Clinical trials: Microbiome Analysis
Cow Milk Allergy, Food Allergy
Detection of Metabolite Biomarkers for the Early Diagnosis and Prognosis of Cow's Milk Allergy in Children
In this study, fecal and urine samples will be collected from children diagnosed with : IgE mediated cow's milk allergy, suspected of a cow's milk allergy, but with negative diagnosis IgE mediated food allergy other than cow's…
- Trial name
- NCT04249973
- Testing
- Collection of urine and feces
- Where
- 8 sites in Belgium
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University Ghent
Healthy
Comparison of Different Methods for the Analysis of Gut Microbiome Composition
The human gastrointestinal tract shelters a complex and dynamic population of microorganisms, the gut microbiota, which plays an important role in immune and metabolic homeostasis.
- Trial name
- COLLECT (NCT04082221)
- Testing
- no intervention
- Where
- Germany
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Amyloidosis, Hereditary, Transthyretin-Related, Microbial Colonization
Analysis of the Instestinal Microbiome of Patients With Transthyretin Amyloidosis
Amyloidosis is a serious systemic disease. Cardiac involvement has a great impact on prognosis and can occur in its three main forms: acquired monoclonal light chain, hereditary transthyretinal and senile form.
- Trial name
- AMIAT (NCT05196594)
- Testing
- collection of stools for genetic analysis
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Laparoscopic Cholecystectomy
Analysis of the Impact of Cholecystectomy on Gut Microbiome in Adults
Laparoscopic cholecystectomy (LC) is widely used in the gallbladder stone, gallbladder polyp, gallbladder cancer and other diseases.
- Trial name
- NCT03836170
- Testing
- Laparoscopic cholecystectomy
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Oral Microbiome, Sampling Methods
16SRDNA Sequencing of 30 Samples of Human Oral Microbial Samples by Tianjin Medical University
Study Objective: To explore suitable sampling sites and methods for oral epidemiological surveys in large populations, we aim to compare the distribution of the oral core microbiome at different sites and using different sampling…
- Conditions
- Oral Microbiome, Sampling Methods, Epidemiological Studies
- Trial name
- NCT06522841
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University
Sepsis, Septic Shock
Sepsis ICU Gut Microbiome Analysis
Sepsis is a life-threatening condition in which the body's response to an infection damages its own organs. This study aims to understand how the bacteria living in the gut change during sepsis and whether patterns of gut…
- Trial name
- SIGMA (NCT07864818)
- Testing
- Naturally Occurring Exposures
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Lupus Erythematosus, Systemic, Gastrointestinal Microbiome
Assessment of Cognitive Function and Gut Microbiota Analysis in Real World Patients With Lupus Cerebrovascular Disease
Based on clinical manifestations, laboratory data and intestinal microflora detection, the cognitive function characteristics of patients with systemic lupus erythematosus and cerebrovascular disease and its relationship with…
- Trial name
- NCT05636670
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Ankylosing Spondylitis
Multi-omics Database for Integrative Microbiome Analysis in a Cohort of Korean Patients With Ankylosing Spondylitis
Multicenter Human Derivatives Prospective Cohort Study: Clinical information will be collected from patients with ankylosing spondylitis and their families who have provided research consent.
- Trial name
- NCT06076083
- Where
- 2 sites in South Korea
- Volunteers
- 600 people
- Sponsor
- Tae-Hwan Kim
Autism Spectrum Disorder
Autism Clinical Risk Factors Investigation With Microbiome and Metabolome Profiling
The role of gut microbiome was recently raised in the pathogenesis of neurodevelopmental disorders including autism spectrum disorder (ASD).
- Trial name
- NCT05849233
- Testing
- no intervention
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- October University for Modern Sciences and Arts
Non Small Cell Lung Cancer Stage III, Immunotherapy
Response and Toxicity Prediction by Microbiome Analysis After (Concurrent) Chemoradiotherapy
The predictive value of the microbiome (throat swabs, stool and of bronchial samples) to identify patients who will relapse during durvalumab treatment after CRT (False negative Rate) at 6 months.
- Trial name
- Prediction (NCT04711330)
- Where
- 6 sites in Belgium, Netherlands
- Volunteers
- 126 people
- Sponsor
- Leiden University Medical Center
Hyperlipidemia
Ezetimibe and Orlistat Affect the Intestinal Flora of Hyperlipidemia.
