Clinical trials: Methodology Study
Massive Rotator Cuff Tears, Shoulder Disease
Effectiveness of Treatments for Massive Rotator Cuff Tears: Mixed Methodology.
The purpose of this study is: 1) to identify relevant treatment outcomes for people with massive rotator cuff tears of the shoulder joint, according to the experience of the affected people, to facilitate treatment shared…
- Trial name
- NCT05780229
- Testing
- Conservative treatment, Arthroscopic Decompression Surgery, Reverse Prosthesis
- Where
- 6 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Parc de Salut Mar
Healthy Subjects
A Study to Evaluate the Pharmacodynamic Effects of Single Oral Doses of PF-06648671 on β-Amyloid (Aβ) Concentrations in Cerebrospinal Fluid (CSF)
This is phase 1 investigator-and-subject blind, sponsor open, randomized, placebo controlled, parallel study in healthy subjects to evaluate the pharmacodynamics effect of single oral doses of PF-06648671 on CSF Aβ concentrations…
- Trial name
- NCT02407353
- Testing
- PF-06648671
- Where
- 2 sites in United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy
Study In Healthy Subjects To Evaluate The Changes In The Protein sAPP-Alpha In Cerebrospinal Fluid Following A Single Oral Dose Of PF-04995274
The primary purpose of the study is to evaluate the effect of PF-04995274 on cerebrospinal fluid levels of soluble Amyloid precursor protein fragments and Amyloid beta fragments following single oral dose in healthy volunteers.
- Trial name
- NCT01193062
- Testing
- PF-04995274
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pfizer
Ovarian Cancer, Recurrent Ovarian Cancer
HERCULES: Ultrasound-Based Liver Involvement Classification in Ovarian Cancer
This monocentric observational pilot study aims to assess the feasibility of a standardized two-dimensional ultrasound (2D US) approach for the preoperative assessment and anatomo-surgical classification of liver-area involvement…
- Trial name
- HERCULES (NCT07808320)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Dengue
Investigating and Modelling the Natural History of Dengue in Hospitalised Patients to Improve Future Research
The goal of this observational study is to investigate the natural history of dengue in hospitalised patients in Vietnam, to better understand the disease process, and utilise the data to improve future clinical trials.
- Trial name
- DENEM (NCT07799168)
- Where
- Vietnam
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
Atrial Arrhythmia
ACORYS AI4AF PILOT STUDY
This is a Pilot Observational Study designed to record atrial electrophysiological activity in patients with atrial arrhythmias using non-invasive mapping technology.
- Trial name
- NCT07904377
- Testing
- Acorys Mapping System
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Mayo Clinic
Static Spinal Disorder
Interest of Walking Sticks to Increase Walking Activity of People With Sagittal Imbalance of Spine
The purpose of this pilot study is to assess the impact of using walking sticks on walking perimeter in people with anterior spinal imbalance.
- Trial name
- WALKSPINE (NCT07127250)
- Testing
- Walking sticks
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Type 2 Diabetes
"Information Technology Methodology for Patient Motivation in Diabetes Management."
Type 2 diabetes is a chronic metabolic disorder requiring lifestyle modification and medicines, adherence to which has to be practised on a daily basis.
- Trial name
- NCT00727896
- Testing
- Pre-coded messages, Diabetes Treatment
- Where
- India
- Volunteers
- 200 people
- Sponsor
- India Diabetes Research Foundation & Dr. A. Ramachandran's Diabetes Hospitals
Healthy Subjects, Chronic Liver Disease
¹³C-Methacetin Breath Test (MBT) Methodology Study
Several factors will be tested to see if they have an influence on the methacetin breath test results. Each one of the factors has been raised as a possible source of distortion of the MBT result. I.
- Conditions
- Healthy Subjects, Chronic Liver Disease, Cirrhosis
- Trial name
- NCT01205074
- Testing
- 13C Methacetin Breath Test, Grape fruit juice, Non selective beta blocker - Propranolol
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Cough, Wheezing
A Methodology Trial Using the VR647 Inhalation System in Pediatric Subjects Who Have Previously Received Inhaled Therapy
This is an open-label, non-drug methodology trial in which subjects undergo a stepwise series of tests to evaluate their ability to use a mouthpiece to deliver nebulized therapy.
- Trial name
- NCT04011709
- Testing
- VR647 Inhalation System + VR647 Smart Card 3 Secs, VR647 Inhalation System + VR647 Smart Card 2 Secs, VR647 Inhalation System + VR647 Smart Card 4 Secs
- Where
- 5 sites in United States
- Volunteers
- 41 people
- Sponsor
- Vectura Limited
Medical Education
Comparison of Learning in Traditional Versus "Flipped" Classrooms
This is an educational research study to compare knowledge retention of neonatal-perinatal medicine (NPM) fellowship trainees instructed on a subsection of the American Board of Pediatrics (ABP) NPM Content Outline using…
- Trial name
- NCT03758391
- Testing
- Flipped Classroom education
- Where
- United States
- Volunteers
- 538 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Stillbirth
Saving Babies' Lives Project Impact and Results Evaluation: a Mixed Methodology Study
The study is a multicentre evaluation of maternity care delivered through the Saving Babies' Lives care bundle using both quantitative and qualitative methodologies.
