Clinical trials: Methylation
Pulmonary Nodule, Solitary, Whole-genome Methylation Sequencing
Benign/Malignant Pulmonary Nodule Classification Based on High-throughput Whole-genome Methylation Sequencing(GM-seq)
Lung cancer is the first cancer in China in terms of morbidity and mortality. The problem of early diagnosis/treatment has always been concerned.
- Trial name
- NCT05415670
- Testing
- Whole-genome Methylation Sequencing(GM-seq)
- Where
- 2 sites in China
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Geneplus-Beijing Co. Ltd.
Lung Cancer, Small Cell Lung Cancer
A Multicenter Clinical Trial of Sputum DNA Testing for Lung Cancer in China
The primary objective of this study is to assess the safety and effectiveness of Human Multigene Methylation Detection Kit (Fluorescent PCR Method) for help diagnose lung cancer by comparing with clinical standard method…
- Conditions
- Lung Cancer, Small Cell Lung Cancer, Non-Small Cell Lung Cancer, Squamous Cell Carcinoma
- Trial name
- NCT05337163
- Testing
- Diagnostic Test: Sputum DNA methylation analysis, chest CT or pathological examination
- Where
- China
- Volunteers
- 1,564 people, healthy volunteers welcome
- Sponsor
- Creative Biosciences (Guangzhou) Co., Ltd.
Colorectal Cancer, Colorectal Neoplasms
Longitudinal Performance of Epi proColon
This study will evaluate longitudinal performance of Epi proColon with respect to test positivity, longitudinal adherence to Epi proColon screening, adherence to follow-up colonoscopy and diagnostic yield, as well as assay…
- Trial name
- PERT (NCT03218423)
- Testing
- Epi proColon
- Where
- 6 sites in United States
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- Epigenomics, Inc
Lung Cancer, Lung Cancer, Nonsmall Cell
Lung Cancer Screening Using DNA Methylation Changes in Circulated Tumor and PBMC DNA
A central challenge in the fight against lung cancers is how to detect disease in a noninvasive manner before it is detectable by imaging methods.
- Conditions
- Lung Cancer, Lung Cancer, Nonsmall Cell, Lung Cancer, Small Cell
- Trial name
- NCT03499678
- Where
- Kazakhstan
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- HKGepitherapeutics
Colo-rectal Cancer
Plasma-based Colorectal Cancer Screening Research & Development
The objective of this Clinical Sample Collection Study is to develop a biobank of appropriately collected plasma samples from colorectal cancer patients (i.e.
- Trial name
- NCT04027790
- Testing
- Epi proColon
- Where
- 5 sites in United States
- Volunteers
- 354 people, healthy volunteers welcome
- Sponsor
- Epigenomics, Inc
Colorectal Cancer
Clinical Validation of ColonAiQ (a Blood-based Assay Targeting ctDNA Methylation) for Colorectal Cancer Detection
The DNA methylation targets in preoperative plasma samples of the subjects will be detected by the multi-gene methylation test (ColonAiQ), and the test accuracy will be evaluated by compared with the clinical diagnosis evidence.
- Trial name
- NCT06347887
- Testing
- ColonAiQ test and Colonoscopy
- Where
- 7 sites in China
- Volunteers
- 1,965 people, healthy volunteers welcome
- Sponsor
- Singlera Genomics Inc.
Cancer
a PROspective Case Control Study to Develop and Validate a Blood Test FOr mUlti-caNcers Early Detection（PROFOUND）
This study is a multi-center, case-control study aiming at developing and blinded testing machine learning-based multiple cancers early detection model by prospectively collecting blood samples from newly diagnosed cancer…
- Trial name
- PROFOUND (NCT06217900)
- Where
- 8 sites in China
- Volunteers
- 16,666 people, healthy volunteers welcome
- Sponsor
- Shanghai Weihe Medical Laboratory Co., Ltd.
Colorectal Cancer (CRC)
Colon Cancer Liquid Biopsy Investigation of Methylation-based Biomarkers Evaluation Using Delta-HLD (CLIMBED)
CLIMBED (Colon cancer Liquid biopsy Investigation of Methylation-based Biomarkers Evaluation using Delta-HLD) is a non-randomized, observational, cross-sectional clinical validation study designed to assess the performance of…
- Trial name
- CLIMBED (NCT07168876)
- Where
- Argentina
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- Epiliquid Holding, Inc
Mild Cognitive Impairment, Metabolic Syndrome
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation
The study explores whether selective memory complaints (SMC), mild cognitive impairment (MCI) and the comorbidity of Metabolic Syndrome symptomatic of peripheral and cerebral hypo-metabolism with corresponding epigenetic shifts…
- Trial name
- NCT03319173
- Testing
- Dietary intervention
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Bristlecone Health, Inc.
Cancer, Solid Tumor
Characterization of Methylation Patterns in Cancer and Non-Cancer cfDNA
Nucleix EpiCheck® tests analyzes the methylation pattern in a panel of DNA methylation biomarkers and determines whether this pattern is consistent with cancer under test or with non-cancer tissue.
- Conditions
- Cancer, Solid Tumor, Hematologic Neoplasms
- Trial name
- NCT04264767
- Testing
- Blood collection
- Where
- 3 sites in United States, Israel
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Nucleix Ltd.
Colorectal Cancer
A Community Population Screening Cohort Study Based on Polygene Methylation Detection for Colorectal Cancer in Yangzhou
This is a cross-sectional cohort study based on community population jointly developed by Northern Jiangsu People's Hospital and Shanghai Kunyuan Biological Technology Co., LTD.
- Trial name
- NCT05336539
- Where
- 2 sites in China
- Volunteers
- 80,000 people, healthy volunteers welcome
- Sponsor
- Singlera Genomics Inc.
Colorectal Cancer, Polyps
Clinical Validation of Stool DNA-based SDC2 Methylation Test for Colorectal Cancer Detection
Pivotal trials of SDC2 methylation biomarker test in stool DNA to estimate clinical sensitivity and specificity in detection of colorectal cancer.
- Conditions
- Colorectal Cancer, Polyps, Other Cancers, Healthy
- Trial name
- NCT03146520
- Testing
- EarlyTect Colon Cancer
- Where
- South Korea
- Volunteers
- 634 people, healthy volunteers welcome
- Sponsor
- Genomictree, Inc.
Breast Cancer, Breast Cancer Female
Detection of Breast Cancer With Non-invasive Method Based on DNA Methylation of Circulated Tumor DNA, PBMC
A central challenge in the fight against breast cancer is how to detect disease in a noninvasive manner before it is detectable by imaging methods.
- Trial name
- NCT03480659
- Where
- Kazakhstan
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- HKGepitherapeutics
Lung Cancer, Colorectal Cancer
ProSight: A Multi-centre Interventional Study Evaluating MCED in Asymptomatic Population
This is a prospective, multi-centre interventional study evaluating the feasibility of blood-based multi-cancer early detection test in asymptomatic screening cohort.
- Conditions
- Lung Cancer, Colorectal Cancer, Liver Cancer, Grastic Cancer
- Trial name
- NCT06790355
- Testing
- multi-cancer early detection
- Where
- 4 sites in China
- Volunteers
- 2,527 people, healthy volunteers welcome
- Sponsor
- Shanghai Weihe Medical Laboratory Co., Ltd.
Bladder Cancer, Urocystitis
A Multicenter Clinical Trial of Urine DNA Testing for Bladder Cancer in China
The primary objective of this study is to assess the safety and effectiveness of Human Multigene Methylation Detection Kit (Fluorescent PCR Method) for help diagnose bladder cancer by comparing with clinical standard method…
- Conditions
- Bladder Cancer, Urocystitis, Urinary Bladder Stone, Urothelial Carcinoma
- Trial name
- NCT05337189
- Testing
- Urine DNA methylation analysis, medical imaging and/or cystoscopy and/or pathological examination
- Where
- China
- Volunteers
- 482 people, healthy volunteers welcome
- Sponsor
- Creative Biosciences (Guangzhou) Co., Ltd.
Stomach Cancer
Development of Free DNA Multi-target Methylated PCR for Auxiliary Diagnosis of Gastric Cancer
This was a case control, non-intervention study jointly developed by Fudan University Cancer Hospital and Shanghai Singlera Genomics Company.
- Trial name
- NCT05336058
- Testing
- No intervention
- Where
- China
- Volunteers
- 1,140 people, healthy volunteers welcome
- Sponsor
- Singlera Genomics Inc.
Healthy
Effects of Fenofibrate on Gene Expression in Healthy Volunteers
The purpose of this study is to assess how fenofibrate modify gene expression in circulating monocytes of healthy volunteers after 6 weeks.
- Trial name
- NCT01109758
- Testing
- Fenofibrate
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Solvay Pharmaceuticals
Colorectal Cancer
A Prospective Cohort Study on Colorectal Cancer Screening in Community Population
This study will validate the real world results of polygene methylation detection in colorectal cancer in a large prospective community cohort.
- Trial name
- NCT05485077
- Where
- China
- Volunteers
- 18,000 people, healthy volunteers welcome
- Sponsor
- Singlera Genomics Inc.
Colorectal Cancer
PRESEPT Study: Evaluation of SEPT9 Biomarker Performance for Colorectal Cancer Screening
The purpose of this study is to collect blood specimens and clinical data from screening guideline eligible individuals designated by their physician to receive a screening colonoscopy, and to evaluate the performance of a…
- Trial name
- PRESEPT (NCT00855348)
- Testing
- All eligible subjects will provide blood for SEPT9 biomarker testing
- Where
- 23 sites in United States, Germany
- Volunteers
- 7,929 people, healthy volunteers welcome
- Sponsor
- Epigenomics, Inc
Aging
Targeting the Nine Hallmarks of Aging on DNA Methylation
SRW Laboratories has formulated the Cel System protocol, a group of three formulas designed to interact with each of the 9 Hallmarks of Aging and combined this with an App that supports positive lifestyle changes, with a view…
- Trial name
- NCT05535608
- Testing
- SRW Cel System
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- TruDiagnostic