At present,the prevalence of hyperlipidemia in Chinese adults is 40.40%,which is related to atherosclerotic cardiovascular disease and diabetes independent risk factors,while increasing the risk of cancer.Lipid metabolism affects…
- Trial name
- NCT03884127
- Testing
- Ezetimibe 10mg, Orlistat 120 MG
- Volunteers
- 58 people
- Sponsor
- Fifth Affiliated Hospital of Xinjiang Medical University
Hailey-Hailey Disease
Skin Microbiome Profile in Hailey-Hailey Disease
"Hailey-Hailey disease is an autosomal dominant disorder caused by a genetic defect in a calcium ATPase (ATP2C1) leading to a defect in keratinocyte adhesion.
- Trial name
- NCT05007223
- Testing
- Doxycycline
- Where
- South Korea
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Gangnam Severance Hospital
Solid Tumor
Prospective Analysis of Intestinal Microbiome and Autoimmune Panels as Predictors of Toxicity in ImmunOncology Patients
This is a single-center, investigator-initiated, non-interventional study evaluating the role of the intestinal microbiome and autoimmune panels as a predictor for developing ≥ Grade 2 CTCAE v5.0 immune-related adverse event…
- Trial name
- INSPECT-IO (NCT04107311)
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University Health Network, Toronto
Glucose Metabolism Disorders, Health Behavior
Relationship Between Individual Effect of Diet on Postprandial Glycemia and Gut Microbiome Profile in Healthy Subjects
When all the food we eat is digested, it will increase blood glucose. Two people can have different glucose blood levels to the same food and one reason can be bacteria live in our gut.
- Conditions
- Glucose Metabolism Disorders, Health Behavior, Diabetes, Metabolic Disease
- Trial name
- NCT06051318
- Testing
- Standardized breakfast A, Standardized breakfast B
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- BiomeHub Biotechnology Company
Prostate Cancer
Microbiome Molecular Charaterisation
Preclinical models of prostate cancer have proved to be poorly predictive of the behaviour of the disease in patients. This protocol describes the acquisition of prostate cancer tissue or cells from patients with treatment…
- Trial name
- MMC (NCT06423976)
- Testing
- Sequencing study
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Institute of Cancer Research, United Kingdom
Lung Transplant Infection, Lung Transplant Rejection
Clinical Significance of Community-acquired Respiratory Virus Infection and Longitudinal Analysis of the Lung Microbiome in Lung Transplantation
The purpose of this study is to evaluate the clinical significance of community-acquired respiratory virus (CARV) infection in patients with lung transplantation;Explore the lung microbiome dynamics within one year after lung…
- Trial name
- NCT03545919
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Capital Medical University
Bronchopulmonary Dysplasia
The Role of Volatile Organic Compounds (VOCs), Airway Mucins and the Microbiome in the Early Prediction of Bronchopulmonary Dysplasia (BPD)
Bronchopulmonary dysplasia (BPD), the most common respiratory complication of extremely preterm birth, significantly impacts healthcare with high morbidity and mortality rates.
- Trial name
- INFANCY (NCT06342752)
- Testing
- Breath test, Throat swabs, Placental samples
- Where
- Belgium
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Food Allergy
Pectin Intervention Study and Long-term Follow-up in Lipid Transfer Proteins Allergic Patients
Pectins are dietary fibers that have shown a health effect on patients with food allergy, as they are capable of modifying the composition of gastrointestinal microbiota, and producing an immunomodulatory effect.
- Trial name
- PI23/00820 (NCT06558526)
- Testing
- Apple pectin (DE 57%)
- Where
- Spain
- Volunteers
- 62 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Acute Respiratory Distress Syndrome (ARDS), Microbiome Dysbiosis
Multi-Omics Integrative Analysis of Serum and Sputum to Uncover Key Determinants of Prognosis in Patients With ARDS
This study is a prospective observational investigation designed to systematically characterize key microbial signatures, metabolite profiles, and gene-expression features in serum and sputum from patients with acute respiratory…
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Microbiome Dysbiosis, Multiomics Analysis, Metabolomics
- Trial name
- NCT07380997
- Volunteers
- 411 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Sarcopenia in Elderly, Sarcopenia
Effect of the Consumption of Cookies Enriched With Plant Proteins and of a Vitamin D Supplement on the Progression of Sarcopenia in the Elderly
The ageing population makes it necessary to find effective strategies for the prevention of sarcopenia (the progressive loss of muscle mass and strength and a decline in physical performance) that can be counteracted with foods…
- Conditions
- Sarcopenia in Elderly, Sarcopenia, Nutritional Intervention, Microbiome Analysis
- Trial name
- SARC-PEA (NCT07356440)
- Testing
- Vitamin D3 supplement, Protein-enriched biscuits, Control biscuit
- Where
- 3 sites in Italy
- Volunteers
- 74 people
- Sponsor
- University of Udine