- Trial name
- SPiRE (NCT03231007)
- Testing
- Questionnaire
- Where
- 20 sites in United Kingdom
- Volunteers
- 4,952 people
- Sponsor
- University of Manchester
Fibromyalgia
Effectiveness of an Intervention Based on Arts In Health in the Quality of Life of People With Fibromyalgia.
The aim of this intervention is to measure the impact of a 12-session intervention with Arts in Health methodology on the quality of life of the population with fibromyalgia.
- Trial name
- NCT05993663
- Testing
- Arts in health group intervention
- Where
- Spain
- Volunteers
- 121 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Alzheimer's Disease, Dementia
Effect of Aricept on Biomarkers (Acetylcholine, sAPP Alpha) In Cerebrospinal Fluid
It is hypothesized that the acetylcholinesterase inhibitor, donepezil, will increase acute cerebrospinal fluid (CSF) actylcholine levels in healthy volunteers following a 5mg single dose oral administration.
- Trial name
- NCT00987220
- Testing
- donepezil (Aricept)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Fibromyalgia
A Study to Compare Two Ways of Completing Pain and Sleep Questions and to Evaluate a New Daily Questionaire for Assessing Fatigue in Fibromyalgia Patients
The study has two goals. The first goal of the study is to compare two methods of administering questions about pain and sleep interference.
- Trial name
- NCT00819624
- Testing
- Interactive Voice Response System (IVRS), Personal Digital Assisstant (PDA)
- Where
- 15 sites in United States
- Volunteers
- 185 people
- Sponsor
- Pfizer
Myofascial Pain Syndrome
Delphi Study on Myofascial Pain Syndrome Challenges in Turkey: Patient Journey, Burden, Diagnosis & Treatment Needs.
Myofascial pain syndrome is a chronic pain disorder that affects many people in Turkey. This research study aims to explore the challenges faced by patients with myofascial pain syndrome in Turkey, including the disease burden…
- Trial name
- NCT05854446
- Testing
- Survey
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Uskudar State Hospital
The Methodology Assessment of Glucose Dependent Insulin Secretion
A Study to Compare Methodologies for Assessing Glucose-Dependent Insulin Secretion (0000-104)(COMPLETED)
This study will compare graded glucose infusion (GGI) to the hyperglycemic clamp (HGC) for assessment of glucose-dependent insulin secretion (GDIS) using exenatide as a probe.
- Trial name
- NCT00782418
- Testing
- Comparator: exenatide
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Osteoarthritis Thumbs
A Study To Assess The Ability Of Tramadol, Naproxen And Oxycodone To Affect The Pain Thresholds Of Patients With Osteoarthritis Of The Thumb
The purpose of this study is to determine if the measurement of pressure pain thresholds, in patients suffering osteoarthritis of the thumb, can be used to assess the activity of potential analgesic agents after a single dose.
- Trial name
- NCT00743587
- Testing
- Oxycodone, Tramadol, Naproxen
- Where
- Belgium
- Volunteers
- 36 people
- Sponsor
- Pfizer
Long-term Care Centres for Old Adults Users, Relatives of Long-term Care Centres for Old Adults Users
Validation of a Life Stories Methodologies in Long-Term Care Centres
The objective of the research is to validate a methodology for implementing narrative care, through the incorporation of people's biographies and life stories, in interventions in long-term care centres for older adults.
- Conditions
- Long-term Care Centres for Old Adults Users, Relatives of Long-term Care Centres for Old Adults Users, Long-term Care Centres for Old Adults Professionals
- Trial name
- NCT06569628
- Testing
- Envita Stories Methodology in Long-term care Centres for old adults, Contact Methodology in Long-term Care Centres for old adults
- Where
- 2 sites in Spain
- Volunteers
- 378 people
- Sponsor
- Envita Digital Solutions S.L.
Arthritis, Rheumatoid
Lipopolysaccharide (LPS) or Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Challenge Study on Healthy Subjects
This exploratory study aims to assess exposure of healthy subjects to systemic challenge with either LPS or GM-CSF. This will be done by measuring inflammatory mediators and cellular activation markers both in circulation and in…
- Trial name
- NCT03306589
- Testing
- Cantharidin, Lipopolysaccharide, Granulocyte-Macrophage Colony-Stimulating Factor
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline