Clinical trials: Methylation
Epithelial Ovarian Cancer, DNA Methylation
Cell-free DNA Methylation for Epithelial Ovarian Cancer
Liquid biopsy is challenging for the diagnosis of epithelial ovarian cancer (EOC). In this study, we performed the methylation testing of host DNA, namely, OPCML, FODX3 and CDH13, in the peripheral serum to discover the…
- Conditions
- Epithelial Ovarian Cancer, DNA Methylation, Benign Ovarian Tumor, Training Set
- Trial name
- NCT04651946
- Testing
- DNA methylation testing
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Lei Li
Cervical Cancer, Cervical Intraepithelial Neoplasia
DNA Methylation Testing for the Screening of Uterine Cervical Lesion
In our published work, host DNA methylation testing has been proved to be sensitive and specific to cervical intraepithelial neoplasia (CIN) 2 or more severe lesions (CIN2+).
- Conditions
- Cervical Cancer, Cervical Intraepithelial Neoplasia, DNA Methylation, High-risk Human Papillomavirus
- Trial name
- NCT04646954
- Testing
- Host DNA methylation testing, Cervical cytology and/or high-risk human papillomavirus assays
- Where
- China
- Volunteers
- 12,000 people
- Sponsor
- Lei Li
Cholangiocarcinoma, Biliary Stricture
DNA Methylation Biomarker for Diagnosis of Cholangiocarcinoma in Patients With Bile Duct Stricture
DNA methylation biomarker for diagnosis of cholangiocarcinoma in patients with bile duct stricture has high sensitivity and specificity compared with cytology from the brush specimens
- Conditions
- Cholangiocarcinoma, Biliary Stricture, DNA Methylation, Brush Cytology
- Trial name
- DNA (NCT04568512)
- Testing
- Control, Cholangiocarcinoma
- Where
- Thailand
- Volunteers
- 67 people
- Sponsor
- Mahidol University
Gastrointestinal Microbiome, DNA Methylation
Analysis of Intestinal Microflora Combined With DNA Methylation in Stool to Detect Colorectal Cancer
Introduction: Colorectal cancer (CRC) has the third highest incidence rate and the fourth mortality rate in the world. Traditional colonoscopy as an invasive examination method cannot be widely used in screening for colorectal…
- Conditions
- Gastrointestinal Microbiome, DNA Methylation, Colorectal Neoplasms
- Trial name
- IMMDC (NCT04302363)
- Testing
- Fecal microbiota detection and exfoliated cell gene detection
- Where
- China
- Volunteers
- 500 people
- Sponsor
- WEIDONG LIU，MD
Methylation, Body Composition
Diet and Nutrition Pilot Study for Chinese Adolescents and Their Mothers
Background: Researchers want to collect information on diet, physical activity, and sun exposure in children and young adults. The data can provide information on the effect these factors might have on the development of cancer…
- Conditions
- Methylation, Body Composition, Physical Activity, Puberty
- Trial name
- NCT01517139
- Where
- China
- Volunteers
- 278 people
- Sponsor
- National Cancer Institute (NCI)
DNA Methylation, Uterine Cervical Cancer
DNA Methylation for Screening Uterine Cervical Lesions
The primary objective of this study is to compare the testing of DNA methylation, high-risk HPV subtypes, and cytology with the definite histological results for uterine cervical lesions in a prospective cohort study.
- Conditions
- DNA Methylation, Uterine Cervical Cancer, High Grade Squamous Intraepithelial Lesions, Low Grade Squamous Intraepithelial Lesions
- Trial name
- NCT03960879
- Testing
- DNA methylation, High-risk HPV, TCT
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Lei Li
DNA Methylation, Uterine Cervical Cancer
DNA Methylation for Screening Uterine Cervical Lesions: A Case-control Study
The primary objective of this study is to compare the testing of DNA methylation, high-risk HPV subtypes, and cytology with the definite histological results in a case-control study, so as to determine the accuracy of DNA…
- Conditions
- DNA Methylation, Uterine Cervical Cancer, High Grade Squamous Intraepithelial Lesions, Low Grade Squamous Intraepithelial Lesions
- Trial name
- NCT03961191
- Testing
- DNA methylation, high-risk HPV, TCT
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Lei Li
Crohn Disease, Methylation
Comprehensive DNA Methylation Profiling in Crohn's Disease
Previous studies have indicated that abnormal DNA methylation frequently occurs in the mucosa in Crohn's disease. Comprehensive DNA methylation profiling of the inflamed and non-inflamed ileal mucosa of patients with Crohn's…
- Conditions
- Crohn Disease, Methylation, Illumina Human Methylation 850k BeadChip
- Trial name
- NCT03272152
- Testing
- Genome-wide DNA methylation
- Where
- China
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Jinling Hospital, China
DNA Methylation
DNA Methylation and 1-C Metabolism Nutrient Intake
The present study used a sub-sample of the Melbourne Collaborative Cohort Study (MCCS) (Milne RL et al, Int J Epidemiol, 2017), who had valid data on dietary intakes (121-item food frequency questionnaire) and valid measures of…
- Trial name
- NCT03227003
- Volunteers
- 5,983 people, healthy volunteers welcome
- Sponsor
- Cancer Council Victoria
Colorectal Neoplasms, Aberrant DNA Methylation
Diagnostic Potential of Hypermethylated DNA in Colorectal Cancer
Colorectal cancer (CRC) is one of the most common forms of cancer and the second leading cause of cancer-related deaths in the western world.
- Trial name
- NCT02928120
- Where
- Denmark
- Volunteers
- 658 people, healthy volunteers welcome
- Sponsor
- Ole Thorlacius-Ussing, MD, DMSc, Professor of Surgery
Aberrant DNA Methylation
Methyl-Donors and EpiGenetics in The Gambia
Accumulating evidence suggests that early-life nutrition can affect metabolism and thus increase the risk of disease in adulthood (e.g. type II diabetes and obesity).
- Trial name
- MDEG (NCT01811641)
- Testing
- season, dietary intake
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Medical Research Council
BDNF, DNA Methylation, Suicide, Drug Responses.
Epigenetic Regulation of BDNF in Schizophrenia
In this proposal, we will (1) detect the associations between BDNF and Trk B gene DNA methylation, histone modification, psychotic symptoms, obesity, suicide and antipsychotic drug responses in Taiwanese patients (2) discuss the…
- Trial name
- NCT01021449
- Where
- Taiwan
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital