitive and poorly…
- Trial name
- NCT04418258
- Testing
- Capillary Endoscopy Aspiration Catheter, Endoscopy Aspiration Catheter
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Cedars-Sinai Medical Center
Deep Brain Stimulation, Gastrointestinal Microbiome
Deep Brain Stimulation Therapy and Intestinal Microbiota
This study aims to observe the changes of intestinal microbiota after deep brain stimulation (DBS) therapy for Parkinson's disease, and explore the role of intestinal microbiota in the neuroprotective effect of DBS.
- Trial name
- NCT04855344
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Parkinson's Disease (PD)
Untreated Parkinson's Disease Work-up Assessing Resident Microbiota and Duodenal Barrier Function
The UPWARD study is a prospective hypothesis-generating study in individuals with untreated Parkinson's disease (PD) and age-matched healthy controls (HCs).
- Trial name
- UPWARD (NCT07418658)
- Testing
- Invasive sampling procedures, Non-invasive sampling procedures
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven